Exploring the use of the verbal intelligence quotient as a proxy for language ability in autism spectrum disorder / Leticia RIBEIRO DE OLIVEIRA in Research in Autism Spectrum Disorders, 73 (May 2019)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 73 (May 2019) . - 101548 Titre : Exploring the use of the verbal intelligence quotient as a proxy for language ability in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Leticia RIBEIRO DE OLIVEIRA, Auteur ; Jessica BRIAN, Auteur ; Elizabeth KELLEY, Auteur ; Deryk BEAL, Auteur ; Robert NICOLSON, Auteur ; Stelios GEORGIADES, Auteur ; Alana IABONI, Auteur ; Susan Day FRAGIADAKIS, Auteur ; Leanne RISTIC, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Teenu SANJEEVAN, Auteur Article en page(s) : 101548 Langues : Anglais (eng) Mots-clés : ASD  Verbal intelligence quotient  Receptive language  Expressive language  Wechsler scales  Oral and Written Language Scales – Second Edition Index. décimale : PER Périodiques Résumé : Background There is growing interest in understanding the brain and language associations in Autism Spectrum Disorder (ASD). A considerable number of studies investigating these associations have used the verbal intelligence quotient (VIQ) as their primary measure of language form and content. Given this current trend, we aimed to establish whether the VIQ could reliably be used as a measure of receptive and expressive language form and content in individuals with ASD and in typical development (TD). Method We examined the VIQ standard scores derived from a Wechsler cognitive battery as well as receptive and expressive language standard scores from the Oral Written Language Scales – Second Edition (OWLS-II) of 714 participants aged 3–21 years: 488 with ASD and 226 with TD. Results Regression analyses revealed that VIQ scores predicted greater variance in receptive and expressive language scores in males with ASD relative to males with TD, and predicted less variance in receptive and expressive language scores in females with ASD relative to females with TD. Overall, VIQ accounted for a small proportion of variance in receptive and expressive language scores. Conclusions Our findings indicate that the VIQ does not accurately capture language form and content evaluated by language measures like the OWLS-II, but may perhaps be used as a proxy for language content only. En ligne : https://doi.org/10.1016/j.rasd.2020.101548 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422 [article] Exploring the use of the verbal intelligence quotient as a proxy for language ability in autism spectrum disorder [Texte imprimé et/ou numérique] / Leticia RIBEIRO DE OLIVEIRA, Auteur ; Jessica BRIAN, Auteur ; Elizabeth KELLEY, Auteur ; Deryk BEAL, Auteur ; Robert NICOLSON, Auteur ; Stelios GEORGIADES, Auteur ; Alana IABONI, Auteur ; Susan Day FRAGIADAKIS, Auteur ; Leanne RISTIC, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Teenu SANJEEVAN, Auteur . - 101548. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 73 (May 2019) . - 101548 Mots-clés : ASD  Verbal intelligence quotient  Receptive language  Expressive language  Wechsler scales  Oral and Written Language Scales – Second Edition Index. décimale : PER Périodiques Résumé : Background There is growing interest in understanding the brain and language associations in Autism Spectrum Disorder (ASD). A considerable number of studies investigating these associations have used the verbal intelligence quotient (VIQ) as their primary measure of language form and content. Given this current trend, we aimed to establish whether the VIQ could reliably be used as a measure of receptive and expressive language form and content in individuals with ASD and in typical development (TD). Method We examined the VIQ standard scores derived from a Wechsler cognitive battery as well as receptive and expressive language standard scores from the Oral Written Language Scales – Second Edition (OWLS-II) of 714 participants aged 3–21 years: 488 with ASD and 226 with TD. Results Regression analyses revealed that VIQ scores predicted greater variance in receptive and expressive language scores in males with ASD relative to males with TD, and predicted less variance in receptive and expressive language scores in females with ASD relative to females with TD. Overall, VIQ accounted for a small proportion of variance in receptive and expressive language scores. Conclusions Our findings indicate that the VIQ does not accurately capture language form and content evaluated by language measures like the OWLS-II, but may perhaps be used as a proxy for language content only. En ligne : https://doi.org/10.1016/j.rasd.2020.101548 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422

Gender diversity is correlated with dimensional neurodivergent traits but not categorical neurodevelopmental diagnoses in children / Evdokia ANAGNOSTOU ; Jason P. LERCH ; Margot J. TAYLOR ; Doug P. VANDERLAAN ; Peter SZATMARI ; Jennifer CROSBIE ; Robert NICOLSON ; Stelios GEORGIADIS ; Elizabeth KELLEY ; Muhammad AYUB ; Jessica BRIAN ; Meng-Chuan LAI ; Mark R. PALMERT in Journal of Child Psychology and Psychiatry, 65-9 (September 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-9 (September 2024) . - p.1223-1236 Titre : Gender diversity is correlated with dimensional neurodivergent traits but not categorical neurodevelopmental diagnoses in children Type de document : Texte imprimé et/ou numérique Auteurs : Evdokia ANAGNOSTOU, Auteur ; Jason P. LERCH, Auteur ; Margot J. TAYLOR, Auteur ; Doug P. VANDERLAAN, Auteur ; Peter SZATMARI, Auteur ; Jennifer CROSBIE, Auteur ; Robert NICOLSON, Auteur ; Stelios GEORGIADIS, Auteur ; Elizabeth KELLEY, Auteur ; Muhammad AYUB, Auteur ; Jessica BRIAN, Auteur ; Meng-Chuan LAI, Auteur ; Mark R. PALMERT, Auteur Article en page(s) : p.1223-1236 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Gender clinic and single-item questionnaire-based data report increased co-occurrence of gender diversity and neurodevelopmental conditions. The nuances of these associations are under-studied. We used a transdiagnostic approach, combining categorical and dimensional characterization of neurodiversity, to further the understanding of its associations with gender diversity in identity and expression in children. Methods Data from 291 children (Autism N = 104, ADHD N = 104, Autism?+?ADHD N = 17, neurotypical N = 66) aged 4-12?years enrolled in the Province of Ontario Neurodevelopmental Network were analyzed. Gender diversity was measured multi-dimensionally using a well-validated parent-report instrument, the Gender Identity Questionnaire for Children (GIQC). We used gamma regression models to determine the significant correlates of gender diversity among age, puberty, sex-assigned-at-birth, categorical neurodevelopmental diagnoses, and dimensional neurodivergent traits (using the Social Communication Questionnaire and the Strengths and Weaknesses of ADHD Symptoms and Normal Behavior Rating Scales). Internalizing and externalizing problems were included as covariates. Results Neither a categorical diagnosis of autism nor ADHD significantly correlated with current GIQC-derived scores. Instead, higher early-childhood dimensional autistic social-communication traits correlated with higher current overall gender incongruence (as defined by GIQC-14 score). This correlation was potentially moderated by sex-assigned-at-birth: greater early-childhood autistic social-communication traits were associated with higher current overall gender incongruence in assigned-males-at-birth, but not assigned-females-at-birth. For fine-grained gender diversity domains, greater autistic restricted-repetitive behavior traits were associated with greater diversity in gender identity across sexes-assigned-at-birth; greater autistic social-communication traits were associated with lower stereotypical male expression across sexes-assigned-at-birth. Conclusions Dimensional autistic traits, rather than ADHD traits or categorical neurodevelopmental diagnoses, were associated with gender diversity domains across neurodivergent and neurotypical children. The association between early-childhood autistic social-communication traits and overall current gender diversity was most evident in assigned-males-at-birth. Nuanced interrelationships between neurodivergence and gender diversity should be better understood to clarify developmental links and to offer tailored support for neurodivergent and gender-diverse populations. En ligne : https://doi.org/10.1111/jcpp.13965 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=534 [article] Gender diversity is correlated with dimensional neurodivergent traits but not categorical neurodevelopmental diagnoses in children [Texte imprimé et/ou numérique] / Evdokia ANAGNOSTOU, Auteur ; Jason P. LERCH, Auteur ; Margot J. TAYLOR, Auteur ; Doug P. VANDERLAAN, Auteur ; Peter SZATMARI, Auteur ; Jennifer CROSBIE, Auteur ; Robert NICOLSON, Auteur ; Stelios GEORGIADIS, Auteur ; Elizabeth KELLEY, Auteur ; Muhammad AYUB, Auteur ; Jessica BRIAN, Auteur ; Meng-Chuan LAI, Auteur ; Mark R. PALMERT, Auteur . - p.1223-1236. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-9 (September 2024) . - p.1223-1236 Index. décimale : PER Périodiques Résumé : Background Gender clinic and single-item questionnaire-based data report increased co-occurrence of gender diversity and neurodevelopmental conditions. The nuances of these associations are under-studied. We used a transdiagnostic approach, combining categorical and dimensional characterization of neurodiversity, to further the understanding of its associations with gender diversity in identity and expression in children. Methods Data from 291 children (Autism N = 104, ADHD N = 104, Autism?+?ADHD N = 17, neurotypical N = 66) aged 4-12?years enrolled in the Province of Ontario Neurodevelopmental Network were analyzed. Gender diversity was measured multi-dimensionally using a well-validated parent-report instrument, the Gender Identity Questionnaire for Children (GIQC). We used gamma regression models to determine the significant correlates of gender diversity among age, puberty, sex-assigned-at-birth, categorical neurodevelopmental diagnoses, and dimensional neurodivergent traits (using the Social Communication Questionnaire and the Strengths and Weaknesses of ADHD Symptoms and Normal Behavior Rating Scales). Internalizing and externalizing problems were included as covariates. Results Neither a categorical diagnosis of autism nor ADHD significantly correlated with current GIQC-derived scores. Instead, higher early-childhood dimensional autistic social-communication traits correlated with higher current overall gender incongruence (as defined by GIQC-14 score). This correlation was potentially moderated by sex-assigned-at-birth: greater early-childhood autistic social-communication traits were associated with higher current overall gender incongruence in assigned-males-at-birth, but not assigned-females-at-birth. For fine-grained gender diversity domains, greater autistic restricted-repetitive behavior traits were associated with greater diversity in gender identity across sexes-assigned-at-birth; greater autistic social-communication traits were associated with lower stereotypical male expression across sexes-assigned-at-birth. Conclusions Dimensional autistic traits, rather than ADHD traits or categorical neurodevelopmental diagnoses, were associated with gender diversity domains across neurodivergent and neurotypical children. The association between early-childhood autistic social-communication traits and overall current gender diversity was most evident in assigned-males-at-birth. Nuanced interrelationships between neurodivergence and gender diversity should be better understood to clarify developmental links and to offer tailored support for neurodivergent and gender-diverse populations. En ligne : https://doi.org/10.1111/jcpp.13965 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=534

Investigating language skills as a mediator between IQ and anxiety in autistic youth / Ethan RINALDO in Research in Autism Spectrum Disorders, 88 (October 2021)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 88 (October 2021) . - 101846 Titre : Investigating language skills as a mediator between IQ and anxiety in autistic youth Type de document : Texte imprimé et/ou numérique Auteurs : Ethan RINALDO, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Stelios GEORGIADES, Auteur ; Muhammad AYUB, Auteur ; Robert NICOLSON, Auteur ; Elizabeth KELLEY, Auteur Article en page(s) : 101846 Langues : Anglais (eng) Mots-clés : Autism  Autism spectrum disorder  IQ  Language  Anxiety Index. décimale : PER Périodiques Résumé : Background Anxiety is a common condition noted to cause significant impairment in some autistic youth. Previous research has found that autistic youth tend to exhibit higher levels of traditional anxiety symptoms with higher IQ scores and higher language abilities. In this study of the relationship between anxiety, intelligence, and language skills in autistic youth, it was hypothesized that a mediational relationship would be observed in which IQ exerts its influence over anxiety through language skills. Method Participants consisted of 293 autistic youth between the ages of 7 and 18. Anxiety was assessed with the Revised Children’s Anxiety and Depression Scale, language with the Oral and Written Language Scales Version II, and IQ (performance, verbal, and full-scale) was measured with the Wechsler Abbreviated Scale of Intelligence Version II. A simple mediation model was used with IQ as the predictor variable, language as the mediator variable, and anxiety as the outcome variable. This analysis was conducted three times so that performance, verbal, and full-scale IQ could be examined as separate predictors. Results The results of this study confirmed our hypothesis with a full mediation effect for each IQ scale, although verbal IQ was too strongly correlated with language scores for it to be considered a separate construct from our language measure. Conclusions This model should inform further autism research in that the influence of IQ and language over anxiety should not be viewed as independent factors but as a set of constructs that exert a shared influence. En ligne : https://doi.org/10.1016/j.rasd.2021.101846 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458 [article] Investigating language skills as a mediator between IQ and anxiety in autistic youth [Texte imprimé et/ou numérique] / Ethan RINALDO, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Stelios GEORGIADES, Auteur ; Muhammad AYUB, Auteur ; Robert NICOLSON, Auteur ; Elizabeth KELLEY, Auteur . - 101846. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 88 (October 2021) . - 101846 Mots-clés : Autism  Autism spectrum disorder  IQ  Language  Anxiety Index. décimale : PER Périodiques Résumé : Background Anxiety is a common condition noted to cause significant impairment in some autistic youth. Previous research has found that autistic youth tend to exhibit higher levels of traditional anxiety symptoms with higher IQ scores and higher language abilities. In this study of the relationship between anxiety, intelligence, and language skills in autistic youth, it was hypothesized that a mediational relationship would be observed in which IQ exerts its influence over anxiety through language skills. Method Participants consisted of 293 autistic youth between the ages of 7 and 18. Anxiety was assessed with the Revised Children’s Anxiety and Depression Scale, language with the Oral and Written Language Scales Version II, and IQ (performance, verbal, and full-scale) was measured with the Wechsler Abbreviated Scale of Intelligence Version II. A simple mediation model was used with IQ as the predictor variable, language as the mediator variable, and anxiety as the outcome variable. This analysis was conducted three times so that performance, verbal, and full-scale IQ could be examined as separate predictors. Results The results of this study confirmed our hypothesis with a full mediation effect for each IQ scale, although verbal IQ was too strongly correlated with language scores for it to be considered a separate construct from our language measure. Conclusions This model should inform further autism research in that the influence of IQ and language over anxiety should not be viewed as independent factors but as a set of constructs that exert a shared influence. En ligne : https://doi.org/10.1016/j.rasd.2021.101846 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458

Linkage of whole genome sequencing and administrative health data in autism: A proof of concept study / Danielle A. BARIBEAU in Autism Research, 16-8 (August 2023)  

Public ISBD [article]  inAutism Research > 16-8 (August 2023) . - p.1600-1608 Titre : Linkage of whole genome sequencing and administrative health data in autism: A proof of concept study Type de document : Texte imprimé et/ou numérique Auteurs : Danielle A. BARIBEAU, Auteur ; Jasleen ARNEJA, Auteur ; Xuesong WANG, Auteur ; Jennifer HOWE, Auteur ; John R. MCLAUGHLIN, Auteur ; Karen TU, Auteur ; Jun GUAN, Auteur ; Alana IABONI, Auteur ; Elizabeth KELLEY, Auteur ; Muhammad AYUB, Auteur ; Robert NICOLSON, Auteur ; Stelios GEORGIADES, Auteur ; Stephen W. SCHERER, Auteur ; Susan E. BRONSKILL, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Jennifer D. BROOKS, Auteur Article en page(s) : p.1600-1608 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Whether genetic testing in autism can help understand longitudinal health outcomes and health service needs is unclear. The objective of this study was to determine whether carrying an autism-associated rare genetic variant is associated with differences in health system utilization by autistic children and youth. This retrospective cohort study examined 415 autistic children/youth who underwent genome sequencing and data collection through a translational neuroscience program (Province of Ontario Neurodevelopmental Disorders Network). Participant data were linked to provincial health administrative databases to identify historical health service utilization, health care costs, and complex chronic medical conditions during a 3-year period. Health administrative data were compared between participants with and without a rare genetic variant in at least 1 of 74 genes associated with autism. Participants with a rare variant impacting an autism-associated gene (n=83, 20%) were less likely to have received psychiatric care (at least one psychiatrist visit: 19.3% vs. 34.3%, p=0.01; outpatient mental health visit: 66% vs. 77%, p=0.04). Health care costs were similar between groups (median: $5589 vs. $4938, p=0.4) and genetic status was not associated with odds of being a high-cost participant (top 20%) in this cohort. There were no differences in the proportion with complex chronic medical conditions between those with and without an autism-associated genetic variant. Our study highlights the feasibility and potential value of genomic and health system data linkage to understand health service needs, disparities, and health trajectories in individuals with neurodevelopmental conditions. En ligne : https://doi.org/10.1002/aur.2999 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510 [article] Linkage of whole genome sequencing and administrative health data in autism: A proof of concept study [Texte imprimé et/ou numérique] / Danielle A. BARIBEAU, Auteur ; Jasleen ARNEJA, Auteur ; Xuesong WANG, Auteur ; Jennifer HOWE, Auteur ; John R. MCLAUGHLIN, Auteur ; Karen TU, Auteur ; Jun GUAN, Auteur ; Alana IABONI, Auteur ; Elizabeth KELLEY, Auteur ; Muhammad AYUB, Auteur ; Robert NICOLSON, Auteur ; Stelios GEORGIADES, Auteur ; Stephen W. SCHERER, Auteur ; Susan E. BRONSKILL, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Jennifer D. BROOKS, Auteur . - p.1600-1608. Langues : Anglais (eng) in Autism Research > 16-8 (August 2023) . - p.1600-1608 Index. décimale : PER Périodiques Résumé : Abstract Whether genetic testing in autism can help understand longitudinal health outcomes and health service needs is unclear. The objective of this study was to determine whether carrying an autism-associated rare genetic variant is associated with differences in health system utilization by autistic children and youth. This retrospective cohort study examined 415 autistic children/youth who underwent genome sequencing and data collection through a translational neuroscience program (Province of Ontario Neurodevelopmental Disorders Network). Participant data were linked to provincial health administrative databases to identify historical health service utilization, health care costs, and complex chronic medical conditions during a 3-year period. Health administrative data were compared between participants with and without a rare genetic variant in at least 1 of 74 genes associated with autism. Participants with a rare variant impacting an autism-associated gene (n=83, 20%) were less likely to have received psychiatric care (at least one psychiatrist visit: 19.3% vs. 34.3%, p=0.01; outpatient mental health visit: 66% vs. 77%, p=0.04). Health care costs were similar between groups (median: $5589 vs. $4938, p=0.4) and genetic status was not associated with odds of being a high-cost participant (top 20%) in this cohort. There were no differences in the proportion with complex chronic medical conditions between those with and without an autism-associated genetic variant. Our study highlights the feasibility and potential value of genomic and health system data linkage to understand health service needs, disparities, and health trajectories in individuals with neurodevelopmental conditions. En ligne : https://doi.org/10.1002/aur.2999 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510

Transdiagnostic Patterns of Sensory Processing in Autism and ADHD / Anahid POURTOUSI ; Connie YANG ; Zining DING ; Bobby STOJANOSKI ; Evdokia ANAGNOSTOU ; Robert NICOLSON ; Elizabeth KELLEY ; Stelios GEORGIADES ; Jennifer CROSBIE ; Russell SCHACHAR ; Muhammad AYUB ; Ryan A. STEVENSON in Journal of Autism and Developmental Disorders, 54-1 (January 2024)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 54-1 (January 2024) . - p.280-292 Titre : Transdiagnostic Patterns of Sensory Processing in Autism and ADHD Type de document : Texte imprimé et/ou numérique Auteurs : Anahid POURTOUSI, Auteur ; Connie YANG, Auteur ; Zining DING, Auteur ; Bobby STOJANOSKI, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Robert NICOLSON, Auteur ; Elizabeth KELLEY, Auteur ; Stelios GEORGIADES, Auteur ; Jennifer CROSBIE, Auteur ; Russell SCHACHAR, Auteur ; Muhammad AYUB, Auteur ; Ryan A. STEVENSON, Auteur Article en page(s) : p.280-292 Index. décimale : PER Périodiques Résumé : Sensory processing abilities are highly variable within and across people diagnosed with autism and attention-deficit/hyperactivity disorder (ADHD). This study examined the transdiagnostic nature of sensory processing abilities, and their association with features of autism and ADHD, in a large sample of autistic people (n?=?495) and people with ADHD (n?=?461). Five similar data-driven sensory phenotypes characterized sensory processing abilities, and showed similar patterns of association with features of autism and ADHD, across both diagnostic groups. These results demonstrate the transdiagnostic nature of sensory processing abilities, while contributing to a growing body of literature that suggests the autism and ADHD diagnostic labels have poor explanatory power. En ligne : https://doi.org/10.1007/s10803-022-05798-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=520 [article] Transdiagnostic Patterns of Sensory Processing in Autism and ADHD [Texte imprimé et/ou numérique] / Anahid POURTOUSI, Auteur ; Connie YANG, Auteur ; Zining DING, Auteur ; Bobby STOJANOSKI, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Robert NICOLSON, Auteur ; Elizabeth KELLEY, Auteur ; Stelios GEORGIADES, Auteur ; Jennifer CROSBIE, Auteur ; Russell SCHACHAR, Auteur ; Muhammad AYUB, Auteur ; Ryan A. STEVENSON, Auteur . - p.280-292. in Journal of Autism and Developmental Disorders > 54-1 (January 2024) . - p.280-292 Index. décimale : PER Périodiques Résumé : Sensory processing abilities are highly variable within and across people diagnosed with autism and attention-deficit/hyperactivity disorder (ADHD). This study examined the transdiagnostic nature of sensory processing abilities, and their association with features of autism and ADHD, in a large sample of autistic people (n?=?495) and people with ADHD (n?=?461). Five similar data-driven sensory phenotypes characterized sensory processing abilities, and showed similar patterns of association with features of autism and ADHD, across both diagnostic groups. These results demonstrate the transdiagnostic nature of sensory processing abilities, while contributing to a growing body of literature that suggests the autism and ADHD diagnostic labels have poor explanatory power. En ligne : https://doi.org/10.1007/s10803-022-05798-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=520

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