Dépouillements

Cognitive and Cerebral Aging Research in Autism: A Systematic Review on an Emerging Topic / Shasha MOREL-KOHLMEYER ; Emmanuelle HOUY-DURAND ; Philippe PREVOST ; Laurie TULLER ; Badiâa BOUAZZAOUI ; Laurence TACONNAT ; Julia CAPDEVILLE ; Lucie ANGEL ; Marie GOMOT in Autism Research, 18-6 (June 2025)  

Public ISBD [article]  inAutism Research > 18-6 (June 2025) . - p.1122-1145 Titre : Cognitive and Cerebral Aging Research in Autism: A Systematic Review on an Emerging Topic Type de document : Texte imprimé et/ou numérique Auteurs : Shasha MOREL-KOHLMEYER, Auteur ; Emmanuelle HOUY-DURAND, Auteur ; Philippe PREVOST, Auteur ; Laurie TULLER, Auteur ; Badiâa BOUAZZAOUI, Auteur ; Laurence TACONNAT, Auteur ; Julia CAPDEVILLE, Auteur ; Lucie ANGEL, Auteur ; Marie GOMOT, Auteur Article en page(s) : p.1122-1145 Langues : Anglais (eng) Mots-clés : aging  autism  cerebral  cognitive  systematic review Index. décimale : PER Périodiques Résumé : ABSTRACT Aging in autism is an emerging and under-explored area of research. This systematic review provides a comprehensive overview of studies on cognitive and both structural and functional cerebral aging in autism. A systematic search of PubMed and APA PsycInfo was conducted up to and including January 2024. Two researchers independently screened and identified relevant English studies on cognitive (i.e., processing speed, executive function, working memory, episodic memory) and/or cerebral (i.e., structural and functional aspects) aging in autism. Study quality was assessed using the QualSyst quantitative scale to minimize bias. Thirty-six studies met the inclusion criteria, with nine focusing on cerebral mechanisms, 19 on cognitive function, and eight addressing both. We examined cerebral and cognitive aging profiles in autism within the context of three hypotheses: accelerated aging, parallel aging, and the safeguard hypothesis. The synthesis does not reveal a consistent pattern with respect to any of the three hypotheses, as results varied across methodology types (cross-sectional vs. longitudinal) and studies, even with similar measures of cerebral or cognitive function. This systematic review highlights the ongoing lack of consensus in this area, which may be attributed to various internal or external factors (e.g., participants age, co-occurring conditions, lifestyle, cognitive reserve). Despite divergent findings, this review suggests that cross-sectional studies on cerebral and cognitive autistic aging predominantly align with the parallel or safeguard hypothesis. In contrast, the few longitudinal studies, which are the only ones capable of directly informing the aging process, are more consistent with the parallel or accelerated hypothesis. Further research is crucial to understand how cerebral and cognitive aging impact autistic symptomatology, enabling tailored support. En ligne : https://doi.org/10.1002/aur.70031 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Cognitive and Cerebral Aging Research in Autism: A Systematic Review on an Emerging Topic [Texte imprimé et/ou numérique] / Shasha MOREL-KOHLMEYER, Auteur ; Emmanuelle HOUY-DURAND, Auteur ; Philippe PREVOST, Auteur ; Laurie TULLER, Auteur ; Badiâa BOUAZZAOUI, Auteur ; Laurence TACONNAT, Auteur ; Julia CAPDEVILLE, Auteur ; Lucie ANGEL, Auteur ; Marie GOMOT, Auteur . - p.1122-1145. Langues : Anglais (eng) in Autism Research > 18-6 (June 2025) . - p.1122-1145 Mots-clés : aging  autism  cerebral  cognitive  systematic review Index. décimale : PER Périodiques Résumé : ABSTRACT Aging in autism is an emerging and under-explored area of research. This systematic review provides a comprehensive overview of studies on cognitive and both structural and functional cerebral aging in autism. A systematic search of PubMed and APA PsycInfo was conducted up to and including January 2024. Two researchers independently screened and identified relevant English studies on cognitive (i.e., processing speed, executive function, working memory, episodic memory) and/or cerebral (i.e., structural and functional aspects) aging in autism. Study quality was assessed using the QualSyst quantitative scale to minimize bias. Thirty-six studies met the inclusion criteria, with nine focusing on cerebral mechanisms, 19 on cognitive function, and eight addressing both. We examined cerebral and cognitive aging profiles in autism within the context of three hypotheses: accelerated aging, parallel aging, and the safeguard hypothesis. The synthesis does not reveal a consistent pattern with respect to any of the three hypotheses, as results varied across methodology types (cross-sectional vs. longitudinal) and studies, even with similar measures of cerebral or cognitive function. This systematic review highlights the ongoing lack of consensus in this area, which may be attributed to various internal or external factors (e.g., participants age, co-occurring conditions, lifestyle, cognitive reserve). Despite divergent findings, this review suggests that cross-sectional studies on cerebral and cognitive autistic aging predominantly align with the parallel or safeguard hypothesis. In contrast, the few longitudinal studies, which are the only ones capable of directly informing the aging process, are more consistent with the parallel or accelerated hypothesis. Further research is crucial to understand how cerebral and cognitive aging impact autistic symptomatology, enabling tailored support. En ligne : https://doi.org/10.1002/aur.70031 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

Identifying and Addressing the Missing Links Between Research, Policy, and Practice in Autism Research: Lessons From Early Autism Screening and Intervention Research / Anne M. ROUX ; Diana L. ROBINS ; Andrea Trubanova WIECKOWSKI ; Allison S. NAHMAIS ; Kaitlin Koffer MILLER ; Lindsay L. SHEA in Autism Research, 18-6 (June 2025)  

Public ISBD [article]  inAutism Research > 18-6 (June 2025) . - p.1146-1155 Titre : Identifying and Addressing the Missing Links Between Research, Policy, and Practice in Autism Research: Lessons From Early Autism Screening and Intervention Research Type de document : Texte imprimé et/ou numérique Auteurs : Anne M. ROUX, Auteur ; Diana L. ROBINS, Auteur ; Andrea Trubanova WIECKOWSKI, Auteur ; Allison S. NAHMAIS, Auteur ; Kaitlin Koffer MILLER, Auteur ; Lindsay L. SHEA, Auteur Article en page(s) : p.1146-1155 Langues : Anglais (eng) Mots-clés : autism screening  autism spectrum disorder  developmental screening  implementation  policy  translation Index. décimale : PER Périodiques Résumé : ABSTRACT The evidence base on autism diagnosis and intervention has grown exponentially in the past two decades, but there continue to be gaps in the path connecting research, policy, and practice. For example, although standardized autism screening tools have been shown to be helpful for identifying early signs of autism and facilitating early diagnosis, many pediatricians in the United States do not use them as recommended. Similarly, despite the sound evidence supporting Naturalistic Developmental Behavioral Interventions, they are seldom used in early intervention practice. This commentary examines the nature of these gaps using the Exploration, Preparation, Implementation, Sustainment (EPIS) framework, with a focus on the role of ?big P? policies, which include legislation and agency regulations, and ?little p? policies, which include guidelines set by professional organizations. Efforts to bridge the gap between research and practice through policy offer the potential for improving the lives of those on the autism spectrum through early detection and intervention programs and beyond. En ligne : https://doi.org/10.1002/aur.70055 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Identifying and Addressing the Missing Links Between Research, Policy, and Practice in Autism Research: Lessons From Early Autism Screening and Intervention Research [Texte imprimé et/ou numérique] / Anne M. ROUX, Auteur ; Diana L. ROBINS, Auteur ; Andrea Trubanova WIECKOWSKI, Auteur ; Allison S. NAHMAIS, Auteur ; Kaitlin Koffer MILLER, Auteur ; Lindsay L. SHEA, Auteur . - p.1146-1155. Langues : Anglais (eng) in Autism Research > 18-6 (June 2025) . - p.1146-1155 Mots-clés : autism screening  autism spectrum disorder  developmental screening  implementation  policy  translation Index. décimale : PER Périodiques Résumé : ABSTRACT The evidence base on autism diagnosis and intervention has grown exponentially in the past two decades, but there continue to be gaps in the path connecting research, policy, and practice. For example, although standardized autism screening tools have been shown to be helpful for identifying early signs of autism and facilitating early diagnosis, many pediatricians in the United States do not use them as recommended. Similarly, despite the sound evidence supporting Naturalistic Developmental Behavioral Interventions, they are seldom used in early intervention practice. This commentary examines the nature of these gaps using the Exploration, Preparation, Implementation, Sustainment (EPIS) framework, with a focus on the role of ?big P? policies, which include legislation and agency regulations, and ?little p? policies, which include guidelines set by professional organizations. Efforts to bridge the gap between research and practice through policy offer the potential for improving the lives of those on the autism spectrum through early detection and intervention programs and beyond. En ligne : https://doi.org/10.1002/aur.70055 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

Multisensory Integration of Naturalistic Speech and Gestures in Autistic Adults / Sotaro KITA ; Mireia Torralba CUELLO ; Salvador Soto FARACO in Autism Research, 18-6 (June 2025)  

Public ISBD [article]  inAutism Research > 18-6 (June 2025) . - p.1156-1169 Titre : Multisensory Integration of Naturalistic Speech and Gestures in Autistic Adults Type de document : Texte imprimé et/ou numérique Auteurs : Sotaro KITA, Auteur ; Mireia Torralba CUELLO, Auteur ; Salvador Soto FARACO, Auteur Article en page(s) : p.1156-1169 Langues : Anglais (eng) Mots-clés : audio-visual speech  autism  EEG  iconic gestures  multisensory integration Index. décimale : PER Périodiques Résumé : ABSTRACT Seeing the speaker often facilitates auditory speech comprehension through audio-visual integration. This audio-visual facilitation is stronger under challenging listening conditions, such as in real-life social environments. Autism has been associated with atypicalities in integrating audio-visual information, potentially underlying social difficulties in this population. The present study investigated multisensory integration (MSI) of audio-visual speech information among autistic and neurotypical adults. Participants performed a speech-in-noise task in a realistic multispeaker social scenario with audio-visual, auditory, or visual trials while their brain activity was recorded using EEG. The neurotypical group demonstrated a non-linear audio-visual effect in alpha oscillations, whereas the autistic group showed merely additive processing. Despite these differences in neural correlates, both groups achieved similar behavioral audio-visual facilitation outcomes. These findings suggest that although autistic and neurotypical brains might process multisensory cues differently, they achieve comparable benefits from audio-visual speech. These results contribute to the growing body of literature on MSI atypicalities in autism. En ligne : https://doi.org/10.1002/aur.70042 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Multisensory Integration of Naturalistic Speech and Gestures in Autistic Adults [Texte imprimé et/ou numérique] / Sotaro KITA, Auteur ; Mireia Torralba CUELLO, Auteur ; Salvador Soto FARACO, Auteur . - p.1156-1169. Langues : Anglais (eng) in Autism Research > 18-6 (June 2025) . - p.1156-1169 Mots-clés : audio-visual speech  autism  EEG  iconic gestures  multisensory integration Index. décimale : PER Périodiques Résumé : ABSTRACT Seeing the speaker often facilitates auditory speech comprehension through audio-visual integration. This audio-visual facilitation is stronger under challenging listening conditions, such as in real-life social environments. Autism has been associated with atypicalities in integrating audio-visual information, potentially underlying social difficulties in this population. The present study investigated multisensory integration (MSI) of audio-visual speech information among autistic and neurotypical adults. Participants performed a speech-in-noise task in a realistic multispeaker social scenario with audio-visual, auditory, or visual trials while their brain activity was recorded using EEG. The neurotypical group demonstrated a non-linear audio-visual effect in alpha oscillations, whereas the autistic group showed merely additive processing. Despite these differences in neural correlates, both groups achieved similar behavioral audio-visual facilitation outcomes. These findings suggest that although autistic and neurotypical brains might process multisensory cues differently, they achieve comparable benefits from audio-visual speech. These results contribute to the growing body of literature on MSI atypicalities in autism. En ligne : https://doi.org/10.1002/aur.70042 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

Effective Autism Classification Through Grasping Kinematics / Zoha AHMAD ; Eitan SHELEF ; Bat Sheva HADAD in Autism Research, 18-6 (June 2025)  

Public ISBD [article]  inAutism Research > 18-6 (June 2025) . - p.1170-1181 Titre : Effective Autism Classification Through Grasping Kinematics Type de document : Texte imprimé et/ou numérique Auteurs : Zoha AHMAD, Auteur ; Eitan SHELEF, Auteur ; Bat Sheva HADAD, Auteur Article en page(s) : p.1170-1181 Langues : Anglais (eng) Mots-clés : autism  grasping  machine learning  motion tracking  visuomotor control Index. décimale : PER Périodiques Résumé : ABSTRACT Autism is a complex neurodevelopmental condition, where motor abnormalities play a central role alongside social and communication difficulties. These motor symptoms often manifest in early childhood, making them critical targets for early diagnosis and intervention. This study aimed to assess whether kinematic features from a naturalistic grasping task could accurately distinguish autistic participants from non-autistic ones. We analyzed grasping movements of autistic and non-autistic young adults, tracking two markers placed on the thumb and index finger. Using a subject-wise cross-validated classifiers, we achieved accuracy scores of above 84%. Receiver operating characteristic analysis revealed strong classification performance with area under the curve values of above 0.95 at the subject-wise analysis and above 0.85 at the trial-wise analysis. These findings indicate strong reliability in accurately distinguishing autistic participants from non-autistic ones. These findings suggest that subtle motor control differences can be effectively captured, offering a promising approach for developing accessible and reliable diagnostic tools for autism. En ligne : https://doi.org/10.1002/aur.70049 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Effective Autism Classification Through Grasping Kinematics [Texte imprimé et/ou numérique] / Zoha AHMAD, Auteur ; Eitan SHELEF, Auteur ; Bat Sheva HADAD, Auteur . - p.1170-1181. Langues : Anglais (eng) in Autism Research > 18-6 (June 2025) . - p.1170-1181 Mots-clés : autism  grasping  machine learning  motion tracking  visuomotor control Index. décimale : PER Périodiques Résumé : ABSTRACT Autism is a complex neurodevelopmental condition, where motor abnormalities play a central role alongside social and communication difficulties. These motor symptoms often manifest in early childhood, making them critical targets for early diagnosis and intervention. This study aimed to assess whether kinematic features from a naturalistic grasping task could accurately distinguish autistic participants from non-autistic ones. We analyzed grasping movements of autistic and non-autistic young adults, tracking two markers placed on the thumb and index finger. Using a subject-wise cross-validated classifiers, we achieved accuracy scores of above 84%. Receiver operating characteristic analysis revealed strong classification performance with area under the curve values of above 0.95 at the subject-wise analysis and above 0.85 at the trial-wise analysis. These findings indicate strong reliability in accurately distinguishing autistic participants from non-autistic ones. These findings suggest that subtle motor control differences can be effectively captured, offering a promising approach for developing accessible and reliable diagnostic tools for autism. En ligne : https://doi.org/10.1002/aur.70049 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

Estimated Nutrient Intake and Association With Psychiatric and Sleep Problems in Autistic Youth in the Adolescent Brain Cognitive DevelopmentSM Study / Elizabeth A. LI ; Christopher H. LEGERE ; Jared M. SALETIN ; Noah S. PHILIP ; Daniel P. DICKSTEIN in Autism Research, 18-6 (June 2025)  

Public ISBD [article]  inAutism Research > 18-6 (June 2025) . - p.1182-1186 Titre : Estimated Nutrient Intake and Association With Psychiatric and Sleep Problems in Autistic Youth in the Adolescent Brain Cognitive DevelopmentSM Study Type de document : Texte imprimé et/ou numérique Auteurs : Elizabeth A. LI, Auteur ; Christopher H. LEGERE, Auteur ; Jared M. SALETIN, Auteur ; Noah S. PHILIP, Auteur ; Daniel P. DICKSTEIN, Auteur Article en page(s) : p.1182-1186 Langues : Anglais (eng) Mots-clés : ABCD (adolescent brain cognitive development) study  autism  CBCL (child behavior checklist)  macronutrients  micronutrients  sleep Index. décimale : PER Périodiques Résumé : ABSTRACT Autistic children often consume less varied diets, experience sleep difficulties, and have higher rates of mental health problems as compared to neurotypical peers. Yet, the direct relationship between all of these domains is not well characterized. We leveraged the Adolescent Brain Cognitive DevelopmentSM study (ABCD study) dataset to explore whether estimated levels of consumption of specific macro- and micronutrients correlated with the severity of mental health and sleep problems in autistic youth. We found that low vitamin B3, B6, C, and iron intake was associated with more severe psychiatric problems in autistic children in the ABCD cohort, though these findings did not reach statistical significance after correction for multiple comparisons. In a post hoc analysis, we found that the severity of sleep difficulties was correlated with estimated levels of Vitamins B3, B6, C, and iron intake and with the severity of anxiety/depressive symptoms and/or thought problems. Our analysis on a large number of nutrients, psychiatric symptoms, and sleep serves as an exploratory, initial analysis to identify specific nutrients and psychiatric symptoms that could be the focus of future (confirmatory) studies on the relationship between nutrition, sleep, and mental health in autistic individuals. En ligne : https://doi.org/10.1002/aur.70040 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Estimated Nutrient Intake and Association With Psychiatric and Sleep Problems in Autistic Youth in the Adolescent Brain Cognitive DevelopmentSM Study [Texte imprimé et/ou numérique] / Elizabeth A. LI, Auteur ; Christopher H. LEGERE, Auteur ; Jared M. SALETIN, Auteur ; Noah S. PHILIP, Auteur ; Daniel P. DICKSTEIN, Auteur . - p.1182-1186. Langues : Anglais (eng) in Autism Research > 18-6 (June 2025) . - p.1182-1186 Mots-clés : ABCD (adolescent brain cognitive development) study  autism  CBCL (child behavior checklist)  macronutrients  micronutrients  sleep Index. décimale : PER Périodiques Résumé : ABSTRACT Autistic children often consume less varied diets, experience sleep difficulties, and have higher rates of mental health problems as compared to neurotypical peers. Yet, the direct relationship between all of these domains is not well characterized. We leveraged the Adolescent Brain Cognitive DevelopmentSM study (ABCD study) dataset to explore whether estimated levels of consumption of specific macro- and micronutrients correlated with the severity of mental health and sleep problems in autistic youth. We found that low vitamin B3, B6, C, and iron intake was associated with more severe psychiatric problems in autistic children in the ABCD cohort, though these findings did not reach statistical significance after correction for multiple comparisons. In a post hoc analysis, we found that the severity of sleep difficulties was correlated with estimated levels of Vitamins B3, B6, C, and iron intake and with the severity of anxiety/depressive symptoms and/or thought problems. Our analysis on a large number of nutrients, psychiatric symptoms, and sleep serves as an exploratory, initial analysis to identify specific nutrients and psychiatric symptoms that could be the focus of future (confirmatory) studies on the relationship between nutrition, sleep, and mental health in autistic individuals. En ligne : https://doi.org/10.1002/aur.70040 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

Relationship Between Antipsychotic Use and Cholesterol Levels in a Retrospective Chart Review of an Adult Autism Clinic Patient Population / Alisha J. STEIGERWALD ; Malori CHRISMAN ; Tanvi YADLAPALLI ; David Q. BEVERSDORF in Autism Research, 18-6 (June 2025)  

Public ISBD [article]  inAutism Research > 18-6 (June 2025) . - p.1187-1194 Titre : Relationship Between Antipsychotic Use and Cholesterol Levels in a Retrospective Chart Review of an Adult Autism Clinic Patient Population Type de document : Texte imprimé et/ou numérique Auteurs : Alisha J. STEIGERWALD, Auteur ; Malori CHRISMAN, Auteur ; Tanvi YADLAPALLI, Auteur ; David Q. BEVERSDORF, Auteur Article en page(s) : p.1187-1194 Langues : Anglais (eng) Mots-clés : antipsychotics  autism  cholesterol  GI comorbidities  metabolic comorbidities Index. décimale : PER Périodiques Résumé : ABSTRACT Individuals with autism spectrum disorder (ASD) experience a high prevalence of metabolic and gastrointestinal (GI) comorbidities. Antipsychotics are commonly prescribed for adults with ASD. Our study investigated the effect of antipsychotic medication on metabolic and GI comorbidities, as well as effects across age, in an adult ASD population. We retrospectively analyzed 279 charts from patients with ASD, ages 16?62 (mean?=?27.97, SD?=?8.89, 18.3% female). Data abstracted included demographic information, medications taken, GI and metabolic comorbidities, and recent values for body mass index (BMI), triglycerides, and total cholesterol. Participants were separated into two groups based on antipsychotic use. Between-group differences were calculated for the prevalence of GI comorbidities and mean values for BMI, triglycerides, and total cholesterol. Lastly, binary correlations were calculated for age and total cholesterol as well as triglycerides, and age and BMI. No significant difference was found between the prevalence of GI comorbidities for the two groups. For metabolic factors, no significant difference was found in the mean BMI, triglycerides, or total cholesterol. Binary correlation analysis also revealed no significant correlation between age and BMI or triglycerides for patients in either group. A significant correlation was found between age and total cholesterol for patients both taking and not taking antipsychotics. Despite approximately one in three patients in this study taking an antipsychotic medication, no significant differences in GI or metabolic comorbidities were found. However, cholesterol increased with age regardless of the presence or absence of antipsychotics. Future research is needed to better understand the long-term effects of antipsychotics on adults with ASD and metabolic monitoring in those not on antipsychotics. En ligne : https://doi.org/10.1002/aur.70047 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Relationship Between Antipsychotic Use and Cholesterol Levels in a Retrospective Chart Review of an Adult Autism Clinic Patient Population [Texte imprimé et/ou numérique] / Alisha J. STEIGERWALD, Auteur ; Malori CHRISMAN, Auteur ; Tanvi YADLAPALLI, Auteur ; David Q. BEVERSDORF, Auteur . - p.1187-1194. Langues : Anglais (eng) in Autism Research > 18-6 (June 2025) . - p.1187-1194 Mots-clés : antipsychotics  autism  cholesterol  GI comorbidities  metabolic comorbidities Index. décimale : PER Périodiques Résumé : ABSTRACT Individuals with autism spectrum disorder (ASD) experience a high prevalence of metabolic and gastrointestinal (GI) comorbidities. Antipsychotics are commonly prescribed for adults with ASD. Our study investigated the effect of antipsychotic medication on metabolic and GI comorbidities, as well as effects across age, in an adult ASD population. We retrospectively analyzed 279 charts from patients with ASD, ages 16?62 (mean?=?27.97, SD?=?8.89, 18.3% female). Data abstracted included demographic information, medications taken, GI and metabolic comorbidities, and recent values for body mass index (BMI), triglycerides, and total cholesterol. Participants were separated into two groups based on antipsychotic use. Between-group differences were calculated for the prevalence of GI comorbidities and mean values for BMI, triglycerides, and total cholesterol. Lastly, binary correlations were calculated for age and total cholesterol as well as triglycerides, and age and BMI. No significant difference was found between the prevalence of GI comorbidities for the two groups. For metabolic factors, no significant difference was found in the mean BMI, triglycerides, or total cholesterol. Binary correlation analysis also revealed no significant correlation between age and BMI or triglycerides for patients in either group. A significant correlation was found between age and total cholesterol for patients both taking and not taking antipsychotics. Despite approximately one in three patients in this study taking an antipsychotic medication, no significant differences in GI or metabolic comorbidities were found. However, cholesterol increased with age regardless of the presence or absence of antipsychotics. Future research is needed to better understand the long-term effects of antipsychotics on adults with ASD and metabolic monitoring in those not on antipsychotics. En ligne : https://doi.org/10.1002/aur.70047 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

Interaction and association between multiple vitamins and social adaptability and severity of autism: A large-scale retrospective study from China / Dongchuan YU in Autism Research, 18-6 (June 2025)  

Public ISBD [article]  inAutism Research > 18-6 (June 2025) . - p.1195-1205 Titre : Interaction and association between multiple vitamins and social adaptability and severity of autism: A large-scale retrospective study from China Type de document : Texte imprimé et/ou numérique Auteurs : Dongchuan YU, Auteur Article en page(s) : p.1195-1205 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  interaction effect  intervention  serum vitamin Index. décimale : PER Périodiques Résumé : Abstract Since children with autism spectrum disorder (ASD) often exhibit selective eating behaviors, it is generally believed that they may have abnormal nutrient structure, leading to aberrant concentrations of some serum vitamins. However, previous studies on serum vitamins in individuals with ASD are mixed. Additionally, the interaction and association between multiple serum vitamin and ASD-related symptoms remain unclear. This study utilized a cross-sectional survey with a large sample size (n?=?1235) from China to clarify previous mixed findings, and examine the interaction and association between multiple serum vitamins (including folic acid [FA], vitamin A [VA], vitamin E [VE], vitamin B12 [VB12], and vitamin D [VD]) and social adaptability and symptom severity in children with ASD. Findings found that symptom severity was negatively associated with concentrations of serum VA, VE, VB12, and VD; while, social adaptability was significantly associated with the natural log-transformed concentrations of FA and VB12. Finding also revealed the interaction of VA and VE on the association between both vitamins and severity of ASD symptoms, as well as the interaction of VB12 and FA on the association between both vitamins and social adaptability. In particular, the combination of low concentration of VA and high concentration of VE is associated with the lowest risk of being ?severely autistic?; while, the combination of low concentration of FA and high concentration of VB12 is associated with the lowest risk of being ?poor social adaptability?. This study offers the evidence for the requirement of considering multiple vitamins comprehensively, as well as valuable references for revealing the association between vitamin disparities and food selectivity in children with ASD. En ligne : https://doi.org/10.1002/aur.3241 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Interaction and association between multiple vitamins and social adaptability and severity of autism: A large-scale retrospective study from China [Texte imprimé et/ou numérique] / Dongchuan YU, Auteur . - p.1195-1205. Langues : Anglais (eng) in Autism Research > 18-6 (June 2025) . - p.1195-1205 Mots-clés : autism spectrum disorder  interaction effect  intervention  serum vitamin Index. décimale : PER Périodiques Résumé : Abstract Since children with autism spectrum disorder (ASD) often exhibit selective eating behaviors, it is generally believed that they may have abnormal nutrient structure, leading to aberrant concentrations of some serum vitamins. However, previous studies on serum vitamins in individuals with ASD are mixed. Additionally, the interaction and association between multiple serum vitamin and ASD-related symptoms remain unclear. This study utilized a cross-sectional survey with a large sample size (n?=?1235) from China to clarify previous mixed findings, and examine the interaction and association between multiple serum vitamins (including folic acid [FA], vitamin A [VA], vitamin E [VE], vitamin B12 [VB12], and vitamin D [VD]) and social adaptability and symptom severity in children with ASD. Findings found that symptom severity was negatively associated with concentrations of serum VA, VE, VB12, and VD; while, social adaptability was significantly associated with the natural log-transformed concentrations of FA and VB12. Finding also revealed the interaction of VA and VE on the association between both vitamins and severity of ASD symptoms, as well as the interaction of VB12 and FA on the association between both vitamins and social adaptability. In particular, the combination of low concentration of VA and high concentration of VE is associated with the lowest risk of being ?severely autistic?; while, the combination of low concentration of FA and high concentration of VB12 is associated with the lowest risk of being ?poor social adaptability?. This study offers the evidence for the requirement of considering multiple vitamins comprehensively, as well as valuable references for revealing the association between vitamin disparities and food selectivity in children with ASD. En ligne : https://doi.org/10.1002/aur.3241 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

Motor-Communication Skill Link in Minimally Speaking Children on the Autism Spectrum from the U.S. and India / Kristen MULLER in Autism Research, 18-6 (June 2025)  

Public ISBD [article]  inAutism Research > 18-6 (June 2025) . - p.1206-1216 Titre : Motor-Communication Skill Link in Minimally Speaking Children on the Autism Spectrum from the U.S. and India Type de document : Texte imprimé et/ou numérique Auteurs : Kristen MULLER, Auteur Article en page(s) : p.1206-1216 Langues : Anglais (eng) Mots-clés : autism  communication skills  communicative functions  cross-cultural research  minimally speaking  motor skills Index. décimale : PER Périodiques Résumé : ABSTRACT We aimed to examine the interrelations between motor and communication skills, as well as associations between motor skill subdomains and different communicative functions in minimally speaking children on the autism spectrum, whereas accounting for the child's age, country of residence, educational setting, and communication modalities (covariates). Data from 67 minimally speaking children on the autism spectrum (ages 4?9) from India and the U.S. were analyzed. Motor and communication skills were assessed using the Vineland Adaptive Behavior Scales?Third Edition and the Communication Matrix. Linear regression was used to examine associations between communication and motor skills, and partial correlations were conducted to explore relations between motor skill subdomains and communicative functions. Motor skills were significantly associated with communication skills, independent of covariates. Significant relations were also observed between both motor skill subdomains and refusal functions, as well as between gross motor skills and the obtain function. No significant associations were found between social or information functions and any motor skill subdomain, independent of covariates. The findings underscore the complex and interrelated nature of motor and communication skills. Consideration of both motor and communication skills in intervention approaches may provide insights into ways to support communication development in minimally speaking children on the autism spectrum. En ligne : https://doi.org/10.1002/aur.70033 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Motor-Communication Skill Link in Minimally Speaking Children on the Autism Spectrum from the U.S. and India [Texte imprimé et/ou numérique] / Kristen MULLER, Auteur . - p.1206-1216. Langues : Anglais (eng) in Autism Research > 18-6 (June 2025) . - p.1206-1216 Mots-clés : autism  communication skills  communicative functions  cross-cultural research  minimally speaking  motor skills Index. décimale : PER Périodiques Résumé : ABSTRACT We aimed to examine the interrelations between motor and communication skills, as well as associations between motor skill subdomains and different communicative functions in minimally speaking children on the autism spectrum, whereas accounting for the child's age, country of residence, educational setting, and communication modalities (covariates). Data from 67 minimally speaking children on the autism spectrum (ages 4?9) from India and the U.S. were analyzed. Motor and communication skills were assessed using the Vineland Adaptive Behavior Scales?Third Edition and the Communication Matrix. Linear regression was used to examine associations between communication and motor skills, and partial correlations were conducted to explore relations between motor skill subdomains and communicative functions. Motor skills were significantly associated with communication skills, independent of covariates. Significant relations were also observed between both motor skill subdomains and refusal functions, as well as between gross motor skills and the obtain function. No significant associations were found between social or information functions and any motor skill subdomain, independent of covariates. The findings underscore the complex and interrelated nature of motor and communication skills. Consideration of both motor and communication skills in intervention approaches may provide insights into ways to support communication development in minimally speaking children on the autism spectrum. En ligne : https://doi.org/10.1002/aur.70033 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

Autism Digital Phenotyping in Preschool- and School-Age Children / Kimberly L. H. CARPENTER ; Pradeep Raj Krishnappa BABU ; J. Matias DI MARTINO ; Steven ESPINOSA ; Scott COMPTON ; Naomi DAVIS ; Lauren FRANZ ; Marina SPANOS ; Guillermo SAPIRO ; Geraldine DAWSON in Autism Research, 18-6 (June 2025)  

Public ISBD [article]  inAutism Research > 18-6 (June 2025) . - p.1217-1233 Titre : Autism Digital Phenotyping in Preschool- and School-Age Children Type de document : Texte imprimé et/ou numérique Auteurs : Kimberly L. H. CARPENTER, Auteur ; Pradeep Raj Krishnappa BABU, Auteur ; J. Matias DI MARTINO, Auteur ; Steven ESPINOSA, Auteur ; Scott COMPTON, Auteur ; Naomi DAVIS, Auteur ; Lauren FRANZ, Auteur ; Marina SPANOS, Auteur ; Guillermo SAPIRO, Auteur ; Geraldine DAWSON, Auteur Article en page(s) : p.1217-1233 Langues : Anglais (eng) Mots-clés : autism  computer vision  digital phenotyping  preschool- and school-age Index. décimale : PER Périodiques Résumé : ABSTRACT There is a critical need for scalable and objective tools for autism screening and outcome monitoring, which can be used alongside traditional caregiver and clinical measures. To address this need, we developed SenseToKnow, a tablet- or smartphone-based digital phenotyping application (app), which uses computer vision and touch data to measure several autism-related behavioral features, such as social attention, facial and head movements, and visual-motor skills. Our previous work demonstrated that the SenseToKnow app can accurately detect and quantify behavioral signs of autism in 18?40-month-old toddlers. In the present study, we administered the SenseToKnow app on an iPad to 149 preschool- and school-age children (45 neurotypical and 104 autistic) between 3 and 8?years of age. Results revealed significant group differences between autistic and neurotypical children in terms of several behavioral features, which remained after controlling for sex and age. Repeat administration with a subgroup demonstrated stability in the individual digital phenotypes. Examining correlations between the Vineland Adaptive Behavior Scales and individual digital phenotypes, we found that autistic children with higher levels of communication, daily living, socialization, motor, and adaptive skills exhibited higher levels of social attention and coordinated gaze with speech, less frequent head movements, higher complexity of facial movements, higher overall attention, lower blink rates, and higher visual motor skills, demonstrating convergent validity between app features and clinical measures. App features were also significantly correlated with ratings on the Social Responsiveness Scale. These results suggest that the SenseToKnow app can be used as an accessible, scalable, and objective digital tool to measure autism-related behaviors in preschool- and school-age children. En ligne : https://doi.org/10.1002/aur.70032 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Autism Digital Phenotyping in Preschool- and School-Age Children [Texte imprimé et/ou numérique] / Kimberly L. H. CARPENTER, Auteur ; Pradeep Raj Krishnappa BABU, Auteur ; J. Matias DI MARTINO, Auteur ; Steven ESPINOSA, Auteur ; Scott COMPTON, Auteur ; Naomi DAVIS, Auteur ; Lauren FRANZ, Auteur ; Marina SPANOS, Auteur ; Guillermo SAPIRO, Auteur ; Geraldine DAWSON, Auteur . - p.1217-1233. Langues : Anglais (eng) in Autism Research > 18-6 (June 2025) . - p.1217-1233 Mots-clés : autism  computer vision  digital phenotyping  preschool- and school-age Index. décimale : PER Périodiques Résumé : ABSTRACT There is a critical need for scalable and objective tools for autism screening and outcome monitoring, which can be used alongside traditional caregiver and clinical measures. To address this need, we developed SenseToKnow, a tablet- or smartphone-based digital phenotyping application (app), which uses computer vision and touch data to measure several autism-related behavioral features, such as social attention, facial and head movements, and visual-motor skills. Our previous work demonstrated that the SenseToKnow app can accurately detect and quantify behavioral signs of autism in 18?40-month-old toddlers. In the present study, we administered the SenseToKnow app on an iPad to 149 preschool- and school-age children (45 neurotypical and 104 autistic) between 3 and 8?years of age. Results revealed significant group differences between autistic and neurotypical children in terms of several behavioral features, which remained after controlling for sex and age. Repeat administration with a subgroup demonstrated stability in the individual digital phenotypes. Examining correlations between the Vineland Adaptive Behavior Scales and individual digital phenotypes, we found that autistic children with higher levels of communication, daily living, socialization, motor, and adaptive skills exhibited higher levels of social attention and coordinated gaze with speech, less frequent head movements, higher complexity of facial movements, higher overall attention, lower blink rates, and higher visual motor skills, demonstrating convergent validity between app features and clinical measures. App features were also significantly correlated with ratings on the Social Responsiveness Scale. These results suggest that the SenseToKnow app can be used as an accessible, scalable, and objective digital tool to measure autism-related behaviors in preschool- and school-age children. En ligne : https://doi.org/10.1002/aur.70032 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

Theory of Mind Mediates the Association Between Autistic Traits and Social Isolation in Middle-Aged and Older Adults / Clemie DALE ; Francesca HAPPE ; Gavin R. STEWART in Autism Research, 18-6 (June 2025)  

Public ISBD [article]  inAutism Research > 18-6 (June 2025) . - p.1234-1244 Titre : Theory of Mind Mediates the Association Between Autistic Traits and Social Isolation in Middle-Aged and Older Adults Type de document : Texte imprimé et/ou numérique Auteurs : Clemie DALE, Auteur ; Francesca HAPPE, Auteur ; Gavin R. STEWART, Auteur Article en page(s) : p.1234-1244 Langues : Anglais (eng) Mots-clés : aging  autism  autistic traits  midlife  older age  social connectedness  social isolation  theory of mind Index. décimale : PER Périodiques Résumé : ABSTRACT Social isolation has detrimental effects on wellbeing. While isolation can occur at any age, its prevalence has been found to increase in older adulthood. Populations with social functioning differences, such as autistic people, have also been found to be at particular risk of isolation across the lifespan, including in older age. Despite the widespread impacts of isolation, little is known about the underlying factors that may contribute to social isolation in autistic people and the general populations. While social isolation has been linked to autistic traits and theory of mind (ToM), no study has yet considered their inter-relationship. Taking a dimensional approach to autistic traits, this study examined the association between autistic traits (assessed by the AQ-10), ToM (CarToM and Frith?Happé Triangles) and social isolation (Lubben Social Connectedness Scale) among 111 adults (n?=?53 autistic, 58 non-autistic), aged 40?86?years. The study also assessed the putative mediating role of ToM in the association between autistic traits and isolation. Pearson correlational analyses showed middle-aged and older adults with higher social connectedness reported fewer autistic traits and showed better performance in ToM tasks, even when accounting for the effect of age and mental health symptoms. Mediation analyses suggested the association between autistic traits and social isolation was partially mediated by ToM when age and mental health symptoms were accounted for. These findings suggest one possible mechanism for the experience of social isolation. Additionally, the findings highlight that autistic people and people with high autistic traits may be particularly susceptible to social isolation in midlife and older age, and may benefit from additional support and possible interventions to maintain desired levels of social connectedness in later life. En ligne : https://doi.org/10.1002/aur.70036 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Theory of Mind Mediates the Association Between Autistic Traits and Social Isolation in Middle-Aged and Older Adults [Texte imprimé et/ou numérique] / Clemie DALE, Auteur ; Francesca HAPPE, Auteur ; Gavin R. STEWART, Auteur . - p.1234-1244. Langues : Anglais (eng) in Autism Research > 18-6 (June 2025) . - p.1234-1244 Mots-clés : aging  autism  autistic traits  midlife  older age  social connectedness  social isolation  theory of mind Index. décimale : PER Périodiques Résumé : ABSTRACT Social isolation has detrimental effects on wellbeing. While isolation can occur at any age, its prevalence has been found to increase in older adulthood. Populations with social functioning differences, such as autistic people, have also been found to be at particular risk of isolation across the lifespan, including in older age. Despite the widespread impacts of isolation, little is known about the underlying factors that may contribute to social isolation in autistic people and the general populations. While social isolation has been linked to autistic traits and theory of mind (ToM), no study has yet considered their inter-relationship. Taking a dimensional approach to autistic traits, this study examined the association between autistic traits (assessed by the AQ-10), ToM (CarToM and Frith?Happé Triangles) and social isolation (Lubben Social Connectedness Scale) among 111 adults (n?=?53 autistic, 58 non-autistic), aged 40?86?years. The study also assessed the putative mediating role of ToM in the association between autistic traits and isolation. Pearson correlational analyses showed middle-aged and older adults with higher social connectedness reported fewer autistic traits and showed better performance in ToM tasks, even when accounting for the effect of age and mental health symptoms. Mediation analyses suggested the association between autistic traits and social isolation was partially mediated by ToM when age and mental health symptoms were accounted for. These findings suggest one possible mechanism for the experience of social isolation. Additionally, the findings highlight that autistic people and people with high autistic traits may be particularly susceptible to social isolation in midlife and older age, and may benefit from additional support and possible interventions to maintain desired levels of social connectedness in later life. En ligne : https://doi.org/10.1002/aur.70036 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

Linguistic and Musical Syntax Processing in Autistic and Non-Autistic Individuals: An Event-Related Potential (ERP) Study / Anna PETROVA ; Zivile BERNOTAITE ; Maleeha SUJAWAL ; Chen ZHAO ; Hiba AHMED ; Cunmei JIANG ; Fang LIU in Autism Research, 18-6 (June 2025)  

Public ISBD [article]  inAutism Research > 18-6 (June 2025) . - p.1245-1256 Titre : Linguistic and Musical Syntax Processing in Autistic and Non-Autistic Individuals: An Event-Related Potential (ERP) Study Type de document : Texte imprimé et/ou numérique Auteurs : Anna PETROVA, Auteur ; Zivile BERNOTAITE, Auteur ; Maleeha SUJAWAL, Auteur ; Chen ZHAO, Auteur ; Hiba AHMED, Auteur ; Cunmei JIANG, Auteur ; Fang LIU, Auteur Article en page(s) : p.1245-1256 Langues : Anglais (eng) Mots-clés : autism  language  music  P600  syntax Index. décimale : PER Périodiques Résumé : ABSTRACT Syntactic processing in both language and music involves combining elements?such as words or chords?into coherent structures. The Shared Syntactic Integration Resource Hypothesis (SSIRH) was introduced based on observations of similar neural responses to syntactic violations across both domains. This hypothesis suggests that difficulties in syntactic processing in one domain may result in similar challenges in the other. The current study tested the SSIRH in autism, a neurodevelopmental condition often associated with language difficulties but relatively preserved musical abilities. Thirty-one autistic and 31 non-autistic participants judged the acceptability of syntactically congruent and incongruent sentences and musical sequences while their neural responses were recorded using electroencephalography. Autistic participants exhibited a reduced and delayed P600 effect?a marker of syntactic integration?across both domains, despite achieving similar behavioral accuracy to the non-autistic group. These findings suggest parallel difficulties in syntactic processing in autism for both language and music, providing support for the SSIRH. This is the first study to directly examine real-time syntactic integration in both domains in autistic individuals, offering novel insights into cross-domain syntactic processing in autism and contributing to a deeper understanding of language and music processing more broadly. En ligne : https://doi.org/10.1002/aur.70038 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Linguistic and Musical Syntax Processing in Autistic and Non-Autistic Individuals: An Event-Related Potential (ERP) Study [Texte imprimé et/ou numérique] / Anna PETROVA, Auteur ; Zivile BERNOTAITE, Auteur ; Maleeha SUJAWAL, Auteur ; Chen ZHAO, Auteur ; Hiba AHMED, Auteur ; Cunmei JIANG, Auteur ; Fang LIU, Auteur . - p.1245-1256. Langues : Anglais (eng) in Autism Research > 18-6 (June 2025) . - p.1245-1256 Mots-clés : autism  language  music  P600  syntax Index. décimale : PER Périodiques Résumé : ABSTRACT Syntactic processing in both language and music involves combining elements?such as words or chords?into coherent structures. The Shared Syntactic Integration Resource Hypothesis (SSIRH) was introduced based on observations of similar neural responses to syntactic violations across both domains. This hypothesis suggests that difficulties in syntactic processing in one domain may result in similar challenges in the other. The current study tested the SSIRH in autism, a neurodevelopmental condition often associated with language difficulties but relatively preserved musical abilities. Thirty-one autistic and 31 non-autistic participants judged the acceptability of syntactically congruent and incongruent sentences and musical sequences while their neural responses were recorded using electroencephalography. Autistic participants exhibited a reduced and delayed P600 effect?a marker of syntactic integration?across both domains, despite achieving similar behavioral accuracy to the non-autistic group. These findings suggest parallel difficulties in syntactic processing in autism for both language and music, providing support for the SSIRH. This is the first study to directly examine real-time syntactic integration in both domains in autistic individuals, offering novel insights into cross-domain syntactic processing in autism and contributing to a deeper understanding of language and music processing more broadly. En ligne : https://doi.org/10.1002/aur.70038 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

Intact Susceptibility to Visual Illusions in Autistic Individuals / Bat-Sheva HADAD ; Tzvi GANEL in Autism Research, 18-6 (June 2025)  

Public ISBD [article]  inAutism Research > 18-6 (June 2025) . - p.1257-1268 Titre : Intact Susceptibility to Visual Illusions in Autistic Individuals Type de document : Texte imprimé et/ou numérique Auteurs : Bat-Sheva HADAD, Auteur ; Tzvi GANEL, Auteur Article en page(s) : p.1257-1268 Langues : Anglais (eng) Mots-clés : Autism  Perceptual priors  Size discrimination  Size perception  Visual Illusions Index. décimale : PER Périodiques Résumé : ABSTRACT Altered sensory perception, a core characteristic of autism, has been attributed to attenuated use of stimuli context or prior information in perception. Reduced susceptibility to perceptual illusions was extensively used to support these accounts for autistic perception. However, empirical evidence has been inconsistent. The current study systematically investigated susceptibility to size illusions in autistic and non-autistic individuals using a standardized psychophysical battery. Eighty-one participants, 41 autistic and 40 non-autistic individuals, completed the Ben-Gurion University Test for Perceptual Illusions (BTPI), measuring susceptibility to the Ponzo, Ebbinghaus, and Height-width illusions. The results demonstrate clear evidence for susceptibility to illusions in the perception of size both in the autistic and non-autistic groups. No significant differences were found between groups in the magnitude of illusion on the perceived size, or on the perceptual resolutions of size (discrimination thresholds) in any of the illusory settings tested. The results challenge current theories suggesting reduced reliance on priors or enhanced sensory measurement in autism. Instead, using robust psychophysical methods, the study provides clear evidence for autistic people forming priors and using long-term knowledge in perception. En ligne : https://doi.org/10.1002/aur.70044 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Intact Susceptibility to Visual Illusions in Autistic Individuals [Texte imprimé et/ou numérique] / Bat-Sheva HADAD, Auteur ; Tzvi GANEL, Auteur . - p.1257-1268. Langues : Anglais (eng) in Autism Research > 18-6 (June 2025) . - p.1257-1268 Mots-clés : Autism  Perceptual priors  Size discrimination  Size perception  Visual Illusions Index. décimale : PER Périodiques Résumé : ABSTRACT Altered sensory perception, a core characteristic of autism, has been attributed to attenuated use of stimuli context or prior information in perception. Reduced susceptibility to perceptual illusions was extensively used to support these accounts for autistic perception. However, empirical evidence has been inconsistent. The current study systematically investigated susceptibility to size illusions in autistic and non-autistic individuals using a standardized psychophysical battery. Eighty-one participants, 41 autistic and 40 non-autistic individuals, completed the Ben-Gurion University Test for Perceptual Illusions (BTPI), measuring susceptibility to the Ponzo, Ebbinghaus, and Height-width illusions. The results demonstrate clear evidence for susceptibility to illusions in the perception of size both in the autistic and non-autistic groups. No significant differences were found between groups in the magnitude of illusion on the perceived size, or on the perceptual resolutions of size (discrimination thresholds) in any of the illusory settings tested. The results challenge current theories suggesting reduced reliance on priors or enhanced sensory measurement in autism. Instead, using robust psychophysical methods, the study provides clear evidence for autistic people forming priors and using long-term knowledge in perception. En ligne : https://doi.org/10.1002/aur.70044 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

The Intersection of Variability in Gross Motor Performance and Adaptive Behavior in Young Autistic Children: Combining Video Data Analysis and Standardized Assessments / Laura KEEGAN ; Michele Z. LUO ; Helen TAGER-FLUSBERG ; Karen CHENAUSKY ; Marc F. MAFFEI ; Jordan R. GREEN ; Simone V. GILL in Autism Research, 18-6 (June 2025)  

Public ISBD [article]  inAutism Research > 18-6 (June 2025) . - p.1269-1278 Titre : The Intersection of Variability in Gross Motor Performance and Adaptive Behavior in Young Autistic Children: Combining Video Data Analysis and Standardized Assessments Type de document : Texte imprimé et/ou numérique Auteurs : Laura KEEGAN, Auteur ; Michele Z. LUO, Auteur ; Helen TAGER-FLUSBERG, Auteur ; Karen CHENAUSKY, Auteur ; Marc F. MAFFEI, Auteur ; Jordan R. GREEN, Auteur ; Simone V. GILL, Auteur Article en page(s) : p.1269-1278 Langues : Anglais (eng) Mots-clés : adaptive behavior  autism  behavior  motor activity  walking Index. décimale : PER Périodiques Résumé : ABSTRACT Autism research has shown relationships between motor skills and other developmental domains. However, little research has examined variability in gross motor performance and its potential relation to adaptive behavior in this population. The purpose of this study was to use task-based measures of gross motor performance to quantify variability and to determine if gross motor variability was associated with adaptive behavior. We collected video data of autistic children aged 4?7?years (N?=?71) performing two task-based measures of gross motor performance: walking over flat ground and balancing on one leg. We also computed walking behaviors: behaviors exhibited by children during walking (e.g., jumping). We used the Vineland Adaptive Behavior Scale Adaptive Behavior Composite (VABS-ABC) to measure adaptive behavior. Results showed high intra-subject variability during walking skill, walking behaviors, and balance performance. Less variable walking velocity was correlated with higher adaptive behavior scores. In contrast, less variability in walking behaviors was correlated with lower adaptive behavior scores. These results highlight that variability in gross motor performance may be a feature of ASD and examining gross motor variability in relation to other developmental domains (e.g., adaptive behavior) may provide a more comprehensive understanding of autism. En ligne : https://doi.org/10.1002/aur.70048 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] The Intersection of Variability in Gross Motor Performance and Adaptive Behavior in Young Autistic Children: Combining Video Data Analysis and Standardized Assessments [Texte imprimé et/ou numérique] / Laura KEEGAN, Auteur ; Michele Z. LUO, Auteur ; Helen TAGER-FLUSBERG, Auteur ; Karen CHENAUSKY, Auteur ; Marc F. MAFFEI, Auteur ; Jordan R. GREEN, Auteur ; Simone V. GILL, Auteur . - p.1269-1278. Langues : Anglais (eng) in Autism Research > 18-6 (June 2025) . - p.1269-1278 Mots-clés : adaptive behavior  autism  behavior  motor activity  walking Index. décimale : PER Périodiques Résumé : ABSTRACT Autism research has shown relationships between motor skills and other developmental domains. However, little research has examined variability in gross motor performance and its potential relation to adaptive behavior in this population. The purpose of this study was to use task-based measures of gross motor performance to quantify variability and to determine if gross motor variability was associated with adaptive behavior. We collected video data of autistic children aged 4?7?years (N?=?71) performing two task-based measures of gross motor performance: walking over flat ground and balancing on one leg. We also computed walking behaviors: behaviors exhibited by children during walking (e.g., jumping). We used the Vineland Adaptive Behavior Scale Adaptive Behavior Composite (VABS-ABC) to measure adaptive behavior. Results showed high intra-subject variability during walking skill, walking behaviors, and balance performance. Less variable walking velocity was correlated with higher adaptive behavior scores. In contrast, less variability in walking behaviors was correlated with lower adaptive behavior scores. These results highlight that variability in gross motor performance may be a feature of ASD and examining gross motor variability in relation to other developmental domains (e.g., adaptive behavior) may provide a more comprehensive understanding of autism. En ligne : https://doi.org/10.1002/aur.70048 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

Limited Effect of Masking During COVID-19 Pandemic on ADOS-2 Algorithm Scores in Toddlers With and Without Autism / Morgan CHELSEA ; Powell KELLY ; Macari SUZANNE ; Chawarska KATARZYNA in Autism Research, 18-6 (June 2025)  

Public ISBD [article]  inAutism Research > 18-6 (June 2025) . - p.1279-1289 Titre : Limited Effect of Masking During COVID-19 Pandemic on ADOS-2 Algorithm Scores in Toddlers With and Without Autism Type de document : Texte imprimé et/ou numérique Auteurs : Morgan CHELSEA, Auteur ; Powell KELLY, Auteur ; Macari SUZANNE, Auteur ; Chawarska KATARZYNA, Auteur Article en page(s) : p.1279-1289 Langues : Anglais (eng) Mots-clés : ADOS-2  algorithm scores  autism  COVID-19  item level  mask  pandemic  toddler Index. décimale : PER Périodiques Résumé : ABSTRACT The Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) constitutes one of the most widely used diagnostic instruments for autism and involves a direct face-to-face interaction between clinician and child. During the COVID-19 pandemic, administration of the ADOS-2 continued in several countries, with the requirement of face mask protection. It has been hypothesized that mask wearing may have disrupted the dynamic of child-clinician interaction and differentially affected toddlers with autism. We compared ADOS-2 algorithm scores between cohorts of toddlers evaluated before (pre-COVID-19, n?=?232) and during the pandemic (COVID-19, n?=?116). The COVID-19 cohort included 41 toddlers with autism spectrum disorders (AUT, Mage?=?25.4, SD?=?3.8), 34 toddlers with other neurodevelopmental conditions (NDC, Mage?=?22.3, SD?=?5.0), and 41 typically developing toddlers (TD, Mage?=?20.4, SD?=?3.6) recruited between September 2020 and April 2023. The pre-COVID-19 cohort was selected from 409 assessments conducted from January 2013 to March 2020. Propensity matching was used to match the pre- and COVID-19 cohorts on sex, chronological age, and verbal and nonverbal developmental quotient (DQ) scores. Ordered logistic regression analyses were computed for social affect (SA) and restricted and repetitive behaviors (RRB) algorithm total and item scores, with cohort (pre-COVID-19/COVID-19) as a fixed factor for each diagnostic group. The analyses revealed a limited impact of cohort on the algorithm scores in all three diagnostic groups. Item-level analysis revealed a significant cohort effect only on two out of 20?items: shared enjoyment and joint attention, with higher (more atypical) scores found in the COVID-19 than in the pre-COVID-19 cohorts. The resiliency of the algorithm and item-level scores to the effect of masking speaks to the strength of the diagnostic tool and its ability to capture a range of social, communication, and repetitive behaviors under both standard and nonstandard conditions. En ligne : https://doi.org/10.1002/aur.70050 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Limited Effect of Masking During COVID-19 Pandemic on ADOS-2 Algorithm Scores in Toddlers With and Without Autism [Texte imprimé et/ou numérique] / Morgan CHELSEA, Auteur ; Powell KELLY, Auteur ; Macari SUZANNE, Auteur ; Chawarska KATARZYNA, Auteur . - p.1279-1289. Langues : Anglais (eng) in Autism Research > 18-6 (June 2025) . - p.1279-1289 Mots-clés : ADOS-2  algorithm scores  autism  COVID-19  item level  mask  pandemic  toddler Index. décimale : PER Périodiques Résumé : ABSTRACT The Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) constitutes one of the most widely used diagnostic instruments for autism and involves a direct face-to-face interaction between clinician and child. During the COVID-19 pandemic, administration of the ADOS-2 continued in several countries, with the requirement of face mask protection. It has been hypothesized that mask wearing may have disrupted the dynamic of child-clinician interaction and differentially affected toddlers with autism. We compared ADOS-2 algorithm scores between cohorts of toddlers evaluated before (pre-COVID-19, n?=?232) and during the pandemic (COVID-19, n?=?116). The COVID-19 cohort included 41 toddlers with autism spectrum disorders (AUT, Mage?=?25.4, SD?=?3.8), 34 toddlers with other neurodevelopmental conditions (NDC, Mage?=?22.3, SD?=?5.0), and 41 typically developing toddlers (TD, Mage?=?20.4, SD?=?3.6) recruited between September 2020 and April 2023. The pre-COVID-19 cohort was selected from 409 assessments conducted from January 2013 to March 2020. Propensity matching was used to match the pre- and COVID-19 cohorts on sex, chronological age, and verbal and nonverbal developmental quotient (DQ) scores. Ordered logistic regression analyses were computed for social affect (SA) and restricted and repetitive behaviors (RRB) algorithm total and item scores, with cohort (pre-COVID-19/COVID-19) as a fixed factor for each diagnostic group. The analyses revealed a limited impact of cohort on the algorithm scores in all three diagnostic groups. Item-level analysis revealed a significant cohort effect only on two out of 20?items: shared enjoyment and joint attention, with higher (more atypical) scores found in the COVID-19 than in the pre-COVID-19 cohorts. The resiliency of the algorithm and item-level scores to the effect of masking speaks to the strength of the diagnostic tool and its ability to capture a range of social, communication, and repetitive behaviors under both standard and nonstandard conditions. En ligne : https://doi.org/10.1002/aur.70050 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

Comparative Analysis of Phenotypic and Genotypic Differences Between Individuals Affected by Regressive and Non-Regressive Autism: A Cross-Sectional Study / Alana IABONI ; Brett TROST ; Miriam REUTER ; Zsuzsa LINDENMAIER ; Azadeh KUSHKI ; Elizabeth KELLEY ; Jessica JONES ; Muhammed AYUB ; Stelios GEORGIADES ; Robert NICOLSON ; Elim CHAN ; Andrada CRETU ; Jessica BRIAN ; Evdokia ANAGNOSTOU in Autism Research, 18-6 (June 2025)  

Public ISBD [article]  inAutism Research > 18-6 (June 2025) . - p.1290-1300 Titre : Comparative Analysis of Phenotypic and Genotypic Differences Between Individuals Affected by Regressive and Non-Regressive Autism: A Cross-Sectional Study Type de document : Texte imprimé et/ou numérique Auteurs : Alana IABONI, Auteur ; Brett TROST, Auteur ; Miriam REUTER, Auteur ; Zsuzsa LINDENMAIER, Auteur ; Azadeh KUSHKI, Auteur ; Elizabeth KELLEY, Auteur ; Jessica JONES, Auteur ; Muhammed AYUB, Auteur ; Stelios GEORGIADES, Auteur ; Robert NICOLSON, Auteur ; Elim CHAN, Auteur ; Andrada CRETU, Auteur ; Jessica BRIAN, Auteur ; Evdokia ANAGNOSTOU, Auteur Article en page(s) : p.1290-1300 Langues : Anglais (eng) Mots-clés : autism Spectrum disorder  child  genotype  neurodevelopmental disorder  phenotype  regressive autism  retrospective studies Index. décimale : PER Périodiques Résumé : ABSTRACT Development among autistic youth varies widely. A subgroup of children experiences regression, defined as the loss of previously acquired developmental skills. Various genetic and environmental factors have been suggested as potential contributors. This study aimed to compare the developmental profiles of children and youth with regression to those without and identify factors associated with regression. Data from the Province of Ontario Neurodevelopmental Disorders (POND) Network was analyzed, including 930 eligible participants. Regression classification was based on the Autism Diagnostic Interview-Revised (ADI-R). Differences in demographic information, medical history, mental health, cognitive and adaptive functioning, and molecular genetic findings were examined between individuals with regressive and non-regressive autism. Among participants, 211 (22.7%) had regressive autism. Lower Full-Scale IQ (p corrected?=?0.015) and adaptive function (ABAS-2) scores (p corrected?=?0.015) were identified in the regressive group. No statistically significant differences in mental health outcomes (measured by the Child Behavior Checklist, CBCL) or socialization and core symptom severity (measured by the Social Communication Questionnaire, SCQ) were found. There were no notable differences in other factors hypothesized to contribute to regression, such as pregnancy duration, family history of autism, caregivers' education levels, or sleep disorders, except for a higher prevalence of epilepsy in the regressive group (p?=?0.001). Rare and common genetic features of both groups are described. In conclusion, autistic youth with regression tend to have lower cognitive and adaptive scores and may experience higher epilepsy rates. Further powered studies are needed to explore the genomic architecture of autistic regression. En ligne : https://doi.org/10.1002/aur.70029 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Comparative Analysis of Phenotypic and Genotypic Differences Between Individuals Affected by Regressive and Non-Regressive Autism: A Cross-Sectional Study [Texte imprimé et/ou numérique] / Alana IABONI, Auteur ; Brett TROST, Auteur ; Miriam REUTER, Auteur ; Zsuzsa LINDENMAIER, Auteur ; Azadeh KUSHKI, Auteur ; Elizabeth KELLEY, Auteur ; Jessica JONES, Auteur ; Muhammed AYUB, Auteur ; Stelios GEORGIADES, Auteur ; Robert NICOLSON, Auteur ; Elim CHAN, Auteur ; Andrada CRETU, Auteur ; Jessica BRIAN, Auteur ; Evdokia ANAGNOSTOU, Auteur . - p.1290-1300. Langues : Anglais (eng) in Autism Research > 18-6 (June 2025) . - p.1290-1300 Mots-clés : autism Spectrum disorder  child  genotype  neurodevelopmental disorder  phenotype  regressive autism  retrospective studies Index. décimale : PER Périodiques Résumé : ABSTRACT Development among autistic youth varies widely. A subgroup of children experiences regression, defined as the loss of previously acquired developmental skills. Various genetic and environmental factors have been suggested as potential contributors. This study aimed to compare the developmental profiles of children and youth with regression to those without and identify factors associated with regression. Data from the Province of Ontario Neurodevelopmental Disorders (POND) Network was analyzed, including 930 eligible participants. Regression classification was based on the Autism Diagnostic Interview-Revised (ADI-R). Differences in demographic information, medical history, mental health, cognitive and adaptive functioning, and molecular genetic findings were examined between individuals with regressive and non-regressive autism. Among participants, 211 (22.7%) had regressive autism. Lower Full-Scale IQ (p corrected?=?0.015) and adaptive function (ABAS-2) scores (p corrected?=?0.015) were identified in the regressive group. No statistically significant differences in mental health outcomes (measured by the Child Behavior Checklist, CBCL) or socialization and core symptom severity (measured by the Social Communication Questionnaire, SCQ) were found. There were no notable differences in other factors hypothesized to contribute to regression, such as pregnancy duration, family history of autism, caregivers' education levels, or sleep disorders, except for a higher prevalence of epilepsy in the regressive group (p?=?0.001). Rare and common genetic features of both groups are described. In conclusion, autistic youth with regression tend to have lower cognitive and adaptive scores and may experience higher epilepsy rates. Further powered studies are needed to explore the genomic architecture of autistic regression. En ligne : https://doi.org/10.1002/aur.70029 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

Evaluating More Granular Options for Socio-Demographic Questions in Autism Research / Kristn CURRANS ; Kate WALLIS ; Amanda BENNETT ; Judith S. MILLER in Autism Research, 18-6 (June 2025)  

Public ISBD [article]  inAutism Research > 18-6 (June 2025) . - p.1301-1308 Titre : Evaluating More Granular Options for Socio-Demographic Questions in Autism Research Type de document : Texte imprimé et/ou numérique Auteurs : Kristn CURRANS, Auteur ; Kate WALLIS, Auteur ; Amanda BENNETT, Auteur ; Judith S. MILLER, Auteur Article en page(s) : p.1301-1308 Langues : Anglais (eng) Mots-clés : demographics  inclusive research  surveys Index. décimale : PER Périodiques Résumé : ABSTRACT We evaluated the feasibility and acceptability of adding more detailed choices for race, ethnicity, sex, gender, and socio-economic status for a demographic survey used by families both within and outside a large learning health network, the Autism Care Network (ACNet). We updated our demographic survey using an iterative approach, incorporating qualitative and quantitative feedback from interested parties across the US and Canada. Pilot testing of the revised survey was conducted with families with and without autism served by two large academic pediatric tertiary care centers. Through purposive sampling, recruitment was enriched for families from ethnic, racial, or gender minority backgrounds. The updated demographic survey increased the number of response options for race and ethnicity, sex, gender, and language. 85 families within the ACNet and 242 families outside the ACNet provided feasibility and acceptability data. 41% of respondents were from nonWhite or multiple race groups. 99% of respondents rated the updated form same or better than the original. 91% of respondents rated the updated form as acceptable, while 97% rated the survey as feasible. Despite concerns about the burden on respondents, we found high rates of feasibility and acceptability of more granular response options in demographic surveys. Researchers can adapt this approach to make their own more granular demographic forms focused on the specific variables relevant to their study and local contexts. More granular demographic data can identify strengths and gaps in representation that could impact a study's generalizability. En ligne : https://doi.org/10.1002/aur.70041 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Evaluating More Granular Options for Socio-Demographic Questions in Autism Research [Texte imprimé et/ou numérique] / Kristn CURRANS, Auteur ; Kate WALLIS, Auteur ; Amanda BENNETT, Auteur ; Judith S. MILLER, Auteur . - p.1301-1308. Langues : Anglais (eng) in Autism Research > 18-6 (June 2025) . - p.1301-1308 Mots-clés : demographics  inclusive research  surveys Index. décimale : PER Périodiques Résumé : ABSTRACT We evaluated the feasibility and acceptability of adding more detailed choices for race, ethnicity, sex, gender, and socio-economic status for a demographic survey used by families both within and outside a large learning health network, the Autism Care Network (ACNet). We updated our demographic survey using an iterative approach, incorporating qualitative and quantitative feedback from interested parties across the US and Canada. Pilot testing of the revised survey was conducted with families with and without autism served by two large academic pediatric tertiary care centers. Through purposive sampling, recruitment was enriched for families from ethnic, racial, or gender minority backgrounds. The updated demographic survey increased the number of response options for race and ethnicity, sex, gender, and language. 85 families within the ACNet and 242 families outside the ACNet provided feasibility and acceptability data. 41% of respondents were from nonWhite or multiple race groups. 99% of respondents rated the updated form same or better than the original. 91% of respondents rated the updated form as acceptable, while 97% rated the survey as feasible. Despite concerns about the burden on respondents, we found high rates of feasibility and acceptability of more granular response options in demographic surveys. Researchers can adapt this approach to make their own more granular demographic forms focused on the specific variables relevant to their study and local contexts. More granular demographic data can identify strengths and gaps in representation that could impact a study's generalizability. En ligne : https://doi.org/10.1002/aur.70041 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558