Dépouillements

Motor impairment should be a "Specifier" for autism spectrum disorder / Melissa K. LICARI in Autism Research, 15-11 (November 2022)  

Public ISBD [article]  inAutism Research > 15-11 (November 2022) . - p.2010-2011 Titre : Motor impairment should be a "Specifier" for autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Melissa K. LICARI, Auteur ; Gail A. ALVARES, Auteur ; Jess E. REYNOLDS, Auteur ; Mirko ULJAVERIC, Auteur Article en page(s) : p.2010-2011 Langues : Anglais (eng) Mots-clés : Humans  Autism Spectrum Disorder  Motor Disorders  Motor Skills Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.2819 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Motor impairment should be a "Specifier" for autism spectrum disorder [Texte imprimé et/ou numérique] / Melissa K. LICARI, Auteur ; Gail A. ALVARES, Auteur ; Jess E. REYNOLDS, Auteur ; Mirko ULJAVERIC, Auteur . - p.2010-2011. Langues : Anglais (eng) in Autism Research > 15-11 (November 2022) . - p.2010-2011 Mots-clés : Humans  Autism Spectrum Disorder  Motor Disorders  Motor Skills Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.2819 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Exploring brainstem auditory evoked potentials and mental development index as early indicators of autism spectrum disorders in high-risk infants / Xiaoyan WANG in Autism Research, 15-11 (November 2022)  

Public ISBD [article]  inAutism Research > 15-11 (November 2022) . - p.2012-2025 Titre : Exploring brainstem auditory evoked potentials and mental development index as early indicators of autism spectrum disorders in high-risk infants Type de document : Texte imprimé et/ou numérique Auteurs : Xiaoyan WANG, Auteur ; Xianming CARROLL, Auteur ; Ping ZHANG, Auteur ; Jean-Baptist DU PREL, Auteur ; Hong WANG, Auteur ; Haiqing XU, Auteur ; Sandra LEEPER-WOODFORD, Auteur Article en page(s) : p.2012-2025 Langues : Anglais (eng) Mots-clés : Infant  Humans  Evoked Potentials, Auditory, Brain Stem/physiology  Autism Spectrum Disorder/diagnosis  Mass Screening  Odds Ratio  China  Evoked Potentials, Auditory  absolute latencies  autism spectrum disorders  brainstem auditory evoked potential  infants  interpeak latencies  mental development index Index. décimale : PER Périodiques Résumé : This study of infants from Hubei Province, China examined brainstem auditory evoked potentials (BAEP) and mental development index (MDI) as possible early indicators associated with autism spectrum disorders (ASD). The 34 ASD cases and 102 controls who had recovered from perinatal conditions were matched for age, sex, gestational age, birth weight and maternal age. BAEP absolute latencies (AL) I, III, V and interpeak latencies (IPL) I-III, III-V, I-V were compared in ASD cases and controls at ages 1, 3 and 6 months. MDI scores were compared in these infants from 1 month to 2 years old. Multiple logistic regression analysis was performed to test associations among ASD, BAEP and MDI. Results showed BAEP AL I, V and IPL III-V prolonged in the ASD group (p < 0.001), and MDI scores in ASD cases sharply declining from 12 to 24 months (p < 0.001). Regression analysis revealed odds ratios (OR) indicating that ASD was likely associated with abnormal values of BAEP AL I at 1 and 3 months (OR(AL I) : 4.27; OR(AL I) : 4.13), and AL V at 6 months (OR(AL V) : 7.85). Lower MDI scores (MDI < 80) in infants at 1, 3, and 6 months were likely associated with ASD (OR(MDI) : 2.58; OR(MDI) : 3.83; OR(MDI) : 4.87). These data show that abnormal BAEP values and low MDI scores are independent factors associated with ASD, and that monitoring of BAEP and MDI during infancy might facilitate screening for ASD development. En ligne : http://dx.doi.org/10.1002/aur.2821 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Exploring brainstem auditory evoked potentials and mental development index as early indicators of autism spectrum disorders in high-risk infants [Texte imprimé et/ou numérique] / Xiaoyan WANG, Auteur ; Xianming CARROLL, Auteur ; Ping ZHANG, Auteur ; Jean-Baptist DU PREL, Auteur ; Hong WANG, Auteur ; Haiqing XU, Auteur ; Sandra LEEPER-WOODFORD, Auteur . - p.2012-2025. Langues : Anglais (eng) in Autism Research > 15-11 (November 2022) . - p.2012-2025 Mots-clés : Infant  Humans  Evoked Potentials, Auditory, Brain Stem/physiology  Autism Spectrum Disorder/diagnosis  Mass Screening  Odds Ratio  China  Evoked Potentials, Auditory  absolute latencies  autism spectrum disorders  brainstem auditory evoked potential  infants  interpeak latencies  mental development index Index. décimale : PER Périodiques Résumé : This study of infants from Hubei Province, China examined brainstem auditory evoked potentials (BAEP) and mental development index (MDI) as possible early indicators associated with autism spectrum disorders (ASD). The 34 ASD cases and 102 controls who had recovered from perinatal conditions were matched for age, sex, gestational age, birth weight and maternal age. BAEP absolute latencies (AL) I, III, V and interpeak latencies (IPL) I-III, III-V, I-V were compared in ASD cases and controls at ages 1, 3 and 6 months. MDI scores were compared in these infants from 1 month to 2 years old. Multiple logistic regression analysis was performed to test associations among ASD, BAEP and MDI. Results showed BAEP AL I, V and IPL III-V prolonged in the ASD group (p < 0.001), and MDI scores in ASD cases sharply declining from 12 to 24 months (p < 0.001). Regression analysis revealed odds ratios (OR) indicating that ASD was likely associated with abnormal values of BAEP AL I at 1 and 3 months (OR(AL I) : 4.27; OR(AL I) : 4.13), and AL V at 6 months (OR(AL V) : 7.85). Lower MDI scores (MDI < 80) in infants at 1, 3, and 6 months were likely associated with ASD (OR(MDI) : 2.58; OR(MDI) : 3.83; OR(MDI) : 4.87). These data show that abnormal BAEP values and low MDI scores are independent factors associated with ASD, and that monitoring of BAEP and MDI during infancy might facilitate screening for ASD development. En ligne : http://dx.doi.org/10.1002/aur.2821 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Electroretinography in adults with high-functioning autism spectrum disorder / Evelyn B. N. FRIEDEL in Autism Research, 15-11 (November 2022)  

Public ISBD [article]  inAutism Research > 15-11 (November 2022) . - p.2026-2037 Titre : Electroretinography in adults with high-functioning autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Evelyn B. N. FRIEDEL, Auteur ; Mirjam SCHAFER, Auteur ; Dominique ENDRES, Auteur ; Simon MAIER, Auteur ; Kimon RUNGE, Auteur ; Michael BACH, Auteur ; Sven P. HEINRICH, Auteur ; Dieter EBERT, Auteur ; Katharina DOMSCHKE, Auteur ; Ludger TEBARTZ VAN ELST, Auteur ; Kathrin NICKEL, Auteur Article en page(s) : p.2026-2037 Langues : Anglais (eng) Mots-clés : Adult  Humans  Electroretinography/methods  Retinal Ganglion Cells/physiology  Autism Spectrum Disorder  Photic Stimulation  Retina/physiology  Asd  Erg  PhNR  a-wave  autism spectrum disorder  b-wave  electroretinogram  photopic negative response Index. décimale : PER Périodiques Résumé : The electroretinogram (ERG) allows the investigation of retinal signaling pathways and has increasingly been applied in individuals with mental disorders in search for potential biomarkers of neurodevelopmental disorders. Preceding ERG examinations in individuals with autism spectrum disorders (ASD) showed inconsistent results, which might be due to the small number of participants, heterogeneity of the ASD population, differences in age ranges, and stimulation methods. The aim of this study was to investigate functional retinal responses in adults with ASD by means of the light-adapted (photopic) ERG. Light-adapted ERG measurements were obtained with the RETeval® system applying three different stimulation protocols. In the final analysis, the ERG parameters a-wave, b-wave, the photopic negative response (PhNR), the photopic hill parameters as well as additional amplitude ratios were compared between 32 adults with high-functioning ASD and 31 non-autistic controls. Both groups were matched with regard to sex and age. No significant functional retinal differences in amplitude or peak time of the a- or b-wave, PhNR, the photopic hill parameters or the ERG-amplitude ratios could be detected in individuals with ASD compared to non-autistic participants. The absence of electrophysiological functional retinal alterations in ASD, suggests that changes in visual perception, such as increased attention to detail or visual hypersensitivity in ASD, are not due to impairments at early levels of retinal signal processing. En ligne : http://dx.doi.org/10.1002/aur.2823 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Electroretinography in adults with high-functioning autism spectrum disorder [Texte imprimé et/ou numérique] / Evelyn B. N. FRIEDEL, Auteur ; Mirjam SCHAFER, Auteur ; Dominique ENDRES, Auteur ; Simon MAIER, Auteur ; Kimon RUNGE, Auteur ; Michael BACH, Auteur ; Sven P. HEINRICH, Auteur ; Dieter EBERT, Auteur ; Katharina DOMSCHKE, Auteur ; Ludger TEBARTZ VAN ELST, Auteur ; Kathrin NICKEL, Auteur . - p.2026-2037. Langues : Anglais (eng) in Autism Research > 15-11 (November 2022) . - p.2026-2037 Mots-clés : Adult  Humans  Electroretinography/methods  Retinal Ganglion Cells/physiology  Autism Spectrum Disorder  Photic Stimulation  Retina/physiology  Asd  Erg  PhNR  a-wave  autism spectrum disorder  b-wave  electroretinogram  photopic negative response Index. décimale : PER Périodiques Résumé : The electroretinogram (ERG) allows the investigation of retinal signaling pathways and has increasingly been applied in individuals with mental disorders in search for potential biomarkers of neurodevelopmental disorders. Preceding ERG examinations in individuals with autism spectrum disorders (ASD) showed inconsistent results, which might be due to the small number of participants, heterogeneity of the ASD population, differences in age ranges, and stimulation methods. The aim of this study was to investigate functional retinal responses in adults with ASD by means of the light-adapted (photopic) ERG. Light-adapted ERG measurements were obtained with the RETeval® system applying three different stimulation protocols. In the final analysis, the ERG parameters a-wave, b-wave, the photopic negative response (PhNR), the photopic hill parameters as well as additional amplitude ratios were compared between 32 adults with high-functioning ASD and 31 non-autistic controls. Both groups were matched with regard to sex and age. No significant functional retinal differences in amplitude or peak time of the a- or b-wave, PhNR, the photopic hill parameters or the ERG-amplitude ratios could be detected in individuals with ASD compared to non-autistic participants. The absence of electrophysiological functional retinal alterations in ASD, suggests that changes in visual perception, such as increased attention to detail or visual hypersensitivity in ASD, are not due to impairments at early levels of retinal signal processing. En ligne : http://dx.doi.org/10.1002/aur.2823 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Maternal risk factors vary between subpopulations of children with autism spectrum disorder / Genevieve GRIVAS in Autism Research, 15-11 (November 2022)  

Public ISBD [article]  inAutism Research > 15-11 (November 2022) . - p.2038-2055 Titre : Maternal risk factors vary between subpopulations of children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Genevieve GRIVAS, Auteur ; Richard E. FRYE, Auteur ; Juergen HAHN, Auteur Article en page(s) : p.2038-2055 Langues : Anglais (eng) Mots-clés : Child  Pregnancy  Female  Humans  Autism Spectrum Disorder/complications/epidemiology/diagnosis  Case-Control Studies  Pregnancy Complications  Risk Factors  Immune System Diseases/complications  Seizures/complications  associated risk  autism spectrum disorder  co-occurring conditions  logistic regression  medical claims  retrospective analysis  subgroups Index. décimale : PER Périodiques Résumé : Previous work identified three subgroups of children with ASD based upon co-occurring conditions (COCs) diagnosed during the first 5 years of life. This work examines prenatal risk factors, given by maternal medical claims, for each of the three subgroups: children with a High-Prevalence of COCs, children with mainly developmental delay and seizures (DD/Seizure COCs), and children with a Low-Prevalence of COCs. While some risk factors are shared by all three subgroups, the majority of the factors identified for each subgroup were unique; infections, anti-inflammatory and other complex medications were associated with the High-Prevalence COCs group; immune deregulatory conditions such as asthma and joint disorders were associated with the DD/Seizure COCs group; and overall pregnancy complications were associated with the Low-Prevalence COCs group. Thus, we have found that the previously identified subgroups of children with ASD have distinct associated prenatal risk factors. As such, this work supports subgrouping children with ASD based upon COCs, which may provide a framework for elucidating some of the heterogeneity associated with ASD. En ligne : http://dx.doi.org/10.1002/aur.2809 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Maternal risk factors vary between subpopulations of children with autism spectrum disorder [Texte imprimé et/ou numérique] / Genevieve GRIVAS, Auteur ; Richard E. FRYE, Auteur ; Juergen HAHN, Auteur . - p.2038-2055. Langues : Anglais (eng) in Autism Research > 15-11 (November 2022) . - p.2038-2055 Mots-clés : Child  Pregnancy  Female  Humans  Autism Spectrum Disorder/complications/epidemiology/diagnosis  Case-Control Studies  Pregnancy Complications  Risk Factors  Immune System Diseases/complications  Seizures/complications  associated risk  autism spectrum disorder  co-occurring conditions  logistic regression  medical claims  retrospective analysis  subgroups Index. décimale : PER Périodiques Résumé : Previous work identified three subgroups of children with ASD based upon co-occurring conditions (COCs) diagnosed during the first 5 years of life. This work examines prenatal risk factors, given by maternal medical claims, for each of the three subgroups: children with a High-Prevalence of COCs, children with mainly developmental delay and seizures (DD/Seizure COCs), and children with a Low-Prevalence of COCs. While some risk factors are shared by all three subgroups, the majority of the factors identified for each subgroup were unique; infections, anti-inflammatory and other complex medications were associated with the High-Prevalence COCs group; immune deregulatory conditions such as asthma and joint disorders were associated with the DD/Seizure COCs group; and overall pregnancy complications were associated with the Low-Prevalence COCs group. Thus, we have found that the previously identified subgroups of children with ASD have distinct associated prenatal risk factors. As such, this work supports subgrouping children with ASD based upon COCs, which may provide a framework for elucidating some of the heterogeneity associated with ASD. En ligne : http://dx.doi.org/10.1002/aur.2809 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Behavioral responses to fevers and other medical events in children with and without ASD / Katherine BYRNE in Autism Research, 15-11 (November 2022)  

Public ISBD [article]  inAutism Research > 15-11 (November 2022) . - p.2056-2063 Titre : Behavioral responses to fevers and other medical events in children with and without ASD Type de document : Texte imprimé et/ou numérique Auteurs : Katherine BYRNE, Auteur ; Shuting ZHENG, Auteur ; Somer BISHOP, Auteur ; Juliana BOUCHER, Auteur ; Sheila GHODS, Auteur ; So Hyun KIM, Auteur ; Catherine LORD, Auteur Article en page(s) : p.2056-2063 Langues : Anglais (eng) Mots-clés : Child  Humans  Autism Spectrum Disorder/complications/psychology  Retrospective Studies  Prospective Studies  Emotions  Parents  Fever/complications  autism spectrum disorder  behavioral symptoms  fever  illness behavior Index. décimale : PER Périodiques Résumé : Anecdotal reports and a small number of research studies suggest possible behavioral improvements in children with autism spectrum disorders (ASD) during a fever. However, previous studies rely largely on retrospective reports of this phenomenon. Establishing a robust association between fever and reduction of ASD-related symptoms would promote opportunities for the development of innovative therapeutic interventions for children with ASD. In the current study, prospective data were collected from 141 children with ASD and 103 typically developing (TD) controls using parent responses to an 11-item behavioral survey. Behaviors when no illness was present, during a fever, the week after a fever, and during non-febrile illnesses for TD and ASD children were compared. Profiles of cases in which caregivers reported consistent behavioral improvements during fever are described. Data indicated worsening social, emotional/behavioral, and somatic symptoms during a fever regardless of diagnosis, with children with ASD demonstrating greater worsening of behaviors during a fever than TD children. Only three out of 141 children with ASD demonstrated consistent behavioral improvements during a fever; these children had a range of cognitive and adaptive skills. Children with ASD had stronger negative responses to fever than TD children. These findings contradict previous literature suggesting behavioral improvements for children with ASD. While improvements may occur for some children, it does not appear to be a common phenomenon. Additional research is needed to elucidate the nature of behavioral improvements in the subset of children with ASD who may respond positively to fever. En ligne : http://dx.doi.org/10.1002/aur.2810 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Behavioral responses to fevers and other medical events in children with and without ASD [Texte imprimé et/ou numérique] / Katherine BYRNE, Auteur ; Shuting ZHENG, Auteur ; Somer BISHOP, Auteur ; Juliana BOUCHER, Auteur ; Sheila GHODS, Auteur ; So Hyun KIM, Auteur ; Catherine LORD, Auteur . - p.2056-2063. Langues : Anglais (eng) in Autism Research > 15-11 (November 2022) . - p.2056-2063 Mots-clés : Child  Humans  Autism Spectrum Disorder/complications/psychology  Retrospective Studies  Prospective Studies  Emotions  Parents  Fever/complications  autism spectrum disorder  behavioral symptoms  fever  illness behavior Index. décimale : PER Périodiques Résumé : Anecdotal reports and a small number of research studies suggest possible behavioral improvements in children with autism spectrum disorders (ASD) during a fever. However, previous studies rely largely on retrospective reports of this phenomenon. Establishing a robust association between fever and reduction of ASD-related symptoms would promote opportunities for the development of innovative therapeutic interventions for children with ASD. In the current study, prospective data were collected from 141 children with ASD and 103 typically developing (TD) controls using parent responses to an 11-item behavioral survey. Behaviors when no illness was present, during a fever, the week after a fever, and during non-febrile illnesses for TD and ASD children were compared. Profiles of cases in which caregivers reported consistent behavioral improvements during fever are described. Data indicated worsening social, emotional/behavioral, and somatic symptoms during a fever regardless of diagnosis, with children with ASD demonstrating greater worsening of behaviors during a fever than TD children. Only three out of 141 children with ASD demonstrated consistent behavioral improvements during a fever; these children had a range of cognitive and adaptive skills. Children with ASD had stronger negative responses to fever than TD children. These findings contradict previous literature suggesting behavioral improvements for children with ASD. While improvements may occur for some children, it does not appear to be a common phenomenon. Additional research is needed to elucidate the nature of behavioral improvements in the subset of children with ASD who may respond positively to fever. En ligne : http://dx.doi.org/10.1002/aur.2810 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Parasympathetic withdrawal indexes risk for emotion dysregulation in children with autism spectrum disorder / Jason K. BAKER in Autism Research, 15-11 (November 2022)  

Public ISBD [article]  inAutism Research > 15-11 (November 2022) . - p.2064-2068 Titre : Parasympathetic withdrawal indexes risk for emotion dysregulation in children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Jason K. BAKER, Auteur ; Rachel M. FENNING, Auteur ; Stephen A. ERATH, Auteur ; Sarah FABIAN, Auteur Article en page(s) : p.2064-2068 Langues : Anglais (eng) Mots-clés : Child  Humans  Autism Spectrum Disorder  Respiratory Sinus Arrhythmia/physiology  Parasympathetic Nervous System  Arrhythmia, Sinus  Emotions/physiology  autism spectrum disorder  emotion regulation  psychophysiology  respiratory sinus arrythmia  risk Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorder (ASD) experience significant difficulties with emotion regulation. Theory and empirical evidence suggest substantial biological contributions to regulatory challenges, which may be related to core ASD symptoms. Respiratory sinus arrythmia (RSA) is a measure of parasympathetic nervous system activity that serves as a putative biomarker for emotion regulation. Higher baseline RSA and more RSA reactivity (parasympathetic withdrawal; RSA-R) in response to challenge appear adaptive in non-clinical populations, but existing evidence for children with ASD remains inconclusive. The current study examined correlates of observed emotion dysregulation in 61 children with ASD between the ages of 6 and 10 years, including ASD symptom levels as well as both baseline RSA and concurrent RSA reactivity. Consistent with previous research, ASD symptom level was significantly correlated with observed dysregulation whereas additional factors such as child IQ were not. Baseline RSA was unrelated to observed dysregulation, but higher RSA reactivity predicted concurrent dysregulation above and beyond the contribution of child ASD symptoms. Findings contribute to an emerging understanding of dysregulation in these children, raise questions about the utility of traditional baseline RSA measures for this population, and clarify the functional significance of RSA reactivity as a risk factor for emotion dysregulation in children with ASD. En ligne : http://dx.doi.org/10.1002/aur.2814 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Parasympathetic withdrawal indexes risk for emotion dysregulation in children with autism spectrum disorder [Texte imprimé et/ou numérique] / Jason K. BAKER, Auteur ; Rachel M. FENNING, Auteur ; Stephen A. ERATH, Auteur ; Sarah FABIAN, Auteur . - p.2064-2068. Langues : Anglais (eng) in Autism Research > 15-11 (November 2022) . - p.2064-2068 Mots-clés : Child  Humans  Autism Spectrum Disorder  Respiratory Sinus Arrhythmia/physiology  Parasympathetic Nervous System  Arrhythmia, Sinus  Emotions/physiology  autism spectrum disorder  emotion regulation  psychophysiology  respiratory sinus arrythmia  risk Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorder (ASD) experience significant difficulties with emotion regulation. Theory and empirical evidence suggest substantial biological contributions to regulatory challenges, which may be related to core ASD symptoms. Respiratory sinus arrythmia (RSA) is a measure of parasympathetic nervous system activity that serves as a putative biomarker for emotion regulation. Higher baseline RSA and more RSA reactivity (parasympathetic withdrawal; RSA-R) in response to challenge appear adaptive in non-clinical populations, but existing evidence for children with ASD remains inconclusive. The current study examined correlates of observed emotion dysregulation in 61 children with ASD between the ages of 6 and 10 years, including ASD symptom levels as well as both baseline RSA and concurrent RSA reactivity. Consistent with previous research, ASD symptom level was significantly correlated with observed dysregulation whereas additional factors such as child IQ were not. Baseline RSA was unrelated to observed dysregulation, but higher RSA reactivity predicted concurrent dysregulation above and beyond the contribution of child ASD symptoms. Findings contribute to an emerging understanding of dysregulation in these children, raise questions about the utility of traditional baseline RSA measures for this population, and clarify the functional significance of RSA reactivity as a risk factor for emotion dysregulation in children with ASD. En ligne : http://dx.doi.org/10.1002/aur.2814 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Separate scoring algorithms for specific identification priorities optimize the screening properties of the Screening Tool for Autism in Toddlers (STAT) / Shana M. ATTAR in Autism Research, 15-11 (November 2022)  

Public ISBD [article]  inAutism Research > 15-11 (November 2022) . - p.2069-2080 Titre : Separate scoring algorithms for specific identification priorities optimize the screening properties of the Screening Tool for Autism in Toddlers (STAT) Type de document : Texte imprimé et/ou numérique Auteurs : Shana M. ATTAR, Auteur ; Lisa V. IBANEZ, Auteur ; Wendy L. STONE, Auteur Article en page(s) : p.2069-2080 Langues : Anglais (eng) Mots-clés : Child, Preschool  Humans  Autism Spectrum Disorder/diagnosis  Autistic Disorder/diagnosis  Mass Screening/methods  Algorithms  ROC Curve  Asd  autism  community  diagnosis  novel assessments  screening  author’s share of royalties from Vanderbilt University for sales. Index. décimale : PER Périodiques Résumé : The Screening Tool for Autism in Toddlers (STAT) is a validated stage-2 autism spectrum disorder (ASD) screening measure that takes 20 minutes to administer and comprises 12 play-based items that are scored according to specific criteria. This study examines an expanded version (STAT-E) that includes the examiner's subjective ratings of children's social engagement (SE) and atypical behaviors (AB) in the scoring algorithm. The sample comprised 238 children who were 24-35 months old. The STAT-E assessors had limited ASD experience to mimic its use by community-based non-specialists, and were trained using a scalable web-based platform. A diagnostic evaluation was completed by clinical experts who were blind to the STAT-E results. Logistic regression, ROC curves, and classification matrices and metrics were used to determine the screening properties of STAT-E when scored using the original STAT scoring algorithm versus a new algorithm that included the SE and AB ratings. Inclusion of the SE and AB ratings improved positive risk classification appreciably, while the specificity declined. These results suggest that the STAT-E using the original STAT scoring algorithm optimizes specificity, while the STAT-E scoring algorithm with the two new ratings optimizes the positive risk classification. Using multiple scoring algorithms on the STAT may provide improved screening accuracy for diverse contexts, and a scalable web-based tutorial may be a pathway for increasing the number of community providers who can administer the STAT and contribute toward increased rates of autism screening. En ligne : http://dx.doi.org/10.1002/aur.2799 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Separate scoring algorithms for specific identification priorities optimize the screening properties of the Screening Tool for Autism in Toddlers (STAT) [Texte imprimé et/ou numérique] / Shana M. ATTAR, Auteur ; Lisa V. IBANEZ, Auteur ; Wendy L. STONE, Auteur . - p.2069-2080. Langues : Anglais (eng) in Autism Research > 15-11 (November 2022) . - p.2069-2080 Mots-clés : Child, Preschool  Humans  Autism Spectrum Disorder/diagnosis  Autistic Disorder/diagnosis  Mass Screening/methods  Algorithms  ROC Curve  Asd  autism  community  diagnosis  novel assessments  screening  author’s share of royalties from Vanderbilt University for sales. Index. décimale : PER Périodiques Résumé : The Screening Tool for Autism in Toddlers (STAT) is a validated stage-2 autism spectrum disorder (ASD) screening measure that takes 20 minutes to administer and comprises 12 play-based items that are scored according to specific criteria. This study examines an expanded version (STAT-E) that includes the examiner's subjective ratings of children's social engagement (SE) and atypical behaviors (AB) in the scoring algorithm. The sample comprised 238 children who were 24-35 months old. The STAT-E assessors had limited ASD experience to mimic its use by community-based non-specialists, and were trained using a scalable web-based platform. A diagnostic evaluation was completed by clinical experts who were blind to the STAT-E results. Logistic regression, ROC curves, and classification matrices and metrics were used to determine the screening properties of STAT-E when scored using the original STAT scoring algorithm versus a new algorithm that included the SE and AB ratings. Inclusion of the SE and AB ratings improved positive risk classification appreciably, while the specificity declined. These results suggest that the STAT-E using the original STAT scoring algorithm optimizes specificity, while the STAT-E scoring algorithm with the two new ratings optimizes the positive risk classification. Using multiple scoring algorithms on the STAT may provide improved screening accuracy for diverse contexts, and a scalable web-based tutorial may be a pathway for increasing the number of community providers who can administer the STAT and contribute toward increased rates of autism screening. En ligne : http://dx.doi.org/10.1002/aur.2799 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Sensory processing in 16p11.2 deletion and 16p11.2 duplication / Harriet SMITH in Autism Research, 15-11 (November 2022)  

Public ISBD [article]  inAutism Research > 15-11 (November 2022) . - p.2081-2098 Titre : Sensory processing in 16p11.2 deletion and 16p11.2 duplication Type de document : Texte imprimé et/ou numérique Auteurs : Harriet SMITH, Auteur ; Chloe LANE, Auteur ; Reem AL-JAWAHIRI, Auteur ; Megan FREETH, Auteur Article en page(s) : p.2081-2098 Langues : Anglais (eng) Mots-clés : Child  Humans  Chromosome Deletion  Autism Spectrum Disorder/genetics  Autistic Disorder/genetics  Intellectual Disability/genetics  Perception  Chromosomes, Human, Pair 16/genetics  Chromosome Disorders/complications/genetics  Adhd  anxiety  autistic  sensory processing  sensory systems Index. décimale : PER Périodiques Résumé : Deletions and duplications at the chromosomal region of 16p11.2 have a broad range of phenotypic effects including increased likelihood of intellectual disability, autism, attention deficit hyperactivity disorder (ADHD), epilepsy, and language and motor delays. However, whether and how sensory processing is affected has not yet been considered in detail. Parents/caregivers of 38 children with a 16p11.2 deletion and 31 children with a 16p11.2 duplication completed the Sensory Behavior Questionnaire (SBQ) and the Child Sensory Profile 2 (CSP-2) along with other standardized questionnaires assessing autistic traits (SRS-2), ADHD traits (Conners 3), anxiety (SCAS-P) and adaptive behavior (VABS-3). SBQ and CSP-2 responses found that sensory processing differences were clearly evident in both 16p11.2 deletion and 16p11.2 duplication, though there was significant variation in both cohorts. SBQ data indicated the frequency and impact of sensory behavior were more severe when compared to neurotypical children, with levels being similar to autistic children. CSP-2 data indicated over 70% of children displayed clear differences in sensory registration (missing sensory input). Seventy-one percent with 16p11.2 duplications were also unusually sensitive to sensory information and 57% with 16p11.2 duplications were unusually avoidant of sensory stimuli. This first detailed assessment of sensory processing, alongside other clinical features, in relatively large cohorts of children with a 16p11.2 deletion and 16p11.2 duplication demonstrates that sensory processing differences have a profound impact on their lives. En ligne : http://dx.doi.org/10.1002/aur.2802 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Sensory processing in 16p11.2 deletion and 16p11.2 duplication [Texte imprimé et/ou numérique] / Harriet SMITH, Auteur ; Chloe LANE, Auteur ; Reem AL-JAWAHIRI, Auteur ; Megan FREETH, Auteur . - p.2081-2098. Langues : Anglais (eng) in Autism Research > 15-11 (November 2022) . - p.2081-2098 Mots-clés : Child  Humans  Chromosome Deletion  Autism Spectrum Disorder/genetics  Autistic Disorder/genetics  Intellectual Disability/genetics  Perception  Chromosomes, Human, Pair 16/genetics  Chromosome Disorders/complications/genetics  Adhd  anxiety  autistic  sensory processing  sensory systems Index. décimale : PER Périodiques Résumé : Deletions and duplications at the chromosomal region of 16p11.2 have a broad range of phenotypic effects including increased likelihood of intellectual disability, autism, attention deficit hyperactivity disorder (ADHD), epilepsy, and language and motor delays. However, whether and how sensory processing is affected has not yet been considered in detail. Parents/caregivers of 38 children with a 16p11.2 deletion and 31 children with a 16p11.2 duplication completed the Sensory Behavior Questionnaire (SBQ) and the Child Sensory Profile 2 (CSP-2) along with other standardized questionnaires assessing autistic traits (SRS-2), ADHD traits (Conners 3), anxiety (SCAS-P) and adaptive behavior (VABS-3). SBQ and CSP-2 responses found that sensory processing differences were clearly evident in both 16p11.2 deletion and 16p11.2 duplication, though there was significant variation in both cohorts. SBQ data indicated the frequency and impact of sensory behavior were more severe when compared to neurotypical children, with levels being similar to autistic children. CSP-2 data indicated over 70% of children displayed clear differences in sensory registration (missing sensory input). Seventy-one percent with 16p11.2 duplications were also unusually sensitive to sensory information and 57% with 16p11.2 duplications were unusually avoidant of sensory stimuli. This first detailed assessment of sensory processing, alongside other clinical features, in relatively large cohorts of children with a 16p11.2 deletion and 16p11.2 duplication demonstrates that sensory processing differences have a profound impact on their lives. En ligne : http://dx.doi.org/10.1002/aur.2802 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Child language and autism diagnosis impact hierarchical temporal structure of parent-child vocal interactions in early childhood / Olivia BOOROM in Autism Research, 15-11 (November 2022)  

Public ISBD [article]  inAutism Research > 15-11 (November 2022) . - p.2099-2111 Titre : Child language and autism diagnosis impact hierarchical temporal structure of parent-child vocal interactions in early childhood Type de document : Texte imprimé et/ou numérique Auteurs : Olivia BOOROM, Auteur ; Camila ALVIAR, Auteur ; Yumeng ZHANG, Auteur ; Valerie A. MUÑOZ, Auteur ; Christopher T. KELLO, Auteur ; Miriam D. LENSE, Auteur Article en page(s) : p.2099-2111 Langues : Anglais (eng) Mots-clés : Infant  Child  Child, Preschool  Male  Humans  Female  Child Language  Autistic Disorder/complications  Autism Spectrum Disorder/diagnosis/complications  Parent-Child Relations  Social Skills  autism spectrum disorder  hierarchical temporal structure  interaction dynamics  language development  parent-child interaction  social reciprocity Index. décimale : PER Périodiques Résumé : Timing is critical to successful social interactions. The temporal structure of dyadic vocal interactions emerges from the rhythm, timing, and frequency of each individuals' vocalizations and reflects how the dyad dynamically organizes and adapts during an interaction. This study investigated the temporal structure of vocal interactions longitudinally in parent-child dyads of typically developing (TD) infants (n = 49; 9-18 months; 48% male) and toddlers with ASD (n = 23; 27.2 Â+ 5.0 months; 91.3% male) to identify how developing language and social skills impact the temporal dynamics of the interaction. Acoustic hierarchical temporal structure (HTS), a measure of the nested clustering of acoustic events across multiple timescales, was measured in free play interactions using Allan Factor. HTS reflects a signal's temporal complexity and variability, with greater HTS indicating reduced flexibility of the dyadic system. Child expressive language significantly predicted HTS (ß = -0.2) longitudinally across TD infants, with greater dyadic HTS associated with lower child language skills. ASD dyads exhibited greater HTS (i.e., more rigid temporal structure) than nonverbal matched (d = 0.41) and expressive language matched TD dyads (d = 0.28). Increased HTS in ASD dyads occurred at timescales>1 s, suggesting greater structuring of pragmatic aspects of interaction. Results provide a new window into how language development and social reciprocity serve as constraints to shape parent-child interaction dynamics and showcase a novel automated approach to characterizing vocal interactions across multiple timescales during early childhood. En ligne : http://dx.doi.org/10.1002/aur.2804 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Child language and autism diagnosis impact hierarchical temporal structure of parent-child vocal interactions in early childhood [Texte imprimé et/ou numérique] / Olivia BOOROM, Auteur ; Camila ALVIAR, Auteur ; Yumeng ZHANG, Auteur ; Valerie A. MUÑOZ, Auteur ; Christopher T. KELLO, Auteur ; Miriam D. LENSE, Auteur . - p.2099-2111. Langues : Anglais (eng) in Autism Research > 15-11 (November 2022) . - p.2099-2111 Mots-clés : Infant  Child  Child, Preschool  Male  Humans  Female  Child Language  Autistic Disorder/complications  Autism Spectrum Disorder/diagnosis/complications  Parent-Child Relations  Social Skills  autism spectrum disorder  hierarchical temporal structure  interaction dynamics  language development  parent-child interaction  social reciprocity Index. décimale : PER Périodiques Résumé : Timing is critical to successful social interactions. The temporal structure of dyadic vocal interactions emerges from the rhythm, timing, and frequency of each individuals' vocalizations and reflects how the dyad dynamically organizes and adapts during an interaction. This study investigated the temporal structure of vocal interactions longitudinally in parent-child dyads of typically developing (TD) infants (n = 49; 9-18 months; 48% male) and toddlers with ASD (n = 23; 27.2 Â+ 5.0 months; 91.3% male) to identify how developing language and social skills impact the temporal dynamics of the interaction. Acoustic hierarchical temporal structure (HTS), a measure of the nested clustering of acoustic events across multiple timescales, was measured in free play interactions using Allan Factor. HTS reflects a signal's temporal complexity and variability, with greater HTS indicating reduced flexibility of the dyadic system. Child expressive language significantly predicted HTS (ß = -0.2) longitudinally across TD infants, with greater dyadic HTS associated with lower child language skills. ASD dyads exhibited greater HTS (i.e., more rigid temporal structure) than nonverbal matched (d = 0.41) and expressive language matched TD dyads (d = 0.28). Increased HTS in ASD dyads occurred at timescales>1 s, suggesting greater structuring of pragmatic aspects of interaction. Results provide a new window into how language development and social reciprocity serve as constraints to shape parent-child interaction dynamics and showcase a novel automated approach to characterizing vocal interactions across multiple timescales during early childhood. En ligne : http://dx.doi.org/10.1002/aur.2804 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Associations between co-occurring conditions and age of autism diagnosis: Implications for mental health training and adult autism research / Nikita JADAV in Autism Research, 15-11 (November 2022)  

Public ISBD [article]  inAutism Research > 15-11 (November 2022) . - p.2112-2125 Titre : Associations between co-occurring conditions and age of autism diagnosis: Implications for mental health training and adult autism research Type de document : Texte imprimé et/ou numérique Auteurs : Nikita JADAV, Auteur ; Vanessa H. BAL, Auteur Article en page(s) : p.2112-2125 Langues : Anglais (eng) Mots-clés : Adult  Female  Infant, Newborn  Humans  Adolescent  Young Adult  Middle Aged  Aged  Aged, 80 and over  Autistic Disorder/complications/diagnosis/epidemiology  Autism Spectrum Disorder/complications/diagnosis/epidemiology  Mental Health  Surveys and Questionnaires  adults  aging/ASD in adults  clinical psychology  co-morbid conditions  Psychological Services and has received honoraria and/or consulting fees from  Regeneron, Janssen and Simons Foundation for unrelated work. Index. décimale : PER Périodiques Résumé : Adult autism studies are increasingly comprised of later-diagnosed adults, yet little is known about how these adults compare to those diagnosed earlier in life. The present study examines medical and psychiatric conditions endorsed by autistic adults and documents differences between those diagnosed with ASD in childhood versus adulthood, as well as across age groups and sex at birth. 4657 legally independent adults (ages 18-85, M = 33.4 years) with professional ASD diagnoses who completed a medical questionnaire were drawn from the Simons Powering Autism Research Knowledge (SPARK) study. Chi square analyses, t-tests, and logistic regressions were used to compare medical and psychiatric conditions between age groups, sex at birth and adults diagnosed in childhood (before age 21) versus adulthood (at or after 21 years). Overall number of conditions endorsed as being diagnosed by a professional was high, with an average of 1.69 (SD = 2.01) medical or developmental and 2.98 (SD = 2.29) psychiatric conditions reported across the sample. Females were more likely to endorse psychiatric conditions (OR = 1.68). Adult-diagnosed adults were more likely to endorse psychiatric conditions (OR = 2.71) and reported more lifetime psychiatric diagnoses (M = 3.15, SD = 2.23) than their childhood-diagnosed counterparts (M = 2.81, SD = 2.33). These findings underscore the need for research to better understand and treat co-occurring psychiatric conditions in autistic adults and report and consider the age of diagnosis in adult autism samples. Moreover, results suggest it is imperative that mental health professionals receive autism training to promote accurate differential diagnosis and equitable access to mental health care for autistic adults with co-occurring psychiatric conditions. En ligne : http://dx.doi.org/10.1002/aur.2808 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Associations between co-occurring conditions and age of autism diagnosis: Implications for mental health training and adult autism research [Texte imprimé et/ou numérique] / Nikita JADAV, Auteur ; Vanessa H. BAL, Auteur . - p.2112-2125. Langues : Anglais (eng) in Autism Research > 15-11 (November 2022) . - p.2112-2125 Mots-clés : Adult  Female  Infant, Newborn  Humans  Adolescent  Young Adult  Middle Aged  Aged  Aged, 80 and over  Autistic Disorder/complications/diagnosis/epidemiology  Autism Spectrum Disorder/complications/diagnosis/epidemiology  Mental Health  Surveys and Questionnaires  adults  aging/ASD in adults  clinical psychology  co-morbid conditions  Psychological Services and has received honoraria and/or consulting fees from  Regeneron, Janssen and Simons Foundation for unrelated work. Index. décimale : PER Périodiques Résumé : Adult autism studies are increasingly comprised of later-diagnosed adults, yet little is known about how these adults compare to those diagnosed earlier in life. The present study examines medical and psychiatric conditions endorsed by autistic adults and documents differences between those diagnosed with ASD in childhood versus adulthood, as well as across age groups and sex at birth. 4657 legally independent adults (ages 18-85, M = 33.4 years) with professional ASD diagnoses who completed a medical questionnaire were drawn from the Simons Powering Autism Research Knowledge (SPARK) study. Chi square analyses, t-tests, and logistic regressions were used to compare medical and psychiatric conditions between age groups, sex at birth and adults diagnosed in childhood (before age 21) versus adulthood (at or after 21 years). Overall number of conditions endorsed as being diagnosed by a professional was high, with an average of 1.69 (SD = 2.01) medical or developmental and 2.98 (SD = 2.29) psychiatric conditions reported across the sample. Females were more likely to endorse psychiatric conditions (OR = 1.68). Adult-diagnosed adults were more likely to endorse psychiatric conditions (OR = 2.71) and reported more lifetime psychiatric diagnoses (M = 3.15, SD = 2.23) than their childhood-diagnosed counterparts (M = 2.81, SD = 2.33). These findings underscore the need for research to better understand and treat co-occurring psychiatric conditions in autistic adults and report and consider the age of diagnosis in adult autism samples. Moreover, results suggest it is imperative that mental health professionals receive autism training to promote accurate differential diagnosis and equitable access to mental health care for autistic adults with co-occurring psychiatric conditions. En ligne : http://dx.doi.org/10.1002/aur.2808 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Patterns of sleep disturbances and associations with depressive symptoms in autistic young adults / Linnea A. LAMPINEN in Autism Research, 15-11 (November 2022)  

Public ISBD [article]  inAutism Research > 15-11 (November 2022) . - p.2126-2137 Titre : Patterns of sleep disturbances and associations with depressive symptoms in autistic young adults Type de document : Texte imprimé et/ou numérique Auteurs : Linnea A. LAMPINEN, Auteur ; Shuting ZHENG, Auteur ; Julie LOUNDS TAYLOR, Auteur ; Ryan E. ADAMS, Auteur ; Florencia PEZZIMENTI, Auteur ; Lauren D. ASARNOW, Auteur ; Somer L. BISHOP, Auteur Article en page(s) : p.2126-2137 Langues : Anglais (eng) Mots-clés : Humans  Young Adult  Child  Adolescent  Adult  Autistic Disorder/complications  Depression/complications/epidemiology  Autism Spectrum Disorder/complications/epidemiology  Sleep Wake Disorders/complications/epidemiology  Sleep  delayed phase  depression  sleep efficiency  young adults Index. décimale : PER Périodiques Résumé : Autistic individuals are at an increased risk for both sleep disturbances and depression. While studies in the general population and in autistic adults have drawn general links between sleep disturbances and mental health, few studies have examined the extent to which specific sleep problems may be implicated in the extremely high rates of depression among autistic adults. This study aimed to describe the patterns of sleep disturbances in autistic young adults, and their associations with depressive symptoms while controlling for relevant demographic factors. A sample of 304 legally independent adults (age 18-35 years old) with a childhood diagnosis of autism spectrum disorder self-reported on their average sleep behaviors during the past week and depressive symptoms on the Beck Depressive Inventory-II. A significant proportion (86.01%) of autistic young adults experienced at least one of the primary sleep disturbances of interest, including short total sleep time (39.59%), poor sleep efficiency (60.07%), and delayed sleep phase (36.18%). Additionally, lower sleep efficiency and delayed sleep phase were both associated with higher depressive symptoms. The associations between sleep and depressive symptoms identified in our study suggest that sleep treatments may hold potential for ameliorating depressive symptoms in autistic adults who also experience sleep problems. Further research using daily sleep diaries and objective measures of sleep behaviors, as well as longitudinal studies, are needed to understand how changes in sleep may relate to changes in depressive symptoms in autistic adults. En ligne : http://dx.doi.org/10.1002/aur.2812 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Patterns of sleep disturbances and associations with depressive symptoms in autistic young adults [Texte imprimé et/ou numérique] / Linnea A. LAMPINEN, Auteur ; Shuting ZHENG, Auteur ; Julie LOUNDS TAYLOR, Auteur ; Ryan E. ADAMS, Auteur ; Florencia PEZZIMENTI, Auteur ; Lauren D. ASARNOW, Auteur ; Somer L. BISHOP, Auteur . - p.2126-2137. Langues : Anglais (eng) in Autism Research > 15-11 (November 2022) . - p.2126-2137 Mots-clés : Humans  Young Adult  Child  Adolescent  Adult  Autistic Disorder/complications  Depression/complications/epidemiology  Autism Spectrum Disorder/complications/epidemiology  Sleep Wake Disorders/complications/epidemiology  Sleep  delayed phase  depression  sleep efficiency  young adults Index. décimale : PER Périodiques Résumé : Autistic individuals are at an increased risk for both sleep disturbances and depression. While studies in the general population and in autistic adults have drawn general links between sleep disturbances and mental health, few studies have examined the extent to which specific sleep problems may be implicated in the extremely high rates of depression among autistic adults. This study aimed to describe the patterns of sleep disturbances in autistic young adults, and their associations with depressive symptoms while controlling for relevant demographic factors. A sample of 304 legally independent adults (age 18-35 years old) with a childhood diagnosis of autism spectrum disorder self-reported on their average sleep behaviors during the past week and depressive symptoms on the Beck Depressive Inventory-II. A significant proportion (86.01%) of autistic young adults experienced at least one of the primary sleep disturbances of interest, including short total sleep time (39.59%), poor sleep efficiency (60.07%), and delayed sleep phase (36.18%). Additionally, lower sleep efficiency and delayed sleep phase were both associated with higher depressive symptoms. The associations between sleep and depressive symptoms identified in our study suggest that sleep treatments may hold potential for ameliorating depressive symptoms in autistic adults who also experience sleep problems. Further research using daily sleep diaries and objective measures of sleep behaviors, as well as longitudinal studies, are needed to understand how changes in sleep may relate to changes in depressive symptoms in autistic adults. En ligne : http://dx.doi.org/10.1002/aur.2812 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Parasympathetic functioning and sleep problems in children with autism spectrum disorder / Hillary K. SCHILTZ in Autism Research, 15-11 (November 2022)  

Public ISBD [article]  inAutism Research > 15-11 (November 2022) . - p.2138-2148 Titre : Parasympathetic functioning and sleep problems in children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Hillary K. SCHILTZ, Auteur ; Rachel M. FENNING, Auteur ; Stephen A. ERATH, Auteur ; Jason K. BAKER, Auteur Article en page(s) : p.2138-2148 Langues : Anglais (eng) Mots-clés : Child  Humans  Autism Spectrum Disorder/complications  Respiratory Sinus Arrhythmia/physiology  Parasympathetic Nervous System  Arrhythmia, Sinus  Sleep Wake Disorders/complications/epidemiology  Asd  Rsa  autism spectrum disorder  respiratory sinus arrhythmia  sleep Index. décimale : PER Périodiques Résumé : Respiratory sinus arrhythmia (RSA), an index of parasympathetic nervous system activity, has been linked with sleep quality among children with neurotypical development. The current study extended examination of these processes to children with autism spectrum disorder (ASD), a group at considerable risk for sleep problems. Participants included 54 children with ASD (aged 6-10 years, 43% Hispanic). RSA data were collected via a wired MindWare system during a 3-min baseline and a 3-min challenge task. Parents reported on their children's sleep problems and sleep duration using the Children's Sleep Habits Questionnaire, Abbreviated. Although no significant correlations emerged between RSA indices and parent-reported child sleep, baseline RSA and RSA reactivity interacted in the prediction of sleep problems. For children with higher RSA reactivity, higher baseline RSA was associated with fewer sleep problems, but for children with lower RSA reactivity, baseline RSA was not predictive. No main effects or interactions of RSA predicted sleep duration. Findings suggest resilience against sleep problems for children with ASD presenting with higher baseline RSA and higher RSA reactivity. Implications of these results center upon directly targeting psychophysiology (i.e., parasympathetic nervous system regulation) as a possible mechanism to improve sleep in children with ASD, and developing personalized interventions based on physiological markers of risk and resilience. En ligne : http://dx.doi.org/10.1002/aur.2816 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Parasympathetic functioning and sleep problems in children with autism spectrum disorder [Texte imprimé et/ou numérique] / Hillary K. SCHILTZ, Auteur ; Rachel M. FENNING, Auteur ; Stephen A. ERATH, Auteur ; Jason K. BAKER, Auteur . - p.2138-2148. Langues : Anglais (eng) in Autism Research > 15-11 (November 2022) . - p.2138-2148 Mots-clés : Child  Humans  Autism Spectrum Disorder/complications  Respiratory Sinus Arrhythmia/physiology  Parasympathetic Nervous System  Arrhythmia, Sinus  Sleep Wake Disorders/complications/epidemiology  Asd  Rsa  autism spectrum disorder  respiratory sinus arrhythmia  sleep Index. décimale : PER Périodiques Résumé : Respiratory sinus arrhythmia (RSA), an index of parasympathetic nervous system activity, has been linked with sleep quality among children with neurotypical development. The current study extended examination of these processes to children with autism spectrum disorder (ASD), a group at considerable risk for sleep problems. Participants included 54 children with ASD (aged 6-10 years, 43% Hispanic). RSA data were collected via a wired MindWare system during a 3-min baseline and a 3-min challenge task. Parents reported on their children's sleep problems and sleep duration using the Children's Sleep Habits Questionnaire, Abbreviated. Although no significant correlations emerged between RSA indices and parent-reported child sleep, baseline RSA and RSA reactivity interacted in the prediction of sleep problems. For children with higher RSA reactivity, higher baseline RSA was associated with fewer sleep problems, but for children with lower RSA reactivity, baseline RSA was not predictive. No main effects or interactions of RSA predicted sleep duration. Findings suggest resilience against sleep problems for children with ASD presenting with higher baseline RSA and higher RSA reactivity. Implications of these results center upon directly targeting psychophysiology (i.e., parasympathetic nervous system regulation) as a possible mechanism to improve sleep in children with ASD, and developing personalized interventions based on physiological markers of risk and resilience. En ligne : http://dx.doi.org/10.1002/aur.2816 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Coping-resilience profiles and experiences of stress in autistic adults / Melanie MUNIANDY in Autism Research, 15-11 (November 2022)  

Public ISBD [article]  inAutism Research > 15-11 (November 2022) . - p.2149-2166 Titre : Coping-resilience profiles and experiences of stress in autistic adults Type de document : Texte imprimé et/ou numérique Auteurs : Melanie MUNIANDY, Auteur ; Amanda L. RICHDALE, Auteur ; Lauren P. LAWSON, Auteur Article en page(s) : p.2149-2166 Langues : Anglais (eng) Mots-clés : Adult  Humans  Autistic Disorder  Autism Spectrum Disorder  Adaptation, Psychological  adults  autism spectrum disorders  coping  resilience  stress Index. décimale : PER Périodiques Résumé : Emerging studies allude to high stress in autistic adults. Considering the detrimental impact of stress on health outcomes, examining individual resources which may influence the extent to which stress is experienced (e.g., coping and resilience) is vital. Using a person-focused approach, this study aimed to identify coping-resilience profiles, and examine their relations to general perceived stress and daily hassles in a sample of autistic adults (N = 86; aged 19-74 years). Cluster analysis identified four coping-resilience profiles (i.e., high cope/ low resilience, low cope/ high resilience, engage cope/ high resilience, and disengage cope/ low resilience). The high cope/ low resilience and disengage cope/ low resilience groups had significantly higher general perceived stress than the remaining groups. No significant group differences were noted in relation to daily hassles. Jointly addressing coping and resilience may be beneficial on the perceived stress experienced in autistic adults. The use of coping-resilience profiles may also allow for the personalization of stress management and support options in the autistic adult population. En ligne : http://dx.doi.org/10.1002/aur.2817 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Coping-resilience profiles and experiences of stress in autistic adults [Texte imprimé et/ou numérique] / Melanie MUNIANDY, Auteur ; Amanda L. RICHDALE, Auteur ; Lauren P. LAWSON, Auteur . - p.2149-2166. Langues : Anglais (eng) in Autism Research > 15-11 (November 2022) . - p.2149-2166 Mots-clés : Adult  Humans  Autistic Disorder  Autism Spectrum Disorder  Adaptation, Psychological  adults  autism spectrum disorders  coping  resilience  stress Index. décimale : PER Périodiques Résumé : Emerging studies allude to high stress in autistic adults. Considering the detrimental impact of stress on health outcomes, examining individual resources which may influence the extent to which stress is experienced (e.g., coping and resilience) is vital. Using a person-focused approach, this study aimed to identify coping-resilience profiles, and examine their relations to general perceived stress and daily hassles in a sample of autistic adults (N = 86; aged 19-74 years). Cluster analysis identified four coping-resilience profiles (i.e., high cope/ low resilience, low cope/ high resilience, engage cope/ high resilience, and disengage cope/ low resilience). The high cope/ low resilience and disengage cope/ low resilience groups had significantly higher general perceived stress than the remaining groups. No significant group differences were noted in relation to daily hassles. Jointly addressing coping and resilience may be beneficial on the perceived stress experienced in autistic adults. The use of coping-resilience profiles may also allow for the personalization of stress management and support options in the autistic adult population. En ligne : http://dx.doi.org/10.1002/aur.2817 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Pupillometric measures of altered stimulus-evoked locus coeruleus-norepinephrine activity explain attenuated social attention in preschoolers with autism spectrum disorder / Leonie POLZER in Autism Research, 15-11 (November 2022)  

Public ISBD [article]  inAutism Research > 15-11 (November 2022) . - p.2167-2180 Titre : Pupillometric measures of altered stimulus-evoked locus coeruleus-norepinephrine activity explain attenuated social attention in preschoolers with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Leonie POLZER, Auteur ; Christine M. FREITAG, Auteur ; Nico BAST, Auteur Article en page(s) : p.2167-2180 Langues : Anglais (eng) Mots-clés : Child  Humans  Child, Preschool  Autism Spectrum Disorder/diagnosis  Locus Coeruleus  Norepinephrine  Attention/physiology  Pupil/physiology  attention  eye-tracking technology  preschool  pupil Index. décimale : PER Périodiques Résumé : Attenuated social attention has been described as a reduced preference for social compared to geometric motion in preschoolers with autism spectrum disorder (ASD). The locus coeruleus-norpinephrine (LC-NE) system modulates sensory reactivity and is a promising underlying mechanism. LC-NE activity is indexed by a stimulus-evoked pupillary response (SEPR) and partially by a luminance-adaptation pupillary response (LAPR), which were both shown to be aberrant in ASD. We examined whether SEPR and LAPR explain an attenuated social motion preference. We applied pupillometry via video-based eye tracking in young children (18-65 months) with ASD (n = 57) and typically developing (TD) children (n = 39) during a preferential looking paradigm of competing social and geometric motion and a changing light condition paradigm. We found an attenuated social motion preference in the ASD compared to the TD group. This was accompanied by atypical pupillometry showing a smaller SEPR to social motion, a larger SEPR to geometric motion and a reduced LAPR to a dark screen. SEPR but not LAPR explained the group difference in social motion preference. An ASD diagnosis was statistically predicted by the social motion preference, while this effect was mediated by the inclusion of SEPR to geometric and social motion. Our findings suggest a decreased sensory reactivity to social and increased reactivity to non-social motion in ASD, which may concurrently contribute to an attenuated social attention. The LC-NE system is supported as a promising underlying mechanism of altered social attention in young children with ASD, while the specificity of findings remains to be addressed. En ligne : http://dx.doi.org/10.1002/aur.2818 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Pupillometric measures of altered stimulus-evoked locus coeruleus-norepinephrine activity explain attenuated social attention in preschoolers with autism spectrum disorder [Texte imprimé et/ou numérique] / Leonie POLZER, Auteur ; Christine M. FREITAG, Auteur ; Nico BAST, Auteur . - p.2167-2180. Langues : Anglais (eng) in Autism Research > 15-11 (November 2022) . - p.2167-2180 Mots-clés : Child  Humans  Child, Preschool  Autism Spectrum Disorder/diagnosis  Locus Coeruleus  Norepinephrine  Attention/physiology  Pupil/physiology  attention  eye-tracking technology  preschool  pupil Index. décimale : PER Périodiques Résumé : Attenuated social attention has been described as a reduced preference for social compared to geometric motion in preschoolers with autism spectrum disorder (ASD). The locus coeruleus-norpinephrine (LC-NE) system modulates sensory reactivity and is a promising underlying mechanism. LC-NE activity is indexed by a stimulus-evoked pupillary response (SEPR) and partially by a luminance-adaptation pupillary response (LAPR), which were both shown to be aberrant in ASD. We examined whether SEPR and LAPR explain an attenuated social motion preference. We applied pupillometry via video-based eye tracking in young children (18-65 months) with ASD (n = 57) and typically developing (TD) children (n = 39) during a preferential looking paradigm of competing social and geometric motion and a changing light condition paradigm. We found an attenuated social motion preference in the ASD compared to the TD group. This was accompanied by atypical pupillometry showing a smaller SEPR to social motion, a larger SEPR to geometric motion and a reduced LAPR to a dark screen. SEPR but not LAPR explained the group difference in social motion preference. An ASD diagnosis was statistically predicted by the social motion preference, while this effect was mediated by the inclusion of SEPR to geometric and social motion. Our findings suggest a decreased sensory reactivity to social and increased reactivity to non-social motion in ASD, which may concurrently contribute to an attenuated social attention. The LC-NE system is supported as a promising underlying mechanism of altered social attention in young children with ASD, while the specificity of findings remains to be addressed. En ligne : http://dx.doi.org/10.1002/aur.2818 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Replication study for ADOS-2 cut-offs to assist evaluation of autism spectrum disorder / Ji Su HONG in Autism Research, 15-11 (November 2022)  

Public ISBD [article]  inAutism Research > 15-11 (November 2022) . - p.2181-2191 Titre : Replication study for ADOS-2 cut-offs to assist evaluation of autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Ji Su HONG, Auteur ; Vini SINGH, Auteur ; Luke G. KALB, Auteur ; Rachel REETZKE, Auteur ; Natasha N. LUDWIG, Auteur ; Danika PFEIFFER, Auteur ; Calliope HOLINGUE, Auteur ; Deepa MENON, Auteur ; Qing LU, Auteur ; Ahlam ASHKAR, Auteur ; Rebecca LANDA, Auteur Article en page(s) : p.2181-2191 Langues : Anglais (eng) Mots-clés : Child  Humans  Male  Female  Autism Spectrum Disorder/diagnosis  Sensitivity and Specificity  Predictive Value of Tests  Algorithms  Autistic Disorder  autism spectrum disorder  classification  cut-off score  diagnosis Index. décimale : PER Périodiques Résumé : The Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) has been widely used for ASD assessment. While prior studies investigated sensitivity and specificity of ADOS-2 Modules 1-3, there has been limited research addressing algorithm cut-off scores to optimize ADOS-2 classification. The goal of this study was to assess algorithm cut-off scores for diagnosing ASD with Modules 1-3, and to evaluate alignment of the ADOS-2 classification with the best estimate clinical diagnosis. Participants included 3144 children aged 31 months or older who received ADOS-2 Modules 1-3, as well as the best estimate clinical diagnosis. Five classification statistics were reported for each module: sensitivity, specificity, positive predictive value, negative predictive value, and accuracy (i.e., Receiver Operator Classification Statistic), and these statistics were calculated for the optimal cut-off score. Frequency tables were used to compare ADOS-2 classification and the best estimate clinical diagnosis. Half of the sample received Module 3, 21% received Module 2, and 29% received Module 1. The overall prevalence of ASD was 60%; the male-to-female ratio was 4:1, and half of the sample was non-White. Across all modules, the autism spectrum cut-off score from the ADOS-2 manual resulted in high sensitivity (95%+) and low specificity (63%-73%). The autism cut-off score resulted in better specificity (76%-86%) with favorable sensitivity (81%-94%). The optimal cut-off scores for all modules based on the current sample were within the autism spectrum classification range except Module 2 Algorithm 2. In the No ASD group, 29% had false positives (ADOS-2 autism spectrum classification or autism classification). The ADOS-2 autism spectrum classification did not indicate directionality for diagnostic outcome (ASD 56% vs. No ASD 44%). While cut-off scores of ADOS-2 Modules 1-3 in the manual yielded good clinical utility in ASD assessment, false positives and low predictability of the autism spectrum classification remain challenging for clinicians. En ligne : http://dx.doi.org/10.1002/aur.2801 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Replication study for ADOS-2 cut-offs to assist evaluation of autism spectrum disorder [Texte imprimé et/ou numérique] / Ji Su HONG, Auteur ; Vini SINGH, Auteur ; Luke G. KALB, Auteur ; Rachel REETZKE, Auteur ; Natasha N. LUDWIG, Auteur ; Danika PFEIFFER, Auteur ; Calliope HOLINGUE, Auteur ; Deepa MENON, Auteur ; Qing LU, Auteur ; Ahlam ASHKAR, Auteur ; Rebecca LANDA, Auteur . - p.2181-2191. Langues : Anglais (eng) in Autism Research > 15-11 (November 2022) . - p.2181-2191 Mots-clés : Child  Humans  Male  Female  Autism Spectrum Disorder/diagnosis  Sensitivity and Specificity  Predictive Value of Tests  Algorithms  Autistic Disorder  autism spectrum disorder  classification  cut-off score  diagnosis Index. décimale : PER Périodiques Résumé : The Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) has been widely used for ASD assessment. While prior studies investigated sensitivity and specificity of ADOS-2 Modules 1-3, there has been limited research addressing algorithm cut-off scores to optimize ADOS-2 classification. The goal of this study was to assess algorithm cut-off scores for diagnosing ASD with Modules 1-3, and to evaluate alignment of the ADOS-2 classification with the best estimate clinical diagnosis. Participants included 3144 children aged 31 months or older who received ADOS-2 Modules 1-3, as well as the best estimate clinical diagnosis. Five classification statistics were reported for each module: sensitivity, specificity, positive predictive value, negative predictive value, and accuracy (i.e., Receiver Operator Classification Statistic), and these statistics were calculated for the optimal cut-off score. Frequency tables were used to compare ADOS-2 classification and the best estimate clinical diagnosis. Half of the sample received Module 3, 21% received Module 2, and 29% received Module 1. The overall prevalence of ASD was 60%; the male-to-female ratio was 4:1, and half of the sample was non-White. Across all modules, the autism spectrum cut-off score from the ADOS-2 manual resulted in high sensitivity (95%+) and low specificity (63%-73%). The autism cut-off score resulted in better specificity (76%-86%) with favorable sensitivity (81%-94%). The optimal cut-off scores for all modules based on the current sample were within the autism spectrum classification range except Module 2 Algorithm 2. In the No ASD group, 29% had false positives (ADOS-2 autism spectrum classification or autism classification). The ADOS-2 autism spectrum classification did not indicate directionality for diagnostic outcome (ASD 56% vs. No ASD 44%). While cut-off scores of ADOS-2 Modules 1-3 in the manual yielded good clinical utility in ASD assessment, false positives and low predictability of the autism spectrum classification remain challenging for clinicians. En ligne : http://dx.doi.org/10.1002/aur.2801 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Risk of exposure to prescription opioids in children and adolescents with autism spectrum disorder: A nationwide longitudinal study / Ju-Wei HSU in Autism Research, 15-11 (November 2022)  

Public ISBD [article]  inAutism Research > 15-11 (November 2022) . - p.2192-2199 Titre : Risk of exposure to prescription opioids in children and adolescents with autism spectrum disorder: A nationwide longitudinal study Type de document : Texte imprimé et/ou numérique Auteurs : Ju-Wei HSU, Auteur ; Shih-Jen TSAI, Auteur ; Ya-Mei BAI, Auteur ; Kai-Lin HUANG, Auteur ; Tung-Ping SU, Auteur ; Tzeng-Ji CHEN, Auteur ; Mu-Hong CHEN, Auteur Article en page(s) : p.2192-2199 Langues : Anglais (eng) Mots-clés : Child  Adolescent  Humans  Autism Spectrum Disorder/drug therapy  Longitudinal Studies  Analgesics, Opioid/adverse effects  Chronic Pain/complications/drug therapy  Prescriptions  autism  medical conditions  mental disorders  prescription opioids Index. décimale : PER Périodiques Résumé : Whether children and adolescents with autism spectrum disorder (ASD) are more likely to be exposed to prescription opioids than others remains unknown. The Taiwan National Health Insurance Research Database was employed, and 14,849 children and adolescents with ASD and 148,490 age- and sex-matched non-ASD controls were enrolled between 2001 and 2009 and followed up till the end of 2011. Those exposed to prescription opioids during the follow-up period were identified. Patients with ASD were more likely to be exposed to prescription opioids (hazard ratio [HR]: 4.95, 95% confidence interval [CI]: 4.50-5.45), including intravenous or intramuscular opioids (HR: 5.80, 95% CI: 5.23-6.43) and oral or transcutaneous opioids (HR: 2.32, 95% CI: 1.87-2.89), than were non-ASD controls. Furthermore, the ASD cohort had the increased likelihood of cumulative exposure of>14 days (HR: 6.19, 95% CI: 4.91-7.79) and>30 days (HR: 7.17, 95% CI: 5.19-9.90) to prescription opioids compared with the control cohort. ASD was a risk factor for exposure to prescription opioids. Close monitoring of prescription opioid use is necessary for at-risk children and adolescents with ASD, such as those having with or chronic pain. We found that patients with ASD were more likely to be exposed to prescription opioids, including intravenous or intramuscular opioids and oral or transcutaneous opioids, than were non-ASD controls. We suggest that close monitoring of prescription opioid use is necessary for at-risk children and adolescents with ASD, such as those having with or chronic pain. En ligne : http://dx.doi.org/10.1002/aur.2806 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Risk of exposure to prescription opioids in children and adolescents with autism spectrum disorder: A nationwide longitudinal study [Texte imprimé et/ou numérique] / Ju-Wei HSU, Auteur ; Shih-Jen TSAI, Auteur ; Ya-Mei BAI, Auteur ; Kai-Lin HUANG, Auteur ; Tung-Ping SU, Auteur ; Tzeng-Ji CHEN, Auteur ; Mu-Hong CHEN, Auteur . - p.2192-2199. Langues : Anglais (eng) in Autism Research > 15-11 (November 2022) . - p.2192-2199 Mots-clés : Child  Adolescent  Humans  Autism Spectrum Disorder/drug therapy  Longitudinal Studies  Analgesics, Opioid/adverse effects  Chronic Pain/complications/drug therapy  Prescriptions  autism  medical conditions  mental disorders  prescription opioids Index. décimale : PER Périodiques Résumé : Whether children and adolescents with autism spectrum disorder (ASD) are more likely to be exposed to prescription opioids than others remains unknown. The Taiwan National Health Insurance Research Database was employed, and 14,849 children and adolescents with ASD and 148,490 age- and sex-matched non-ASD controls were enrolled between 2001 and 2009 and followed up till the end of 2011. Those exposed to prescription opioids during the follow-up period were identified. Patients with ASD were more likely to be exposed to prescription opioids (hazard ratio [HR]: 4.95, 95% confidence interval [CI]: 4.50-5.45), including intravenous or intramuscular opioids (HR: 5.80, 95% CI: 5.23-6.43) and oral or transcutaneous opioids (HR: 2.32, 95% CI: 1.87-2.89), than were non-ASD controls. Furthermore, the ASD cohort had the increased likelihood of cumulative exposure of>14 days (HR: 6.19, 95% CI: 4.91-7.79) and>30 days (HR: 7.17, 95% CI: 5.19-9.90) to prescription opioids compared with the control cohort. ASD was a risk factor for exposure to prescription opioids. Close monitoring of prescription opioid use is necessary for at-risk children and adolescents with ASD, such as those having with or chronic pain. We found that patients with ASD were more likely to be exposed to prescription opioids, including intravenous or intramuscular opioids and oral or transcutaneous opioids, than were non-ASD controls. We suggest that close monitoring of prescription opioid use is necessary for at-risk children and adolescents with ASD, such as those having with or chronic pain. En ligne : http://dx.doi.org/10.1002/aur.2806 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Characteristics of children on the autism spectrum who benefit the most from receiving intervention in inclusive versus specialised early childhood education settings / Giacomo VIVANTI in Autism Research, 15-11 (November 2022)  

Public ISBD [article]  inAutism Research > 15-11 (November 2022) . - p.2200-2209 Titre : Characteristics of children on the autism spectrum who benefit the most from receiving intervention in inclusive versus specialised early childhood education settings Type de document : Texte imprimé et/ou numérique Auteurs : Giacomo VIVANTI, Auteur ; Catherine BENT, Auteur ; Kristy CAPES, Auteur ; Shannon UPSON, Auteur ; Kristelle HUDRY, Auteur ; Cheryl DISSANAYAKE, Auteur Article en page(s) : p.2200-2209 Langues : Anglais (eng) Mots-clés : Child  Child, Preschool  Humans  Autism Spectrum Disorder/therapy/psychology  Autistic Disorder  Child Development Disorders, Pervasive/psychology  Early Intervention, Educational  Social Behavior  autism spectrum disorder  early intervention  early start Denver model  inclusion  mainstream education  moderators  predictors Index. décimale : PER Périodiques Résumé : This study examined the factors associated with social-communicative outcomes for children on the autism spectrum receiving early intervention in inclusive versus specialised early childhood education programmes. Fifty-eight preschool-aged children randomly assigned to receive the Group-Early Start Denver Model (G-ESDM) in either inclusive or specialised (i.e., autism-specific) classrooms across one calendar year showed similar outcomes at group mean-level across measures of communication and social behaviour. We examined factors moderating outcomes across settings. Novel moderation analyses revealed that higher baseline social interest and nonverbal cognitive skills were associated with increased social communication gains for children in the inclusive classrooms, but not for those in specialised settings. Children who spend more time paying attention to people and have higher cognitive skills might benefit from receiving early intervention in inclusive settings, whilst these factors might be less relevant for children educated in specialised settings. En ligne : http://dx.doi.org/10.1002/aur.2815 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Characteristics of children on the autism spectrum who benefit the most from receiving intervention in inclusive versus specialised early childhood education settings [Texte imprimé et/ou numérique] / Giacomo VIVANTI, Auteur ; Catherine BENT, Auteur ; Kristy CAPES, Auteur ; Shannon UPSON, Auteur ; Kristelle HUDRY, Auteur ; Cheryl DISSANAYAKE, Auteur . - p.2200-2209. Langues : Anglais (eng) in Autism Research > 15-11 (November 2022) . - p.2200-2209 Mots-clés : Child  Child, Preschool  Humans  Autism Spectrum Disorder/therapy/psychology  Autistic Disorder  Child Development Disorders, Pervasive/psychology  Early Intervention, Educational  Social Behavior  autism spectrum disorder  early intervention  early start Denver model  inclusion  mainstream education  moderators  predictors Index. décimale : PER Périodiques Résumé : This study examined the factors associated with social-communicative outcomes for children on the autism spectrum receiving early intervention in inclusive versus specialised early childhood education programmes. Fifty-eight preschool-aged children randomly assigned to receive the Group-Early Start Denver Model (G-ESDM) in either inclusive or specialised (i.e., autism-specific) classrooms across one calendar year showed similar outcomes at group mean-level across measures of communication and social behaviour. We examined factors moderating outcomes across settings. Novel moderation analyses revealed that higher baseline social interest and nonverbal cognitive skills were associated with increased social communication gains for children in the inclusive classrooms, but not for those in specialised settings. Children who spend more time paying attention to people and have higher cognitive skills might benefit from receiving early intervention in inclusive settings, whilst these factors might be less relevant for children educated in specialised settings. En ligne : http://dx.doi.org/10.1002/aur.2815 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488