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Auteur Chimei M. LEE
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Documents disponibles écrits par cet auteur (4)
Faire une suggestion Affiner la rechercheAgreement of parent-reported cognitive level with standardized measures among children with autism spectrum disorder / Chimei M. LEE in Autism Research, 16-6 (June 2023)
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[article]
Titre : Agreement of parent-reported cognitive level with standardized measures among children with autism spectrum disorder Type de document : texte imprimé Auteurs : Chimei M. LEE, Auteur ; LeeAnne GREEN SNYDER, Auteur ; Laura A. CARPENTER, Auteur ; Jill HARRIS, Auteur ; Stephen M. KANNE, Auteur ; Cora M. TAYLOR, Auteur ; Dustin E. SARVER, Auteur ; Kevin G. STEPHENSON, Auteur ; Lisa H. SHULMAN, Auteur ; Ericka L. WODKA, Auteur ; Amy N. ESLER, Auteur ; THE SPARK CONSORTIUM, Auteur Article en page(s) : p.1210-1224 Langues : Anglais (eng) Mots-clés : autism spectrum disorder cognitive ability intellectual disability parent report standardized measure Index. décimale : PER Périodiques Résumé : Abstract Assessing cognitive development is critical in clinical research of autism spectrum disorder (ASD). However, collecting cognitive data from clinically administered assessments can add a significant burden to clinical research in ASD due to the substantial cost and time required, and it is often prohibitive in large-scale studies. There is a need for more efficient, but reliable, methods to estimate cognitive functioning for researchers, clinicians, and families. To examine the degree to which caregiver estimates of cognitive level agree with actual measured intelligence/developmental scores and understand factors that may impact that agreement, 1,555 autistic individuals (81.74% male; age 18 months 18 years) were selected from a large cohort (Simons Foundation Powering Autism Research for Knowledge, SPARK). Results suggest that querying parents about recent testing results and developmental diagnoses can provide valid and useful information on cognitive ability. The agreement of parental estimates varied with age, measured cognitive ability, autistic traits, and adaptive skills. In the context of large-scale research efforts, parent-reported cognitive impairment may be a good proxy for categorical IQ range for survey-based studies when specific IQ scores are not available, circumventing the logistical and financial obstacles of obtaining neuropsychological or neurodevelopmental testing. En ligne : https://doi.org/10.1002/aur.2934 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=507
in Autism Research > 16-6 (June 2023) . - p.1210-1224[article] Agreement of parent-reported cognitive level with standardized measures among children with autism spectrum disorder [texte imprimé] / Chimei M. LEE, Auteur ; LeeAnne GREEN SNYDER, Auteur ; Laura A. CARPENTER, Auteur ; Jill HARRIS, Auteur ; Stephen M. KANNE, Auteur ; Cora M. TAYLOR, Auteur ; Dustin E. SARVER, Auteur ; Kevin G. STEPHENSON, Auteur ; Lisa H. SHULMAN, Auteur ; Ericka L. WODKA, Auteur ; Amy N. ESLER, Auteur ; THE SPARK CONSORTIUM, Auteur . - p.1210-1224.
Langues : Anglais (eng)
in Autism Research > 16-6 (June 2023) . - p.1210-1224
Mots-clés : autism spectrum disorder cognitive ability intellectual disability parent report standardized measure Index. décimale : PER Périodiques Résumé : Abstract Assessing cognitive development is critical in clinical research of autism spectrum disorder (ASD). However, collecting cognitive data from clinically administered assessments can add a significant burden to clinical research in ASD due to the substantial cost and time required, and it is often prohibitive in large-scale studies. There is a need for more efficient, but reliable, methods to estimate cognitive functioning for researchers, clinicians, and families. To examine the degree to which caregiver estimates of cognitive level agree with actual measured intelligence/developmental scores and understand factors that may impact that agreement, 1,555 autistic individuals (81.74% male; age 18 months 18 years) were selected from a large cohort (Simons Foundation Powering Autism Research for Knowledge, SPARK). Results suggest that querying parents about recent testing results and developmental diagnoses can provide valid and useful information on cognitive ability. The agreement of parental estimates varied with age, measured cognitive ability, autistic traits, and adaptive skills. In the context of large-scale research efforts, parent-reported cognitive impairment may be a good proxy for categorical IQ range for survey-based studies when specific IQ scores are not available, circumventing the logistical and financial obstacles of obtaining neuropsychological or neurodevelopmental testing. En ligne : https://doi.org/10.1002/aur.2934 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=507 Challenges of case identification and diagnosis of Autism Spectrum Disorders in China: A critical review of procedures, assessment, and diagnostic criteria / YanLi PANG in Research in Autism Spectrum Disorders, 53 (September 2018)
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Titre : Challenges of case identification and diagnosis of Autism Spectrum Disorders in China: A critical review of procedures, assessment, and diagnostic criteria Type de document : texte imprimé Auteurs : YanLi PANG, Auteur ; Chimei M. LEE, Auteur ; Morgan WRIGHT, Auteur ; Jiaming SHEN, Auteur ; Bo SHEN, Auteur ; Jin BO, Auteur Article en page(s) : p.53-66 Langues : Anglais (eng) Mots-clés : ASD Screening Assessment Diagnosis Chinese Index. décimale : PER Périodiques Résumé : The estimated prevalence of Autism Spectrum Disorders (ASD) in China has been consistently lower than most of the studies in the West. The current article addressed several challenges in identifying and diagnosing ASD in mainland China. The underestimated prevalence may due to a variety of reasons, including inconsistencies in screening and diagnostic procedures, variations in translated instruments, and discrepancies between diagnostic criteria. This review provides insight into ASD assessment and diagnosis in the Chinese population and discusses strategies for the further advancement of ASD identification and intervention in mainland China. En ligne : https://doi.org/10.1016/j.rasd.2018.06.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368
in Research in Autism Spectrum Disorders > 53 (September 2018) . - p.53-66[article] Challenges of case identification and diagnosis of Autism Spectrum Disorders in China: A critical review of procedures, assessment, and diagnostic criteria [texte imprimé] / YanLi PANG, Auteur ; Chimei M. LEE, Auteur ; Morgan WRIGHT, Auteur ; Jiaming SHEN, Auteur ; Bo SHEN, Auteur ; Jin BO, Auteur . - p.53-66.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 53 (September 2018) . - p.53-66
Mots-clés : ASD Screening Assessment Diagnosis Chinese Index. décimale : PER Périodiques Résumé : The estimated prevalence of Autism Spectrum Disorders (ASD) in China has been consistently lower than most of the studies in the West. The current article addressed several challenges in identifying and diagnosing ASD in mainland China. The underestimated prevalence may due to a variety of reasons, including inconsistencies in screening and diagnostic procedures, variations in translated instruments, and discrepancies between diagnostic criteria. This review provides insight into ASD assessment and diagnosis in the Chinese population and discusses strategies for the further advancement of ASD identification and intervention in mainland China. En ligne : https://doi.org/10.1016/j.rasd.2018.06.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 Functional connectivity between the visual and salience networks and autistic social features at school-age / Jessica B. GIRAULT in Journal of Neurodevelopmental Disorders, 17 (2025)
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[article]
Titre : Functional connectivity between the visual and salience networks and autistic social features at school-age Type de document : texte imprimé Auteurs : Jessica B. GIRAULT, Auteur ; Tomoyuki NISHINO, Auteur ; Muhamed TALOVIĆ, Auteur ; Mary Beth NEBEL, Auteur ; Margaret REYNOLDS, Auteur ; Catherine A. BURROWS, Auteur ; Jed T. ELISON, Auteur ; Chimei M. LEE, Auteur ; Abraham Z. SNYDER, Auteur ; Mark D. SHEN, Auteur ; Audrey M. SHEN, Auteur ; Kelly N. BOTTERON, Auteur ; Annette M. ESTES, Auteur ; Stephen R. DAGER, Auteur ; Guido GERIG, Auteur ; Heather C. HAZLETT, Auteur ; Natasha MARRUS, Auteur ; Robert C. MCKINSTRY, Auteur ; Juhi PANDEY, Auteur ; Robert T. SCHULTZ, Auteur ; Tanya ST JOHN, Auteur ; Martin A. STYNER, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Alexandre A. TODOROV, Auteur ; Joseph PIVEN, Auteur ; John R. Jr PRUETT, Auteur ; IBIS NETWORK, Auteur Langues : Anglais (eng) Mots-clés : Humans Male Child Female Magnetic Resonance Imaging Autism Spectrum Disorder/physiopathology/diagnostic imaging/psychology Longitudinal Studies Brain/physiopathology/diagnostic imaging Social Behavior Neural Pathways/physiopathology/diagnostic imaging Nerve Net/physiopathology/diagnostic imaging Autism Brain networks Functional connectivity Mri Social behavior provided by all participating families. Study procedures were approved by the Institutional Review Boards (IRB) at each research site: University of North Carolina at Chapel Hill, Washington University in St. Louis, University of Washington in Seattle, and the Children’s Hospital of Philadelphia. A single governing IRB at UNC Chapel Hill was in place (IRB #17–1871, PI: Piven). Consent for publication: Not applicable. Competing interests: Dr. Robert McKinstry serves on the medical advisory board and receives stock options for Turing Medical he also receives funding for meals and travel from Siemens Healthineers, Philips Healthcare, RadiAction Medical, and meals from Hyperfine, Inc. Abraham Z. Snyder is a consultant for Sora Neuroscience, LLC. A.M. Shen discloses a familial relationship with M.D. Shen, but their institution’s COI Office has determined there is no scientific or financial conflict of interest. All other authors report no financial relationships with commercial interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is highly heritable and phenotypically variable. Neuroimaging markers reflecting variation in behavior will provide insights into circuitry subserving core features. We examined functional correlates of ASD symptomology at school-age, while accounting for associated behavioral and cognitive domains, in a longitudinal sample followed from infancy and enriched for those with a genetic liability for ASD. METHODS: Resting state functional connectivity MRIs (fcMRI) and behavioral data were analyzed from 97 school-age children (8.1-12.0 years, 55 males, 15 ASD) with (n = 63) or without (n = 34) a family history of ASD. fcMRI enrichment analysis (EA) was used to screen for associations between network-level functional connectivity and six behaviors of interest in a data-driven manner: social affect, restricted and repetitive behavior (RRB), generalized anxiety, inattention, motor coordination, and matrix reasoning. RESULTS: Functional connectivity between the visual and salience networks was significantly associated with social affect symptoms at school-age after accounting for all other behaviors. Results indicated that stronger connectivity was associated with higher social affect scores. No other behaviors were robustly associated with functional connectivity, though trends were observed between visual-salience connectivity and RRBs. CONCLUSIONS: Connectivity between the visual and salience networks may play an important role in social affect symptom variability among children with ASD and those with genetic liability for ASD. These findings align with and extend earlier reports in this sample of the central role of the visual system during infancy in ASD. En ligne : https://dx.doi.org/10.1186/s11689-025-09613-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576
in Journal of Neurodevelopmental Disorders > 17 (2025)[article] Functional connectivity between the visual and salience networks and autistic social features at school-age [texte imprimé] / Jessica B. GIRAULT, Auteur ; Tomoyuki NISHINO, Auteur ; Muhamed TALOVIĆ, Auteur ; Mary Beth NEBEL, Auteur ; Margaret REYNOLDS, Auteur ; Catherine A. BURROWS, Auteur ; Jed T. ELISON, Auteur ; Chimei M. LEE, Auteur ; Abraham Z. SNYDER, Auteur ; Mark D. SHEN, Auteur ; Audrey M. SHEN, Auteur ; Kelly N. BOTTERON, Auteur ; Annette M. ESTES, Auteur ; Stephen R. DAGER, Auteur ; Guido GERIG, Auteur ; Heather C. HAZLETT, Auteur ; Natasha MARRUS, Auteur ; Robert C. MCKINSTRY, Auteur ; Juhi PANDEY, Auteur ; Robert T. SCHULTZ, Auteur ; Tanya ST JOHN, Auteur ; Martin A. STYNER, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Alexandre A. TODOROV, Auteur ; Joseph PIVEN, Auteur ; John R. Jr PRUETT, Auteur ; IBIS NETWORK, Auteur.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 17 (2025)
Mots-clés : Humans Male Child Female Magnetic Resonance Imaging Autism Spectrum Disorder/physiopathology/diagnostic imaging/psychology Longitudinal Studies Brain/physiopathology/diagnostic imaging Social Behavior Neural Pathways/physiopathology/diagnostic imaging Nerve Net/physiopathology/diagnostic imaging Autism Brain networks Functional connectivity Mri Social behavior provided by all participating families. Study procedures were approved by the Institutional Review Boards (IRB) at each research site: University of North Carolina at Chapel Hill, Washington University in St. Louis, University of Washington in Seattle, and the Children’s Hospital of Philadelphia. A single governing IRB at UNC Chapel Hill was in place (IRB #17–1871, PI: Piven). Consent for publication: Not applicable. Competing interests: Dr. Robert McKinstry serves on the medical advisory board and receives stock options for Turing Medical he also receives funding for meals and travel from Siemens Healthineers, Philips Healthcare, RadiAction Medical, and meals from Hyperfine, Inc. Abraham Z. Snyder is a consultant for Sora Neuroscience, LLC. A.M. Shen discloses a familial relationship with M.D. Shen, but their institution’s COI Office has determined there is no scientific or financial conflict of interest. All other authors report no financial relationships with commercial interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is highly heritable and phenotypically variable. Neuroimaging markers reflecting variation in behavior will provide insights into circuitry subserving core features. We examined functional correlates of ASD symptomology at school-age, while accounting for associated behavioral and cognitive domains, in a longitudinal sample followed from infancy and enriched for those with a genetic liability for ASD. METHODS: Resting state functional connectivity MRIs (fcMRI) and behavioral data were analyzed from 97 school-age children (8.1-12.0 years, 55 males, 15 ASD) with (n = 63) or without (n = 34) a family history of ASD. fcMRI enrichment analysis (EA) was used to screen for associations between network-level functional connectivity and six behaviors of interest in a data-driven manner: social affect, restricted and repetitive behavior (RRB), generalized anxiety, inattention, motor coordination, and matrix reasoning. RESULTS: Functional connectivity between the visual and salience networks was significantly associated with social affect symptoms at school-age after accounting for all other behaviors. Results indicated that stronger connectivity was associated with higher social affect scores. No other behaviors were robustly associated with functional connectivity, though trends were observed between visual-salience connectivity and RRBs. CONCLUSIONS: Connectivity between the visual and salience networks may play an important role in social affect symptom variability among children with ASD and those with genetic liability for ASD. These findings align with and extend earlier reports in this sample of the central role of the visual system during infancy in ASD. En ligne : https://dx.doi.org/10.1186/s11689-025-09613-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576 Why are only some children with autism spectrum disorder misclassified by the social communication questionnaire? An empirical investigation of individual differences in sensitivity and specificity in a clinic-referred sample / Chimei M. LEE in Journal of Neurodevelopmental Disorders, 15 (2023)
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Titre : Why are only some children with autism spectrum disorder misclassified by the social communication questionnaire? An empirical investigation of individual differences in sensitivity and specificity in a clinic-referred sample Type de document : texte imprimé Auteurs : Chimei M. LEE, Auteur ; Melody R. ALTSCHULER, Auteur ; Amy N. ESLER, Auteur ; Catherine A. BURROWS, Auteur ; Rebekah L. HUDOCK, Auteur Langues : Anglais (eng) Mots-clés : Humans Child Child, Preschool Autism Spectrum Disorder/diagnosis Individuality Communication Psychometrics Adaptive behavior Autism spectrum disorder Diagnosis Early identification Externalizing Individual differences Internalizing Screening Sensitivity Social Communication Questionnaire Specificity Index. décimale : PER Périodiques Résumé : BACKGROUND: The Social Communication Questionnaire (SCQ) is a checklist for autism spectrum disorder (ASD) commonly used in research and clinical practice. While the original validation study suggested that the SCQ was an accurate ASD screener with satisfactory sensitivity and specificity, subsequent studies have yielded mixed results, with some revealing low sensitivity, low specificity, and low utility in some settings. METHOD: The present study examined the psychometric properties of the SCQ as well as the individual difference characteristics of 187 individuals with and without autism spectrum disorder (ASD) who were misclassified or accurately classified by the SCQ in a clinic-referred sample. RESULTS: The SCQ showed suboptimal sensitivity and specificity, regardless of age and sex. Compared to true positives, individuals classified as false positives displayed greater externalizing and internalizing problems, whereas individuals classified as false negatives displayed better social communication and adaptive skills. CONCLUSIONS: The findings suggest that non-autistic developmental and behavioral individual difference characteristics may explain high rates of misclassification using the SCQ. Clinicians and researchers could consider using the SCQ in combination with other tools for young children with internalizing and externalizing symptoms and other more complex clinical presentations. En ligne : https://dx.doi.org/10.1186/s11689-023-09497-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575
in Journal of Neurodevelopmental Disorders > 15 (2023)[article] Why are only some children with autism spectrum disorder misclassified by the social communication questionnaire? An empirical investigation of individual differences in sensitivity and specificity in a clinic-referred sample [texte imprimé] / Chimei M. LEE, Auteur ; Melody R. ALTSCHULER, Auteur ; Amy N. ESLER, Auteur ; Catherine A. BURROWS, Auteur ; Rebekah L. HUDOCK, Auteur.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 15 (2023)
Mots-clés : Humans Child Child, Preschool Autism Spectrum Disorder/diagnosis Individuality Communication Psychometrics Adaptive behavior Autism spectrum disorder Diagnosis Early identification Externalizing Individual differences Internalizing Screening Sensitivity Social Communication Questionnaire Specificity Index. décimale : PER Périodiques Résumé : BACKGROUND: The Social Communication Questionnaire (SCQ) is a checklist for autism spectrum disorder (ASD) commonly used in research and clinical practice. While the original validation study suggested that the SCQ was an accurate ASD screener with satisfactory sensitivity and specificity, subsequent studies have yielded mixed results, with some revealing low sensitivity, low specificity, and low utility in some settings. METHOD: The present study examined the psychometric properties of the SCQ as well as the individual difference characteristics of 187 individuals with and without autism spectrum disorder (ASD) who were misclassified or accurately classified by the SCQ in a clinic-referred sample. RESULTS: The SCQ showed suboptimal sensitivity and specificity, regardless of age and sex. Compared to true positives, individuals classified as false positives displayed greater externalizing and internalizing problems, whereas individuals classified as false negatives displayed better social communication and adaptive skills. CONCLUSIONS: The findings suggest that non-autistic developmental and behavioral individual difference characteristics may explain high rates of misclassification using the SCQ. Clinicians and researchers could consider using the SCQ in combination with other tools for young children with internalizing and externalizing symptoms and other more complex clinical presentations. En ligne : https://dx.doi.org/10.1186/s11689-023-09497-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575

