Comparative Analysis of Phenotypic and Genotypic Differences Between Individuals Affected by Regressive and Non-Regressive Autism: A Cross-Sectional Study / Alana IABONI ; Brett TROST ; Miriam REUTER ; Zsuzsa LINDENMAIER ; Azadeh KUSHKI ; Elizabeth KELLEY ; Jessica JONES ; Muhammed AYUB ; Stelios GEORGIADES ; Robert NICOLSON ; Elim CHAN ; Andrada CRETU ; Jessica BRIAN ; Evdokia ANAGNOSTOU in Autism Research, 18-6 (June 2025)  

Public ISBD [article]  inAutism Research > 18-6 (June 2025) . - p.1290-1300 Titre : Comparative Analysis of Phenotypic and Genotypic Differences Between Individuals Affected by Regressive and Non-Regressive Autism: A Cross-Sectional Study Type de document : Texte imprimé et/ou numérique Auteurs : Alana IABONI, Auteur ; Brett TROST, Auteur ; Miriam REUTER, Auteur ; Zsuzsa LINDENMAIER, Auteur ; Azadeh KUSHKI, Auteur ; Elizabeth KELLEY, Auteur ; Jessica JONES, Auteur ; Muhammed AYUB, Auteur ; Stelios GEORGIADES, Auteur ; Robert NICOLSON, Auteur ; Elim CHAN, Auteur ; Andrada CRETU, Auteur ; Jessica BRIAN, Auteur ; Evdokia ANAGNOSTOU, Auteur Article en page(s) : p.1290-1300 Langues : Anglais (eng) Mots-clés : autism Spectrum disorder  child  genotype  neurodevelopmental disorder  phenotype  regressive autism  retrospective studies Index. décimale : PER Périodiques Résumé : ABSTRACT Development among autistic youth varies widely. A subgroup of children experiences regression, defined as the loss of previously acquired developmental skills. Various genetic and environmental factors have been suggested as potential contributors. This study aimed to compare the developmental profiles of children and youth with regression to those without and identify factors associated with regression. Data from the Province of Ontario Neurodevelopmental Disorders (POND) Network was analyzed, including 930 eligible participants. Regression classification was based on the Autism Diagnostic Interview-Revised (ADI-R). Differences in demographic information, medical history, mental health, cognitive and adaptive functioning, and molecular genetic findings were examined between individuals with regressive and non-regressive autism. Among participants, 211 (22.7%) had regressive autism. Lower Full-Scale IQ (p corrected?=?0.015) and adaptive function (ABAS-2) scores (p corrected?=?0.015) were identified in the regressive group. No statistically significant differences in mental health outcomes (measured by the Child Behavior Checklist, CBCL) or socialization and core symptom severity (measured by the Social Communication Questionnaire, SCQ) were found. There were no notable differences in other factors hypothesized to contribute to regression, such as pregnancy duration, family history of autism, caregivers' education levels, or sleep disorders, except for a higher prevalence of epilepsy in the regressive group (p?=?0.001). Rare and common genetic features of both groups are described. In conclusion, autistic youth with regression tend to have lower cognitive and adaptive scores and may experience higher epilepsy rates. Further powered studies are needed to explore the genomic architecture of autistic regression. En ligne : https://doi.org/10.1002/aur.70029 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Comparative Analysis of Phenotypic and Genotypic Differences Between Individuals Affected by Regressive and Non-Regressive Autism: A Cross-Sectional Study [Texte imprimé et/ou numérique] / Alana IABONI, Auteur ; Brett TROST, Auteur ; Miriam REUTER, Auteur ; Zsuzsa LINDENMAIER, Auteur ; Azadeh KUSHKI, Auteur ; Elizabeth KELLEY, Auteur ; Jessica JONES, Auteur ; Muhammed AYUB, Auteur ; Stelios GEORGIADES, Auteur ; Robert NICOLSON, Auteur ; Elim CHAN, Auteur ; Andrada CRETU, Auteur ; Jessica BRIAN, Auteur ; Evdokia ANAGNOSTOU, Auteur . - p.1290-1300. Langues : Anglais (eng) in Autism Research > 18-6 (June 2025) . - p.1290-1300 Mots-clés : autism Spectrum disorder  child  genotype  neurodevelopmental disorder  phenotype  regressive autism  retrospective studies Index. décimale : PER Périodiques Résumé : ABSTRACT Development among autistic youth varies widely. A subgroup of children experiences regression, defined as the loss of previously acquired developmental skills. Various genetic and environmental factors have been suggested as potential contributors. This study aimed to compare the developmental profiles of children and youth with regression to those without and identify factors associated with regression. Data from the Province of Ontario Neurodevelopmental Disorders (POND) Network was analyzed, including 930 eligible participants. Regression classification was based on the Autism Diagnostic Interview-Revised (ADI-R). Differences in demographic information, medical history, mental health, cognitive and adaptive functioning, and molecular genetic findings were examined between individuals with regressive and non-regressive autism. Among participants, 211 (22.7%) had regressive autism. Lower Full-Scale IQ (p corrected?=?0.015) and adaptive function (ABAS-2) scores (p corrected?=?0.015) were identified in the regressive group. No statistically significant differences in mental health outcomes (measured by the Child Behavior Checklist, CBCL) or socialization and core symptom severity (measured by the Social Communication Questionnaire, SCQ) were found. There were no notable differences in other factors hypothesized to contribute to regression, such as pregnancy duration, family history of autism, caregivers' education levels, or sleep disorders, except for a higher prevalence of epilepsy in the regressive group (p?=?0.001). Rare and common genetic features of both groups are described. In conclusion, autistic youth with regression tend to have lower cognitive and adaptive scores and may experience higher epilepsy rates. Further powered studies are needed to explore the genomic architecture of autistic regression. En ligne : https://doi.org/10.1002/aur.70029 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

Exploring the use of the verbal intelligence quotient as a proxy for language ability in autism spectrum disorder / Leticia RIBEIRO DE OLIVEIRA in Research in Autism Spectrum Disorders, 73 (May 2019)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 73 (May 2019) . - 101548 Titre : Exploring the use of the verbal intelligence quotient as a proxy for language ability in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Leticia RIBEIRO DE OLIVEIRA, Auteur ; Jessica BRIAN, Auteur ; Elizabeth KELLEY, Auteur ; Deryk BEAL, Auteur ; Robert NICOLSON, Auteur ; Stelios GEORGIADES, Auteur ; Alana IABONI, Auteur ; Susan Day FRAGIADAKIS, Auteur ; Leanne RISTIC, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Teenu SANJEEVAN, Auteur Article en page(s) : 101548 Langues : Anglais (eng) Mots-clés : ASD  Verbal intelligence quotient  Receptive language  Expressive language  Wechsler scales  Oral and Written Language Scales – Second Edition Index. décimale : PER Périodiques Résumé : Background There is growing interest in understanding the brain and language associations in Autism Spectrum Disorder (ASD). A considerable number of studies investigating these associations have used the verbal intelligence quotient (VIQ) as their primary measure of language form and content. Given this current trend, we aimed to establish whether the VIQ could reliably be used as a measure of receptive and expressive language form and content in individuals with ASD and in typical development (TD). Method We examined the VIQ standard scores derived from a Wechsler cognitive battery as well as receptive and expressive language standard scores from the Oral Written Language Scales – Second Edition (OWLS-II) of 714 participants aged 3–21 years: 488 with ASD and 226 with TD. Results Regression analyses revealed that VIQ scores predicted greater variance in receptive and expressive language scores in males with ASD relative to males with TD, and predicted less variance in receptive and expressive language scores in females with ASD relative to females with TD. Overall, VIQ accounted for a small proportion of variance in receptive and expressive language scores. Conclusions Our findings indicate that the VIQ does not accurately capture language form and content evaluated by language measures like the OWLS-II, but may perhaps be used as a proxy for language content only. En ligne : https://doi.org/10.1016/j.rasd.2020.101548 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422 [article] Exploring the use of the verbal intelligence quotient as a proxy for language ability in autism spectrum disorder [Texte imprimé et/ou numérique] / Leticia RIBEIRO DE OLIVEIRA, Auteur ; Jessica BRIAN, Auteur ; Elizabeth KELLEY, Auteur ; Deryk BEAL, Auteur ; Robert NICOLSON, Auteur ; Stelios GEORGIADES, Auteur ; Alana IABONI, Auteur ; Susan Day FRAGIADAKIS, Auteur ; Leanne RISTIC, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Teenu SANJEEVAN, Auteur . - 101548. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 73 (May 2019) . - 101548 Mots-clés : ASD  Verbal intelligence quotient  Receptive language  Expressive language  Wechsler scales  Oral and Written Language Scales – Second Edition Index. décimale : PER Périodiques Résumé : Background There is growing interest in understanding the brain and language associations in Autism Spectrum Disorder (ASD). A considerable number of studies investigating these associations have used the verbal intelligence quotient (VIQ) as their primary measure of language form and content. Given this current trend, we aimed to establish whether the VIQ could reliably be used as a measure of receptive and expressive language form and content in individuals with ASD and in typical development (TD). Method We examined the VIQ standard scores derived from a Wechsler cognitive battery as well as receptive and expressive language standard scores from the Oral Written Language Scales – Second Edition (OWLS-II) of 714 participants aged 3–21 years: 488 with ASD and 226 with TD. Results Regression analyses revealed that VIQ scores predicted greater variance in receptive and expressive language scores in males with ASD relative to males with TD, and predicted less variance in receptive and expressive language scores in females with ASD relative to females with TD. Overall, VIQ accounted for a small proportion of variance in receptive and expressive language scores. Conclusions Our findings indicate that the VIQ does not accurately capture language form and content evaluated by language measures like the OWLS-II, but may perhaps be used as a proxy for language content only. En ligne : https://doi.org/10.1016/j.rasd.2020.101548 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422

Gender diversity is correlated with dimensional neurodivergent traits but not categorical neurodevelopmental diagnoses in children / Evdokia ANAGNOSTOU ; Jason P. LERCH ; Margot J. TAYLOR ; Doug P. VANDERLAAN ; Peter SZATMARI ; Jennifer CROSBIE ; Robert NICOLSON ; Stelios GEORGIADIS ; Elizabeth KELLEY ; Muhammad AYUB ; Jessica BRIAN ; Meng-Chuan LAI ; Mark R. PALMERT in Journal of Child Psychology and Psychiatry, 65-9 (September 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-9 (September 2024) . - p.1223-1236 Titre : Gender diversity is correlated with dimensional neurodivergent traits but not categorical neurodevelopmental diagnoses in children Type de document : Texte imprimé et/ou numérique Auteurs : Evdokia ANAGNOSTOU, Auteur ; Jason P. LERCH, Auteur ; Margot J. TAYLOR, Auteur ; Doug P. VANDERLAAN, Auteur ; Peter SZATMARI, Auteur ; Jennifer CROSBIE, Auteur ; Robert NICOLSON, Auteur ; Stelios GEORGIADIS, Auteur ; Elizabeth KELLEY, Auteur ; Muhammad AYUB, Auteur ; Jessica BRIAN, Auteur ; Meng-Chuan LAI, Auteur ; Mark R. PALMERT, Auteur Article en page(s) : p.1223-1236 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Gender clinic and single-item questionnaire-based data report increased co-occurrence of gender diversity and neurodevelopmental conditions. The nuances of these associations are under-studied. We used a transdiagnostic approach, combining categorical and dimensional characterization of neurodiversity, to further the understanding of its associations with gender diversity in identity and expression in children. Methods Data from 291 children (Autism N = 104, ADHD N = 104, Autism?+?ADHD N = 17, neurotypical N = 66) aged 4-12?years enrolled in the Province of Ontario Neurodevelopmental Network were analyzed. Gender diversity was measured multi-dimensionally using a well-validated parent-report instrument, the Gender Identity Questionnaire for Children (GIQC). We used gamma regression models to determine the significant correlates of gender diversity among age, puberty, sex-assigned-at-birth, categorical neurodevelopmental diagnoses, and dimensional neurodivergent traits (using the Social Communication Questionnaire and the Strengths and Weaknesses of ADHD Symptoms and Normal Behavior Rating Scales). Internalizing and externalizing problems were included as covariates. Results Neither a categorical diagnosis of autism nor ADHD significantly correlated with current GIQC-derived scores. Instead, higher early-childhood dimensional autistic social-communication traits correlated with higher current overall gender incongruence (as defined by GIQC-14 score). This correlation was potentially moderated by sex-assigned-at-birth: greater early-childhood autistic social-communication traits were associated with higher current overall gender incongruence in assigned-males-at-birth, but not assigned-females-at-birth. For fine-grained gender diversity domains, greater autistic restricted-repetitive behavior traits were associated with greater diversity in gender identity across sexes-assigned-at-birth; greater autistic social-communication traits were associated with lower stereotypical male expression across sexes-assigned-at-birth. Conclusions Dimensional autistic traits, rather than ADHD traits or categorical neurodevelopmental diagnoses, were associated with gender diversity domains across neurodivergent and neurotypical children. The association between early-childhood autistic social-communication traits and overall current gender diversity was most evident in assigned-males-at-birth. Nuanced interrelationships between neurodivergence and gender diversity should be better understood to clarify developmental links and to offer tailored support for neurodivergent and gender-diverse populations. En ligne : https://doi.org/10.1111/jcpp.13965 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=534 [article] Gender diversity is correlated with dimensional neurodivergent traits but not categorical neurodevelopmental diagnoses in children [Texte imprimé et/ou numérique] / Evdokia ANAGNOSTOU, Auteur ; Jason P. LERCH, Auteur ; Margot J. TAYLOR, Auteur ; Doug P. VANDERLAAN, Auteur ; Peter SZATMARI, Auteur ; Jennifer CROSBIE, Auteur ; Robert NICOLSON, Auteur ; Stelios GEORGIADIS, Auteur ; Elizabeth KELLEY, Auteur ; Muhammad AYUB, Auteur ; Jessica BRIAN, Auteur ; Meng-Chuan LAI, Auteur ; Mark R. PALMERT, Auteur . - p.1223-1236. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-9 (September 2024) . - p.1223-1236 Index. décimale : PER Périodiques Résumé : Background Gender clinic and single-item questionnaire-based data report increased co-occurrence of gender diversity and neurodevelopmental conditions. The nuances of these associations are under-studied. We used a transdiagnostic approach, combining categorical and dimensional characterization of neurodiversity, to further the understanding of its associations with gender diversity in identity and expression in children. Methods Data from 291 children (Autism N = 104, ADHD N = 104, Autism?+?ADHD N = 17, neurotypical N = 66) aged 4-12?years enrolled in the Province of Ontario Neurodevelopmental Network were analyzed. Gender diversity was measured multi-dimensionally using a well-validated parent-report instrument, the Gender Identity Questionnaire for Children (GIQC). We used gamma regression models to determine the significant correlates of gender diversity among age, puberty, sex-assigned-at-birth, categorical neurodevelopmental diagnoses, and dimensional neurodivergent traits (using the Social Communication Questionnaire and the Strengths and Weaknesses of ADHD Symptoms and Normal Behavior Rating Scales). Internalizing and externalizing problems were included as covariates. Results Neither a categorical diagnosis of autism nor ADHD significantly correlated with current GIQC-derived scores. Instead, higher early-childhood dimensional autistic social-communication traits correlated with higher current overall gender incongruence (as defined by GIQC-14 score). This correlation was potentially moderated by sex-assigned-at-birth: greater early-childhood autistic social-communication traits were associated with higher current overall gender incongruence in assigned-males-at-birth, but not assigned-females-at-birth. For fine-grained gender diversity domains, greater autistic restricted-repetitive behavior traits were associated with greater diversity in gender identity across sexes-assigned-at-birth; greater autistic social-communication traits were associated with lower stereotypical male expression across sexes-assigned-at-birth. Conclusions Dimensional autistic traits, rather than ADHD traits or categorical neurodevelopmental diagnoses, were associated with gender diversity domains across neurodivergent and neurotypical children. The association between early-childhood autistic social-communication traits and overall current gender diversity was most evident in assigned-males-at-birth. Nuanced interrelationships between neurodivergence and gender diversity should be better understood to clarify developmental links and to offer tailored support for neurodivergent and gender-diverse populations. En ligne : https://doi.org/10.1111/jcpp.13965 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=534

Harmonizing two measures of adaptive functioning using computational approaches: prediction of vineland adaptive behavior scales II (VABS-II) from the adaptive behavior assessment system II (ABAS-II) scores / Alexandra LAUTARESCU ; Tony CHARMAN ; Jennifer CROSBIE ; Russell J SCHACHAR ; Alana IABONI ; Stelios GEORGIADES ; Robert NICOLSON ; Elizabeth KELLEY ; Muhammad AYUB ; Jessica JONES ; Paul D ARNOLD ; Jason P LERCH ; Evdokia ANAGNOSTOU ; Azadeh KUSHKI in Molecular Autism, 15 (2024)  

Public ISBD [article]  inMolecular Autism > 15 (2024) . - 51 Titre : Harmonizing two measures of adaptive functioning using computational approaches: prediction of vineland adaptive behavior scales II (VABS-II) from the adaptive behavior assessment system II (ABAS-II) scores Type de document : Texte imprimé et/ou numérique Auteurs : Alexandra LAUTARESCU, Auteur ; Tony CHARMAN, Auteur ; Jennifer CROSBIE, Auteur ; Russell J SCHACHAR, Auteur ; Alana IABONI, Auteur ; Stelios GEORGIADES, Auteur ; Robert NICOLSON, Auteur ; Elizabeth KELLEY, Auteur ; Muhammad AYUB, Auteur ; Jessica JONES, Auteur ; Paul D ARNOLD, Auteur ; Jason P LERCH, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Azadeh KUSHKI, Auteur Article en page(s) : 51 Langues : Anglais (eng) Mots-clés : Humans  Male  Female  Child  Adolescent  *Adaptation, Psychological  Autistic Disorder/diagnosis/psychology Index. décimale : PER Périodiques Résumé : BACKGROUND: Very large sample sizes are often needed to capture heterogeneity in autism, necessitating data sharing across multiple studies with diverse assessment instruments. In these cases, data harmonization can be a critical tool for deriving a single dataset for analysis. This can be done through computational approaches that enable the conversion of scores across various instruments. To this end, our study examined the use of analytical approaches for mapping scores on two measures of adaptive functioning, namely predicting the scores on the vineland adaptive behavior scales II (VABS) from the scores on the adaptive behavior assessment system II (ABAS). METHODS: Data from the province of Ontario neurodevelopmental disorders network were used. The dataset included scores VABS and the ABAS for 720 participants (autism n = 547, 433 male, age: 11.31?+?3.63 years; neurotypical n = 173, 95 male, age: 12.53?+?4.05 years). Six regression approaches (ordinary least squares (OLS) linear regression, ridge regression, ElasticNet, LASSO, AdaBoost, random forest) were used to predict VABS total scores from the ABAS scores, demographic variables (age, sex), and phenotypic measures (diagnosis; core and co-occurring features; IQ; internalizing and externalizing symptoms). RESULTS: The VABS scores were significantly higher than the ABAS scores in the autism group, but not the neurotypical group (median difference: 8, 95% CI = (7,9)). The difference was negatively associated with age (beta = -1.2?+?0.12, t = -10.6, p < 0.0001). All estimators demonstrated similar performance, with no statistically significant differences in mean absolute error (MAE) values across estimators (MAE range: 4.96-6.91). The highest contributing features to the prediction model were ABAS composite score, diagnosis, and age. LIMITATIONS: This study has several strengths, including the large sample. We did not examine the conversion of domain scores across the two measures of adaptive functioning and suggest this as a future area of investigation. CONCLUSION: Overall, our results supported the feasibility of harmonization. Our results suggest that a linear regression model trained on the ABAS composite score, the ABAS raw domain scores, and age, sex, and diagnosis would provide an acceptable trade-off between accuracy, parsimony, and data collection and processing complexity. En ligne : https://dx.doi.org/10.1186/s13229-024-00630-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555 [article] Harmonizing two measures of adaptive functioning using computational approaches: prediction of vineland adaptive behavior scales II (VABS-II) from the adaptive behavior assessment system II (ABAS-II) scores [Texte imprimé et/ou numérique] / Alexandra LAUTARESCU, Auteur ; Tony CHARMAN, Auteur ; Jennifer CROSBIE, Auteur ; Russell J SCHACHAR, Auteur ; Alana IABONI, Auteur ; Stelios GEORGIADES, Auteur ; Robert NICOLSON, Auteur ; Elizabeth KELLEY, Auteur ; Muhammad AYUB, Auteur ; Jessica JONES, Auteur ; Paul D ARNOLD, Auteur ; Jason P LERCH, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Azadeh KUSHKI, Auteur . - 51. Langues : Anglais (eng) in Molecular Autism > 15 (2024) . - 51 Mots-clés : Humans  Male  Female  Child  Adolescent  *Adaptation, Psychological  Autistic Disorder/diagnosis/psychology Index. décimale : PER Périodiques Résumé : BACKGROUND: Very large sample sizes are often needed to capture heterogeneity in autism, necessitating data sharing across multiple studies with diverse assessment instruments. In these cases, data harmonization can be a critical tool for deriving a single dataset for analysis. This can be done through computational approaches that enable the conversion of scores across various instruments. To this end, our study examined the use of analytical approaches for mapping scores on two measures of adaptive functioning, namely predicting the scores on the vineland adaptive behavior scales II (VABS) from the scores on the adaptive behavior assessment system II (ABAS). METHODS: Data from the province of Ontario neurodevelopmental disorders network were used. The dataset included scores VABS and the ABAS for 720 participants (autism n = 547, 433 male, age: 11.31?+?3.63 years; neurotypical n = 173, 95 male, age: 12.53?+?4.05 years). Six regression approaches (ordinary least squares (OLS) linear regression, ridge regression, ElasticNet, LASSO, AdaBoost, random forest) were used to predict VABS total scores from the ABAS scores, demographic variables (age, sex), and phenotypic measures (diagnosis; core and co-occurring features; IQ; internalizing and externalizing symptoms). RESULTS: The VABS scores were significantly higher than the ABAS scores in the autism group, but not the neurotypical group (median difference: 8, 95% CI = (7,9)). The difference was negatively associated with age (beta = -1.2?+?0.12, t = -10.6, p < 0.0001). All estimators demonstrated similar performance, with no statistically significant differences in mean absolute error (MAE) values across estimators (MAE range: 4.96-6.91). The highest contributing features to the prediction model were ABAS composite score, diagnosis, and age. LIMITATIONS: This study has several strengths, including the large sample. We did not examine the conversion of domain scores across the two measures of adaptive functioning and suggest this as a future area of investigation. CONCLUSION: Overall, our results supported the feasibility of harmonization. Our results suggest that a linear regression model trained on the ABAS composite score, the ABAS raw domain scores, and age, sex, and diagnosis would provide an acceptable trade-off between accuracy, parsimony, and data collection and processing complexity. En ligne : https://dx.doi.org/10.1186/s13229-024-00630-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555

Investigating language skills as a mediator between IQ and anxiety in autistic youth / Ethan RINALDO in Research in Autism Spectrum Disorders, 88 (October 2021)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 88 (October 2021) . - 101846 Titre : Investigating language skills as a mediator between IQ and anxiety in autistic youth Type de document : Texte imprimé et/ou numérique Auteurs : Ethan RINALDO, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Stelios GEORGIADES, Auteur ; Muhammad AYUB, Auteur ; Robert NICOLSON, Auteur ; Elizabeth KELLEY, Auteur Article en page(s) : 101846 Langues : Anglais (eng) Mots-clés : Autism  Autism spectrum disorder  IQ  Language  Anxiety Index. décimale : PER Périodiques Résumé : Background Anxiety is a common condition noted to cause significant impairment in some autistic youth. Previous research has found that autistic youth tend to exhibit higher levels of traditional anxiety symptoms with higher IQ scores and higher language abilities. In this study of the relationship between anxiety, intelligence, and language skills in autistic youth, it was hypothesized that a mediational relationship would be observed in which IQ exerts its influence over anxiety through language skills. Method Participants consisted of 293 autistic youth between the ages of 7 and 18. Anxiety was assessed with the Revised Children’s Anxiety and Depression Scale, language with the Oral and Written Language Scales Version II, and IQ (performance, verbal, and full-scale) was measured with the Wechsler Abbreviated Scale of Intelligence Version II. A simple mediation model was used with IQ as the predictor variable, language as the mediator variable, and anxiety as the outcome variable. This analysis was conducted three times so that performance, verbal, and full-scale IQ could be examined as separate predictors. Results The results of this study confirmed our hypothesis with a full mediation effect for each IQ scale, although verbal IQ was too strongly correlated with language scores for it to be considered a separate construct from our language measure. Conclusions This model should inform further autism research in that the influence of IQ and language over anxiety should not be viewed as independent factors but as a set of constructs that exert a shared influence. En ligne : https://doi.org/10.1016/j.rasd.2021.101846 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458 [article] Investigating language skills as a mediator between IQ and anxiety in autistic youth [Texte imprimé et/ou numérique] / Ethan RINALDO, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Stelios GEORGIADES, Auteur ; Muhammad AYUB, Auteur ; Robert NICOLSON, Auteur ; Elizabeth KELLEY, Auteur . - 101846. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 88 (October 2021) . - 101846 Mots-clés : Autism  Autism spectrum disorder  IQ  Language  Anxiety Index. décimale : PER Périodiques Résumé : Background Anxiety is a common condition noted to cause significant impairment in some autistic youth. Previous research has found that autistic youth tend to exhibit higher levels of traditional anxiety symptoms with higher IQ scores and higher language abilities. In this study of the relationship between anxiety, intelligence, and language skills in autistic youth, it was hypothesized that a mediational relationship would be observed in which IQ exerts its influence over anxiety through language skills. Method Participants consisted of 293 autistic youth between the ages of 7 and 18. Anxiety was assessed with the Revised Children’s Anxiety and Depression Scale, language with the Oral and Written Language Scales Version II, and IQ (performance, verbal, and full-scale) was measured with the Wechsler Abbreviated Scale of Intelligence Version II. A simple mediation model was used with IQ as the predictor variable, language as the mediator variable, and anxiety as the outcome variable. This analysis was conducted three times so that performance, verbal, and full-scale IQ could be examined as separate predictors. Results The results of this study confirmed our hypothesis with a full mediation effect for each IQ scale, although verbal IQ was too strongly correlated with language scores for it to be considered a separate construct from our language measure. Conclusions This model should inform further autism research in that the influence of IQ and language over anxiety should not be viewed as independent factors but as a set of constructs that exert a shared influence. En ligne : https://doi.org/10.1016/j.rasd.2021.101846 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458

Linkage of whole genome sequencing and administrative health data in autism: A proof of concept study / Danielle A. BARIBEAU in Autism Research, 16-8 (August 2023)  

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Transdiagnostic Patterns of Sensory Processing in Autism and ADHD / Anahid POURTOUSI ; Connie YANG ; Zining DING ; Bobby STOJANOSKI ; Evdokia ANAGNOSTOU ; Robert NICOLSON ; Elizabeth KELLEY ; Stelios GEORGIADES ; Jennifer CROSBIE ; Russell SCHACHAR ; Muhammad AYUB ; Ryan A. STEVENSON in Journal of Autism and Developmental Disorders, 54-1 (January 2024)  

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