Annual Research Review: Exposure to environmental chemicals and psychosocial stress and the development of children's learning difficulties / Amy E. MARGOLIS in Journal of Child Psychology and Psychiatry, 66-4 (April 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-4 (April 2025) . - p.547-568 Titre : Annual Research Review: Exposure to environmental chemicals and psychosocial stress and the development of children's learning difficulties Type de document : texte imprimé Auteurs : Amy E. MARGOLIS, Auteur ; Alex DRANOVSKY, Auteur ; David PAGLIACCIO, Auteur ; Gazi F. AZAD, Auteur ; Virginia A. RAUH, Auteur ; Julie B. HERBSTMAN, Auteur Article en page(s) : p.547-568 Langues : Anglais (eng) Mots-clés : Learning difficulties  environmental exposures  brain development  stress Index. décimale : PER Périodiques Résumé : Although awareness of the role of environmental exposures in children's cognitive development is increasing, learning difficulties have not yet been a major focus of environmental health science. Learning difficulties disproportionately affect children living in economic disadvantage, yielding an ?achievement gap.? Studies examining the neurobiology of reading and math have mostly included economically advantaged youth, leaving a great deal unknown about the neural underpinnings of reading and math difficulties in youth living in disadvantaged contexts. Critically, due to environmental injustice, these youth are disproportionately exposed to environmental neurotoxicants. Herein, we review literature supporting a theoretical framework of environmentally associated phenotypes of learning difficulties. We propose that prenatal exposure to neurotoxicants and early-life exposure to psychosocial stressors increases risk for learning difficulties via effects on neural circuits that support cognitive processes which, in addition to literacy and numeracy, are integral to acquiring and performing academic skills. We describe models in which (1) prenatal exposure to air pollution has a main effect on learning via brain structure and function or associated domain-general cognitive processes and (2) a joint ?two-hit? pathway in which prenatal air pollution exposure followed by early life stress?when combined and sequential?increases risk for learning difficulties also via effects on brain structure, function, and/or associated cognitive processes. We review a select literature documenting effects of exposure to pollutants and early life stress on relevant neural circuits and associated cognitive processes in animal models and parallel findings in human epidemiologic studies. We advocate for team science in which researchers, practitioners, and policymakers collaborate to increase health literacy about environmentally associated phenotypes of learning difficulties and support the development of precision-oriented instructional and environmental intervention methods for youth living in economic disadvantage. En ligne : https://doi.org/10.1111/jcpp.14137 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=550 [article] Annual Research Review: Exposure to environmental chemicals and psychosocial stress and the development of children's learning difficulties [texte imprimé] / Amy E. MARGOLIS, Auteur ; Alex DRANOVSKY, Auteur ; David PAGLIACCIO, Auteur ; Gazi F. AZAD, Auteur ; Virginia A. RAUH, Auteur ; Julie B. HERBSTMAN, Auteur . - p.547-568. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-4 (April 2025) . - p.547-568 Mots-clés : Learning difficulties  environmental exposures  brain development  stress Index. décimale : PER Périodiques Résumé : Although awareness of the role of environmental exposures in children's cognitive development is increasing, learning difficulties have not yet been a major focus of environmental health science. Learning difficulties disproportionately affect children living in economic disadvantage, yielding an ?achievement gap.? Studies examining the neurobiology of reading and math have mostly included economically advantaged youth, leaving a great deal unknown about the neural underpinnings of reading and math difficulties in youth living in disadvantaged contexts. Critically, due to environmental injustice, these youth are disproportionately exposed to environmental neurotoxicants. Herein, we review literature supporting a theoretical framework of environmentally associated phenotypes of learning difficulties. We propose that prenatal exposure to neurotoxicants and early-life exposure to psychosocial stressors increases risk for learning difficulties via effects on neural circuits that support cognitive processes which, in addition to literacy and numeracy, are integral to acquiring and performing academic skills. We describe models in which (1) prenatal exposure to air pollution has a main effect on learning via brain structure and function or associated domain-general cognitive processes and (2) a joint ?two-hit? pathway in which prenatal air pollution exposure followed by early life stress?when combined and sequential?increases risk for learning difficulties also via effects on brain structure, function, and/or associated cognitive processes. We review a select literature documenting effects of exposure to pollutants and early life stress on relevant neural circuits and associated cognitive processes in animal models and parallel findings in human epidemiologic studies. We advocate for team science in which researchers, practitioners, and policymakers collaborate to increase health literacy about environmentally associated phenotypes of learning difficulties and support the development of precision-oriented instructional and environmental intervention methods for youth living in economic disadvantage. En ligne : https://doi.org/10.1111/jcpp.14137 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=550

Causal effects of psychostimulants on neural connectivity: a mechanistic, randomized clinical trial / Yun WANG in Journal of Child Psychology and Psychiatry, 63-11 (November 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1381-1391 Titre : Causal effects of psychostimulants on neural connectivity: a mechanistic, randomized clinical trial Type de document : texte imprimé Auteurs : Yun WANG, Auteur ; Ellen M. KESSEL, Auteur ; Seonjoo LEE, Auteur ; Susie HONG, Auteur ; Elizabeth RAFFANELLO, Auteur ; Leslie A. HULVERSHORN, Auteur ; Amy E. MARGOLIS, Auteur ; Bradley S. PETERSON, Auteur ; Jonathan POSNER, Auteur Article en page(s) : p.1381-1391 Langues : Anglais (eng) Mots-clés : Adolescent  Humans  Child  Young Adult  Adult  Lisdexamfetamine Dimesylate/pharmacology/therapeutic use  Central Nervous System Stimulants/pharmacology  Attention Deficit Disorder with Hyperactivity  Brain Mapping  Brain/diagnostic imaging  Magnetic Resonance Imaging  Adhd  Dynamic Functional MRI (fMRI)  Lisdexamfetamine  Striatum  Structural Equation Modeling  Thalamus Index. décimale : PER Périodiques Résumé : BACKGROUND: Psychostimulants are frequently used to treat attention-deficit/hyperactivity disorder (ADHD), but side effects are common leading to many patients discontinuing treatment. Identifying neural mechanisms by which psychostimulants attenuate symptoms may guide the development of more refined and tolerable therapeutics. METHODS: We conducted a 12-week, randomized, placebo-controlled trial (RCT) of a long-acting amphetamine, lisdexamfetamine (LDEX), in patients with ADHD, ages 6-25 years old. Of the 58 participants who participated in the RCT, 49 completed pre- and post-RCT magnetic resonance imaging scanning with adequate data quality. Healthy controls (HCs; n=46) were included for comparison. Treatment effects on striatal and thalamic functional connectivity (FC) were identified using static (time-averaged) and dynamic (time-varying) measures and then correlated with symptom improvement. Analyses were repeated in independent samples from the Adolescent Brain Cognitive Development study (n=103) and the ADHD-200 Consortium (n=213). RESULTS: In 49 participants (25 LDEX; 24 Placebo), LDEX increased static and decreased dynamic FC (DFC). However, only DFC was associated with the therapeutic effects of LDEX. Additionally, at baseline, DFC was elevated in unmedicated-ADHD participants relative to HCs. Independent samples yielded similar findings - ADHD was associated with increased DFC, and psychostimulants with reduced DFC. Static FC findings were inconsistent across samples. CONCLUSIONS: Changes in dynamic, but not static, FC were associated with the therapeutic effects of psychostimulants. While prior research has focused on static FC, DFC may offer a more reliable target for new ADHD interventions aimed at stabilizing network dynamics, though this needs confirmation with subsequent investigations. En ligne : http://dx.doi.org/10.1111/jcpp.13585 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] Causal effects of psychostimulants on neural connectivity: a mechanistic, randomized clinical trial [texte imprimé] / Yun WANG, Auteur ; Ellen M. KESSEL, Auteur ; Seonjoo LEE, Auteur ; Susie HONG, Auteur ; Elizabeth RAFFANELLO, Auteur ; Leslie A. HULVERSHORN, Auteur ; Amy E. MARGOLIS, Auteur ; Bradley S. PETERSON, Auteur ; Jonathan POSNER, Auteur . - p.1381-1391. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1381-1391 Mots-clés : Adolescent  Humans  Child  Young Adult  Adult  Lisdexamfetamine Dimesylate/pharmacology/therapeutic use  Central Nervous System Stimulants/pharmacology  Attention Deficit Disorder with Hyperactivity  Brain Mapping  Brain/diagnostic imaging  Magnetic Resonance Imaging  Adhd  Dynamic Functional MRI (fMRI)  Lisdexamfetamine  Striatum  Structural Equation Modeling  Thalamus Index. décimale : PER Périodiques Résumé : BACKGROUND: Psychostimulants are frequently used to treat attention-deficit/hyperactivity disorder (ADHD), but side effects are common leading to many patients discontinuing treatment. Identifying neural mechanisms by which psychostimulants attenuate symptoms may guide the development of more refined and tolerable therapeutics. METHODS: We conducted a 12-week, randomized, placebo-controlled trial (RCT) of a long-acting amphetamine, lisdexamfetamine (LDEX), in patients with ADHD, ages 6-25 years old. Of the 58 participants who participated in the RCT, 49 completed pre- and post-RCT magnetic resonance imaging scanning with adequate data quality. Healthy controls (HCs; n=46) were included for comparison. Treatment effects on striatal and thalamic functional connectivity (FC) were identified using static (time-averaged) and dynamic (time-varying) measures and then correlated with symptom improvement. Analyses were repeated in independent samples from the Adolescent Brain Cognitive Development study (n=103) and the ADHD-200 Consortium (n=213). RESULTS: In 49 participants (25 LDEX; 24 Placebo), LDEX increased static and decreased dynamic FC (DFC). However, only DFC was associated with the therapeutic effects of LDEX. Additionally, at baseline, DFC was elevated in unmedicated-ADHD participants relative to HCs. Independent samples yielded similar findings - ADHD was associated with increased DFC, and psychostimulants with reduced DFC. Static FC findings were inconsistent across samples. CONCLUSIONS: Changes in dynamic, but not static, FC were associated with the therapeutic effects of psychostimulants. While prior research has focused on static FC, DFC may offer a more reliable target for new ADHD interventions aimed at stabilizing network dynamics, though this needs confirmation with subsequent investigations. En ligne : http://dx.doi.org/10.1111/jcpp.13585 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

Cognitive correlates of autism spectrum disorder symptoms / Camille N. JOHNSON in Autism Research, 14-11 (November 2021)  

Public ISBD [article]  inAutism Research > 14-11 (November 2021) . - p.2405-2411 Titre : Cognitive correlates of autism spectrum disorder symptoms Type de document : texte imprimé Auteurs : Camille N. JOHNSON, Auteur ; Bruce RAMPHAL, Auteur ; Emily KOE, Auteur ; Amarelis RAUDALES, Auteur ; Jeff GOLDSMITH, Auteur ; Amy E. MARGOLIS, Auteur Article en page(s) : p.2405-2411 Langues : Anglais (eng) Mots-clés : Adult  Autism Spectrum Disorder/complications  Brain  Child  Cognition  Humans  Intelligence  Intelligence Tests  adult  autism spectrum disorder  child  cognition  communication  intelligence  intelligence tests Index. décimale : PER Périodiques Résumé : Due to the diverse behavioral presentation of autism spectrum disorder (ASD), identifying ASD subtypes using patterns of cognitive abilities has become an important point of research. Some previous studies on cognitive profiles in ASD suggest that the discrepancy between verbal intelligence quotient (VIQ) and performance IQ (PIQ) is associated with ASD symptoms, while others have pointed to VIQ as the critical predictor. Given that VIQ is a component of the VIQ-PIQ discrepancy, it was unclear which was most driving these associations. This study tested whether VIQ, PIQ, or the VIQ-PIQ discrepancy was most associated with ASD symptoms in children and adults with ASD (N = 527). Using data from the Autism Brain Imaging Data Exchange (ABIDE), we tested the independent contribution of each IQ index and their discrepancy to ASD symptom severity using multiple linear regressions predicting ASD symptoms. VIQ was most associated with lower symptom severity as measured by the Autism Diagnostic Observation Schedule (ADOS) total score, and when VIQ was included in models predicting ASD symptoms, associations with PIQ and IQ discrepancy were not significant. An association between VIQ and ASD communication symptoms drove the association with ASD symptom severity. These results suggest that associations between ASD communication symptoms and IQ discrepancy or PIQ reported in prior studies likely resulted from variance shared with VIQ. Subtyping ASD on the basis of VIQ should be a point of future research, as it may allow for the development of more personalized approaches to intervention. LAY SUMMARY: Previous research on links between autism severity and verbal and nonverbal intelligence has produced mixed results. Our study examined whether verbal intelligence, nonverbal intelligence, or the discrepancy between the two was most related to autism symptoms. We found that higher verbal intelligence was most associated with less severe autism communication symptoms. Given the relevance of verbal intelligence in predicting autism symptom severity, subtyping autism on the basis of verbal intelligence could lead to more personalized treatments. En ligne : http://dx.doi.org/10.1002/aur.2577 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Cognitive correlates of autism spectrum disorder symptoms [texte imprimé] / Camille N. JOHNSON, Auteur ; Bruce RAMPHAL, Auteur ; Emily KOE, Auteur ; Amarelis RAUDALES, Auteur ; Jeff GOLDSMITH, Auteur ; Amy E. MARGOLIS, Auteur . - p.2405-2411. Langues : Anglais (eng) in Autism Research > 14-11 (November 2021) . - p.2405-2411 Mots-clés : Adult  Autism Spectrum Disorder/complications  Brain  Child  Cognition  Humans  Intelligence  Intelligence Tests  adult  autism spectrum disorder  child  cognition  communication  intelligence  intelligence tests Index. décimale : PER Périodiques Résumé : Due to the diverse behavioral presentation of autism spectrum disorder (ASD), identifying ASD subtypes using patterns of cognitive abilities has become an important point of research. Some previous studies on cognitive profiles in ASD suggest that the discrepancy between verbal intelligence quotient (VIQ) and performance IQ (PIQ) is associated with ASD symptoms, while others have pointed to VIQ as the critical predictor. Given that VIQ is a component of the VIQ-PIQ discrepancy, it was unclear which was most driving these associations. This study tested whether VIQ, PIQ, or the VIQ-PIQ discrepancy was most associated with ASD symptoms in children and adults with ASD (N = 527). Using data from the Autism Brain Imaging Data Exchange (ABIDE), we tested the independent contribution of each IQ index and their discrepancy to ASD symptom severity using multiple linear regressions predicting ASD symptoms. VIQ was most associated with lower symptom severity as measured by the Autism Diagnostic Observation Schedule (ADOS) total score, and when VIQ was included in models predicting ASD symptoms, associations with PIQ and IQ discrepancy were not significant. An association between VIQ and ASD communication symptoms drove the association with ASD symptom severity. These results suggest that associations between ASD communication symptoms and IQ discrepancy or PIQ reported in prior studies likely resulted from variance shared with VIQ. Subtyping ASD on the basis of VIQ should be a point of future research, as it may allow for the development of more personalized approaches to intervention. LAY SUMMARY: Previous research on links between autism severity and verbal and nonverbal intelligence has produced mixed results. Our study examined whether verbal intelligence, nonverbal intelligence, or the discrepancy between the two was most related to autism symptoms. We found that higher verbal intelligence was most associated with less severe autism communication symptoms. Given the relevance of verbal intelligence in predicting autism symptom severity, subtyping autism on the basis of verbal intelligence could lead to more personalized treatments. En ligne : http://dx.doi.org/10.1002/aur.2577 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Demographic Correlates of Autism: How Do Associations Compare Between Diagnosis and a Quantitative Trait Measure? / Kristen LYALL in Autism Research, 18-3 (March 2025)  

Public ISBD [article]  inAutism Research > 18-3 (March 2025) . - p.648-659 Titre : Demographic Correlates of Autism: How Do Associations Compare Between Diagnosis and a Quantitative Trait Measure? Type de document : texte imprimé Auteurs : Kristen LYALL, Auteur ; Aisha S. DICKERSON, Auteur ; Annette M. GREEN, Auteur ; Seth FRNDAK, Auteur ; Lisa A. CROEN, Auteur ; Jennifer L. AMES, Auteur ; Lyndsay A. AVALOS, Auteur ; Judy L. ASCHNER, Auteur ; Nicole R. BUSH, Auteur ; Carlos A. CAMARGO, Auteur ; Viren D'SA, Auteur ; Stephen R. DAGER, Auteur ; Anne L. DUNLOP, Auteur ; Assiamira FERRARA, Auteur ; Jody M. GANIBAN, Auteur ; James E. GERN, Auteur ; Tre D. GISSANDANER, Auteur ; J. Carolyn GRAFF, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Alison E. HIPWELL, Auteur ; Tengfei MA, Auteur ; Meghan MILLER, Auteur ; Laura MURPHY, Auteur ; Margaret R. KARAGAS, Auteur ; Rachel S. KELLY, Auteur ; Amy E. MARGOLIS, Auteur ; Daphne KOINIS-MITCHELL, Auteur ; Cindy MCEVOY, Auteur ; Daniel S. MESSINGER, Auteur ; Ruby NGUYEN, Auteur ; Emily OKEN, Auteur ; Sally OZONOFF, Auteur ; Grier P. PAGE, Auteur ; Susan L. SCHANTZ, Auteur ; Rebecca J. SCHMIDT, Auteur ; Coral L. SHUSTER, Auteur ; Julie B. SCHWEITZER, Auteur ; Stephen J. SHEINKOPF, Auteur ; Joseph B. STANFORD, Auteur ; Cindy O. TREVINO, Auteur ; Scott T. WEISS, Auteur ; Heather E. VOLK, Auteur ; Robert M. JOSEPH, Auteur ; Outcomes PROGRAM COLLABORATORS FOR ENVIRONMENTAL INFLUENCES ON CHILD HEALTH, Auteur Article en page(s) : p.648-659 Langues : Anglais (eng) Mots-clés : autism  diagnosis  social responsiveness scale Index. décimale : PER Périodiques Résumé : ABSTRACT Prevalence of autism diagnosis has historically differed by demographic factors. Using data from 8224 participants drawn from the Environmental influences on Child Health Outcomes (ECHO) Program, we examined relationships between demographic factors and parent-reported autism-related traits as captured by the Social Responsiveness Scale (SRS; T score?> 65) and compared these to relations with parent-reported clinician diagnosis of ASD, in generalized linear mixed effects regression analyses. Results suggested lower odds of autism diagnosis, but not of SRS T?> 65, for non-Hispanic Black children (adjusted odds ratio [OR] 0.76, 95% CI 0.55, 1.06) relative to non-Hispanic White children. Higher maternal education was associated with reduced odds of both outcomes (OR 0.73, 95% CI 0.51, 1.05 for ASD autism diagnosis and 0.4, 95% CI 0.29, 0.55 for SRS score). In addition, results suggested a lower likelihood of autism diagnosis but a higher likelihood of an SRS score?> 65 in Black girls. Findings suggest lower diagnostic recognition of autism in non-Hispanic Black children, despite a similar degree of SRS-assessed autism-related traits falling in the clinically elevated range. Further work is needed to address this disparity. En ligne : https://doi.org/10.1002/aur.3296 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=550 [article] Demographic Correlates of Autism: How Do Associations Compare Between Diagnosis and a Quantitative Trait Measure? [texte imprimé] / Kristen LYALL, Auteur ; Aisha S. DICKERSON, Auteur ; Annette M. GREEN, Auteur ; Seth FRNDAK, Auteur ; Lisa A. CROEN, Auteur ; Jennifer L. AMES, Auteur ; Lyndsay A. AVALOS, Auteur ; Judy L. ASCHNER, Auteur ; Nicole R. BUSH, Auteur ; Carlos A. CAMARGO, Auteur ; Viren D'SA, Auteur ; Stephen R. DAGER, Auteur ; Anne L. DUNLOP, Auteur ; Assiamira FERRARA, Auteur ; Jody M. GANIBAN, Auteur ; James E. GERN, Auteur ; Tre D. GISSANDANER, Auteur ; J. Carolyn GRAFF, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Alison E. HIPWELL, Auteur ; Tengfei MA, Auteur ; Meghan MILLER, Auteur ; Laura MURPHY, Auteur ; Margaret R. KARAGAS, Auteur ; Rachel S. KELLY, Auteur ; Amy E. MARGOLIS, Auteur ; Daphne KOINIS-MITCHELL, Auteur ; Cindy MCEVOY, Auteur ; Daniel S. MESSINGER, Auteur ; Ruby NGUYEN, Auteur ; Emily OKEN, Auteur ; Sally OZONOFF, Auteur ; Grier P. PAGE, Auteur ; Susan L. SCHANTZ, Auteur ; Rebecca J. SCHMIDT, Auteur ; Coral L. SHUSTER, Auteur ; Julie B. SCHWEITZER, Auteur ; Stephen J. SHEINKOPF, Auteur ; Joseph B. STANFORD, Auteur ; Cindy O. TREVINO, Auteur ; Scott T. WEISS, Auteur ; Heather E. VOLK, Auteur ; Robert M. JOSEPH, Auteur ; Outcomes PROGRAM COLLABORATORS FOR ENVIRONMENTAL INFLUENCES ON CHILD HEALTH, Auteur . - p.648-659. Langues : Anglais (eng) in Autism Research > 18-3 (March 2025) . - p.648-659 Mots-clés : autism  diagnosis  social responsiveness scale Index. décimale : PER Périodiques Résumé : ABSTRACT Prevalence of autism diagnosis has historically differed by demographic factors. Using data from 8224 participants drawn from the Environmental influences on Child Health Outcomes (ECHO) Program, we examined relationships between demographic factors and parent-reported autism-related traits as captured by the Social Responsiveness Scale (SRS; T score?> 65) and compared these to relations with parent-reported clinician diagnosis of ASD, in generalized linear mixed effects regression analyses. Results suggested lower odds of autism diagnosis, but not of SRS T?> 65, for non-Hispanic Black children (adjusted odds ratio [OR] 0.76, 95% CI 0.55, 1.06) relative to non-Hispanic White children. Higher maternal education was associated with reduced odds of both outcomes (OR 0.73, 95% CI 0.51, 1.05 for ASD autism diagnosis and 0.4, 95% CI 0.29, 0.55 for SRS score). In addition, results suggested a lower likelihood of autism diagnosis but a higher likelihood of an SRS score?> 65 in Black girls. Findings suggest lower diagnostic recognition of autism in non-Hispanic Black children, despite a similar degree of SRS-assessed autism-related traits falling in the clinically elevated range. Further work is needed to address this disparity. En ligne : https://doi.org/10.1002/aur.3296 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=550

Longitudinal effects of prenatal exposure to air pollutants on self-regulatory capacities and social competence / Amy E. MARGOLIS in Journal of Child Psychology and Psychiatry, 57-7 (July 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-7 (July 2016) . - p.851-860 Titre : Longitudinal effects of prenatal exposure to air pollutants on self-regulatory capacities and social competence Type de document : texte imprimé Auteurs : Amy E. MARGOLIS, Auteur ; Julie B. HERBSTMAN, Auteur ; Katie S. DAVIS, Auteur ; Valerie K. THOMAS, Auteur ; Deliang TANG, Auteur ; Ya WANG, Auteur ; Shuang WANG, Auteur ; Frederica PERERA, Auteur ; Bradley S. PETERSON, Auteur ; Virginia A. RAUH, Auteur Article en page(s) : p.851-860 Langues : Anglais (eng) Mots-clés : Polycyclic aromatic hydrocarbons  self-regulation  prenatal exposure  social competence Index. décimale : PER Périodiques Résumé : Background We evaluated the influence of prenatal exposure to widespread urban air pollutants on the development of self-regulation and social competence in a longitudinal prospective cohort of children born to nonsmoking minority women in New York City. Methods Air pollutant exposure was estimated categorically by level of polycyclic aromatic hydrocarbon (PAH)-DNA adducts in maternal blood collected at delivery, providing a biomarker of maternal exposure to PAH over a 2- to 3-month period. Deficient emotional self-regulation (DESR) was defined as moderate elevations on three specific scales of the child behavior checklist (anxious/depressed, aggressive behavior, and attention problems). We used generalized estimating equations to assess the influence of prenatal exposure to PAH on DESR in children at 3–5, 7, 9, and 11 years of age, adjusted for gender and race/ethnicity. Next, we assessed the association of prenatal exposure to PAH with social competence, as measured by the social responsiveness scale (SRS), the association of impaired self-regulation with social competence, and whether impairment in self-regulation mediated the association of prenatal exposure to PAH with social competence. Results We detected a significant interaction (at p = .05) of exposure with time, in which the developmental trajectory of self-regulatory capacity was delayed in the exposed children. Multiple linear regression revealed a positive association between presence of PAH-DNA adducts and problems with social competence (p < .04), level of dysregulation and problems with social competence (p < .0001), and evidence that self-regulation mediates the association of prenatal exposure to PAH with social competence (p < .0007). Conclusions These data suggest that prenatal exposure to PAH produces long-lasting effects on self-regulatory capacities across early and middle childhood, and that these deficits point to emerging social problems with real-world consequences for high-risk adolescent behaviors in this minority urban cohort. En ligne : http://dx.doi.org/10.1111/jcpp.12548 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=291 [article] Longitudinal effects of prenatal exposure to air pollutants on self-regulatory capacities and social competence [texte imprimé] / Amy E. MARGOLIS, Auteur ; Julie B. HERBSTMAN, Auteur ; Katie S. DAVIS, Auteur ; Valerie K. THOMAS, Auteur ; Deliang TANG, Auteur ; Ya WANG, Auteur ; Shuang WANG, Auteur ; Frederica PERERA, Auteur ; Bradley S. PETERSON, Auteur ; Virginia A. RAUH, Auteur . - p.851-860. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-7 (July 2016) . - p.851-860 Mots-clés : Polycyclic aromatic hydrocarbons  self-regulation  prenatal exposure  social competence Index. décimale : PER Périodiques Résumé : Background We evaluated the influence of prenatal exposure to widespread urban air pollutants on the development of self-regulation and social competence in a longitudinal prospective cohort of children born to nonsmoking minority women in New York City. Methods Air pollutant exposure was estimated categorically by level of polycyclic aromatic hydrocarbon (PAH)-DNA adducts in maternal blood collected at delivery, providing a biomarker of maternal exposure to PAH over a 2- to 3-month period. Deficient emotional self-regulation (DESR) was defined as moderate elevations on three specific scales of the child behavior checklist (anxious/depressed, aggressive behavior, and attention problems). We used generalized estimating equations to assess the influence of prenatal exposure to PAH on DESR in children at 3–5, 7, 9, and 11 years of age, adjusted for gender and race/ethnicity. Next, we assessed the association of prenatal exposure to PAH with social competence, as measured by the social responsiveness scale (SRS), the association of impaired self-regulation with social competence, and whether impairment in self-regulation mediated the association of prenatal exposure to PAH with social competence. Results We detected a significant interaction (at p = .05) of exposure with time, in which the developmental trajectory of self-regulatory capacity was delayed in the exposed children. Multiple linear regression revealed a positive association between presence of PAH-DNA adducts and problems with social competence (p < .04), level of dysregulation and problems with social competence (p < .0001), and evidence that self-regulation mediates the association of prenatal exposure to PAH with social competence (p < .0007). Conclusions These data suggest that prenatal exposure to PAH produces long-lasting effects on self-regulatory capacities across early and middle childhood, and that these deficits point to emerging social problems with real-world consequences for high-risk adolescent behaviors in this minority urban cohort. En ligne : http://dx.doi.org/10.1111/jcpp.12548 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=291

A preliminary study on prenatal polybrominated diphenyl ether serum concentrations and intrinsic functional network organization and executive functioning in childhood / Erik DE WATER in Journal of Child Psychology and Psychiatry, 60-9 (September 2019)  

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Prenatal exposure to air pollution and childhood internalizing problems: roles of shyness and anterior cingulate cortex activity / Ran LIU in Journal of Child Psychology and Psychiatry, 64-7 (July 2023)  

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Prenatal exposure to air pollution and maternal stress predict infant individual differences in reactivity and regulation and socioemotional development / Ran LIU in Journal of Child Psychology and Psychiatry, 63-11 (November 2022)  

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Prenatal exposure to air pollution is associated with altered brain structure, function, and metabolism in childhood / Bradley S. PETERSON in Journal of Child Psychology and Psychiatry, 63-11 (November 2022)  

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Prenatal exposure to polycyclic aromatic hydrocarbons modifies the effects of early life stress on attention and Thought Problems in late childhood / David PAGLIACCIO in Journal of Child Psychology and Psychiatry, 61-11 (November 2020)  

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Research Review: Environmental exposures, neurodevelopment, and child mental health – new paradigms for the study of brain and behavioral effects / Virginia A. RAUH in Journal of Child Psychology and Psychiatry, 57-7 (July 2016)  

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