Dépouillements

Editorial: Let's talk about sex – the gender binary revisited / Albertine J. OLDEHINKEL in Journal of Child Psychology and Psychiatry, 58-8 (August 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-8 (August 2017) . - p.863-864 Titre : Editorial: Let's talk about sex – the gender binary revisited Type de document : Texte imprimé et/ou numérique Auteurs : Albertine J. OLDEHINKEL, Auteur Article en page(s) : p.863-864 Langues : Anglais (eng) Mots-clés : Sex differences  gender  sex binary  diversity  causal mechanisms Index. décimale : PER Périodiques Résumé : Sex refers to biological differences and gender to socioculturally delineated masculine and feminine roles. Sex or gender are included as a covariate or effect modifier in the majority of child psychology and psychiatry studies, and differences found between boys and girls have inspired many researchers to postulate underlying mechanisms. Empirical tests of whether including these proposed explanatory variables actually reduces the variance explained by gender are lagging behind somewhat. That is a pity, because a lot can be gained from a greater focus on the active agents of specific gender differences. As opposed to biological sex as such, some of the processes explaining why a specific outcome shows gender differences may be changeable and so possible prevention targets. Moreover, while the sex binary may be reasonable adequate as a classification variable, the gender binary is far from perfect. Gender is a multidimensional, partly context-dependent factor, and the dichotomy generally used in research does not do justice to the diversity existing within boys and girls. En ligne : http://dx.doi.org/10.1111/jcpp.12777 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316 [article] Editorial: Let's talk about sex – the gender binary revisited [Texte imprimé et/ou numérique] / Albertine J. OLDEHINKEL, Auteur . - p.863-864. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-8 (August 2017) . - p.863-864 Mots-clés : Sex differences  gender  sex binary  diversity  causal mechanisms Index. décimale : PER Périodiques Résumé : Sex refers to biological differences and gender to socioculturally delineated masculine and feminine roles. Sex or gender are included as a covariate or effect modifier in the majority of child psychology and psychiatry studies, and differences found between boys and girls have inspired many researchers to postulate underlying mechanisms. Empirical tests of whether including these proposed explanatory variables actually reduces the variance explained by gender are lagging behind somewhat. That is a pity, because a lot can be gained from a greater focus on the active agents of specific gender differences. As opposed to biological sex as such, some of the processes explaining why a specific outcome shows gender differences may be changeable and so possible prevention targets. Moreover, while the sex binary may be reasonable adequate as a classification variable, the gender binary is far from perfect. Gender is a multidimensional, partly context-dependent factor, and the dichotomy generally used in research does not do justice to the diversity existing within boys and girls. En ligne : http://dx.doi.org/10.1111/jcpp.12777 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316

Practitioner Review: The effects of atypical antipsychotics and mood stabilisers in the treatment of depressive symptoms in paediatric bipolar disorder / Tobias ATKIN in Journal of Child Psychology and Psychiatry, 58-8 (August 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-8 (August 2017) . - p.865-879 Titre : Practitioner Review: The effects of atypical antipsychotics and mood stabilisers in the treatment of depressive symptoms in paediatric bipolar disorder Type de document : Texte imprimé et/ou numérique Auteurs : Tobias ATKIN, Auteur ; Nicolas NUÑEZ, Auteur ; Gabriella GOBBI, Auteur Article en page(s) : p.865-879 Langues : Anglais (eng) Mots-clés : Psychopharmacology  paediatric bipolar disorder  depression  quetiapine  aripiprazole  lithium  valproate  mixed state  depressive symptoms Index. décimale : PER Périodiques Résumé : Background The management of depressive and mixed symptoms in children and adolescents with bipolar disorder (BD) remains a matter of debate. The goal of this review is, thus, to systematically examine the impact of atypical antipsychotics (AAPs) and mood stabilisers in the treatment of bipolar depression and/or mixed states. Methods A literature search was conducted for studies assessing the efficacy of pharmacological treatments for bipolar disorder type I, type II and not otherwise specified with a recent depressive, mixed or manic episode (with depressive symptoms) following DSM-IV criteria in children and adolescents as either acute or maintenance treatment. The databases searched were PubMed/Medline, Google Scholar and Tripdatabase, as well as ClinicalTrials.gov. The search was limited to clinical trials, systematic reviews, meta-analyses and open-label trials published in the English language between the years 2000 and 2015. Sixty clinical studies were found assessing the efficacy of mood stabilisers and AAPs in paediatric BD. Fifteen studies were not included in the primary analysis because they did not assess depressive symptomology/include scores on rating scales of depressive symptoms (Online Supplementary Material). Results There is sufficient evidence for a Grade A recommendation of the use of olanzapine plus fluoxetine at reducing depressive symptoms in bipolar depression and of quetiapine at high doses for depressive symptoms occurring during mixed episodes. Importantly, even though monotherapy with aripiprazole, risperidone, valproate and lithium was effective at controlling mania, these drugs were not effective at reducing depressive symptoms (level A evidence for nonrecommendation). Conclusions These results mostly overlap with the approved treatments for bipolar depression in adults. En ligne : http://dx.doi.org/10.1111/jcpp.12735 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316 [article] Practitioner Review: The effects of atypical antipsychotics and mood stabilisers in the treatment of depressive symptoms in paediatric bipolar disorder [Texte imprimé et/ou numérique] / Tobias ATKIN, Auteur ; Nicolas NUÑEZ, Auteur ; Gabriella GOBBI, Auteur . - p.865-879. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-8 (August 2017) . - p.865-879 Mots-clés : Psychopharmacology  paediatric bipolar disorder  depression  quetiapine  aripiprazole  lithium  valproate  mixed state  depressive symptoms Index. décimale : PER Périodiques Résumé : Background The management of depressive and mixed symptoms in children and adolescents with bipolar disorder (BD) remains a matter of debate. The goal of this review is, thus, to systematically examine the impact of atypical antipsychotics (AAPs) and mood stabilisers in the treatment of bipolar depression and/or mixed states. Methods A literature search was conducted for studies assessing the efficacy of pharmacological treatments for bipolar disorder type I, type II and not otherwise specified with a recent depressive, mixed or manic episode (with depressive symptoms) following DSM-IV criteria in children and adolescents as either acute or maintenance treatment. The databases searched were PubMed/Medline, Google Scholar and Tripdatabase, as well as ClinicalTrials.gov. The search was limited to clinical trials, systematic reviews, meta-analyses and open-label trials published in the English language between the years 2000 and 2015. Sixty clinical studies were found assessing the efficacy of mood stabilisers and AAPs in paediatric BD. Fifteen studies were not included in the primary analysis because they did not assess depressive symptomology/include scores on rating scales of depressive symptoms (Online Supplementary Material). Results There is sufficient evidence for a Grade A recommendation of the use of olanzapine plus fluoxetine at reducing depressive symptoms in bipolar depression and of quetiapine at high doses for depressive symptoms occurring during mixed episodes. Importantly, even though monotherapy with aripiprazole, risperidone, valproate and lithium was effective at controlling mania, these drugs were not effective at reducing depressive symptoms (level A evidence for nonrecommendation). Conclusions These results mostly overlap with the approved treatments for bipolar depression in adults. En ligne : http://dx.doi.org/10.1111/jcpp.12735 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316

‘Mixed blessings’: parental religiousness, parenting, and child adjustment in global perspective / Marc H. BORNSTEIN in Journal of Child Psychology and Psychiatry, 58-8 (August 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-8 (August 2017) . - p.880-892 Titre : ‘Mixed blessings’: parental religiousness, parenting, and child adjustment in global perspective Type de document : Texte imprimé et/ou numérique Auteurs : Marc H. BORNSTEIN, Auteur ; Diane L. PUTNICK, Auteur ; Jennifer E. LANSFORD, Auteur ; Suha M. AL-HASSAN, Auteur ; Dario BACCHINI, Auteur ; Anna Silvia BOMBI, Auteur ; Lei CHANG, Auteur ; Kirby DEATER-DECKARD, Auteur ; Laura DI GIUNTA, Auteur ; Kenneth A. DODGE, Auteur ; Patrick S. MALONE, Auteur ; Paul OBURU, Auteur ; Concetta PASTORELLI, Auteur ; Ann T. SKINNER, Auteur ; Emma SORBRING, Auteur ; Laurence STEINBERG, Auteur ; Sombat TAPANYA, Auteur ; Liliana Maria Uribe TIRADO, Auteur ; Arnaldo ZELLI, Auteur ; Liane Peña ALAMPAY, Auteur Article en page(s) : p.880-892 Langues : Anglais (eng) Mots-clés : Religiousness  parenting  child adjustment  reporter  religion Index. décimale : PER Périodiques Résumé : Background Most studies of the effects of parental religiousness on parenting and child development focus on a particular religion or cultural group, which limits generalizations that can be made about the effects of parental religiousness on family life. Methods We assessed the associations among parental religiousness, parenting, and children's adjustment in a 3-year longitudinal investigation of 1,198 families from nine countries. We included four religions (Catholicism, Protestantism, Buddhism, and Islam) plus unaffiliated parents, two positive (efficacy and warmth) and two negative (control and rejection) parenting practices, and two positive (social competence and school performance) and two negative (internalizing and externalizing) child outcomes. Parents and children were informants. Results Greater parent religiousness had both positive and negative associations with parenting and child adjustment. Greater parent religiousness when children were age 8 was associated with higher parental efficacy at age 9 and, in turn, children's better social competence and school performance and fewer child internalizing and externalizing problems at age 10. However, greater parent religiousness at age 8 was also associated with more parental control at age 9, which in turn was associated with more child internalizing and externalizing problems at age 10. Parental warmth and rejection had inconsistent relations with parental religiousness and child outcomes depending on the informant. With a few exceptions, similar patterns of results held for all four religions and the unaffiliated, nine sites, mothers and fathers, girls and boys, and controlling for demographic covariates. Conclusions Parents and children agree that parental religiousness is associated with more controlling parenting and, in turn, increased child problem behaviors. However, children see religiousness as related to parental rejection, whereas parents see religiousness as related to parental efficacy and warmth, which have different associations with child functioning. Studying both parent and child views of religiousness and parenting are important to understand the effects of parental religiousness on parents and children. En ligne : http://dx.doi.org/10.1111/jcpp.12705 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316 [article] ‘Mixed blessings’: parental religiousness, parenting, and child adjustment in global perspective [Texte imprimé et/ou numérique] / Marc H. BORNSTEIN, Auteur ; Diane L. PUTNICK, Auteur ; Jennifer E. LANSFORD, Auteur ; Suha M. AL-HASSAN, Auteur ; Dario BACCHINI, Auteur ; Anna Silvia BOMBI, Auteur ; Lei CHANG, Auteur ; Kirby DEATER-DECKARD, Auteur ; Laura DI GIUNTA, Auteur ; Kenneth A. DODGE, Auteur ; Patrick S. MALONE, Auteur ; Paul OBURU, Auteur ; Concetta PASTORELLI, Auteur ; Ann T. SKINNER, Auteur ; Emma SORBRING, Auteur ; Laurence STEINBERG, Auteur ; Sombat TAPANYA, Auteur ; Liliana Maria Uribe TIRADO, Auteur ; Arnaldo ZELLI, Auteur ; Liane Peña ALAMPAY, Auteur . - p.880-892. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-8 (August 2017) . - p.880-892 Mots-clés : Religiousness  parenting  child adjustment  reporter  religion Index. décimale : PER Périodiques Résumé : Background Most studies of the effects of parental religiousness on parenting and child development focus on a particular religion or cultural group, which limits generalizations that can be made about the effects of parental religiousness on family life. Methods We assessed the associations among parental religiousness, parenting, and children's adjustment in a 3-year longitudinal investigation of 1,198 families from nine countries. We included four religions (Catholicism, Protestantism, Buddhism, and Islam) plus unaffiliated parents, two positive (efficacy and warmth) and two negative (control and rejection) parenting practices, and two positive (social competence and school performance) and two negative (internalizing and externalizing) child outcomes. Parents and children were informants. Results Greater parent religiousness had both positive and negative associations with parenting and child adjustment. Greater parent religiousness when children were age 8 was associated with higher parental efficacy at age 9 and, in turn, children's better social competence and school performance and fewer child internalizing and externalizing problems at age 10. However, greater parent religiousness at age 8 was also associated with more parental control at age 9, which in turn was associated with more child internalizing and externalizing problems at age 10. Parental warmth and rejection had inconsistent relations with parental religiousness and child outcomes depending on the informant. With a few exceptions, similar patterns of results held for all four religions and the unaffiliated, nine sites, mothers and fathers, girls and boys, and controlling for demographic covariates. Conclusions Parents and children agree that parental religiousness is associated with more controlling parenting and, in turn, increased child problem behaviors. However, children see religiousness as related to parental rejection, whereas parents see religiousness as related to parental efficacy and warmth, which have different associations with child functioning. Studying both parent and child views of religiousness and parenting are important to understand the effects of parental religiousness on parents and children. En ligne : http://dx.doi.org/10.1111/jcpp.12705 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316

The etiology of autistic traits in preschoolers: a population-based twin study / Eveline L. DE ZEEUW in Journal of Child Psychology and Psychiatry, 58-8 (August 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-8 (August 2017) . - p.893-901 Titre : The etiology of autistic traits in preschoolers: a population-based twin study Type de document : Texte imprimé et/ou numérique Auteurs : Eveline L. DE ZEEUW, Auteur ; Catharina E. M. VAN BEIJSTERVELDT, Auteur ; Rosa A. HOEKSTRA, Auteur ; Meike BARTELS, Auteur ; Dorret I. BOOMSMA, Auteur Article en page(s) : p.893-901 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  heritability  child behavior checklist  twins Index. décimale : PER Périodiques Résumé : Background Autism Spectrum Disorders (ASD) are highly heritable, but the exact etiological mechanisms underlying the condition are still unclear. Methods Using a multiple rater twin design in a large sample of general population preschool twins, this study aimed to (a) estimate the contribution of genetic and environmental factors to autistic traits, controlling for the possible effects of rater bias, (b) to explore possible sex differences in etiology and (c) to investigate the discordance in autistic traits in monozygotic and same-sex dizygotic twin pairs. The Netherlands Twin Register collected maternal and paternal ratings on autistic traits from a general population of 38,798 three-year-old twins. Autistic traits were assessed with the DSM-oriented Pervasive Developmental Problems scale of the Child Behavior Check List for preschoolers (1½–5 years). Results Mother and fathers showed high agreement in their assessment of autistic traits (r = .60–.66). Differences between children in autistic traits were largely accounted for by genetic effects (boys: 78% and girls: 83%). Environmental effects that are unique to a child also played a modest role. Environmental effects shared by children growing up in the same family were negligible, once rater bias was controlled for. While the prevalence for clinical ASD is higher in boys than in girls, this study did not find evidence for striking differences in the etiology of autistic traits across the sexes. Even though the heritability was high, 29% of MZ twin pairs were discordant for high autistic traits (clinical range vs. normal development), suggesting that despite high genetic risk, environmental factors might lead to resilience, unaffected status in the context of genetic risk, in some children. Conclusions It is important to focus future research on risk factors that might interplay with a genetic disposition for ASD, but also on protective factors that make a difference in the lives of children at genetic risk. En ligne : http://dx.doi.org/10.1111/jcpp.12741 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316 [article] The etiology of autistic traits in preschoolers: a population-based twin study [Texte imprimé et/ou numérique] / Eveline L. DE ZEEUW, Auteur ; Catharina E. M. VAN BEIJSTERVELDT, Auteur ; Rosa A. HOEKSTRA, Auteur ; Meike BARTELS, Auteur ; Dorret I. BOOMSMA, Auteur . - p.893-901. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-8 (August 2017) . - p.893-901 Mots-clés : Autism spectrum disorder  heritability  child behavior checklist  twins Index. décimale : PER Périodiques Résumé : Background Autism Spectrum Disorders (ASD) are highly heritable, but the exact etiological mechanisms underlying the condition are still unclear. Methods Using a multiple rater twin design in a large sample of general population preschool twins, this study aimed to (a) estimate the contribution of genetic and environmental factors to autistic traits, controlling for the possible effects of rater bias, (b) to explore possible sex differences in etiology and (c) to investigate the discordance in autistic traits in monozygotic and same-sex dizygotic twin pairs. The Netherlands Twin Register collected maternal and paternal ratings on autistic traits from a general population of 38,798 three-year-old twins. Autistic traits were assessed with the DSM-oriented Pervasive Developmental Problems scale of the Child Behavior Check List for preschoolers (1½–5 years). Results Mother and fathers showed high agreement in their assessment of autistic traits (r = .60–.66). Differences between children in autistic traits were largely accounted for by genetic effects (boys: 78% and girls: 83%). Environmental effects that are unique to a child also played a modest role. Environmental effects shared by children growing up in the same family were negligible, once rater bias was controlled for. While the prevalence for clinical ASD is higher in boys than in girls, this study did not find evidence for striking differences in the etiology of autistic traits across the sexes. Even though the heritability was high, 29% of MZ twin pairs were discordant for high autistic traits (clinical range vs. normal development), suggesting that despite high genetic risk, environmental factors might lead to resilience, unaffected status in the context of genetic risk, in some children. Conclusions It is important to focus future research on risk factors that might interplay with a genetic disposition for ASD, but also on protective factors that make a difference in the lives of children at genetic risk. En ligne : http://dx.doi.org/10.1111/jcpp.12741 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316

A life history approach to delineating how harsh environments and hawk temperament traits differentially shape children's problem-solving skills / Jennifer H. SUOR in Journal of Child Psychology and Psychiatry, 58-8 (August 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-8 (August 2017) . - p.902-909 Titre : A life history approach to delineating how harsh environments and hawk temperament traits differentially shape children's problem-solving skills Type de document : Texte imprimé et/ou numérique Auteurs : Jennifer H. SUOR, Auteur ; Melissa L. STURGE-APPLE, Auteur ; Patrick T. DAVIES, Auteur ; Dante CICCHETTI, Auteur Article en page(s) : p.902-909 Langues : Anglais (eng) Mots-clés : Human ecology  adversity  temperament  cognitive development Index. décimale : PER Périodiques Résumé : Background Harsh environments are known to predict deficits in children's cognitive abilities. Life history theory approaches challenge this interpretation, proposing stressed children's cognition becomes specialized to solve problems in fitness-enhancing ways. The goal of this study was to examine associations between early environmental harshness and children's problem-solving outcomes across tasks varying in ecological relevance. In addition, we utilize an evolutionary model of temperament toward further specifying whether hawk temperament traits moderate these associations. Methods Two hundred and one mother–child dyads participated in a prospective multimethod study when children were 2 and 4 years old. At age 2, environmental harshness was assessed via maternal report of earned income and observations of maternal disengagement during a parent–child interaction task. Children's hawk temperament traits were assessed from a series of unfamiliar episodes. At age 4, children's reward-oriented and visual problem-solving were measured. Results Path analyses revealed early environmental harshness and children's hawk temperament traits predicted worse visual problem-solving. Results showed a significant two-way interaction between children's hawk temperament traits and environmental harshness on reward-oriented problem-solving. Simple slope analyses revealed the effect of environmental harshness on reward-oriented problem-solving was specific to children with higher levels of hawk traits. Conclusions Results suggest early experiences of environmental harshness and child hawk temperament traits shape children's trajectories of problem-solving in an environment-fitting manner. En ligne : http://dx.doi.org/10.1111/jcpp.12718 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316 [article] A life history approach to delineating how harsh environments and hawk temperament traits differentially shape children's problem-solving skills [Texte imprimé et/ou numérique] / Jennifer H. SUOR, Auteur ; Melissa L. STURGE-APPLE, Auteur ; Patrick T. DAVIES, Auteur ; Dante CICCHETTI, Auteur . - p.902-909. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-8 (August 2017) . - p.902-909 Mots-clés : Human ecology  adversity  temperament  cognitive development Index. décimale : PER Périodiques Résumé : Background Harsh environments are known to predict deficits in children's cognitive abilities. Life history theory approaches challenge this interpretation, proposing stressed children's cognition becomes specialized to solve problems in fitness-enhancing ways. The goal of this study was to examine associations between early environmental harshness and children's problem-solving outcomes across tasks varying in ecological relevance. In addition, we utilize an evolutionary model of temperament toward further specifying whether hawk temperament traits moderate these associations. Methods Two hundred and one mother–child dyads participated in a prospective multimethod study when children were 2 and 4 years old. At age 2, environmental harshness was assessed via maternal report of earned income and observations of maternal disengagement during a parent–child interaction task. Children's hawk temperament traits were assessed from a series of unfamiliar episodes. At age 4, children's reward-oriented and visual problem-solving were measured. Results Path analyses revealed early environmental harshness and children's hawk temperament traits predicted worse visual problem-solving. Results showed a significant two-way interaction between children's hawk temperament traits and environmental harshness on reward-oriented problem-solving. Simple slope analyses revealed the effect of environmental harshness on reward-oriented problem-solving was specific to children with higher levels of hawk traits. Conclusions Results suggest early experiences of environmental harshness and child hawk temperament traits shape children's trajectories of problem-solving in an environment-fitting manner. En ligne : http://dx.doi.org/10.1111/jcpp.12718 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316

Commentary: An exciting evolutionary framework for new bridges between social-emotional and cognitive development – a reflection on Suor et al. (2017) / Grazyna KOCHANSKA in Journal of Child Psychology and Psychiatry, 58-8 (August 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-8 (August 2017) . - p.910-912 Titre : Commentary: An exciting evolutionary framework for new bridges between social-emotional and cognitive development – a reflection on Suor et al. (2017) Type de document : Texte imprimé et/ou numérique Auteurs : Grazyna KOCHANSKA, Auteur ; Kathryn C. GOFFIN, Auteur Article en page(s) : p.910-912 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Suor et al. () present a compelling new evolutionary framework that offers an alternative interpretation of the well-established findings of cognitive deficits in children raised in harsh early environments. They argue that such findings do not convey a complete picture of those children's cognitive development, because children's cognition becomes specialized to solve problems in fitness-enhancing ways, and traditional abstract problem-solving tasks do not fully capture their abilities. The authors demonstrate that children exposed to early harshness, particularly children with Hawk temperaments, preferentially shift cognition to salient fitness-enhancing stimuli, and thus develop better skills for solving reward-oriented tasks. This intriguing and heuristically generative study inspires multiple new research avenues, of which we outline three: (a) Further examination of the concept of harsh environments, (b) addressing questions about the conceptualization and the role of child temperament, and (c) further advances in the measurement of children's distinct skills. En ligne : http://dx.doi.org/10.1111/jcpp.12761 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316 [article] Commentary: An exciting evolutionary framework for new bridges between social-emotional and cognitive development – a reflection on Suor et al. (2017) [Texte imprimé et/ou numérique] / Grazyna KOCHANSKA, Auteur ; Kathryn C. GOFFIN, Auteur . - p.910-912. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-8 (August 2017) . - p.910-912 Index. décimale : PER Périodiques Résumé : Suor et al. () present a compelling new evolutionary framework that offers an alternative interpretation of the well-established findings of cognitive deficits in children raised in harsh early environments. They argue that such findings do not convey a complete picture of those children's cognitive development, because children's cognition becomes specialized to solve problems in fitness-enhancing ways, and traditional abstract problem-solving tasks do not fully capture their abilities. The authors demonstrate that children exposed to early harshness, particularly children with Hawk temperaments, preferentially shift cognition to salient fitness-enhancing stimuli, and thus develop better skills for solving reward-oriented tasks. This intriguing and heuristically generative study inspires multiple new research avenues, of which we outline three: (a) Further examination of the concept of harsh environments, (b) addressing questions about the conceptualization and the role of child temperament, and (c) further advances in the measurement of children's distinct skills. En ligne : http://dx.doi.org/10.1111/jcpp.12761 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316

Affective empathy, cognitive empathy and social attention in children at high risk of criminal behaviour / Lisette VAN ZONNEVELD in Journal of Child Psychology and Psychiatry, 58-8 (August 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-8 (August 2017) . - p.913-921 Titre : Affective empathy, cognitive empathy and social attention in children at high risk of criminal behaviour Type de document : Texte imprimé et/ou numérique Auteurs : Lisette VAN ZONNEVELD, Auteur ; Evelien PLATJE, Auteur ; Leo DE SONNEVILLE, Auteur ; Stephanie VAN GOOZEN, Auteur ; Hanna SWAAB, Auteur Article en page(s) : p.913-921 Langues : Anglais (eng) Mots-clés : Criminality  antisocial behaviour  empathy  eye gaze  psychophysiology Index. décimale : PER Périodiques Résumé : Background Empathy deficits are hypothesized to underlie impairments in social interaction exhibited by those who engage in antisocial behaviour. Social attention is an essential precursor to empathy; however, no studies have yet examined social attention in relation to cognitive and affective empathy in those exhibiting antisocial behaviour. Methods Participants were 8- to 12-year-old children at high risk of developing criminal behaviour (N = 114, 80.7% boys) and typically developing controls (N = 43, 72.1% boys). The high-risk children were recruited through an ongoing early identification and intervention project of the city of Amsterdam, focusing on the underage siblings or children of delinquents and those failing primary school. Video clips with neutral and emotional content (fear, happiness and pain) were shown, while heart rate (HR), skin conductance level (SCL) and skin conductance responses (SCRs) were recorded to measure affective empathy. Answers to questions about emotions in the clips were coded to measure cognitive empathy. Eye-tracking was used to evaluate visual scanning patterns towards social relevant cues (eyes and face) in the clips. Results The high-risk group did not differ from the control group in social attention and cognitive empathy, but showed reduced HR to pain and fear, and reduced SCL and SCRs to pain. Conclusions Children at high risk of developing criminal behaviour show impaired affective empathy but unimpaired social attention and cognitive empathy. The implications for early identification and intervention studies with antisocial children are discussed. En ligne : http://dx.doi.org/10.1111/jcpp.12724 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316 [article] Affective empathy, cognitive empathy and social attention in children at high risk of criminal behaviour [Texte imprimé et/ou numérique] / Lisette VAN ZONNEVELD, Auteur ; Evelien PLATJE, Auteur ; Leo DE SONNEVILLE, Auteur ; Stephanie VAN GOOZEN, Auteur ; Hanna SWAAB, Auteur . - p.913-921. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-8 (August 2017) . - p.913-921 Mots-clés : Criminality  antisocial behaviour  empathy  eye gaze  psychophysiology Index. décimale : PER Périodiques Résumé : Background Empathy deficits are hypothesized to underlie impairments in social interaction exhibited by those who engage in antisocial behaviour. Social attention is an essential precursor to empathy; however, no studies have yet examined social attention in relation to cognitive and affective empathy in those exhibiting antisocial behaviour. Methods Participants were 8- to 12-year-old children at high risk of developing criminal behaviour (N = 114, 80.7% boys) and typically developing controls (N = 43, 72.1% boys). The high-risk children were recruited through an ongoing early identification and intervention project of the city of Amsterdam, focusing on the underage siblings or children of delinquents and those failing primary school. Video clips with neutral and emotional content (fear, happiness and pain) were shown, while heart rate (HR), skin conductance level (SCL) and skin conductance responses (SCRs) were recorded to measure affective empathy. Answers to questions about emotions in the clips were coded to measure cognitive empathy. Eye-tracking was used to evaluate visual scanning patterns towards social relevant cues (eyes and face) in the clips. Results The high-risk group did not differ from the control group in social attention and cognitive empathy, but showed reduced HR to pain and fear, and reduced SCL and SCRs to pain. Conclusions Children at high risk of developing criminal behaviour show impaired affective empathy but unimpaired social attention and cognitive empathy. The implications for early identification and intervention studies with antisocial children are discussed. En ligne : http://dx.doi.org/10.1111/jcpp.12724 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316

Family-based promotion of mental health in children affected by HIV: a pilot randomized controlled trial / Theresa S. BETANCOURT in Journal of Child Psychology and Psychiatry, 58-8 (August 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-8 (August 2017) . - p.922-930 Titre : Family-based promotion of mental health in children affected by HIV: a pilot randomized controlled trial Type de document : Texte imprimé et/ou numérique Auteurs : Theresa S. BETANCOURT, Auteur ; Lauren C. NG, Auteur ; Catherine M. KIRK, Auteur ; Robert T. BRENNAN, Auteur ; William R. BEARDSLEE, Auteur ; Sara STULAC, Auteur ; Christine MUSHASHI, Auteur ; Estella NDUWIMANA, Auteur ; Sylvere MUKUNZI, Auteur ; Beatha NYIRANDAGIJIMANA, Auteur ; Godfrey KALISA, Auteur ; Cyamatare F. RWABUKWISI, Auteur ; Vincent SEZIBERA, Auteur Article en page(s) : p.922-930 Langues : Anglais (eng) Mots-clés : HIV  depression  Rwanda  adolescents Index. décimale : PER Périodiques Résumé : Background Children affected by HIV are at risk for poor mental health. We conducted a pilot randomized controlled trial (RCT) of the Family Strengthening Intervention (FSI-HIV), a family home-visiting intervention to promote mental health and improve parent–child relationships in families with caregivers living with HIV, hypothesizing that child and family outcomes would be superior to usual care social work services. Methods Eighty two families (N = 170 children, 48.24% female; N = 123 caregivers, 68.29% female) with at least one HIV-positive caregiver (n = 103, 83.74%) and school-aged child (ages 7–17) (HIV+ n = 21, 12.35%) were randomized to receive FSI-HIV or treatment-as-usual (TAU). Local research assistants blind to treatment conducted assessments of child mental health, parenting practices, and family functioning at baseline, post-intervention, and 3-month follow-up. Multilevel modeling assessed effects of FSI-HIV on outcomes across three time points. Trial Registration: NCT01509573, ‘Pilot Feasibility Trial of the Family Strengthening Intervention in Rwanda (FSI-HIV-R).' https://clinicaltrials.gov/ct2/show/;NCT01509573?term=Pilot+Feasibility+Trial+of+the+Family+Strengthening+Intervention+in+Rwanda+%28FSI-HIV-R%29&rank=1. Results At 3-month follow-up, children in FSI-HIV showed fewer symptoms of depression compared to TAU by both self-report (? = ?.246; p = .009) and parent report (? = ?.174; p = .035) but there were no significant differences by group on conduct problems, functional impairment, family connectedness, or parenting. Conclusions Family-based prevention has promise for reducing depression symptoms in children affected by HIV. Future trials should examine the effects of FSI-HIV over time in trials powered to examine treatment mediators. En ligne : http://dx.doi.org/10.1111/jcpp.12729 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316 [article] Family-based promotion of mental health in children affected by HIV: a pilot randomized controlled trial [Texte imprimé et/ou numérique] / Theresa S. BETANCOURT, Auteur ; Lauren C. NG, Auteur ; Catherine M. KIRK, Auteur ; Robert T. BRENNAN, Auteur ; William R. BEARDSLEE, Auteur ; Sara STULAC, Auteur ; Christine MUSHASHI, Auteur ; Estella NDUWIMANA, Auteur ; Sylvere MUKUNZI, Auteur ; Beatha NYIRANDAGIJIMANA, Auteur ; Godfrey KALISA, Auteur ; Cyamatare F. RWABUKWISI, Auteur ; Vincent SEZIBERA, Auteur . - p.922-930. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-8 (August 2017) . - p.922-930 Mots-clés : HIV  depression  Rwanda  adolescents Index. décimale : PER Périodiques Résumé : Background Children affected by HIV are at risk for poor mental health. We conducted a pilot randomized controlled trial (RCT) of the Family Strengthening Intervention (FSI-HIV), a family home-visiting intervention to promote mental health and improve parent–child relationships in families with caregivers living with HIV, hypothesizing that child and family outcomes would be superior to usual care social work services. Methods Eighty two families (N = 170 children, 48.24% female; N = 123 caregivers, 68.29% female) with at least one HIV-positive caregiver (n = 103, 83.74%) and school-aged child (ages 7–17) (HIV+ n = 21, 12.35%) were randomized to receive FSI-HIV or treatment-as-usual (TAU). Local research assistants blind to treatment conducted assessments of child mental health, parenting practices, and family functioning at baseline, post-intervention, and 3-month follow-up. Multilevel modeling assessed effects of FSI-HIV on outcomes across three time points. Trial Registration: NCT01509573, ‘Pilot Feasibility Trial of the Family Strengthening Intervention in Rwanda (FSI-HIV-R).' https://clinicaltrials.gov/ct2/show/;NCT01509573?term=Pilot+Feasibility+Trial+of+the+Family+Strengthening+Intervention+in+Rwanda+%28FSI-HIV-R%29&rank=1. Results At 3-month follow-up, children in FSI-HIV showed fewer symptoms of depression compared to TAU by both self-report (? = ?.246; p = .009) and parent report (? = ?.174; p = .035) but there were no significant differences by group on conduct problems, functional impairment, family connectedness, or parenting. Conclusions Family-based prevention has promise for reducing depression symptoms in children affected by HIV. Future trials should examine the effects of FSI-HIV over time in trials powered to examine treatment mediators. En ligne : http://dx.doi.org/10.1111/jcpp.12729 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316

Neurobehavioural and cognitive development in infants born to mothers with eating disorders / Manuela BARONA in Journal of Child Psychology and Psychiatry, 58-8 (August 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-8 (August 2017) . - p.931-938 Titre : Neurobehavioural and cognitive development in infants born to mothers with eating disorders Type de document : Texte imprimé et/ou numérique Auteurs : Manuela BARONA, Auteur ; Emma TABORELLI, Auteur ; Freya CORFIELD, Auteur ; Susan PAWLBY, Auteur ; Abigail EASTER, Auteur ; Ulrike SCHMIDT, Auteur ; Janet TREASURE, Auteur ; Nadia MICALI, Auteur Article en page(s) : p.931-938 Langues : Anglais (eng) Mots-clés : Brazelton Neonatal Behavioural Assessment Scale  Bayley Scales of Infant and Toddler Development  eating disorders  child development Index. décimale : PER Périodiques Résumé : Introduction Although recent research has focused on the effects of maternal eating disorders (EDs) on children, little is known about the effect of maternal EDs on neurobiological outcomes in newborns and infants. This study is the first to investigate neurobehavioural regulation and cognitive development in newborns and infants of mothers with EDs. Methods Women with an active and past ED and healthy controls were recruited to a prospective longitudinal study during their first trimester or second trimester of pregnancy. Newborns and infants of mothers with ED were compared with newborns and infants of healthy controls on (a) neurobehavioural dysregulation using the Brazelton Neonatal Behavioural Assessment Scale at 8 days postpartum (active ED, n = 15; past ED, n = 20; healthy controls, n = 28); and (b) cognitive development using the Bayley Scales of Infant and Toddler Development at 1-year postpartum (active ED, n = 18; past ED, n = 19; healthy controls, n = 28). In order to maintain the largest possible sample at each time point, sample size varied across time points. Results Newborns of mothers with an active ED had worse autonomic stability when compared with newborns of healthy controls [B = ?0.34 (?1.81, ?0.26)]. Infants of mothers with a past ED had poorer language [B = ?0.33 (?13.6, ?1.9)] and motor development [B = ?0.32 (?18.4, ?1.3)] compared with healthy controls. Conclusions Children of mothers with ED display neurobehavioural dysregulation early after birth and poorer language and motor development at 1 year. These characteristics suggest evidence of early neurobiological markers in children at risk. Differential outcomes in children of women with active versus past ED suggest that active symptomatology during pregnancy might have an effect on physiological reactivity while cognitive characteristics might be more stable markers of risk for ED. En ligne : http://dx.doi.org/10.1111/jcpp.12736 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316 [article] Neurobehavioural and cognitive development in infants born to mothers with eating disorders [Texte imprimé et/ou numérique] / Manuela BARONA, Auteur ; Emma TABORELLI, Auteur ; Freya CORFIELD, Auteur ; Susan PAWLBY, Auteur ; Abigail EASTER, Auteur ; Ulrike SCHMIDT, Auteur ; Janet TREASURE, Auteur ; Nadia MICALI, Auteur . - p.931-938. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-8 (August 2017) . - p.931-938 Mots-clés : Brazelton Neonatal Behavioural Assessment Scale  Bayley Scales of Infant and Toddler Development  eating disorders  child development Index. décimale : PER Périodiques Résumé : Introduction Although recent research has focused on the effects of maternal eating disorders (EDs) on children, little is known about the effect of maternal EDs on neurobiological outcomes in newborns and infants. This study is the first to investigate neurobehavioural regulation and cognitive development in newborns and infants of mothers with EDs. Methods Women with an active and past ED and healthy controls were recruited to a prospective longitudinal study during their first trimester or second trimester of pregnancy. Newborns and infants of mothers with ED were compared with newborns and infants of healthy controls on (a) neurobehavioural dysregulation using the Brazelton Neonatal Behavioural Assessment Scale at 8 days postpartum (active ED, n = 15; past ED, n = 20; healthy controls, n = 28); and (b) cognitive development using the Bayley Scales of Infant and Toddler Development at 1-year postpartum (active ED, n = 18; past ED, n = 19; healthy controls, n = 28). In order to maintain the largest possible sample at each time point, sample size varied across time points. Results Newborns of mothers with an active ED had worse autonomic stability when compared with newborns of healthy controls [B = ?0.34 (?1.81, ?0.26)]. Infants of mothers with a past ED had poorer language [B = ?0.33 (?13.6, ?1.9)] and motor development [B = ?0.32 (?18.4, ?1.3)] compared with healthy controls. Conclusions Children of mothers with ED display neurobehavioural dysregulation early after birth and poorer language and motor development at 1 year. These characteristics suggest evidence of early neurobiological markers in children at risk. Differential outcomes in children of women with active versus past ED suggest that active symptomatology during pregnancy might have an effect on physiological reactivity while cognitive characteristics might be more stable markers of risk for ED. En ligne : http://dx.doi.org/10.1111/jcpp.12736 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316

Modulations of cognitive flexibility in obsessive compulsive disorder reflect dysfunctions of perceptual categorization / Nicole WOLFF in Journal of Child Psychology and Psychiatry, 58-8 (August 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-8 (August 2017) . - p.939-949 Titre : Modulations of cognitive flexibility in obsessive compulsive disorder reflect dysfunctions of perceptual categorization Type de document : Texte imprimé et/ou numérique Auteurs : Nicole WOLFF, Auteur ; Judith BUSE, Auteur ; Jadwiga TOST, Auteur ; Veit ROESSNER, Auteur ; Christian BESTE, Auteur Article en page(s) : p.939-949 Langues : Anglais (eng) Mots-clés : Obsessive compulsive disorder  perception  neurophysiology  event-related potential Index. décimale : PER Périodiques Résumé : Background Despite cognitive inflexibility is trait like in obsessive compulsive disorder (OCD) patients and underlies clinical symptomatology, it is elusive at what stage of information processing deficits, leading to cognitive inflexibility, emerges. We hypothesize that inhibitory control mechanisms during early stimulus categorization and integration into a knowledge system underlie these deficits. Methods We examined N = 25 adolescent OCD patients and matched healthy controls (HC) in a paradigm manipulating the importance of the knowledge system to perform task switching. This was done using a paradigm in which task switches were signaled either by visual stimuli or by working memory processes. This was combined with event-related potential recordings and source localization. Results Obsessive compulsive disorder patients showed increased switch costs in the memory as compared with the cue-based block, while HC showed similar switch costs in both blocks. At the neurophysiological level, these changes in OCD were not reflected by the N2 and P3 reflecting response-associated processes but by the P1 reflecting inhibitory control during sensory categorization processes. Activation differences in the right inferior frontal gyrus and superior temporal gyrus are associated with the P1 effect. Conclusions Cognitive flexibility in adolescent OCD patients is strongly modulated by working memory load. Contrary to common sense, not response-associated processes, but inhibitory control mechanisms during early stimulus categorization processes are likely to underlie cognitive inflexibility in OCD. These processes are associated with right inferior frontal and superior temporal gyrus mechanisms. En ligne : http://dx.doi.org/10.1111/jcpp.12733 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=317 [article] Modulations of cognitive flexibility in obsessive compulsive disorder reflect dysfunctions of perceptual categorization [Texte imprimé et/ou numérique] / Nicole WOLFF, Auteur ; Judith BUSE, Auteur ; Jadwiga TOST, Auteur ; Veit ROESSNER, Auteur ; Christian BESTE, Auteur . - p.939-949. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-8 (August 2017) . - p.939-949 Mots-clés : Obsessive compulsive disorder  perception  neurophysiology  event-related potential Index. décimale : PER Périodiques Résumé : Background Despite cognitive inflexibility is trait like in obsessive compulsive disorder (OCD) patients and underlies clinical symptomatology, it is elusive at what stage of information processing deficits, leading to cognitive inflexibility, emerges. We hypothesize that inhibitory control mechanisms during early stimulus categorization and integration into a knowledge system underlie these deficits. Methods We examined N = 25 adolescent OCD patients and matched healthy controls (HC) in a paradigm manipulating the importance of the knowledge system to perform task switching. This was done using a paradigm in which task switches were signaled either by visual stimuli or by working memory processes. This was combined with event-related potential recordings and source localization. Results Obsessive compulsive disorder patients showed increased switch costs in the memory as compared with the cue-based block, while HC showed similar switch costs in both blocks. At the neurophysiological level, these changes in OCD were not reflected by the N2 and P3 reflecting response-associated processes but by the P1 reflecting inhibitory control during sensory categorization processes. Activation differences in the right inferior frontal gyrus and superior temporal gyrus are associated with the P1 effect. Conclusions Cognitive flexibility in adolescent OCD patients is strongly modulated by working memory load. Contrary to common sense, not response-associated processes, but inhibitory control mechanisms during early stimulus categorization processes are likely to underlie cognitive inflexibility in OCD. These processes are associated with right inferior frontal and superior temporal gyrus mechanisms. En ligne : http://dx.doi.org/10.1111/jcpp.12733 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=317

Increased pupil dilation to angry faces predicts interpersonal stress generation in offspring of depressed mothers / Cope FEURER in Journal of Child Psychology and Psychiatry, 58-8 (August 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-8 (August 2017) . - p.950-957 Titre : Increased pupil dilation to angry faces predicts interpersonal stress generation in offspring of depressed mothers Type de document : Texte imprimé et/ou numérique Auteurs : Cope FEURER, Auteur ; Katie L. BURKHOUSE, Auteur ; Greg SIEGLE, Auteur ; Brandon E. GIBB, Auteur Article en page(s) : p.950-957 Langues : Anglais (eng) Mots-clés : Stress generation  pupillometry  depression  intergenerational transmission Index. décimale : PER Périodiques Résumé : Background Interpersonal stress generation is one mechanism hypothesized to increase risk for the intergenerational transmission of depression. Although there is some evidence of stress generation in offspring of depressed mothers, specific predictors of stress generation in these youth remain unknown. The goal of this study was to examine a peripheral measure of cognitive-affective reactivity (i.e. pupil dilation) to emotional interpersonal stimuli as a predictor of stress generation in offspring of depressed mothers. Method The study included 129 mothers and their offspring (ages 8–15) recruited from the community who participated at two time points separated by 6 months. Youth's average pupil dilation to emotional faces (angry, happy, sad) as well as maternal lifetime history of major depressive disorder were assessed at baseline. In addition, both time points included assessments of youth's levels of self-generated (dependent) and independent episodic life stress in the preceding 6 months. Results Youth's pupil dilation to angry, but not sad or happy, faces predicted prospective increases in dependent interpersonal stress across the follow-up. This effect was only observed in offspring of depressed mothers and was not seen in offspring of never-depressed mothers. Conclusions This study highlights a potential risk factor (heightened reactivity to facial displays of anger) that may identify which offspring of depressed mothers are at greatest risk for interpersonal stress generation. En ligne : http://dx.doi.org/10.1111/jcpp.12739 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=317 [article] Increased pupil dilation to angry faces predicts interpersonal stress generation in offspring of depressed mothers [Texte imprimé et/ou numérique] / Cope FEURER, Auteur ; Katie L. BURKHOUSE, Auteur ; Greg SIEGLE, Auteur ; Brandon E. GIBB, Auteur . - p.950-957. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-8 (August 2017) . - p.950-957 Mots-clés : Stress generation  pupillometry  depression  intergenerational transmission Index. décimale : PER Périodiques Résumé : Background Interpersonal stress generation is one mechanism hypothesized to increase risk for the intergenerational transmission of depression. Although there is some evidence of stress generation in offspring of depressed mothers, specific predictors of stress generation in these youth remain unknown. The goal of this study was to examine a peripheral measure of cognitive-affective reactivity (i.e. pupil dilation) to emotional interpersonal stimuli as a predictor of stress generation in offspring of depressed mothers. Method The study included 129 mothers and their offspring (ages 8–15) recruited from the community who participated at two time points separated by 6 months. Youth's average pupil dilation to emotional faces (angry, happy, sad) as well as maternal lifetime history of major depressive disorder were assessed at baseline. In addition, both time points included assessments of youth's levels of self-generated (dependent) and independent episodic life stress in the preceding 6 months. Results Youth's pupil dilation to angry, but not sad or happy, faces predicted prospective increases in dependent interpersonal stress across the follow-up. This effect was only observed in offspring of depressed mothers and was not seen in offspring of never-depressed mothers. Conclusions This study highlights a potential risk factor (heightened reactivity to facial displays of anger) that may identify which offspring of depressed mothers are at greatest risk for interpersonal stress generation. En ligne : http://dx.doi.org/10.1111/jcpp.12739 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=317

Female-specific association of NOS1 genotype with white matter microstructure in ADHD patients and controls / Hanneke VAN EWIJK in Journal of Child Psychology and Psychiatry, 58-8 (August 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-8 (August 2017) . - p.958-966 Titre : Female-specific association of NOS1 genotype with white matter microstructure in ADHD patients and controls Type de document : Texte imprimé et/ou numérique Auteurs : Hanneke VAN EWIJK, Auteur ; Janita B. BRALTEN, Auteur ; Esther D. A. VAN DUIN, Auteur ; Marina HAKOBJAN, Auteur ; Jan K. BUITELAAR, Auteur ; Dirk J. HESLENFELD, Auteur ; Pieter J. HOEKSTRA, Auteur ; Catharina A. HARTMAN, Auteur ; Martine HOOGMAN, Auteur ; Jaap OOSTERLAAN, Auteur ; Barbara FRANKE, Auteur Article en page(s) : p.958-966 Langues : Anglais (eng) Mots-clés : attention-deficit/hyperactivity disorder  NOS1  imaging genetics  diffusion tensor imaging Index. décimale : PER Périodiques Résumé : Background The nitric oxide synthase gene (NOS1) exon 1f (ex1f) VNTR is a known genetic risk factor for Attention-Deficit/Hyperactivity Disorder (ADHD), particularly in females. NOS1 plays an important role in neurite outgrowth and may thus influence brain development, specifically white matter (WM) microstructure, which is known to be altered in ADHD. The current study aimed to investigate whether NOS1 is associated with WM microstructure in (female) individuals with and without ADHD. Methods Diffusion Tensor Imaging (DTI) scans were collected from 187 participants with ADHD (33% female) and 103 controls (50% female), aged 8–26 years, and NOS1-ex1f VNTR genotype was determined. Whole-brain analyses were conducted for fractional anisotropy (FA) and mean diffusivity (MD) to examine associations between NOS1 and WM microstructure, including possible interactions with gender and diagnosis. Results Consistent with previous literature, NOS1-ex1f was associated with total ADHD and hyperactivity-impulsivity symptoms, but not inattention; this effect was independent of gender. NOS1-ex1f was also associated with MD values in several major WM tracts in females, but not males. In females, homozygosity for the short allele was linked to higher MD values than carriership of the long allele. MD values in these regions did not correlate with ADHD symptoms. Results were similar for participants with and without ADHD. Conclusions NOS1-ex1f VNTR is associated with WM microstructure in females in a large sample of participants with ADHD and healthy controls. Whether this association is part of a neurodevelopmental pathway from NOS1 to ADHD symptoms should be further investigated in future studies. En ligne : http://dx.doi.org/10.1111/jcpp.12742 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=317 [article] Female-specific association of NOS1 genotype with white matter microstructure in ADHD patients and controls [Texte imprimé et/ou numérique] / Hanneke VAN EWIJK, Auteur ; Janita B. BRALTEN, Auteur ; Esther D. A. VAN DUIN, Auteur ; Marina HAKOBJAN, Auteur ; Jan K. BUITELAAR, Auteur ; Dirk J. HESLENFELD, Auteur ; Pieter J. HOEKSTRA, Auteur ; Catharina A. HARTMAN, Auteur ; Martine HOOGMAN, Auteur ; Jaap OOSTERLAAN, Auteur ; Barbara FRANKE, Auteur . - p.958-966. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-8 (August 2017) . - p.958-966 Mots-clés : attention-deficit/hyperactivity disorder  NOS1  imaging genetics  diffusion tensor imaging Index. décimale : PER Périodiques Résumé : Background The nitric oxide synthase gene (NOS1) exon 1f (ex1f) VNTR is a known genetic risk factor for Attention-Deficit/Hyperactivity Disorder (ADHD), particularly in females. NOS1 plays an important role in neurite outgrowth and may thus influence brain development, specifically white matter (WM) microstructure, which is known to be altered in ADHD. The current study aimed to investigate whether NOS1 is associated with WM microstructure in (female) individuals with and without ADHD. Methods Diffusion Tensor Imaging (DTI) scans were collected from 187 participants with ADHD (33% female) and 103 controls (50% female), aged 8–26 years, and NOS1-ex1f VNTR genotype was determined. Whole-brain analyses were conducted for fractional anisotropy (FA) and mean diffusivity (MD) to examine associations between NOS1 and WM microstructure, including possible interactions with gender and diagnosis. Results Consistent with previous literature, NOS1-ex1f was associated with total ADHD and hyperactivity-impulsivity symptoms, but not inattention; this effect was independent of gender. NOS1-ex1f was also associated with MD values in several major WM tracts in females, but not males. In females, homozygosity for the short allele was linked to higher MD values than carriership of the long allele. MD values in these regions did not correlate with ADHD symptoms. Results were similar for participants with and without ADHD. Conclusions NOS1-ex1f VNTR is associated with WM microstructure in females in a large sample of participants with ADHD and healthy controls. Whether this association is part of a neurodevelopmental pathway from NOS1 to ADHD symptoms should be further investigated in future studies. En ligne : http://dx.doi.org/10.1111/jcpp.12742 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=317