Dépouillements

Triple-Network Functional Connectivity in Adolescents With Autism Spectrum Disorder Compared to Early-Onset Psychosis / Aarti NAIR in Autism Research, 19-4 (April 2026)  

Public ISBD [article]  inAutism Research > 19-4 (April 2026) . - e70163 Titre : Triple-Network Functional Connectivity in Adolescents With Autism Spectrum Disorder Compared to Early-Onset Psychosis Type de document : texte imprimé Auteurs : Aarti NAIR, Auteur ; Rhideeta JALAL, Auteur ; Katherine E. LAWRENCE, Auteur ; Niharika VERMA, Auteur ; Hector GUTIERREZ, Auteur ; Kristen LAULETTE, Auteur ; Katherine H. KARLSGODT, Auteur ; Carrie E. BEARDEN, Auteur Article en page(s) : e70163 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  early-onset psychosis  functional connectivity  resting-state  social cognition Index. décimale : PER Périodiques Résumé : ABSTRACT Both autism spectrum disorder (ASD) and psychosis are associated with challenges in social cognition. The triple-network model posits that dysfunction within and between the default mode network (DMN), central executive network (CEN), and salience network (SN) contributes to these deficits. However, the relationship between triple-network connectivity and social cognition has not been systematically compared across these groups during adolescence. We examined whole-brain functional connectivity of the triple-network in a sample of youth with ASD (N?=?24), youth with early-onset psychosis (EOP; N?=?25), and age-matched typically developing (TD) controls (N?=?26, overall mean age?=?16.39?±?2.36, % female?=?41%). Additionally, we examined relationships between connectivity patterns of the triple-network and behavioral measures of social cognition and emotion recognition in each group. ASD youth showed mixed over- and under-connectivity in the DMN, CEN overconnectivity, and SN underconnectivity, while EOP youth showed DMN and CEN overconnectivity, with relatively intact SN connectivity, compared to TD controls. Compared to EOP, ASD participants had reduced SN connectivity and mixed disruptions in DMN connectivity. Across groups, connectivity patterns were linked to social behaviors: in EOP, DMN overconnectivity was associated with poorer social cognition; in ASD, SN underconnectivity was associated with poorer social cognition. These findings highlight both shared and distinct patterns of triple-network dysconnectivity in ASD and EOP, supporting transdiagnostic models of social cognitive dysfunction, and reinforcing adolescence as a key developmental window for network-based brain changes. En ligne : https://doi.org/10.1002/aur.70163 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585 [article] Triple-Network Functional Connectivity in Adolescents With Autism Spectrum Disorder Compared to Early-Onset Psychosis [texte imprimé] / Aarti NAIR, Auteur ; Rhideeta JALAL, Auteur ; Katherine E. LAWRENCE, Auteur ; Niharika VERMA, Auteur ; Hector GUTIERREZ, Auteur ; Kristen LAULETTE, Auteur ; Katherine H. KARLSGODT, Auteur ; Carrie E. BEARDEN, Auteur . - e70163. Langues : Anglais (eng) in Autism Research > 19-4 (April 2026) . - e70163 Mots-clés : autism spectrum disorder  early-onset psychosis  functional connectivity  resting-state  social cognition Index. décimale : PER Périodiques Résumé : ABSTRACT Both autism spectrum disorder (ASD) and psychosis are associated with challenges in social cognition. The triple-network model posits that dysfunction within and between the default mode network (DMN), central executive network (CEN), and salience network (SN) contributes to these deficits. However, the relationship between triple-network connectivity and social cognition has not been systematically compared across these groups during adolescence. We examined whole-brain functional connectivity of the triple-network in a sample of youth with ASD (N?=?24), youth with early-onset psychosis (EOP; N?=?25), and age-matched typically developing (TD) controls (N?=?26, overall mean age?=?16.39?±?2.36, % female?=?41%). Additionally, we examined relationships between connectivity patterns of the triple-network and behavioral measures of social cognition and emotion recognition in each group. ASD youth showed mixed over- and under-connectivity in the DMN, CEN overconnectivity, and SN underconnectivity, while EOP youth showed DMN and CEN overconnectivity, with relatively intact SN connectivity, compared to TD controls. Compared to EOP, ASD participants had reduced SN connectivity and mixed disruptions in DMN connectivity. Across groups, connectivity patterns were linked to social behaviors: in EOP, DMN overconnectivity was associated with poorer social cognition; in ASD, SN underconnectivity was associated with poorer social cognition. These findings highlight both shared and distinct patterns of triple-network dysconnectivity in ASD and EOP, supporting transdiagnostic models of social cognitive dysfunction, and reinforcing adolescence as a key developmental window for network-based brain changes. En ligne : https://doi.org/10.1002/aur.70163 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585

Clinical Value of Early Motor Skill Assessment and Intervention in Autism Spectrum Disorder / Xue YAQI in Autism Research, 19-4 (April 2026)  

Public ISBD [article]  inAutism Research > 19-4 (April 2026) . - e70177 Titre : Clinical Value of Early Motor Skill Assessment and Intervention in Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Xue YAQI, Auteur ; Zhang SHUAI, Auteur ; De MA, Auteur ; Cui YINCHEN, Auteur ; Zhen ZHIPING, Auteur Article en page(s) : e70177 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : https://doi.org/10.1002/aur.70177 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585 [article] Clinical Value of Early Motor Skill Assessment and Intervention in Autism Spectrum Disorder [texte imprimé] / Xue YAQI, Auteur ; Zhang SHUAI, Auteur ; De MA, Auteur ; Cui YINCHEN, Auteur ; Zhen ZHIPING, Auteur . - e70177. Langues : Anglais (eng) in Autism Research > 19-4 (April 2026) . - e70177 Index. décimale : PER Périodiques En ligne : https://doi.org/10.1002/aur.70177 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585

Quantitative but Not Qualitative Differences: A Longitudinal Analysis of Grammatical Marker Development in Mandarin-Speaking Autistic Children / Ziyan MENG in Autism Research, 19-4 (April 2026)  

Public ISBD [article]  inAutism Research > 19-4 (April 2026) . - e70195 Titre : Quantitative but Not Qualitative Differences: A Longitudinal Analysis of Grammatical Marker Development in Mandarin-Speaking Autistic Children Type de document : texte imprimé Auteurs : Ziyan MENG, Auteur ; Li WANG, Auteur ; Hoyee W. HIRAI, Auteur ; Patrick C. M. WONG, Auteur Article en page(s) : e70195 Langues : Anglais (eng) Mots-clés : autism  language development  longitudinal  Mandarin  morphosyntax Index. décimale : PER Périodiques Résumé : ABSTRACT Past research has revealed large differences between typically developing (TD) and autistic children's language development. However, little is known about whether such differences are quantitative or qualitative, especially in the morphosyntactic domain. This study is the first longitudinal research aiming to systematically investigate the developmental patterns of a wide range of Mandarin grammatical markers in autistic children. The mastery of target markers in autistic children (N?=?88, Mage?=?44.9?m, Range?=?26?76?m) was assessed longitudinally across three time points using parent reports and compared with that of TD children (N?=?84, Mage?=?23.2?m, Range?=?16?30?m) assessed at a single time point. We further examined the influence of autism severity and initial language ability. The results suggested that autistic children acquired Mandarin grammatical markers in a typical sequence but at a slower rate. Additionally, this developmental pattern was maintained regardless of autism severity and initial language ability. These findings suggest that autistic children's language development differs quantitatively but not qualitatively from that of TD children, reflecting developmental delay rather than deviance. En ligne : https://doi.org/10.1002/aur.70195 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585 [article] Quantitative but Not Qualitative Differences: A Longitudinal Analysis of Grammatical Marker Development in Mandarin-Speaking Autistic Children [texte imprimé] / Ziyan MENG, Auteur ; Li WANG, Auteur ; Hoyee W. HIRAI, Auteur ; Patrick C. M. WONG, Auteur . - e70195. Langues : Anglais (eng) in Autism Research > 19-4 (April 2026) . - e70195 Mots-clés : autism  language development  longitudinal  Mandarin  morphosyntax Index. décimale : PER Périodiques Résumé : ABSTRACT Past research has revealed large differences between typically developing (TD) and autistic children's language development. However, little is known about whether such differences are quantitative or qualitative, especially in the morphosyntactic domain. This study is the first longitudinal research aiming to systematically investigate the developmental patterns of a wide range of Mandarin grammatical markers in autistic children. The mastery of target markers in autistic children (N?=?88, Mage?=?44.9?m, Range?=?26?76?m) was assessed longitudinally across three time points using parent reports and compared with that of TD children (N?=?84, Mage?=?23.2?m, Range?=?16?30?m) assessed at a single time point. We further examined the influence of autism severity and initial language ability. The results suggested that autistic children acquired Mandarin grammatical markers in a typical sequence but at a slower rate. Additionally, this developmental pattern was maintained regardless of autism severity and initial language ability. These findings suggest that autistic children's language development differs quantitatively but not qualitatively from that of TD children, reflecting developmental delay rather than deviance. En ligne : https://doi.org/10.1002/aur.70195 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585

How Screening and Diagnostic Tools Shape Autism Prevalence in School-Aged Children: A Bibliometric-Systematic Review (2015–2025) / Ahmad Zamir CHE DAUD in Autism Research, 19-4 (April 2026)  

Public ISBD [article]  inAutism Research > 19-4 (April 2026) . - e70196 Titre : How Screening and Diagnostic Tools Shape Autism Prevalence in School-Aged Children: A Bibliometric-Systematic Review (2015–2025) Type de document : texte imprimé Auteurs : Ahmad Zamir CHE DAUD, Auteur ; Noor Aziella MOHD NAYAN, Auteur ; Hasnah TORAN, Auteur ; Kartini ILIAS, Auteur ; Norazlin KAMAL NOR, Auteur ; Khairil Anuar MD ISA, Auteur ; Wai Wai YANG, Auteur ; Tengku Amatullah Madeehah TENGKU MOHD, Auteur ; Nizam BAHAROM, Auteur ; Sazlina KAMARALZAMAN, Auteur Article en page(s) : e70196 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  child  cross-cultural comparison  diagnostic tools  prevalence  psychometrics  screening tools Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) prevalence estimates vary widely across countries and over time, partly due to differences in the screening and diagnostic tools used. This study combined bibliometric analysis and systematic review methods to examine global publication trends and evaluate the use of standardized assessment tools in ASD prevalence studies involving school-aged children (typically 6?12?years). A bibliometric search of the Scopus database (2015?2025) identified 107 publications, which were analyzed for citation patterns, research themes, and geographic distribution. Of these, 18 studies met systematic review inclusion criteria, reporting ASD prevalence in the general population and high-risk samples across diverse regions. The most frequently used screening tools were the Social Communication Questionnaire (SCQ) and Childhood Autism Spectrum Test (CAST), while gold-standard diagnostic tools such as the Autism Diagnostic Observation Schedule (ADOS/ADOS-2) and Autism Diagnostic Interview-Revised (ADI-R) were common for diagnostic confirmation. However, psychometric performance and cultural adaptation processes varied, and many tools were not validated for the study population. Tool selection and adaptation were found to directly influence prevalence estimates, with implications for research comparability and policy planning. Findings highlight the need for culturally validated instruments, standardized sampling approaches, and increased representation of low- and middle-income countries in ASD prevalence research to ensure equitable and accurate identification. En ligne : https://doi.org/10.1002/aur.70196 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585 [article] How Screening and Diagnostic Tools Shape Autism Prevalence in School-Aged Children: A Bibliometric-Systematic Review (2015–2025) [texte imprimé] / Ahmad Zamir CHE DAUD, Auteur ; Noor Aziella MOHD NAYAN, Auteur ; Hasnah TORAN, Auteur ; Kartini ILIAS, Auteur ; Norazlin KAMAL NOR, Auteur ; Khairil Anuar MD ISA, Auteur ; Wai Wai YANG, Auteur ; Tengku Amatullah Madeehah TENGKU MOHD, Auteur ; Nizam BAHAROM, Auteur ; Sazlina KAMARALZAMAN, Auteur . - e70196. Langues : Anglais (eng) in Autism Research > 19-4 (April 2026) . - e70196 Mots-clés : autism spectrum disorder  child  cross-cultural comparison  diagnostic tools  prevalence  psychometrics  screening tools Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) prevalence estimates vary widely across countries and over time, partly due to differences in the screening and diagnostic tools used. This study combined bibliometric analysis and systematic review methods to examine global publication trends and evaluate the use of standardized assessment tools in ASD prevalence studies involving school-aged children (typically 6?12?years). A bibliometric search of the Scopus database (2015?2025) identified 107 publications, which were analyzed for citation patterns, research themes, and geographic distribution. Of these, 18 studies met systematic review inclusion criteria, reporting ASD prevalence in the general population and high-risk samples across diverse regions. The most frequently used screening tools were the Social Communication Questionnaire (SCQ) and Childhood Autism Spectrum Test (CAST), while gold-standard diagnostic tools such as the Autism Diagnostic Observation Schedule (ADOS/ADOS-2) and Autism Diagnostic Interview-Revised (ADI-R) were common for diagnostic confirmation. However, psychometric performance and cultural adaptation processes varied, and many tools were not validated for the study population. Tool selection and adaptation were found to directly influence prevalence estimates, with implications for research comparability and policy planning. Findings highlight the need for culturally validated instruments, standardized sampling approaches, and increased representation of low- and middle-income countries in ASD prevalence research to ensure equitable and accurate identification. En ligne : https://doi.org/10.1002/aur.70196 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585

Changes in Intrinsic Activity of the Primary Somatosensory Cortex Causally Explain Differences in Emotion Perception in Autism / Martina FANGHELLA in Autism Research, 19-4 (April 2026)  

Public ISBD [article]  inAutism Research > 19-4 (April 2026) . - e70197 Titre : Changes in Intrinsic Activity of the Primary Somatosensory Cortex Causally Explain Differences in Emotion Perception in Autism Type de document : texte imprimé Auteurs : Martina FANGHELLA, Auteur ; Danai DIMA, Auteur ; Dimitrios PINOTSIS, Auteur ; Sebastian B. GAIGG, Auteur ; Beatriz CALVO-MERINO, Auteur ; Bettina FORSTER, Auteur Article en page(s) : e70197 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  dynamic causal modeling  EEG  embodiment  emotion  somatosensory Index. décimale : PER Périodiques Résumé : ABSTRACT Autism Spectrum Disorder (ASD) is characterized by certain difficulties in emotion-related processing. Recent research using electroencephalography (EEG) to measure somatosensory evoked potentials during emotion perception has shown reduced embodiment of emotional expressions in autistic compared to neurotypical individuals, independently from differences in visual processing. However, the underlying neural dynamics are not clear. In this study, we use Dynamic Causal Modeling (DCM) on EEG data to investigate whether reduced embodiment during emotion processing in ASD individuals is caused by changes in intrinsic connectivity within the somatosensory cortex, or by top-down modulatory effects from higher-order frontal areas. We constructed a model involving the primary and secondary right somatosensory cortex, the right supplementary motor area and the right inferior frontal gyrus, and tested effective connectivity during emotion or gender discrimination tasks in two groups of ASD and typically developing (TD) participants (n?=?38, male and female, 2 females). Our results reveal that task-related differences in electrocortical activity between the emotion and gender tasks are causally explained by changes in intrinsic activity within the right primary somatosensory cortex (rS1) in both TD and ASD. Importantly, these intrinsic changes in rS1 are significantly different between TD and ASD groups and individual task-related changes in rS1 significantly correlate with alexithymia traits. Our study provides novel evidence on the neural dynamics underlying difficulties in emotion processing in ASD individuals, highlighting that differential intrinsic activations of the rS1 are causally involved in such difficulties, and suggests that they are mediated by alexithymia. En ligne : https://doi.org/10.1002/aur.70197 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585 [article] Changes in Intrinsic Activity of the Primary Somatosensory Cortex Causally Explain Differences in Emotion Perception in Autism [texte imprimé] / Martina FANGHELLA, Auteur ; Danai DIMA, Auteur ; Dimitrios PINOTSIS, Auteur ; Sebastian B. GAIGG, Auteur ; Beatriz CALVO-MERINO, Auteur ; Bettina FORSTER, Auteur . - e70197. Langues : Anglais (eng) in Autism Research > 19-4 (April 2026) . - e70197 Mots-clés : autism spectrum disorder  dynamic causal modeling  EEG  embodiment  emotion  somatosensory Index. décimale : PER Périodiques Résumé : ABSTRACT Autism Spectrum Disorder (ASD) is characterized by certain difficulties in emotion-related processing. Recent research using electroencephalography (EEG) to measure somatosensory evoked potentials during emotion perception has shown reduced embodiment of emotional expressions in autistic compared to neurotypical individuals, independently from differences in visual processing. However, the underlying neural dynamics are not clear. In this study, we use Dynamic Causal Modeling (DCM) on EEG data to investigate whether reduced embodiment during emotion processing in ASD individuals is caused by changes in intrinsic connectivity within the somatosensory cortex, or by top-down modulatory effects from higher-order frontal areas. We constructed a model involving the primary and secondary right somatosensory cortex, the right supplementary motor area and the right inferior frontal gyrus, and tested effective connectivity during emotion or gender discrimination tasks in two groups of ASD and typically developing (TD) participants (n?=?38, male and female, 2 females). Our results reveal that task-related differences in electrocortical activity between the emotion and gender tasks are causally explained by changes in intrinsic activity within the right primary somatosensory cortex (rS1) in both TD and ASD. Importantly, these intrinsic changes in rS1 are significantly different between TD and ASD groups and individual task-related changes in rS1 significantly correlate with alexithymia traits. Our study provides novel evidence on the neural dynamics underlying difficulties in emotion processing in ASD individuals, highlighting that differential intrinsic activations of the rS1 are causally involved in such difficulties, and suggests that they are mediated by alexithymia. En ligne : https://doi.org/10.1002/aur.70197 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585

Does the Extreme Male Brain Hypothesis of Autism Apply More to Females Than Males? A Systematic and Meta-Analytic Approach / Cory SZAKAL in Autism Research, 19-4 (April 2026)  

Public ISBD [article]  inAutism Research > 19-4 (April 2026) . - e70198 Titre : Does the Extreme Male Brain Hypothesis of Autism Apply More to Females Than Males? A Systematic and Meta-Analytic Approach Type de document : texte imprimé Auteurs : Cory SZAKAL, Auteur ; Bernard CRESPI, Auteur Article en page(s) : e70198 Langues : Anglais (eng) Mots-clés : autism  empathizing  extreme male brain  prenatal testosterone  systemizing Index. décimale : PER Périodiques Résumé : ABSTRACT The extreme male brain (EMB) hypothesis posits that autism risk is mediated by high systemizing and low empathizing. This hypothesis has accrued extensive support, but the degree to which it applies in females compared to males, and the relative extent to which autism is associated with empathizing compared to systemizing, is unclear. Systematic review and meta-analyses of studies measuring the empathy quotient (EQ), the systemizing quotient (SQ), and the autism quotient (AQ), among individuals with autism and neurotypical individuals, were used to address these questions. Analyses of results from 34 studies indicated that: (1) Females show larger proportional differences in EQ and SQ between ASD and NT individuals than do males, (2) EQ shows larger proportional differences between autism spectrum (ASD) and neurotypical (NT) individuals than does SQ, (3) sex differences in EQ and SQ are highly attenuated among individuals with ASD, especially for SQ in females, (4) the regressions of EQ and SQ on AQ show significantly steeper slopes among individuals with ASD than in NT individuals, and (5) across studies, EQ and SQ are inversely associated among individuals with ASD, but not in NT individuals. These results provide new insights into the causes of ASD and its male bias. En ligne : https://doi.org/10.1002/aur.70198 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585 [article] Does the Extreme Male Brain Hypothesis of Autism Apply More to Females Than Males? A Systematic and Meta-Analytic Approach [texte imprimé] / Cory SZAKAL, Auteur ; Bernard CRESPI, Auteur . - e70198. Langues : Anglais (eng) in Autism Research > 19-4 (April 2026) . - e70198 Mots-clés : autism  empathizing  extreme male brain  prenatal testosterone  systemizing Index. décimale : PER Périodiques Résumé : ABSTRACT The extreme male brain (EMB) hypothesis posits that autism risk is mediated by high systemizing and low empathizing. This hypothesis has accrued extensive support, but the degree to which it applies in females compared to males, and the relative extent to which autism is associated with empathizing compared to systemizing, is unclear. Systematic review and meta-analyses of studies measuring the empathy quotient (EQ), the systemizing quotient (SQ), and the autism quotient (AQ), among individuals with autism and neurotypical individuals, were used to address these questions. Analyses of results from 34 studies indicated that: (1) Females show larger proportional differences in EQ and SQ between ASD and NT individuals than do males, (2) EQ shows larger proportional differences between autism spectrum (ASD) and neurotypical (NT) individuals than does SQ, (3) sex differences in EQ and SQ are highly attenuated among individuals with ASD, especially for SQ in females, (4) the regressions of EQ and SQ on AQ show significantly steeper slopes among individuals with ASD than in NT individuals, and (5) across studies, EQ and SQ are inversely associated among individuals with ASD, but not in NT individuals. These results provide new insights into the causes of ASD and its male bias. En ligne : https://doi.org/10.1002/aur.70198 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585

Does Camouflaging Predict Functioning, Distress, and Quality of Life for Autistic Adults? / Bruna B. ROISENBERG in Autism Research, 19-4 (April 2026)  

Public ISBD [article]  inAutism Research > 19-4 (April 2026) . - e70199 Titre : Does Camouflaging Predict Functioning, Distress, and Quality of Life for Autistic Adults? Type de document : texte imprimé Auteurs : Bruna B. ROISENBERG, Auteur ; Kelsie A. BOULTON, Auteur ; Emma E. THOMAS, Auteur ; Adam J. GUASTELLA, Auteur Article en page(s) : e70199 Langues : Anglais (eng) Mots-clés : adults  anxiety  autism  depression  psychiatry  social anxiety Index. décimale : PER Périodiques Résumé : ABSTRACT It has been proposed that autistic individuals adopt camouflaging strategies to mask their autistic traits and conform to social norms, and that these camouflaging strategies have been linked to adverse mental health outcomes. This study examined whether camouflaging, measured by the Camouflaging Autistic Traits Questionnaire (CAT-Q), predicted functioning, distress, and quality of life beyond standard clinical measures of social responsiveness and social anxiety. We analysed data from 113 autistic adults experiencing social anxiety who expressed interest in anxiety interventions. Hierarchical regression analyses assessed the unique contribution of camouflaging after accounting for social responsiveness and social anxiety. Results indicated that social responsiveness and social anxiety significantly predicted depression, psychological distress, and disability, whereas camouflaging did not explain additional variance in these outcomes. Although camouflaging correlated with poorer mental health and reduced quality of life, it did not independently predict these outcomes beyond social anxiety and responsiveness. These findings suggest current camouflaging measures may capture overlapping constructs, highlighting the need for more precise conceptualization and measurement tools. En ligne : https://doi.org/10.1002/aur.70199 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585 [article] Does Camouflaging Predict Functioning, Distress, and Quality of Life for Autistic Adults? [texte imprimé] / Bruna B. ROISENBERG, Auteur ; Kelsie A. BOULTON, Auteur ; Emma E. THOMAS, Auteur ; Adam J. GUASTELLA, Auteur . - e70199. Langues : Anglais (eng) in Autism Research > 19-4 (April 2026) . - e70199 Mots-clés : adults  anxiety  autism  depression  psychiatry  social anxiety Index. décimale : PER Périodiques Résumé : ABSTRACT It has been proposed that autistic individuals adopt camouflaging strategies to mask their autistic traits and conform to social norms, and that these camouflaging strategies have been linked to adverse mental health outcomes. This study examined whether camouflaging, measured by the Camouflaging Autistic Traits Questionnaire (CAT-Q), predicted functioning, distress, and quality of life beyond standard clinical measures of social responsiveness and social anxiety. We analysed data from 113 autistic adults experiencing social anxiety who expressed interest in anxiety interventions. Hierarchical regression analyses assessed the unique contribution of camouflaging after accounting for social responsiveness and social anxiety. Results indicated that social responsiveness and social anxiety significantly predicted depression, psychological distress, and disability, whereas camouflaging did not explain additional variance in these outcomes. Although camouflaging correlated with poorer mental health and reduced quality of life, it did not independently predict these outcomes beyond social anxiety and responsiveness. These findings suggest current camouflaging measures may capture overlapping constructs, highlighting the need for more precise conceptualization and measurement tools. En ligne : https://doi.org/10.1002/aur.70199 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585

Impact of Autism Spectrum Disorder on Motor Development of Brazilian Preschool and School-Age Children / Francisco Rosa NETO in Autism Research, 19-4 (April 2026)  

Public ISBD [article]  inAutism Research > 19-4 (April 2026) . - e70200 Titre : Impact of Autism Spectrum Disorder on Motor Development of Brazilian Preschool and School-Age Children Type de document : texte imprimé Auteurs : Francisco Rosa NETO, Auteur ; Lucia Maria ANDREIS, Auteur ; Evandro GAZOLA, Auteur ; Sany FERNANDES, Auteur ; Andresa M. C. GERMANO, Auteur Article en page(s) : e70200 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  children  motor delays  motor development Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) can be identified in early childhood, often manifesting through motor delays, stereotyped behaviors, and atypical developmental profiles, with motor impairments frequently being among the earliest observable indicators. This study aimed to assess the motor development in preschool and school-age children, comparing those with ASD to neurotypical peers. The research focuses on evaluating the overall impact of ASD on motor development and examining specific motor domains. The study included 292 children (73% boys and 27% girls), aged 3 to 10?years. The sample was divided into two groups: the ASD and the neurotypical (NT) groups, with a ratio of 3:1, with three neurotypical children selected for every child with ASD. Motor development was assessed using the Motor Development Scale III (MDS III), which evaluates six specific domains: fine motor skills (FM), gross motor skills (GM), balance (BL), body schema (BS), spatial organization (SO), and temporal organization (TO). Children with ASD, both in the preschool and school-age groups, exhibited a significantly higher incidence of motor impairments across all evaluated motor domains compared to their neurotypical peers. Motor impairments in children with ASD are not only prominent during the preschool years but also tend to intensify as children transition into school age. These findings highlight the need for early identification and targeted interventions to address motor challenges in children with ASD. En ligne : https://doi.org/10.1002/aur.70200 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585 [article] Impact of Autism Spectrum Disorder on Motor Development of Brazilian Preschool and School-Age Children [texte imprimé] / Francisco Rosa NETO, Auteur ; Lucia Maria ANDREIS, Auteur ; Evandro GAZOLA, Auteur ; Sany FERNANDES, Auteur ; Andresa M. C. GERMANO, Auteur . - e70200. Langues : Anglais (eng) in Autism Research > 19-4 (April 2026) . - e70200 Mots-clés : autism spectrum disorder  children  motor delays  motor development Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) can be identified in early childhood, often manifesting through motor delays, stereotyped behaviors, and atypical developmental profiles, with motor impairments frequently being among the earliest observable indicators. This study aimed to assess the motor development in preschool and school-age children, comparing those with ASD to neurotypical peers. The research focuses on evaluating the overall impact of ASD on motor development and examining specific motor domains. The study included 292 children (73% boys and 27% girls), aged 3 to 10?years. The sample was divided into two groups: the ASD and the neurotypical (NT) groups, with a ratio of 3:1, with three neurotypical children selected for every child with ASD. Motor development was assessed using the Motor Development Scale III (MDS III), which evaluates six specific domains: fine motor skills (FM), gross motor skills (GM), balance (BL), body schema (BS), spatial organization (SO), and temporal organization (TO). Children with ASD, both in the preschool and school-age groups, exhibited a significantly higher incidence of motor impairments across all evaluated motor domains compared to their neurotypical peers. Motor impairments in children with ASD are not only prominent during the preschool years but also tend to intensify as children transition into school age. These findings highlight the need for early identification and targeted interventions to address motor challenges in children with ASD. En ligne : https://doi.org/10.1002/aur.70200 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585

A Protective Super-Enhancer Variant Regulating SLC7A7 Modulates Autism Spectrum Disorder Risk: A Cross-Population Study / Jiao ZHANG in Autism Research, 19-4 (April 2026)  

Public ISBD [article]  inAutism Research > 19-4 (April 2026) . - e70201 Titre : A Protective Super-Enhancer Variant Regulating SLC7A7 Modulates Autism Spectrum Disorder Risk: A Cross-Population Study Type de document : texte imprimé Auteurs : Jiao ZHANG, Auteur ; Fang HOU, Auteur ; Yanlin CHEN, Auteur ; Qianhui CHEN, Auteur ; Zhen XIANG, Auteur ; Tianchun WANG, Auteur ; Xi LIANG, Auteur ; Li LI, Auteur ; Ranran SONG, Auteur Article en page(s) : e70201 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  gene expression  genome-wide association study  rs1951568  single nucleotide polymorphism  super enhancers Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is a highly heritable neurodevelopmental condition with a rising global prevalence. However, the functional role of super-enhancers, the key genomic regulatory elements, remains largely uncharacterized in ASD. This study aims to identify functional single-nucleotide polymorphisms (SNPs) within super-enhancers that regulate ASD-associated genes and to validate their contribution to ASD risk. We integrated 1394 ASD susceptibility genes with 1315 differentially expressed genes and 2954 super-enhancers from the cerebral cortex. SNPs located in these regions were prioritized through expression quantitative trait locus (eQTL) analysis (p?A variant, located within the super-enhancer regulating SLC7A7, demonstrated a significant association with reduced ASD risk in the Chinese population (OR?=?0.783, 95% CI: 0.604?0.957, p?=?0.017). The protective association was further replicated in the European population (A allele vs. G allele, OR?=?0.963, 95% CI: 0.935?0.992, p?=?0.012). The eQTL analysis linked the rs1951568-A allele to reduced SLC7A7 expression. Functional characterization confirmed the variant's regulatory activity and predicted that the A allele enhanced binding motifs for the transcriptional repressors TBX5 and ZEB1. Our findings identify rs1951568-A as a novel protective variant for ASD within a SLC7A7 super-enhancer. This allele likely confers protection by modulating SLC7A7 expression, potentially through enhanced repressor binding, highlighting the importance of super-enhancer variants in ASD etiology. En ligne : https://doi.org/10.1002/aur.70201 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585 [article] A Protective Super-Enhancer Variant Regulating SLC7A7 Modulates Autism Spectrum Disorder Risk: A Cross-Population Study [texte imprimé] / Jiao ZHANG, Auteur ; Fang HOU, Auteur ; Yanlin CHEN, Auteur ; Qianhui CHEN, Auteur ; Zhen XIANG, Auteur ; Tianchun WANG, Auteur ; Xi LIANG, Auteur ; Li LI, Auteur ; Ranran SONG, Auteur . - e70201. Langues : Anglais (eng) in Autism Research > 19-4 (April 2026) . - e70201 Mots-clés : autism spectrum disorder  gene expression  genome-wide association study  rs1951568  single nucleotide polymorphism  super enhancers Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is a highly heritable neurodevelopmental condition with a rising global prevalence. However, the functional role of super-enhancers, the key genomic regulatory elements, remains largely uncharacterized in ASD. This study aims to identify functional single-nucleotide polymorphisms (SNPs) within super-enhancers that regulate ASD-associated genes and to validate their contribution to ASD risk. We integrated 1394 ASD susceptibility genes with 1315 differentially expressed genes and 2954 super-enhancers from the cerebral cortex. SNPs located in these regions were prioritized through expression quantitative trait locus (eQTL) analysis (p?A variant, located within the super-enhancer regulating SLC7A7, demonstrated a significant association with reduced ASD risk in the Chinese population (OR?=?0.783, 95% CI: 0.604?0.957, p?=?0.017). The protective association was further replicated in the European population (A allele vs. G allele, OR?=?0.963, 95% CI: 0.935?0.992, p?=?0.012). The eQTL analysis linked the rs1951568-A allele to reduced SLC7A7 expression. Functional characterization confirmed the variant's regulatory activity and predicted that the A allele enhanced binding motifs for the transcriptional repressors TBX5 and ZEB1. Our findings identify rs1951568-A as a novel protective variant for ASD within a SLC7A7 super-enhancer. This allele likely confers protection by modulating SLC7A7 expression, potentially through enhanced repressor binding, highlighting the importance of super-enhancer variants in ASD etiology. En ligne : https://doi.org/10.1002/aur.70201 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585

Integrating Dimensional Personality and Autistic Traits to Predict Suicidal Ideation, Suicide Attempts, and Nonsuicidal Self-Injury in Autistic Adults / Aliona TSYPES in Autism Research, 19-4 (April 2026)  

Public ISBD [article]  inAutism Research > 19-4 (April 2026) . - e70202 Titre : Integrating Dimensional Personality and Autistic Traits to Predict Suicidal Ideation, Suicide Attempts, and Nonsuicidal Self-Injury in Autistic Adults Type de document : texte imprimé Auteurs : Aliona TSYPES, Auteur ; Timothy A. ALLEN, Auteur ; Ligia ANTEZANA, Auteur ; Kelly B. BECK, Auteur ; Caitlin M. CONNER, Auteur ; Lori N. SCOTT, Auteur ; Carla A. MAZEFSKY, Auteur Article en page(s) : e70202 Langues : Anglais (eng) Mots-clés : adults  autism  CATI  NSSI  personality  PID-5  suicide Index. décimale : PER Périodiques Résumé : ABSTRACT Given the elevated rates of suicidal ideation, suicide attempts, and nonsuicidal self-injury (NSSI) in autistic adults, we examined whether autism-informed traits and transdiagnostic personality tendencies jointly relate to these outcomes. One hundred and two adults with clinician-diagnosed autism completed structured clinical interview assessments of lifetime histories of suicidal ideation, attempts, and NSSI. Predictors were six Comprehensive Autistic Trait Inventory (CATI) subscales and selected Personality Inventory for DSM-5 Short Form (PID-5-SF) domains and facets. We fit CATI-only, PID-5 domain, and facet models, then combined significant predictors and refit with age, sex, and IQ as covariates. Shared variance between PID-5-SF facet Anhedonia and CATI Social Interactions showed suppression in joint models, and latent variable modeling confirmed that their shared variance?indexing overlapping reward and social disengagement?was the most consistent correlate of risk across outcomes. PID-5-SF facet Emotional Lability was robustly related to NSSI and to ideation severity. CATI Self-Regulatory Behaviors predicted NSSI. PID-5-SF domain Disinhibition showed no associations. Higher IQ showed a modest protective effect for attempts. Findings highlight central roles of reward-related processes and affective volatility, with added contributions from interpersonal strain and self-regulation. Combining CATI with PID-5 yields complementary targets for assessment and intervention. Key strengths include a clinician-diagnosed autistic sample, a rare direct comparison of people with lifetime suicidal ideation vs. suicide attempts, and an integrated trait framework that moves the field beyond prevalence toward trait-informed risk. Findings support brief screening for anhedonia and emotional lability, autism-adapted behavioral activation, rapid arousal-reduction skills, and attention to social communication needs that may impede disclosure and help-seeking. En ligne : https://doi.org/10.1002/aur.70202 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585 [article] Integrating Dimensional Personality and Autistic Traits to Predict Suicidal Ideation, Suicide Attempts, and Nonsuicidal Self-Injury in Autistic Adults [texte imprimé] / Aliona TSYPES, Auteur ; Timothy A. ALLEN, Auteur ; Ligia ANTEZANA, Auteur ; Kelly B. BECK, Auteur ; Caitlin M. CONNER, Auteur ; Lori N. SCOTT, Auteur ; Carla A. MAZEFSKY, Auteur . - e70202. Langues : Anglais (eng) in Autism Research > 19-4 (April 2026) . - e70202 Mots-clés : adults  autism  CATI  NSSI  personality  PID-5  suicide Index. décimale : PER Périodiques Résumé : ABSTRACT Given the elevated rates of suicidal ideation, suicide attempts, and nonsuicidal self-injury (NSSI) in autistic adults, we examined whether autism-informed traits and transdiagnostic personality tendencies jointly relate to these outcomes. One hundred and two adults with clinician-diagnosed autism completed structured clinical interview assessments of lifetime histories of suicidal ideation, attempts, and NSSI. Predictors were six Comprehensive Autistic Trait Inventory (CATI) subscales and selected Personality Inventory for DSM-5 Short Form (PID-5-SF) domains and facets. We fit CATI-only, PID-5 domain, and facet models, then combined significant predictors and refit with age, sex, and IQ as covariates. Shared variance between PID-5-SF facet Anhedonia and CATI Social Interactions showed suppression in joint models, and latent variable modeling confirmed that their shared variance?indexing overlapping reward and social disengagement?was the most consistent correlate of risk across outcomes. PID-5-SF facet Emotional Lability was robustly related to NSSI and to ideation severity. CATI Self-Regulatory Behaviors predicted NSSI. PID-5-SF domain Disinhibition showed no associations. Higher IQ showed a modest protective effect for attempts. Findings highlight central roles of reward-related processes and affective volatility, with added contributions from interpersonal strain and self-regulation. Combining CATI with PID-5 yields complementary targets for assessment and intervention. Key strengths include a clinician-diagnosed autistic sample, a rare direct comparison of people with lifetime suicidal ideation vs. suicide attempts, and an integrated trait framework that moves the field beyond prevalence toward trait-informed risk. Findings support brief screening for anhedonia and emotional lability, autism-adapted behavioral activation, rapid arousal-reduction skills, and attention to social communication needs that may impede disclosure and help-seeking. En ligne : https://doi.org/10.1002/aur.70202 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585

Racial–Ethnic Comparisons of ADOS-2 Algorithms for Young Verbal Children / B. BARGER in Autism Research, 19-4 (April 2026)  

Public ISBD [article]  inAutism Research > 19-4 (April 2026) . - e70203 Titre : Racial–Ethnic Comparisons of ADOS-2 Algorithms for Young Verbal Children Type de document : texte imprimé Auteurs : B. BARGER, Auteur ; E. J. MOODY, Auteur ; N. REYES, Auteur ; S. ROSENBERG, Auteur ; C. ROBINSON-ROSENBERG, Auteur ; R. PRETZEL, Auteur ; R. GRZADZINSKI, Auteur ; C. NADLER, Auteur ; C. DIGUISEPPI, Auteur Article en page(s) : e70203 Langues : Anglais (eng) Mots-clés : autism assessment  differential item functioning  early identification  item response theorymeasurement Index. décimale : PER Périodiques Résumé : ABSTRACT The current study reports comparative analyses of the ADOS-2 Module 1 (Some Words) (n?=?918) and Module 2 (Phrase Speech) (n?=?881) algorithmic items between Black, Hispanic, and White children aged 3?5 on data from the Study to Explore Early Development (SEED). Significant Differential Item Functioning (DIF) was identified on ADOS-2 Social Affect and Restrictive Repetitive Behavior (RRB) items from both modules, but differential test functioning (DTF) was close to zero for each subscale (range?=??0.07 to 0.08). No discernible patterns were identified when comparing these results with other published studies conducted with older populations. Item level scoring differences may reflect unique study sample variance, and existing data suggests DIF is unlikely to impact scale level ADOS-2 interpretations for clinicians assessing preschool age children from different racial and ethnic backgrounds. En ligne : https://doi.org/10.1002/aur.70203 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585 [article] Racial–Ethnic Comparisons of ADOS-2 Algorithms for Young Verbal Children [texte imprimé] / B. BARGER, Auteur ; E. J. MOODY, Auteur ; N. REYES, Auteur ; S. ROSENBERG, Auteur ; C. ROBINSON-ROSENBERG, Auteur ; R. PRETZEL, Auteur ; R. GRZADZINSKI, Auteur ; C. NADLER, Auteur ; C. DIGUISEPPI, Auteur . - e70203. Langues : Anglais (eng) in Autism Research > 19-4 (April 2026) . - e70203 Mots-clés : autism assessment  differential item functioning  early identification  item response theorymeasurement Index. décimale : PER Périodiques Résumé : ABSTRACT The current study reports comparative analyses of the ADOS-2 Module 1 (Some Words) (n?=?918) and Module 2 (Phrase Speech) (n?=?881) algorithmic items between Black, Hispanic, and White children aged 3?5 on data from the Study to Explore Early Development (SEED). Significant Differential Item Functioning (DIF) was identified on ADOS-2 Social Affect and Restrictive Repetitive Behavior (RRB) items from both modules, but differential test functioning (DTF) was close to zero for each subscale (range?=??0.07 to 0.08). No discernible patterns were identified when comparing these results with other published studies conducted with older populations. Item level scoring differences may reflect unique study sample variance, and existing data suggests DIF is unlikely to impact scale level ADOS-2 interpretations for clinicians assessing preschool age children from different racial and ethnic backgrounds. En ligne : https://doi.org/10.1002/aur.70203 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585

Conversational Topic Shifts and Topic Maintenance in Autistic and Neurotypical Children / Zuriñe ÁBALOS in Autism Research, 19-4 (April 2026)  

Public ISBD [article]  inAutism Research > 19-4 (April 2026) . - e70204 Titre : Conversational Topic Shifts and Topic Maintenance in Autistic and Neurotypical Children Type de document : texte imprimé Auteurs : Zuriñe ÁBALOS, Auteur ; Mikhail KISSINE, Auteur ; Agustín VICENTE, Auteur ; Elena CASTROVIEJO, Auteur Article en page(s) : e70204 Langues : Anglais (eng) Mots-clés : autism  children  communication  language  social interaction Index. décimale : PER Périodiques Résumé : ABSTRACT Topic maintenance and topic shifts are crucial components of conversation; however, existing research lacks a clear quantitative operationalization of these topic management skills. Previous studies suggest that autistic children are less likely than their neurotypical peers to maintain and elaborate on the interlocutor's prior topic, and that they shift topics inappropriately more often. Nevertheless, findings on topic maintenance remain inconclusive, and studies specifically investigating topic shifts are limited. Moreover, little is known about the conversational skills of autistic children from non-English-speaking contexts. We investigated topic maintenance and shifting in 43 autistic and 46 age-matched neurotypical Spanish-speaking children (M?=?8.55, SD?=?1.91) during a semi-spontaneous conversation task. Given their important role in social interactions, we developed a theoretically grounded protocol for systematically coding topic shifts, supported through a rating task conducted with neurotypical adults. Results showed that although autistic and neurotypical children provided a comparable number of topic-supporting responses, autistic participants produced significantly more topic shifts. Furthermore, autistic children's topic shifts corresponded to a less natural end of the empirically supported rating scale, indicating such topic shifts interrupted the conversation flow more drastically. These findings suggest that, while autistic children may not have difficulties maintaining a conversation topic, the frequency and nature of their topic shifts could challenge reciprocal conversations. Our study presents a coding scheme that captures relevant distinctions in how different topic shifts are perceived in conversation, serving as a valuable resource for research and clinical practice in assessing and supporting the conversational skills of autistic individuals. En ligne : https://doi.org/10.1002/aur.70204 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585 [article] Conversational Topic Shifts and Topic Maintenance in Autistic and Neurotypical Children [texte imprimé] / Zuriñe ÁBALOS, Auteur ; Mikhail KISSINE, Auteur ; Agustín VICENTE, Auteur ; Elena CASTROVIEJO, Auteur . - e70204. Langues : Anglais (eng) in Autism Research > 19-4 (April 2026) . - e70204 Mots-clés : autism  children  communication  language  social interaction Index. décimale : PER Périodiques Résumé : ABSTRACT Topic maintenance and topic shifts are crucial components of conversation; however, existing research lacks a clear quantitative operationalization of these topic management skills. Previous studies suggest that autistic children are less likely than their neurotypical peers to maintain and elaborate on the interlocutor's prior topic, and that they shift topics inappropriately more often. Nevertheless, findings on topic maintenance remain inconclusive, and studies specifically investigating topic shifts are limited. Moreover, little is known about the conversational skills of autistic children from non-English-speaking contexts. We investigated topic maintenance and shifting in 43 autistic and 46 age-matched neurotypical Spanish-speaking children (M?=?8.55, SD?=?1.91) during a semi-spontaneous conversation task. Given their important role in social interactions, we developed a theoretically grounded protocol for systematically coding topic shifts, supported through a rating task conducted with neurotypical adults. Results showed that although autistic and neurotypical children provided a comparable number of topic-supporting responses, autistic participants produced significantly more topic shifts. Furthermore, autistic children's topic shifts corresponded to a less natural end of the empirically supported rating scale, indicating such topic shifts interrupted the conversation flow more drastically. These findings suggest that, while autistic children may not have difficulties maintaining a conversation topic, the frequency and nature of their topic shifts could challenge reciprocal conversations. Our study presents a coding scheme that captures relevant distinctions in how different topic shifts are perceived in conversation, serving as a valuable resource for research and clinical practice in assessing and supporting the conversational skills of autistic individuals. En ligne : https://doi.org/10.1002/aur.70204 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585

Altered Brain Structure in an ATRX-Deficient Mouse Model of Autism Spectrum Disorder / Katherine QUESNEL in Autism Research, 19-4 (April 2026)  

Public ISBD [article]  inAutism Research > 19-4 (April 2026) . - e70205 Titre : Altered Brain Structure in an ATRX-Deficient Mouse Model of Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Katherine QUESNEL, Auteur ; Jacob ELLEGOOD, Auteur ; Jason P. LERCH, Auteur ; Nathalie G. BÉRUBÉ, Auteur Article en page(s) : e70205 Langues : Anglais (eng) Mots-clés : autism  brain structure  imaging  mice  sex differences Index. décimale : PER Périodiques Résumé : ABSTRACT Mutations in the ATRX gene are a primary cause of alpha-thalassemia intellectual disability X-linked (ATRX) syndrome, which is characterized by intellectual disability, autism, and a range of brain structural abnormalities, including microcephaly. We previously showed that mice with conditional ATRX ablation in forebrain excitatory neurons display deficits in fear memory and autism-related behaviors, with some effects exhibiting sexual dimorphism. In this study, we used high-resolution magnetic resonance imaging (MRI) to systematically characterize brain structural changes associated with these behavioral abnormalities. Whole-brain analysis revealed male-specific microcephaly, while subregional analysis identified significant reductions in hippocampal structures and increased volume of the caudal cortex in mutant animals of both sexes. We also identified structural alterations in regions retaining ATRX expression, such as the thalamus, midbrain, cerebellum, and several fiber tracts. These findings suggest that ATRX loss disrupts the coordinated development of interconnected brain regions. Overall, our results implicate impaired cortico-thalamic-cerebellar connectivity as a potential neural substrate underlying the autistic-like behaviors observed in this mouse model, providing new insights into the neurobiological basis of ATR-X syndrome. En ligne : https://doi.org/10.1002/aur.70205 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585 [article] Altered Brain Structure in an ATRX-Deficient Mouse Model of Autism Spectrum Disorder [texte imprimé] / Katherine QUESNEL, Auteur ; Jacob ELLEGOOD, Auteur ; Jason P. LERCH, Auteur ; Nathalie G. BÉRUBÉ, Auteur . - e70205. Langues : Anglais (eng) in Autism Research > 19-4 (April 2026) . - e70205 Mots-clés : autism  brain structure  imaging  mice  sex differences Index. décimale : PER Périodiques Résumé : ABSTRACT Mutations in the ATRX gene are a primary cause of alpha-thalassemia intellectual disability X-linked (ATRX) syndrome, which is characterized by intellectual disability, autism, and a range of brain structural abnormalities, including microcephaly. We previously showed that mice with conditional ATRX ablation in forebrain excitatory neurons display deficits in fear memory and autism-related behaviors, with some effects exhibiting sexual dimorphism. In this study, we used high-resolution magnetic resonance imaging (MRI) to systematically characterize brain structural changes associated with these behavioral abnormalities. Whole-brain analysis revealed male-specific microcephaly, while subregional analysis identified significant reductions in hippocampal structures and increased volume of the caudal cortex in mutant animals of both sexes. We also identified structural alterations in regions retaining ATRX expression, such as the thalamus, midbrain, cerebellum, and several fiber tracts. These findings suggest that ATRX loss disrupts the coordinated development of interconnected brain regions. Overall, our results implicate impaired cortico-thalamic-cerebellar connectivity as a potential neural substrate underlying the autistic-like behaviors observed in this mouse model, providing new insights into the neurobiological basis of ATR-X syndrome. En ligne : https://doi.org/10.1002/aur.70205 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585

Multidimensional Acoustic–Prosodic Quantification Framework Using Unscripted Speech for Autism Spectrum Disorder Identification / Minghao DU in Autism Research, 19-4 (April 2026)  

Public ISBD [article]  inAutism Research > 19-4 (April 2026) . - e70206 Titre : Multidimensional Acoustic–Prosodic Quantification Framework Using Unscripted Speech for Autism Spectrum Disorder Identification Type de document : texte imprimé Auteurs : Minghao DU, Auteur ; Ping SHI, Auteur ; Zehao LIU, Auteur ; Xiaoyao LU, Auteur ; Luling CAO, Auteur ; Beibei LIU, Auteur ; Xiaoya LIU, Auteur ; Wei LIU, Auteur ; Shuang LIU, Auteur ; Dong MING, Auteur Article en page(s) : e70206 Langues : Anglais (eng) Mots-clés : acoustic analysis  autism spectrum disorder  classification  speech Index. décimale : PER Périodiques Résumé : ABSTRACT Although clinical observations have noted early speech abnormalities in children with autism spectrum disorder (ASD), automatic speech-based detection remains challenging. This is primarily due to the reliance on scripted tasks, which younger children often struggle to complete and which are not generalizable to large-scale, non-clinical screening. To address this, we developed an unscripted speech-based framework to quantify atypical acoustic?prosodic patterns for automatic ASD identification in naturalistic interactions. It processes free-flowing conversations, extracts multidimensional acoustic features from the time and frequency domains, and models ASD-related prosodic patterns for classification. For evaluation, we collected spontaneous speech from 88 children with ASD (3?10?years) and 82 typically developing (TD) children (3?9?years) during naturalistic interactions on daily topics (e.g., toys, animated movies, storybook reading). Group comparisons revealed atypical prosodic patterns in ASD, including reduced speech continuity, speech rate, and Formant 3, alongside increased zero-crossing rate, pitch, pitch variability, and Formant 1 (all p??0.05), but a pronounced effect of speech context (p? En ligne : https://doi.org/10.1002/aur.70206 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585 [article] Multidimensional Acoustic–Prosodic Quantification Framework Using Unscripted Speech for Autism Spectrum Disorder Identification [texte imprimé] / Minghao DU, Auteur ; Ping SHI, Auteur ; Zehao LIU, Auteur ; Xiaoyao LU, Auteur ; Luling CAO, Auteur ; Beibei LIU, Auteur ; Xiaoya LIU, Auteur ; Wei LIU, Auteur ; Shuang LIU, Auteur ; Dong MING, Auteur . - e70206. Langues : Anglais (eng) in Autism Research > 19-4 (April 2026) . - e70206 Mots-clés : acoustic analysis  autism spectrum disorder  classification  speech Index. décimale : PER Périodiques Résumé : ABSTRACT Although clinical observations have noted early speech abnormalities in children with autism spectrum disorder (ASD), automatic speech-based detection remains challenging. This is primarily due to the reliance on scripted tasks, which younger children often struggle to complete and which are not generalizable to large-scale, non-clinical screening. To address this, we developed an unscripted speech-based framework to quantify atypical acoustic?prosodic patterns for automatic ASD identification in naturalistic interactions. It processes free-flowing conversations, extracts multidimensional acoustic features from the time and frequency domains, and models ASD-related prosodic patterns for classification. For evaluation, we collected spontaneous speech from 88 children with ASD (3?10?years) and 82 typically developing (TD) children (3?9?years) during naturalistic interactions on daily topics (e.g., toys, animated movies, storybook reading). Group comparisons revealed atypical prosodic patterns in ASD, including reduced speech continuity, speech rate, and Formant 3, alongside increased zero-crossing rate, pitch, pitch variability, and Formant 1 (all p??0.05), but a pronounced effect of speech context (p? En ligne : https://doi.org/10.1002/aur.70206 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585

Mixed Evidence for Impact of Early Infant Gut Microbiome and Later Development of Autism Spectrum Disorder in the MARBLES Prospective Cohort Study / Jennie SOTELO-OROZCO in Autism Research, 19-4 (April 2026)  

Public ISBD [article]  inAutism Research > 19-4 (April 2026) . - e70207 Titre : Mixed Evidence for Impact of Early Infant Gut Microbiome and Later Development of Autism Spectrum Disorder in the MARBLES Prospective Cohort Study Type de document : texte imprimé Auteurs : Jennie SOTELO-OROZCO, Auteur ; Diana H. TAFT, Auteur ; Jassim AL-OBOUDI, Auteur ; Brittany C. BAIKIE, Auteur ; Cailyn LAKE, Auteur ; Meghan MILLER, Auteur ; David A. MILLS, Auteur ; Daniel J. TANCREDI, Auteur ; Rebecca J. SCHMIDT, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Deborah H. BENNETT, Auteur Article en page(s) : e70207 Langues : Anglais (eng) Mots-clés : 16S rRNA  autism spectrum disorder (ASD)  bacteria  cohort studies  gut microbiome  infant  microbiota Index. décimale : PER Périodiques Résumé : ABSTRACT This study investigated the relationship between early infant gut microbiome composition and subsequent neurodevelopmental outcomes. Fecal samples from children in the markers of autism risks in babies-learning early signs (MARBLES) study, a cohort with elevated likelihood of autism, were collected between 0 and 7?months of age and analyzed using 16S rRNA sequencing to evaluate whether the gut microbial composition during early infancy is associated with later neurodevelopmental diagnoses. Clinical classification as autism spectrum disorder (ASD), non-typically developing without ASD (non-TD), or typically developing (TD) was completed around 36?months of age using gold-standard assessment tools. Overall, no significant differences in alpha diversity or beta diversity, nor any differentially abundant bacterial taxa, were found between groups of infants who developed ASD or non-TD compared to those who went on to have TD. Nonetheless, our findings highlight some early differences in gut microbial composition during infancy that may relate to later neurodevelopmental outcomes. Before adjusting for multiple comparisons, infants who later developed ASD had slightly lower levels of Veillonella and Flavonifractor genera compared to children who were later found to be TD. These results suggest specific bacterial taxa may already differentiate in early infancy, but may be more subtle than other factors, such as mode of delivery and diet during early infancy. To understand longitudinal trajectories of the gut microbiome in association with later neurodevelopment, future studies should include a larger cohort to detect smaller effect sizes or investigate later time points in infancy. En ligne : https://doi.org/10.1002/aur.70207 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585 [article] Mixed Evidence for Impact of Early Infant Gut Microbiome and Later Development of Autism Spectrum Disorder in the MARBLES Prospective Cohort Study [texte imprimé] / Jennie SOTELO-OROZCO, Auteur ; Diana H. TAFT, Auteur ; Jassim AL-OBOUDI, Auteur ; Brittany C. BAIKIE, Auteur ; Cailyn LAKE, Auteur ; Meghan MILLER, Auteur ; David A. MILLS, Auteur ; Daniel J. TANCREDI, Auteur ; Rebecca J. SCHMIDT, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Deborah H. BENNETT, Auteur . - e70207. Langues : Anglais (eng) in Autism Research > 19-4 (April 2026) . - e70207 Mots-clés : 16S rRNA  autism spectrum disorder (ASD)  bacteria  cohort studies  gut microbiome  infant  microbiota Index. décimale : PER Périodiques Résumé : ABSTRACT This study investigated the relationship between early infant gut microbiome composition and subsequent neurodevelopmental outcomes. Fecal samples from children in the markers of autism risks in babies-learning early signs (MARBLES) study, a cohort with elevated likelihood of autism, were collected between 0 and 7?months of age and analyzed using 16S rRNA sequencing to evaluate whether the gut microbial composition during early infancy is associated with later neurodevelopmental diagnoses. Clinical classification as autism spectrum disorder (ASD), non-typically developing without ASD (non-TD), or typically developing (TD) was completed around 36?months of age using gold-standard assessment tools. Overall, no significant differences in alpha diversity or beta diversity, nor any differentially abundant bacterial taxa, were found between groups of infants who developed ASD or non-TD compared to those who went on to have TD. Nonetheless, our findings highlight some early differences in gut microbial composition during infancy that may relate to later neurodevelopmental outcomes. Before adjusting for multiple comparisons, infants who later developed ASD had slightly lower levels of Veillonella and Flavonifractor genera compared to children who were later found to be TD. These results suggest specific bacterial taxa may already differentiate in early infancy, but may be more subtle than other factors, such as mode of delivery and diet during early infancy. To understand longitudinal trajectories of the gut microbiome in association with later neurodevelopment, future studies should include a larger cohort to detect smaller effect sizes or investigate later time points in infancy. En ligne : https://doi.org/10.1002/aur.70207 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585

Decreased BOLD Signal Variability in Middle-Aged and Older Adults on the Autism Spectrum / Stephanie PEDRAHITA in Autism Research, 19-4 (April 2026)  

Public ISBD [article]  inAutism Research > 19-4 (April 2026) . - e70208 Titre : Decreased BOLD Signal Variability in Middle-Aged and Older Adults on the Autism Spectrum Type de document : texte imprimé Auteurs : Stephanie PEDRAHITA, Auteur ; Annika LINKE, Auteur ; Michaela CORDOVA, Auteur ; Molly WILKINSON, Auteur ; Janice HAU, Auteur ; Gioia TORO, Auteur ; Kalekirstos ALEMU, Auteur ; Jiwandeep KOHLI, Auteur ; Ralph-Axel MULLER, Auteur ; Ruth CARPER, Auteur Article en page(s) : e70208 Langues : Anglais (eng) Mots-clés : aging  autism spectrum disorder  bold signal variability  development  resting state fMRI Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is a lifelong neurodevelopmental disorder. Preliminary evidence suggests an increased risk for early-onset cognitive and neurological decline in ASD. While brain development in children, adolescents, and young adults with ASD diverges from neurotypical (NT) peers, it remains unclear in older adults with ASD. Understanding age-related changes of brain function in ASD is crucial to establish best practices for cognitive and health screenings and develop interventions that might reduce the risk of accelerated decline. Decreases in blood-oxygenation-level-dependent (BOLD) signal variability (BSV) in typical aging have been shown across multiple studies and are associated with poorer cognitive performance. We hypothesized that adults with ASD would show reduced BSV compared to the NT group, with steeper negative age associations in the ASD than NT group. The study assessed BSV during resting state fMRI in adults (40?70?years), 28 with ASD and 39 age-matched NT. General linear models tested diagnostic group, age, and group-by-age interactions, controlling for motion. Significant group-by-age interactions were observed for the right insular, left temporal occipital fusiform, right frontal orbital, and right inferior lateral occipital cortex, with BSV showing strong negative associations with age in the ASD but not NT adults. These findings suggest that BSV decreases may occur earlier in adults with ASD compared to their NT peers. This would be consistent with accelerated aging; however, additional longitudinal analyses are necessary to determine if the results presented truly reflect accelerated aging or arise from lifelong persistent differences in brain function. En ligne : https://doi.org/10.1002/aur.70208 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585 [article] Decreased BOLD Signal Variability in Middle-Aged and Older Adults on the Autism Spectrum [texte imprimé] / Stephanie PEDRAHITA, Auteur ; Annika LINKE, Auteur ; Michaela CORDOVA, Auteur ; Molly WILKINSON, Auteur ; Janice HAU, Auteur ; Gioia TORO, Auteur ; Kalekirstos ALEMU, Auteur ; Jiwandeep KOHLI, Auteur ; Ralph-Axel MULLER, Auteur ; Ruth CARPER, Auteur . - e70208. Langues : Anglais (eng) in Autism Research > 19-4 (April 2026) . - e70208 Mots-clés : aging  autism spectrum disorder  bold signal variability  development  resting state fMRI Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is a lifelong neurodevelopmental disorder. Preliminary evidence suggests an increased risk for early-onset cognitive and neurological decline in ASD. While brain development in children, adolescents, and young adults with ASD diverges from neurotypical (NT) peers, it remains unclear in older adults with ASD. Understanding age-related changes of brain function in ASD is crucial to establish best practices for cognitive and health screenings and develop interventions that might reduce the risk of accelerated decline. Decreases in blood-oxygenation-level-dependent (BOLD) signal variability (BSV) in typical aging have been shown across multiple studies and are associated with poorer cognitive performance. We hypothesized that adults with ASD would show reduced BSV compared to the NT group, with steeper negative age associations in the ASD than NT group. The study assessed BSV during resting state fMRI in adults (40?70?years), 28 with ASD and 39 age-matched NT. General linear models tested diagnostic group, age, and group-by-age interactions, controlling for motion. Significant group-by-age interactions were observed for the right insular, left temporal occipital fusiform, right frontal orbital, and right inferior lateral occipital cortex, with BSV showing strong negative associations with age in the ASD but not NT adults. These findings suggest that BSV decreases may occur earlier in adults with ASD compared to their NT peers. This would be consistent with accelerated aging; however, additional longitudinal analyses are necessary to determine if the results presented truly reflect accelerated aging or arise from lifelong persistent differences in brain function. En ligne : https://doi.org/10.1002/aur.70208 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585

Beyond Gaze: Affective Synchrony and Sensory-Linked Interactional Profiles as Early Markers of Autism Risk / Lan LIN in Autism Research, 19-4 (April 2026)  

Public ISBD [article]  inAutism Research > 19-4 (April 2026) . - e70209 Titre : Beyond Gaze: Affective Synchrony and Sensory-Linked Interactional Profiles as Early Markers of Autism Risk Type de document : texte imprimé Auteurs : Lan LIN, Auteur ; Qian LI, Auteur ; Zenghe YUE, Auteur ; Yaxin DAI, Auteur ; Haozhen CHEN, Auteur ; Yuheng CHEN, Auteur ; Jinyi ZHU, Auteur ; Yazhu HAN, Auteur ; Shengjian YIN, Auteur ; Luyang GUAN, Auteur ; Xiaoyan KE, Auteur Article en page(s) : e70209 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  early identification  high-risk infants  interpersonal affect synchrony  mutual gaze  parent–child interaction  sensory processing Index. décimale : PER Périodiques Résumé : ABSTRACT Identifying early markers for autism spectrum disorder (ASD) is a clinical priority. This study investigated interpersonal affect synchrony (IAS) as a measure of interactional quality in a longitudinal cohort of 90 high-risk infants. We aimed to disentangle its contribution from mutual gaze and identify data-driven social interaction profiles linked to sensory traits. Parent-infant interactions were recorded at 6?18?months; IAS was quantified using Cross-Recurrence Quantification Analysis, and ASD outcomes were determined at 18?24?months. Infants later diagnosed with ASD (n?=?25) showed significantly lower IAS (F(1,84)?=?5.89, p FDR?=?0.023) and synchrony stability (F(1,84)?=?5.37, p FDR?=?0.023) than non-diagnosed infants (n?=?65), yet the groups did not differ in mutual gaze (p?=?0.200). Logistic regression analysis further showed that IAS (OR?=?0.561, p FDR?=?0.038) and synchrony stability (OR?=?0.013, p FDR?=?0.038) both significantly predict clinical outcome. K-means clustering revealed three profiles: ?High Gaze-High Synchrony,? ?Mid Gaze-Low Synchrony,? and ?Low Gaze-High Synchrony.? The ?Mid Gaze-Low Synchrony? profile was significantly associated with a later ASD diagnosis (p adj?=?0.031), while the ?Low Gaze-High Synchrony? profile was linked to higher sensation-seeking traits (p adj?=?0.028). The quality of parent-infant affective connection is a more robust early marker for ASD than the quantity of mutual gaze. These findings reveal critical heterogeneity, identifying a high-risk ?gaze without engagement? pattern and a potential adaptive pathway to synchrony, underscoring the need for individualized strategies in early screening and intervention. En ligne : https://doi.org/10.1002/aur.70209 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585 [article] Beyond Gaze: Affective Synchrony and Sensory-Linked Interactional Profiles as Early Markers of Autism Risk [texte imprimé] / Lan LIN, Auteur ; Qian LI, Auteur ; Zenghe YUE, Auteur ; Yaxin DAI, Auteur ; Haozhen CHEN, Auteur ; Yuheng CHEN, Auteur ; Jinyi ZHU, Auteur ; Yazhu HAN, Auteur ; Shengjian YIN, Auteur ; Luyang GUAN, Auteur ; Xiaoyan KE, Auteur . - e70209. Langues : Anglais (eng) in Autism Research > 19-4 (April 2026) . - e70209 Mots-clés : autism spectrum disorder  early identification  high-risk infants  interpersonal affect synchrony  mutual gaze  parent–child interaction  sensory processing Index. décimale : PER Périodiques Résumé : ABSTRACT Identifying early markers for autism spectrum disorder (ASD) is a clinical priority. This study investigated interpersonal affect synchrony (IAS) as a measure of interactional quality in a longitudinal cohort of 90 high-risk infants. We aimed to disentangle its contribution from mutual gaze and identify data-driven social interaction profiles linked to sensory traits. Parent-infant interactions were recorded at 6?18?months; IAS was quantified using Cross-Recurrence Quantification Analysis, and ASD outcomes were determined at 18?24?months. Infants later diagnosed with ASD (n?=?25) showed significantly lower IAS (F(1,84)?=?5.89, p FDR?=?0.023) and synchrony stability (F(1,84)?=?5.37, p FDR?=?0.023) than non-diagnosed infants (n?=?65), yet the groups did not differ in mutual gaze (p?=?0.200). Logistic regression analysis further showed that IAS (OR?=?0.561, p FDR?=?0.038) and synchrony stability (OR?=?0.013, p FDR?=?0.038) both significantly predict clinical outcome. K-means clustering revealed three profiles: ?High Gaze-High Synchrony,? ?Mid Gaze-Low Synchrony,? and ?Low Gaze-High Synchrony.? The ?Mid Gaze-Low Synchrony? profile was significantly associated with a later ASD diagnosis (p adj?=?0.031), while the ?Low Gaze-High Synchrony? profile was linked to higher sensation-seeking traits (p adj?=?0.028). The quality of parent-infant affective connection is a more robust early marker for ASD than the quantity of mutual gaze. These findings reveal critical heterogeneity, identifying a high-risk ?gaze without engagement? pattern and a potential adaptive pathway to synchrony, underscoring the need for individualized strategies in early screening and intervention. En ligne : https://doi.org/10.1002/aur.70209 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585

Motor Performance in Autistic Youth From Childhood Through Adolescence: Evidence for Both Sustained and Widening Group Differences / Allison R. BLOCK in Autism Research, 19-4 (April 2026)  

Public ISBD [article]  inAutism Research > 19-4 (April 2026) . - e70211 Titre : Motor Performance in Autistic Youth From Childhood Through Adolescence: Evidence for Both Sustained and Widening Group Differences Type de document : texte imprimé Auteurs : Allison R. BLOCK, Auteur ; Emily C. SKALETSKI, Auteur ; Claire M. SHEEDY, Auteur ; Ella A. VANDERPOOL, Auteur ; Brittany G. TRAVERS, Auteur Article en page(s) : e70211 Langues : Anglais (eng) Mots-clés : adolescent  autism spectrum disorder  child  hand strength  motor skills  psychomotor performance Index. décimale : PER Périodiques Résumé : ABSTRACT Although motor-skill differences in autistic individuals are well established, there is diverging evidence regarding what happens to motor skills in autistic children as they become adolescents. Using both cross-sectional and longitudinal data, we examined fine and gross motor skills and grip strength of 187 autistic participants and 136 non-autistic participants (i.e., with no known diagnoses), aged 6?18?years-old. Participants completed the Bruininks-Oseretsky Test of Motor Proficiency-Short Form, Second Edition (BOT-2 SF), and maximal grip strength testing. Linear mixed-effects regression analyses indicated motor-skill differences between autistic and non-autistic participants across this age range; however, the nature of these differences depended on the specific motor domain (i.e., strength) and measure. Specifically, grip strength and BOT-2 SF strength subtest scores showed widening group differences with increasing age, whereas overall BOT-2 SF scores and subtests showed sustained or narrowing group differences through adolescence. However, items on the BOT-2 SF also demonstrated substantial ceiling effects, which may obscure later group differences between autistic and non-autistic participants and highlight the need for measures that encompass a greater range of motor skills into adolescence. These findings have important implications for healthcare, education, and community supports that address age-related motor differences within the autistic population. En ligne : https://doi.org/10.1002/aur.70211 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585 [article] Motor Performance in Autistic Youth From Childhood Through Adolescence: Evidence for Both Sustained and Widening Group Differences [texte imprimé] / Allison R. BLOCK, Auteur ; Emily C. SKALETSKI, Auteur ; Claire M. SHEEDY, Auteur ; Ella A. VANDERPOOL, Auteur ; Brittany G. TRAVERS, Auteur . - e70211. Langues : Anglais (eng) in Autism Research > 19-4 (April 2026) . - e70211 Mots-clés : adolescent  autism spectrum disorder  child  hand strength  motor skills  psychomotor performance Index. décimale : PER Périodiques Résumé : ABSTRACT Although motor-skill differences in autistic individuals are well established, there is diverging evidence regarding what happens to motor skills in autistic children as they become adolescents. Using both cross-sectional and longitudinal data, we examined fine and gross motor skills and grip strength of 187 autistic participants and 136 non-autistic participants (i.e., with no known diagnoses), aged 6?18?years-old. Participants completed the Bruininks-Oseretsky Test of Motor Proficiency-Short Form, Second Edition (BOT-2 SF), and maximal grip strength testing. Linear mixed-effects regression analyses indicated motor-skill differences between autistic and non-autistic participants across this age range; however, the nature of these differences depended on the specific motor domain (i.e., strength) and measure. Specifically, grip strength and BOT-2 SF strength subtest scores showed widening group differences with increasing age, whereas overall BOT-2 SF scores and subtests showed sustained or narrowing group differences through adolescence. However, items on the BOT-2 SF also demonstrated substantial ceiling effects, which may obscure later group differences between autistic and non-autistic participants and highlight the need for measures that encompass a greater range of motor skills into adolescence. These findings have important implications for healthcare, education, and community supports that address age-related motor differences within the autistic population. En ligne : https://doi.org/10.1002/aur.70211 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585

Autistic Youth Being Ignored by Peers: An Early-Stage Study / Nicoletta V. FRANKENSTEIN in Autism Research, 19-4 (April 2026)  

Public ISBD [article]  inAutism Research > 19-4 (April 2026) . - e70213 Titre : Autistic Youth Being Ignored by Peers: An Early-Stage Study Type de document : texte imprimé Auteurs : Nicoletta V. FRANKENSTEIN, Auteur ; Julie Lounds TAYLOR, Auteur ; Shuting ZHENG, Auteur ; Somer L. BISHOP, Auteur ; Natalie LIBSTER, Auteur ; Tanya E. FROEHLICH, Auteur ; Ryan E. ADAMS, Auteur Article en page(s) : e70213 Langues : Anglais (eng) Mots-clés : adolescence  anxiety symptoms  autism  depressive symptoms  social functioning Index. décimale : PER Périodiques Résumé : ABSTRACT Autistic youth have been shown to be at risk for negative peer experiences, but experiences of being ignored are rarely examined in this group. This study is an early-stage examination of the experience of being ignored in autistic youth. Objectives are to test psychometric properties of a measure of being ignored; describe rates of being ignored; identify who is most at risk for being ignored; and test the association of being ignored with other social experiences and psychological health. One hundred and forty-nine autistic high school students with full scale IQs of 70 or above (M?=?99.86, SD?=?16.5) and aged 15?23?years completed self-reported, online surveys regarding day-to-day experiences, well-being, and psychological health. Parents completed additional measures assessing ASD symptomology and other demographic and clinical characteristics. A confirmatory factor analysis and Cronbach's alpha indicated good psychometric properties for the Ignore factor. While the average score on the Ignore scale was relatively low, ~40% reported often having at least one type of experience of being ignored. Being ignored was associated with having more SRS-2 Restricted Interests/Repetitive Behaviors and Social Communication and Interaction Problems. Peer victimization was associated with higher rates on the ignore scale and social inclusion scale was associated with lower rates of being ignored. Multiple regressions controlling for peer victimization and inclusion found being ignored to be associated with higher rates of depression and anxiety. The findings suggest that being ignored may be an especially impactful experience for autistic youth. En ligne : https://doi.org/10.1002/aur.70213 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585 [article] Autistic Youth Being Ignored by Peers: An Early-Stage Study [texte imprimé] / Nicoletta V. FRANKENSTEIN, Auteur ; Julie Lounds TAYLOR, Auteur ; Shuting ZHENG, Auteur ; Somer L. BISHOP, Auteur ; Natalie LIBSTER, Auteur ; Tanya E. FROEHLICH, Auteur ; Ryan E. ADAMS, Auteur . - e70213. Langues : Anglais (eng) in Autism Research > 19-4 (April 2026) . - e70213 Mots-clés : adolescence  anxiety symptoms  autism  depressive symptoms  social functioning Index. décimale : PER Périodiques Résumé : ABSTRACT Autistic youth have been shown to be at risk for negative peer experiences, but experiences of being ignored are rarely examined in this group. This study is an early-stage examination of the experience of being ignored in autistic youth. Objectives are to test psychometric properties of a measure of being ignored; describe rates of being ignored; identify who is most at risk for being ignored; and test the association of being ignored with other social experiences and psychological health. One hundred and forty-nine autistic high school students with full scale IQs of 70 or above (M?=?99.86, SD?=?16.5) and aged 15?23?years completed self-reported, online surveys regarding day-to-day experiences, well-being, and psychological health. Parents completed additional measures assessing ASD symptomology and other demographic and clinical characteristics. A confirmatory factor analysis and Cronbach's alpha indicated good psychometric properties for the Ignore factor. While the average score on the Ignore scale was relatively low, ~40% reported often having at least one type of experience of being ignored. Being ignored was associated with having more SRS-2 Restricted Interests/Repetitive Behaviors and Social Communication and Interaction Problems. Peer victimization was associated with higher rates on the ignore scale and social inclusion scale was associated with lower rates of being ignored. Multiple regressions controlling for peer victimization and inclusion found being ignored to be associated with higher rates of depression and anxiety. The findings suggest that being ignored may be an especially impactful experience for autistic youth. En ligne : https://doi.org/10.1002/aur.70213 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585

Receptive–Expressive Language Phenotypes in Infants and Toddlers With Autism Features / Torrey COHENOUR in Autism Research, 19-4 (April 2026)  

Public ISBD [article]  inAutism Research > 19-4 (April 2026) . - e70214 Titre : Receptive–Expressive Language Phenotypes in Infants and Toddlers With Autism Features Type de document : texte imprimé Auteurs : Torrey COHENOUR, Auteur ; Amanda GULSRUD, Auteur ; Connie KASARI, Auteur Article en page(s) : e70214 Langues : Anglais (eng) Mots-clés : autism  expressive language  infant  language development  language profile  receptive language  toddler Index. décimale : PER Périodiques Résumé : ABSTRACT Children diagnosed with autism often present with an atypical discrepancy between their receptive and expressive language levels, or an atypical receptive?expressive language phenotype. Children with an atypical receptive?expressive phenotype present with a relative receptive language advantage (expressive level??receptive level), whereas those with a typical phenotype have balanced receptive and expressive language levels. It remains unclear whether atypical receptive?expressive language phenotypes are evident before 24?months in children with autism features or whether they are associated with concurrent child developmental functioning or later language growth. Participants (N?=?80) were drawn from a randomized comparative efficacy intervention study for 12?23-month-olds with autism features and elevated scores on an autism diagnostic instrument. Baseline receptive and expressive language age equivalent (AE) scores were used to describe continuous variation in receptive?expressive language phenotypes by quantifying the gap between each child's receptive and expressive language levels. These continuous metrics were then used to classify children into discrete language profile groups: expressive advantage (EA), receptive advantage (RA), and balanced. On average, children had a gap of three AE ?months? between their receptive and expressive language levels. Over 75% of children presented with an atypical receptive?expressive phenotype (40% EA profile, 36% RA profile), whereas only 24% of children had a typical receptive?expressive phenotype (balanced profile). Language profiles were not concurrently associated with age, autism features, joint attention skills, motor or cognitive functioning. However, children with the EA profile at baseline showed significantly slower expressive language growth over 12?months than those with RA or balanced language profiles, suggesting that receptive?expressive language profiles may hold promise as early prognostic markers of expressive language growth in emerging autism. En ligne : https://doi.org/10.1002/aur.70214 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585 [article] Receptive–Expressive Language Phenotypes in Infants and Toddlers With Autism Features [texte imprimé] / Torrey COHENOUR, Auteur ; Amanda GULSRUD, Auteur ; Connie KASARI, Auteur . - e70214. Langues : Anglais (eng) in Autism Research > 19-4 (April 2026) . - e70214 Mots-clés : autism  expressive language  infant  language development  language profile  receptive language  toddler Index. décimale : PER Périodiques Résumé : ABSTRACT Children diagnosed with autism often present with an atypical discrepancy between their receptive and expressive language levels, or an atypical receptive?expressive language phenotype. Children with an atypical receptive?expressive phenotype present with a relative receptive language advantage (expressive level??receptive level), whereas those with a typical phenotype have balanced receptive and expressive language levels. It remains unclear whether atypical receptive?expressive language phenotypes are evident before 24?months in children with autism features or whether they are associated with concurrent child developmental functioning or later language growth. Participants (N?=?80) were drawn from a randomized comparative efficacy intervention study for 12?23-month-olds with autism features and elevated scores on an autism diagnostic instrument. Baseline receptive and expressive language age equivalent (AE) scores were used to describe continuous variation in receptive?expressive language phenotypes by quantifying the gap between each child's receptive and expressive language levels. These continuous metrics were then used to classify children into discrete language profile groups: expressive advantage (EA), receptive advantage (RA), and balanced. On average, children had a gap of three AE ?months? between their receptive and expressive language levels. Over 75% of children presented with an atypical receptive?expressive phenotype (40% EA profile, 36% RA profile), whereas only 24% of children had a typical receptive?expressive phenotype (balanced profile). Language profiles were not concurrently associated with age, autism features, joint attention skills, motor or cognitive functioning. However, children with the EA profile at baseline showed significantly slower expressive language growth over 12?months than those with RA or balanced language profiles, suggesting that receptive?expressive language profiles may hold promise as early prognostic markers of expressive language growth in emerging autism. En ligne : https://doi.org/10.1002/aur.70214 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585

Reciprocal Associations Between Parental Anxiety/Depression and Emotional/Behavioral Difficulties in Autistic Children Following Their Diagnosis / Maëva MONNIER in Autism Research, 19-4 (April 2026)  

Public ISBD [article]  inAutism Research > 19-4 (April 2026) . - e70220 Titre : Reciprocal Associations Between Parental Anxiety/Depression and Emotional/Behavioral Difficulties in Autistic Children Following Their Diagnosis Type de document : texte imprimé Auteurs : Maëva MONNIER, Auteur ; Hugo PEYRE, Auteur ; Marianne PERIES, Auteur ; Valentin SIMONCIC, Auteur ; Guillaume NICOLET, Auteur ; Cécile MICHELON, Auteur ; Yashvin SEETAHUL, Auteur ; Amaria BAGHDADLI, Auteur ; Group THE ELENA STUDY, Auteur Article en page(s) : e70220 Langues : Anglais (eng) Mots-clés : anxiety  autism  behavioral difficulties  children  depression  parents Index. décimale : PER Périodiques Résumé : ABSTRACT Emotional and behavioral difficulties (EBD) are common in autistic children, while anxiety and depressive symptoms (ADS) are prevalent in their parents. However, the bidirectional relationship between the parents' and children's symptoms remains unclear, especially in the years following the child's autism diagnosis. Addressing this gap, our study investigates the bidirectional association between parental ADS and two subdomains of EBD (internalizing and externalizing difficulties) in autistic children from diagnosis (T0) to 3?years later (T1). Data from the French ELENA cohort were analyzed using two-wave cross-lagged panel models (CLPM). At the time of diagnosis, 55.2% of mothers and 42.7% of fathers among 315 parents exhibited clinically significant ADS, while 61.3% of children experienced clinical EBD. The CLPMs did not reveal any directional association between parental ADS and children's EBD. However, we observed significant autoregressive effects for parental ADS and children's EBD, with a moderate positive correlation between the two at the time of diagnosis. Our findings highlight significant psychological distress in both parents and children at the time of diagnosis and therefore recommend suitable interventions for families requiring social, financial, or psychological support. Future longitudinal studies with greater representation of girls, using continuous-time models could clarify whether parent?child associations are time-lag dependent (including identifying potential peak lags) and whether they differ across parent?child sex dyads. En ligne : https://doi.org/10.1002/aur.70220 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585 [article] Reciprocal Associations Between Parental Anxiety/Depression and Emotional/Behavioral Difficulties in Autistic Children Following Their Diagnosis [texte imprimé] / Maëva MONNIER, Auteur ; Hugo PEYRE, Auteur ; Marianne PERIES, Auteur ; Valentin SIMONCIC, Auteur ; Guillaume NICOLET, Auteur ; Cécile MICHELON, Auteur ; Yashvin SEETAHUL, Auteur ; Amaria BAGHDADLI, Auteur ; Group THE ELENA STUDY, Auteur . - e70220. Langues : Anglais (eng) in Autism Research > 19-4 (April 2026) . - e70220 Mots-clés : anxiety  autism  behavioral difficulties  children  depression  parents Index. décimale : PER Périodiques Résumé : ABSTRACT Emotional and behavioral difficulties (EBD) are common in autistic children, while anxiety and depressive symptoms (ADS) are prevalent in their parents. However, the bidirectional relationship between the parents' and children's symptoms remains unclear, especially in the years following the child's autism diagnosis. Addressing this gap, our study investigates the bidirectional association between parental ADS and two subdomains of EBD (internalizing and externalizing difficulties) in autistic children from diagnosis (T0) to 3?years later (T1). Data from the French ELENA cohort were analyzed using two-wave cross-lagged panel models (CLPM). At the time of diagnosis, 55.2% of mothers and 42.7% of fathers among 315 parents exhibited clinically significant ADS, while 61.3% of children experienced clinical EBD. The CLPMs did not reveal any directional association between parental ADS and children's EBD. However, we observed significant autoregressive effects for parental ADS and children's EBD, with a moderate positive correlation between the two at the time of diagnosis. Our findings highlight significant psychological distress in both parents and children at the time of diagnosis and therefore recommend suitable interventions for families requiring social, financial, or psychological support. Future longitudinal studies with greater representation of girls, using continuous-time models could clarify whether parent?child associations are time-lag dependent (including identifying potential peak lags) and whether they differ across parent?child sex dyads. En ligne : https://doi.org/10.1002/aur.70220 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585

Correction to “The Vulnerability Experiences Quotient (VEQ): A Study of Vulnerability, Mental Health and Life Satisfaction in Autistic Adults” in Autism Research, 19-4 (April 2026)  

Public ISBD [article]  inAutism Research > 19-4 (April 2026) . - e70223 Titre : Correction to “The Vulnerability Experiences Quotient (VEQ): A Study of Vulnerability, Mental Health and Life Satisfaction in Autistic Adults” Type de document : texte imprimé Article en page(s) : e70223 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : https://doi.org/10.1002/aur.70223 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585 [article] Correction to “The Vulnerability Experiences Quotient (VEQ): A Study of Vulnerability, Mental Health and Life Satisfaction in Autistic Adults” [texte imprimé] . - e70223. Langues : Anglais (eng) in Autism Research > 19-4 (April 2026) . - e70223 Index. décimale : PER Périodiques En ligne : https://doi.org/10.1002/aur.70223 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585

Reply to Booij, Geurts and Schalbroeck / Nanan NURAINI in Autism Research, 19-4 (April 2026)  

Public ISBD [article]  inAutism Research > 19-4 (April 2026) . - e70231 Titre : Reply to Booij, Geurts and Schalbroeck Type de document : texte imprimé Auteurs : Nanan NURAINI, Auteur ; Carrina APPLING, Auteur ; Bradley J. FERGUSON, Auteur ; Amolak SINGH, Auteur ; Amanda Moffit GUNN, Auteur ; Roopa BHAT, Auteur ; Frank SCHRAML, Auteur ; B. Blair BRADEN, Auteur ; David Q. BEVERSDORF, Auteur Article en page(s) : e70231 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : https://doi.org/10.1002/aur.70231 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585 [article] Reply to Booij, Geurts and Schalbroeck [texte imprimé] / Nanan NURAINI, Auteur ; Carrina APPLING, Auteur ; Bradley J. FERGUSON, Auteur ; Amolak SINGH, Auteur ; Amanda Moffit GUNN, Auteur ; Roopa BHAT, Auteur ; Frank SCHRAML, Auteur ; B. Blair BRADEN, Auteur ; David Q. BEVERSDORF, Auteur . - e70231. Langues : Anglais (eng) in Autism Research > 19-4 (April 2026) . - e70231 Index. décimale : PER Périodiques En ligne : https://doi.org/10.1002/aur.70231 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585

Interpretation of DAT SPECT Findings in Young Autistic Adults / Jan BOOIJ in Autism Research, 19-4 (April 2026)  

Public ISBD [article]  inAutism Research > 19-4 (April 2026) . - e70234 Titre : Interpretation of DAT SPECT Findings in Young Autistic Adults Type de document : texte imprimé Auteurs : Jan BOOIJ, Auteur ; Hilde M. GEURTS, Auteur ; Rik SCHALBROECK, Auteur Article en page(s) : e70234 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : https://doi.org/10.1002/aur.70234 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585 [article] Interpretation of DAT SPECT Findings in Young Autistic Adults [texte imprimé] / Jan BOOIJ, Auteur ; Hilde M. GEURTS, Auteur ; Rik SCHALBROECK, Auteur . - e70234. Langues : Anglais (eng) in Autism Research > 19-4 (April 2026) . - e70234 Index. décimale : PER Périodiques En ligne : https://doi.org/10.1002/aur.70234 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585