Economic Evaluation of anti-epileptic Medicines for Autistic Children with Epilepsy / Aine RODDY ; Martin KNAPP ; Celso ARANGO ; M. Andreina MENDEZ ; James CUSACK ; Declan G.M. MURPHY ; Roberto CANITANO ; Bethany OAKLEY ; Vinciane QUOIDBACH in Journal of Autism and Developmental Disorders, 54-7 (July 2024)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 54-7 (July 2024) . - p.2733-2741 Titre : Economic Evaluation of anti-epileptic Medicines for Autistic Children with Epilepsy Type de document : texte imprimé Auteurs : Aine RODDY, Auteur ; Martin KNAPP, Auteur ; Celso ARANGO, Auteur ; M. Andreina MENDEZ, Auteur ; James CUSACK, Auteur ; Declan G.M. MURPHY, Auteur ; Roberto CANITANO, Auteur ; Bethany OAKLEY, Auteur ; Vinciane QUOIDBACH, Auteur Article en page(s) : p.2733-2741 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : We examine the cost-effectiveness of treating epilepsy with anti-epileptic medicines in autistic children, looking at impacts on healthcare providers (in England, Ireland, Italy and Spain) and children s families (in Ireland). We find carbamazepine to be the most cost-effective drug to try first in children with newly diagnosed focal seizures. For England and Spain, oxcarbazepine is the most cost-effective treatment when taken as additional treatment for those children whose response to monotherapy is suboptimal. In Ireland and Italy, gabapentin is the most cost-effective option. Our additional scenario analysis presents the aggregate cost to families with autistic children who are being treated for epilepsy: this cost is considerably higher than healthcare provider expenditure. En ligne : https://doi.org/10.1007/s10803-023-05941-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Economic Evaluation of anti-epileptic Medicines for Autistic Children with Epilepsy [texte imprimé] / Aine RODDY, Auteur ; Martin KNAPP, Auteur ; Celso ARANGO, Auteur ; M. Andreina MENDEZ, Auteur ; James CUSACK, Auteur ; Declan G.M. MURPHY, Auteur ; Roberto CANITANO, Auteur ; Bethany OAKLEY, Auteur ; Vinciane QUOIDBACH, Auteur . - p.2733-2741. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 54-7 (July 2024) . - p.2733-2741 Index. décimale : PER Périodiques Résumé : We examine the cost-effectiveness of treating epilepsy with anti-epileptic medicines in autistic children, looking at impacts on healthcare providers (in England, Ireland, Italy and Spain) and children s families (in Ireland). We find carbamazepine to be the most cost-effective drug to try first in children with newly diagnosed focal seizures. For England and Spain, oxcarbazepine is the most cost-effective treatment when taken as additional treatment for those children whose response to monotherapy is suboptimal. In Ireland and Italy, gabapentin is the most cost-effective option. Our additional scenario analysis presents the aggregate cost to families with autistic children who are being treated for epilepsy: this cost is considerably higher than healthcare provider expenditure. En ligne : https://doi.org/10.1007/s10803-023-05941-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

Facial expression recognition is linked to clinical and neurofunctional differences in autism / Hannah MEYER-LINDENBERG in Molecular Autism, 13 (2022)  

Public ISBD [article]  inMolecular Autism > 13 (2022) . - 43 p. Titre : Facial expression recognition is linked to clinical and neurofunctional differences in autism Type de document : texte imprimé Auteurs : Hannah MEYER-LINDENBERG, Auteur ; Carolin MOESSNANG, Auteur ; Bethany OAKLEY, Auteur ; Jumana AHMAD, Auteur ; Luke MASON, Auteur ; Emily J.H. JONES, Auteur ; Hannah HAYWARD, Auteur ; Jennifer COOKE, Auteur ; Daisy CRAWLEY, Auteur ; Rosemary J. HOLT, Auteur ; Julian TILLMANN, Auteur ; Tony CHARMAN, Auteur ; Simon BARON-COHEN, Auteur ; Tobias BANASCHEWSKI, Auteur ; Christian F. BECKMANN, Auteur ; Heike TOST, Auteur ; Andreas MEYER-LINDENBERG, Auteur ; Jan K. BUITELAAR, Auteur ; Declan G.M. MURPHY, Auteur ; Michael BRAMMER, Auteur ; Eva LOTH, Auteur Article en page(s) : 43 p. Langues : Anglais (eng) Mots-clés : Humans  Facial Recognition  Autistic Disorder/diagnostic imaging  Emotions  Magnetic Resonance Imaging/methods  Biomarkers  Autism Spectrum Disorder  Facial Expression  Autism  Autism spectrum disorder  Clustering analysis  Development  Facial expression recognition  Multi-site  Social brain  Stratification biomarkers  fMRI  consultant to F. Hoffmann-La Roche Ltd. and Servier and has received royalties  from Sage Publications and Guilford Publications. TB served in an advisory or  consultancy role for Lundbeck, Medice, Neurim Pharmaceuticals, Oberberg GmbH,  Takeda, and Infectopharm. He received conference support or speaker’s fee by  Lilly, Medice, and Takeda. He received royalties from Hogrefe, Kohlhammer, CIP  Medien, Oxford University Press  the present work is unrelated to these  relationships. AM-L has received consultant fees in the past two years from  Boehringer Ingelheim, Elsevier, Lundbeck Int. Neuroscience Foundation, Lundbeck  AS, The Wolfson Foundation, Thieme Verlag, Sage Therapeutics, von Behring  Stiftung, Fondation FondaMental, Janssen-Cilag GmbH, MedinCell, Brain Mind  Institute, CISSN. Furthermore, he has received speaker fees from Italian Society  of biological Psychiatry, Merz-Stiftung, Forum Werkstatt Karlsruhe, Lundbeck SAS  France, BAG Psychiatrie Oberbayern. JB has been in the past 3 years a consultant  to/member of advisory board of/and/or speaker for Takeda/Shire, Roche, Medice,  Angelini, Janssen, and Servier. He is not an employee of any of these companies,  and not a stock shareholder of any of these companies. He has no other financial  or material support, including expert testimony, patents, royalties. EL is an  Associate Editor at Molecular Autism. DM has been paid for advisory board work by  F. Hoffmann-La Roche Ltd. and Servier, and for editorial work by Springer. The  other authors declare that they have no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Difficulties in social communication are a defining clinical feature of autism. However, the underlying neurobiological heterogeneity has impeded targeted therapies and requires new approaches to identifying clinically relevant bio-behavioural subgroups. In the largest autism cohort to date, we comprehensively examined difficulties in facial expression recognition, a key process in social communication, as a bio-behavioural stratification biomarker, and validated them against clinical features and neurofunctional responses. METHODS: Between 255 and 488 participants aged 6-30 years with autism, typical development and/or mild intellectual disability completed the Karolinska Directed Emotional Faces task, the Reading the Mind in the Eyes Task and/or the Films Expression Task. We first examined mean-group differences on each test. Then, we used a novel intersection approach that compares two centroid and connectivity-based clustering methods to derive subgroups based on the combined performance across the three tasks. Measures and subgroups were then related to clinical features and neurofunctional differences measured using fMRI during a fearful face-matching task. RESULTS: We found significant mean-group differences on each expression recognition test. However, cluster analyses showed that these were driven by a low-performing autistic subgroup (~ 30% of autistic individuals who performed below 2SDs of the neurotypical mean on at least one test), while a larger subgroup (~ 70%) performed within 1SD on at least 2 tests. The low-performing subgroup also had on average significantly more social communication difficulties and lower activation in the amygdala and fusiform gyrus than the high-performing subgroup. LIMITATIONS: Findings of autism expression recognition subgroups and their characteristics require independent replication. This is currently not possible, as there is no other existing dataset that includes all relevant measures. However, we demonstrated high internal robustness (91.6%) of findings between two clustering methods with fundamentally different assumptions, which is a critical pre-condition for independent replication. CONCLUSIONS: We identified a subgroup of autistic individuals with expression recognition difficulties and showed that this related to clinical and neurobiological characteristics. If replicated, expression recognition may serve as bio-behavioural stratification biomarker and aid in the development of targeted interventions for a subgroup of autistic individuals. En ligne : http://dx.doi.org/10.1186/s13229-022-00520-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 [article] Facial expression recognition is linked to clinical and neurofunctional differences in autism [texte imprimé] / Hannah MEYER-LINDENBERG, Auteur ; Carolin MOESSNANG, Auteur ; Bethany OAKLEY, Auteur ; Jumana AHMAD, Auteur ; Luke MASON, Auteur ; Emily J.H. JONES, Auteur ; Hannah HAYWARD, Auteur ; Jennifer COOKE, Auteur ; Daisy CRAWLEY, Auteur ; Rosemary J. HOLT, Auteur ; Julian TILLMANN, Auteur ; Tony CHARMAN, Auteur ; Simon BARON-COHEN, Auteur ; Tobias BANASCHEWSKI, Auteur ; Christian F. BECKMANN, Auteur ; Heike TOST, Auteur ; Andreas MEYER-LINDENBERG, Auteur ; Jan K. BUITELAAR, Auteur ; Declan G.M. MURPHY, Auteur ; Michael BRAMMER, Auteur ; Eva LOTH, Auteur . - 43 p. Langues : Anglais (eng) in Molecular Autism > 13 (2022) . - 43 p. Mots-clés : Humans  Facial Recognition  Autistic Disorder/diagnostic imaging  Emotions  Magnetic Resonance Imaging/methods  Biomarkers  Autism Spectrum Disorder  Facial Expression  Autism  Autism spectrum disorder  Clustering analysis  Development  Facial expression recognition  Multi-site  Social brain  Stratification biomarkers  fMRI  consultant to F. Hoffmann-La Roche Ltd. and Servier and has received royalties  from Sage Publications and Guilford Publications. TB served in an advisory or  consultancy role for Lundbeck, Medice, Neurim Pharmaceuticals, Oberberg GmbH,  Takeda, and Infectopharm. He received conference support or speaker’s fee by  Lilly, Medice, and Takeda. He received royalties from Hogrefe, Kohlhammer, CIP  Medien, Oxford University Press  the present work is unrelated to these  relationships. AM-L has received consultant fees in the past two years from  Boehringer Ingelheim, Elsevier, Lundbeck Int. Neuroscience Foundation, Lundbeck  AS, The Wolfson Foundation, Thieme Verlag, Sage Therapeutics, von Behring  Stiftung, Fondation FondaMental, Janssen-Cilag GmbH, MedinCell, Brain Mind  Institute, CISSN. Furthermore, he has received speaker fees from Italian Society  of biological Psychiatry, Merz-Stiftung, Forum Werkstatt Karlsruhe, Lundbeck SAS  France, BAG Psychiatrie Oberbayern. JB has been in the past 3 years a consultant  to/member of advisory board of/and/or speaker for Takeda/Shire, Roche, Medice,  Angelini, Janssen, and Servier. He is not an employee of any of these companies,  and not a stock shareholder of any of these companies. He has no other financial  or material support, including expert testimony, patents, royalties. EL is an  Associate Editor at Molecular Autism. DM has been paid for advisory board work by  F. Hoffmann-La Roche Ltd. and Servier, and for editorial work by Springer. The  other authors declare that they have no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Difficulties in social communication are a defining clinical feature of autism. However, the underlying neurobiological heterogeneity has impeded targeted therapies and requires new approaches to identifying clinically relevant bio-behavioural subgroups. In the largest autism cohort to date, we comprehensively examined difficulties in facial expression recognition, a key process in social communication, as a bio-behavioural stratification biomarker, and validated them against clinical features and neurofunctional responses. METHODS: Between 255 and 488 participants aged 6-30 years with autism, typical development and/or mild intellectual disability completed the Karolinska Directed Emotional Faces task, the Reading the Mind in the Eyes Task and/or the Films Expression Task. We first examined mean-group differences on each test. Then, we used a novel intersection approach that compares two centroid and connectivity-based clustering methods to derive subgroups based on the combined performance across the three tasks. Measures and subgroups were then related to clinical features and neurofunctional differences measured using fMRI during a fearful face-matching task. RESULTS: We found significant mean-group differences on each expression recognition test. However, cluster analyses showed that these were driven by a low-performing autistic subgroup (~ 30% of autistic individuals who performed below 2SDs of the neurotypical mean on at least one test), while a larger subgroup (~ 70%) performed within 1SD on at least 2 tests. The low-performing subgroup also had on average significantly more social communication difficulties and lower activation in the amygdala and fusiform gyrus than the high-performing subgroup. LIMITATIONS: Findings of autism expression recognition subgroups and their characteristics require independent replication. This is currently not possible, as there is no other existing dataset that includes all relevant measures. However, we demonstrated high internal robustness (91.6%) of findings between two clustering methods with fundamentally different assumptions, which is a critical pre-condition for independent replication. CONCLUSIONS: We identified a subgroup of autistic individuals with expression recognition difficulties and showed that this related to clinical and neurobiological characteristics. If replicated, expression recognition may serve as bio-behavioural stratification biomarker and aid in the development of targeted interventions for a subgroup of autistic individuals. En ligne : http://dx.doi.org/10.1186/s13229-022-00520-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491

Feasibility Study of a Novel App-Based Anxiety Intervention for Autistic People / Bethany OAKLEY in Autism Research, 19-1 (January 2026)  

Public ISBD [article]  inAutism Research > 19-1 (January 2026) . - p.e70153 Titre : Feasibility Study of a Novel App-Based Anxiety Intervention for Autistic People Type de document : texte imprimé Auteurs : Bethany OAKLEY, Auteur ; Charlotte A. BOATMAN, Auteur ; Saffron BALDOZA, Auteur ; Amy HEARN, Auteur ; Colin LARKWORTHY, Auteur ; Rachel KENT, Auteur ; Ann OZSIVADJIAN, Auteur ; Sophie DOSWELL, Auteur ; Antonia DITTNER, Auteur ; Amanda ROESTORF, Auteur ; Dhara RAWAL, Auteur ; Ben CARTER, Auteur ; Emily SIMONOFF, Auteur ; Group THE MOLEHILL MOUNTAIN ADVISORY, Auteur Article en page(s) : p.e70153 Langues : Anglais (eng) Mots-clés : anxiety  autism  CBT  digital tools  intervention  mental health  mHealth Index. décimale : PER Périodiques Résumé : ABSTRACT At least 50% of autistic people experience clinically relevant anxiety symptoms. However, reasons for elevated rates of anxiety in autism remain poorly understood and there is a high unmet need for novel and adapted therapies for anxiety that are accessible to autistic people. This study aimed to establish the feasibility of a novel app-based anxiety management tool (?Molehill Mountain?) that has been developed with, and adapted for, autistic people. A single-centre, single-arm feasibility study design was employed, whereby autistic people (≥?16?years) with mild-to-severe symptoms of anxiety were recruited to a 13-week intervention period (King's College London, UK; clinicaltrials.gov identifier NCT05302167). Of 123 prospective participants screened, 100 (81%) participants aged 16?74?years (n?=?69 female) were enrolled within approximately 15 months. n?=?76 (76%) completed an anxiety measure at ~15?weeks (Generalized Anxiety Disorder?7 Item Scale; GAD-7). Most adhered to the full intervention duration: 65% (n?=?47), with most using the app weekly (1?6?days per week; 58%). 73% of participants agreed that they found the app easy to use overall and that an app is a good format for offering anxiety support to autistic people. There was a significant reduction in self-reported anxiety symptom severity with mean difference 2.88 (95% CI 1.88, 3.89; p? En ligne : https://doi.org/10.1002/aur.70153 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] Feasibility Study of a Novel App-Based Anxiety Intervention for Autistic People [texte imprimé] / Bethany OAKLEY, Auteur ; Charlotte A. BOATMAN, Auteur ; Saffron BALDOZA, Auteur ; Amy HEARN, Auteur ; Colin LARKWORTHY, Auteur ; Rachel KENT, Auteur ; Ann OZSIVADJIAN, Auteur ; Sophie DOSWELL, Auteur ; Antonia DITTNER, Auteur ; Amanda ROESTORF, Auteur ; Dhara RAWAL, Auteur ; Ben CARTER, Auteur ; Emily SIMONOFF, Auteur ; Group THE MOLEHILL MOUNTAIN ADVISORY, Auteur . - p.e70153. Langues : Anglais (eng) in Autism Research > 19-1 (January 2026) . - p.e70153 Mots-clés : anxiety  autism  CBT  digital tools  intervention  mental health  mHealth Index. décimale : PER Périodiques Résumé : ABSTRACT At least 50% of autistic people experience clinically relevant anxiety symptoms. However, reasons for elevated rates of anxiety in autism remain poorly understood and there is a high unmet need for novel and adapted therapies for anxiety that are accessible to autistic people. This study aimed to establish the feasibility of a novel app-based anxiety management tool (?Molehill Mountain?) that has been developed with, and adapted for, autistic people. A single-centre, single-arm feasibility study design was employed, whereby autistic people (≥?16?years) with mild-to-severe symptoms of anxiety were recruited to a 13-week intervention period (King's College London, UK; clinicaltrials.gov identifier NCT05302167). Of 123 prospective participants screened, 100 (81%) participants aged 16?74?years (n?=?69 female) were enrolled within approximately 15 months. n?=?76 (76%) completed an anxiety measure at ~15?weeks (Generalized Anxiety Disorder?7 Item Scale; GAD-7). Most adhered to the full intervention duration: 65% (n?=?47), with most using the app weekly (1?6?days per week; 58%). 73% of participants agreed that they found the app easy to use overall and that an app is a good format for offering anxiety support to autistic people. There was a significant reduction in self-reported anxiety symptom severity with mean difference 2.88 (95% CI 1.88, 3.89; p? En ligne : https://doi.org/10.1002/aur.70153 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578

How do core autism traits and associated symptoms relate to quality of life? Findings from the Longitudinal European Autism Project / Bethany OAKLEY in Autism, 25-2 (February 2021)  

Public ISBD [article]  inAutism > 25-2 (February 2021) . - p.389-404 Titre : How do core autism traits and associated symptoms relate to quality of life? Findings from the Longitudinal European Autism Project Type de document : texte imprimé Auteurs : Bethany OAKLEY, Auteur ; Julian TILLMANN, Auteur ; Jumana AHMAD, Auteur ; Daisy CRAWLEY, Auteur ; Antonia SAN JOSE CACERES, Auteur ; Rosemary J. HOLT, Auteur ; Tony CHARMAN, Auteur ; Tobias BANASCHEWSKI, Auteur ; Jan K. BUITELAAR, Auteur ; Emily SIMONOFF, Auteur ; Declan G.M. MURPHY, Auteur ; Eva LOTH, Auteur Article en page(s) : p.389-404 Langues : Anglais (eng) Mots-clés : anxiety  autism  depression  quality of life  well-being Index. décimale : PER Périodiques Résumé : Previous studies suggest that some autistic individuals report lower satisfaction, or well-being, with different aspects of everyday life than those without autism. It is unclear whether this might be partly explained by symptoms of anxiety and/or depression, which affect at least 20%-50% of autistic people. In this study, we measured individual differences in well-being in 573 six to thirty-year-olds with and without a diagnosis of autism. We investigated whether individual differences in well-being were explained by autism traits (e.g. social-communication difficulties) and/or anxiety and depression symptoms. We showed that, though well-being was lower for some autistic individuals, compared to those without autism, many autistic individuals reported good well-being. Where well-being was reduced, this was particularly explained by depression symptoms, across all ages. For children/adolescents, anxiety and social-communication difficulties were also related to some aspects of well-being. Our study suggests that support and services for improving mental health, especially depression symptoms, may also improve broader outcomes for autistic people. En ligne : http://dx.doi.org/10.1177/1362361320959959 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=442 [article] How do core autism traits and associated symptoms relate to quality of life? Findings from the Longitudinal European Autism Project [texte imprimé] / Bethany OAKLEY, Auteur ; Julian TILLMANN, Auteur ; Jumana AHMAD, Auteur ; Daisy CRAWLEY, Auteur ; Antonia SAN JOSE CACERES, Auteur ; Rosemary J. HOLT, Auteur ; Tony CHARMAN, Auteur ; Tobias BANASCHEWSKI, Auteur ; Jan K. BUITELAAR, Auteur ; Emily SIMONOFF, Auteur ; Declan G.M. MURPHY, Auteur ; Eva LOTH, Auteur . - p.389-404. Langues : Anglais (eng) in Autism > 25-2 (February 2021) . - p.389-404 Mots-clés : anxiety  autism  depression  quality of life  well-being Index. décimale : PER Périodiques Résumé : Previous studies suggest that some autistic individuals report lower satisfaction, or well-being, with different aspects of everyday life than those without autism. It is unclear whether this might be partly explained by symptoms of anxiety and/or depression, which affect at least 20%-50% of autistic people. In this study, we measured individual differences in well-being in 573 six to thirty-year-olds with and without a diagnosis of autism. We investigated whether individual differences in well-being were explained by autism traits (e.g. social-communication difficulties) and/or anxiety and depression symptoms. We showed that, though well-being was lower for some autistic individuals, compared to those without autism, many autistic individuals reported good well-being. Where well-being was reduced, this was particularly explained by depression symptoms, across all ages. For children/adolescents, anxiety and social-communication difficulties were also related to some aspects of well-being. Our study suggests that support and services for improving mental health, especially depression symptoms, may also improve broader outcomes for autistic people. En ligne : http://dx.doi.org/10.1177/1362361320959959 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=442

Investigating the factors underlying adaptive functioning in autism in the EU-AIMS Longitudinal European Autism Project / Julian TILLMANN in Autism Research, 12-4 (April 2019)  

Public ISBD [article]  inAutism Research > 12-4 (April 2019) . - p.645-657 Titre : Investigating the factors underlying adaptive functioning in autism in the EU-AIMS Longitudinal European Autism Project Type de document : texte imprimé Auteurs : Julian TILLMANN, Auteur ; Antonia SAN JOSE CACERES, Auteur ; Christopher H. CHATHAM, Auteur ; Daisy CRAWLEY, Auteur ; Richard HOLT, Auteur ; Bethany OAKLEY, Auteur ; Tobias BANASCHEWSKI, Auteur ; Simon BARON-COHEN, Auteur ; Sven BÖLTE, Auteur ; Jan K. BUITELAAR, Auteur ; Sarah DURSTON, Auteur ; Lindsay HAM, Auteur ; Eva LOTH, Auteur ; Emily SIMONOFF, Auteur ; Will SPOOREN, Auteur ; Declan G.M. MURPHY, Auteur ; Tony CHARMAN, Auteur Article en page(s) : p.645-657 Langues : Anglais (eng) Mots-clés : adaptive functioning  autism spectrum disorder  intellectual functioning  psychiatric symptoms  symptom severity Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) exhibit significant impairments in adaptive functioning that impact on their ability to meet the demands of everyday life. A recurrent finding is that there is a pronounced discrepancy between level of cognitive ability and adaptive functioning, and this is particularly prominent among higher-ability individuals. However, the key clinical and demographic associations of these discrepancies remain unclear. This study included a sample of 417 children, adolescents, and adults with ASD as part of the EU-AIMS LEAP cohort. We examined how age, sex, IQ, levels of ASD symptom and autistic trait severity and psychiatric symptomatology are associated with adaptive functioning as measured by the Vineland Adaptive Behavior Scales-Second Edition and IQ-adaptive functioning discrepancies. Older age, lower IQ and higher social-communication symptoms were associated with lower adaptive functioning. Results also demonstrate that older age, higher IQ and higher social-communication symptoms are associated with greater IQ-adaptive functioning discrepancy scores. By contrast, sensory ASD symptoms, repetitive and restricted behaviors, as well as symptoms of attention deficit/hyperactivity disorder (ADHD), anxiety and depression, were not associated with adaptive functioning or IQ-adaptive functioning discrepancy scores. These findings suggest that it is the core social communication problems that define ASD that contribute to adaptive function impairments that people with ASD experience. They show for the first time that sensory symptoms, repetitive behavior and associated psychiatric symptoms do not independently contribute to adaptive function impairments. Individuals with ASD require supportive interventions across the lifespan that take account of social-communicative ASD symptom severity. Autism Res 2019, 12: 645-657. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY: This study investigated key clinical and demographic associations of adaptive functioning impairments in individuals with autism. We found that older age, lower IQ and more severe social-communicative symptoms, but not sensory or repetitive symptoms or co-occurring psychiatric symptoms, are associated with lower adaptive functioning and greater ability-adaptive function discrepancies. This suggests that interventions targeting adaptive skills acquisition should be flexible in their timing and intensity across developmental periods, levels of cognitive ability and take account of social-communicative ASD symptom severity. En ligne : https://dx.doi.org/10.1002/aur.2081 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389 [article] Investigating the factors underlying adaptive functioning in autism in the EU-AIMS Longitudinal European Autism Project [texte imprimé] / Julian TILLMANN, Auteur ; Antonia SAN JOSE CACERES, Auteur ; Christopher H. CHATHAM, Auteur ; Daisy CRAWLEY, Auteur ; Richard HOLT, Auteur ; Bethany OAKLEY, Auteur ; Tobias BANASCHEWSKI, Auteur ; Simon BARON-COHEN, Auteur ; Sven BÖLTE, Auteur ; Jan K. BUITELAAR, Auteur ; Sarah DURSTON, Auteur ; Lindsay HAM, Auteur ; Eva LOTH, Auteur ; Emily SIMONOFF, Auteur ; Will SPOOREN, Auteur ; Declan G.M. MURPHY, Auteur ; Tony CHARMAN, Auteur . - p.645-657. Langues : Anglais (eng) in Autism Research > 12-4 (April 2019) . - p.645-657 Mots-clés : adaptive functioning  autism spectrum disorder  intellectual functioning  psychiatric symptoms  symptom severity Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) exhibit significant impairments in adaptive functioning that impact on their ability to meet the demands of everyday life. A recurrent finding is that there is a pronounced discrepancy between level of cognitive ability and adaptive functioning, and this is particularly prominent among higher-ability individuals. However, the key clinical and demographic associations of these discrepancies remain unclear. This study included a sample of 417 children, adolescents, and adults with ASD as part of the EU-AIMS LEAP cohort. We examined how age, sex, IQ, levels of ASD symptom and autistic trait severity and psychiatric symptomatology are associated with adaptive functioning as measured by the Vineland Adaptive Behavior Scales-Second Edition and IQ-adaptive functioning discrepancies. Older age, lower IQ and higher social-communication symptoms were associated with lower adaptive functioning. Results also demonstrate that older age, higher IQ and higher social-communication symptoms are associated with greater IQ-adaptive functioning discrepancy scores. By contrast, sensory ASD symptoms, repetitive and restricted behaviors, as well as symptoms of attention deficit/hyperactivity disorder (ADHD), anxiety and depression, were not associated with adaptive functioning or IQ-adaptive functioning discrepancy scores. These findings suggest that it is the core social communication problems that define ASD that contribute to adaptive function impairments that people with ASD experience. They show for the first time that sensory symptoms, repetitive behavior and associated psychiatric symptoms do not independently contribute to adaptive function impairments. Individuals with ASD require supportive interventions across the lifespan that take account of social-communicative ASD symptom severity. Autism Res 2019, 12: 645-657. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY: This study investigated key clinical and demographic associations of adaptive functioning impairments in individuals with autism. We found that older age, lower IQ and more severe social-communicative symptoms, but not sensory or repetitive symptoms or co-occurring psychiatric symptoms, are associated with lower adaptive functioning and greater ability-adaptive function discrepancies. This suggests that interventions targeting adaptive skills acquisition should be flexible in their timing and intensity across developmental periods, levels of cognitive ability and take account of social-communicative ASD symptom severity. En ligne : https://dx.doi.org/10.1002/aur.2081 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389

Mapping the link between socio-economic factors, autistic traits and mental health across different settings / Teresa DEL BIANCO in Autism, 28-5 (May 2024)  

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The neuroanatomical substrates of autism and ADHD and their link to putative genomic underpinnings / Caroline GURR ; Johanna LEYHAUSEN ; Hanna SEELEMEYER ; Anke BLETSCH ; Tim SCHAEFER ; Charlotte M. PRETZSCH ; Bethany OAKLEY ; Eva LOTH ; Dorothea L. FLORIS ; Jan K. BUITELAAR ; Christian F. BECKMANN ; Tobias BANASCHEWSKI ; Tony CHARMAN ; Emily J.H. JONES ; Julian TILLMANN ; Christopher H. CHATHAM ; Thomas BOURGERON ; EU-AIMS LEAP GROUP ; Declan G.M. MURPHY ; Christine ECKER in Molecular Autism, 14 (2023)  

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