Dépouillements

Addressing current barriers to autism diagnoses through a tiered diagnostic approach involving pediatric primary care providers / Andrea TRUBANOVA WIECKOWSKI in Autism Research, 15-12 (December 2022)  

Public ISBD [article]  inAutism Research > 15-12 (December 2022) . - p.2216-2222 Titre : Addressing current barriers to autism diagnoses through a tiered diagnostic approach involving pediatric primary care providers Type de document : Texte imprimé et/ou numérique Auteurs : Andrea TRUBANOVA WIECKOWSKI, Auteur ; Katharine E. ZUCKERMAN, Auteur ; Sarabeth BRODER-FINGERT, Auteur ; Diana L. ROBINS, Auteur Article en page(s) : p.2216-2222 Langues : Anglais (eng) Mots-clés : Child  Humans  Child, Preschool  Autistic Disorder  Autism Spectrum Disorder/diagnosis/therapy  Primary Health Care  autism spectrum disorder  diagnosis  early detection  primary care Index. décimale : PER Périodiques Résumé : Formal autism diagnosis from a specialist trained in autism assessment is customary prior to a child accessing early, intensive autism-specific services. However, long wait lists for diagnostic evaluations and limited specialty workforce have created substantial delays. Additionally, lengthy multidisciplinary evaluations are costly to insurers, inconvenient to families, and disproportionally impact under-resourced families. Diagnostic delays can impede access to intervention services. These barriers, combined with evidence regarding the importance of receiving early, autism-specific treatment, demand new approaches enabling access to autism specific services before comprehensive evaluation. Pediatric primary care providers (PCPs) are often the only health care professionals with whom a family interacts during early childhood and can play a crucial role in helping children with autism symptoms access services. Many strategies for autism diagnosis in primary care are being developed and tested; however, they have yet to be broadly adopted by PCPs, primarily due to critical implementation barriers in primary care settings. There is also not enough evidence on the accuracy of PCPs' diagnostic impressions without extensive specialty support, resulting in PCP hesitancy in diagnosing ASD, as well as family and service provider hesitancy in accepting a PCP autism diagnosis. In this commentary, we explore the acute need for shortening waitlists for autism evaluations through a tiered diagnostic approach, in which PCPs can rule in or rule out autism in children, for whom diagnosis is clear, and refer more complex cases for specialist evaluations, and explore implementation challenges to this approach. En ligne : http://dx.doi.org/10.1002/aur.2832 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Addressing current barriers to autism diagnoses through a tiered diagnostic approach involving pediatric primary care providers [Texte imprimé et/ou numérique] / Andrea TRUBANOVA WIECKOWSKI, Auteur ; Katharine E. ZUCKERMAN, Auteur ; Sarabeth BRODER-FINGERT, Auteur ; Diana L. ROBINS, Auteur . - p.2216-2222. Langues : Anglais (eng) in Autism Research > 15-12 (December 2022) . - p.2216-2222 Mots-clés : Child  Humans  Child, Preschool  Autistic Disorder  Autism Spectrum Disorder/diagnosis/therapy  Primary Health Care  autism spectrum disorder  diagnosis  early detection  primary care Index. décimale : PER Périodiques Résumé : Formal autism diagnosis from a specialist trained in autism assessment is customary prior to a child accessing early, intensive autism-specific services. However, long wait lists for diagnostic evaluations and limited specialty workforce have created substantial delays. Additionally, lengthy multidisciplinary evaluations are costly to insurers, inconvenient to families, and disproportionally impact under-resourced families. Diagnostic delays can impede access to intervention services. These barriers, combined with evidence regarding the importance of receiving early, autism-specific treatment, demand new approaches enabling access to autism specific services before comprehensive evaluation. Pediatric primary care providers (PCPs) are often the only health care professionals with whom a family interacts during early childhood and can play a crucial role in helping children with autism symptoms access services. Many strategies for autism diagnosis in primary care are being developed and tested; however, they have yet to be broadly adopted by PCPs, primarily due to critical implementation barriers in primary care settings. There is also not enough evidence on the accuracy of PCPs' diagnostic impressions without extensive specialty support, resulting in PCP hesitancy in diagnosing ASD, as well as family and service provider hesitancy in accepting a PCP autism diagnosis. In this commentary, we explore the acute need for shortening waitlists for autism evaluations through a tiered diagnostic approach, in which PCPs can rule in or rule out autism in children, for whom diagnosis is clear, and refer more complex cases for specialist evaluations, and explore implementation challenges to this approach. En ligne : http://dx.doi.org/10.1002/aur.2832 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Atypical brain network development of infants at elevated likelihood for autism spectrum disorder during the first year of life / Fen ZHANG in Autism Research, 15-12 (December 2022)  

Public ISBD [article]  inAutism Research > 15-12 (December 2022) . - p.2223-2237 Titre : Atypical brain network development of infants at elevated likelihood for autism spectrum disorder during the first year of life Type de document : Texte imprimé et/ou numérique Auteurs : Fen ZHANG, Auteur ; Floor MOERMAN, Auteur ; Haijing NIU, Auteur ; Petra WARREYN, Auteur ; Herbert ROEYERS, Auteur Article en page(s) : p.2223-2237 Langues : Anglais (eng) Mots-clés : Infant  Humans  Autism Spectrum Disorder  Neurodevelopmental Disorders  Brain/diagnostic imaging  Phenotype  autism spectrum disorder  brain network  functional connectivity  functional near-infrared spectroscopy  neurodevelopmental disorder Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by behavioral features that appear early in life. Although studies have shown that atypical brain functional and structural connectivity are associated with these behavioral traits, the occurrence and initial alterations of brain networks have not been fully investigated. The current study aimed to map early brain network efficiency and information transferring in infants at elevated likelihood (EL) compared to infants at typical likelihood (TL) for ASD in the first year of life. This study used a resting-state functional near-infrared spectroscopy (fNIRS) approach to obtain the length and strength of functional connections in the frontal and temporal areas in 45 5-month-old and 38 10-month-old infants. Modular organization and small-world properties were detected in both EL and TL infants at 5 and 10 months. In 5-month-old EL infants, local and nodal efficiency were significantly greater than age-matched TL infants, indicating overgrown local connections. Furthermore, we used a support vector machine (SVM) model to classify infants with or without EL based on the obtained global properties of the network, achieving an accuracy of 77.6%. These results suggest that infants with EL for ASD exhibit inefficiencies in the organization of brain networks during the first year of life. En ligne : http://dx.doi.org/10.1002/aur.2827 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Atypical brain network development of infants at elevated likelihood for autism spectrum disorder during the first year of life [Texte imprimé et/ou numérique] / Fen ZHANG, Auteur ; Floor MOERMAN, Auteur ; Haijing NIU, Auteur ; Petra WARREYN, Auteur ; Herbert ROEYERS, Auteur . - p.2223-2237. Langues : Anglais (eng) in Autism Research > 15-12 (December 2022) . - p.2223-2237 Mots-clés : Infant  Humans  Autism Spectrum Disorder  Neurodevelopmental Disorders  Brain/diagnostic imaging  Phenotype  autism spectrum disorder  brain network  functional connectivity  functional near-infrared spectroscopy  neurodevelopmental disorder Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by behavioral features that appear early in life. Although studies have shown that atypical brain functional and structural connectivity are associated with these behavioral traits, the occurrence and initial alterations of brain networks have not been fully investigated. The current study aimed to map early brain network efficiency and information transferring in infants at elevated likelihood (EL) compared to infants at typical likelihood (TL) for ASD in the first year of life. This study used a resting-state functional near-infrared spectroscopy (fNIRS) approach to obtain the length and strength of functional connections in the frontal and temporal areas in 45 5-month-old and 38 10-month-old infants. Modular organization and small-world properties were detected in both EL and TL infants at 5 and 10 months. In 5-month-old EL infants, local and nodal efficiency were significantly greater than age-matched TL infants, indicating overgrown local connections. Furthermore, we used a support vector machine (SVM) model to classify infants with or without EL based on the obtained global properties of the network, achieving an accuracy of 77.6%. These results suggest that infants with EL for ASD exhibit inefficiencies in the organization of brain networks during the first year of life. En ligne : http://dx.doi.org/10.1002/aur.2827 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Association between body mass index and subcortical volume in pre-adolescent children with autism spectrum disorder: An exploratory study / In-Seong HWANG in Autism Research, 15-12 (December 2022)  

Public ISBD [article]  inAutism Research > 15-12 (December 2022) . - p.2238-2249 Titre : Association between body mass index and subcortical volume in pre-adolescent children with autism spectrum disorder: An exploratory study Type de document : Texte imprimé et/ou numérique Auteurs : In-Seong HWANG, Auteur ; Soon-Beom HONG, Auteur Article en page(s) : p.2238-2249 Langues : Anglais (eng) Mots-clés : Child  Humans  Adolescent  Autism Spectrum Disorder/diagnostic imaging/pathology  Body Mass Index  Pediatric Obesity/complications/diagnostic imaging  Magnetic Resonance Imaging/methods  Brain/diagnostic imaging/pathology  autism spectrum disorder  caudate nucleus  obesity  subcortical volume  ventral diencephalon Index. décimale : PER Périodiques Résumé : Conflicting associations exist between autism spectrum disorder (ASD) and subcortical brain volumes. This study assessed whether obesity might have a confounding influence on associations between ASD and brain subcortical volumes. A comprehensive investigation evaluating the relationship between ASD, obesity, and subcortical structure volumes was conducted. Data obtained included body mass index (BMI) and T1-weighted structural magnetic resonance images for children with and without ASD diagnoses from the Autism Brain Imaging Data Exchange database. Brain subcortical volumes were calculated using vol2Brain software. Hierarchical linear regression analyses were performed to explore the subcortical volumes similarly or differentially associated with BMI in children with or without ASD and examine association and interaction effects regarding ASD and subcortical volume impact on the Social Responsiveness Scale and Vineland Adaptive Behavior Scale (VABS) scores. Bilateral caudate nuclei were smaller in children with ASD than in control participants. Significant interactions were observed between ASD diagnosis and BMI regarding the left caudate, right and left putamen, and right and left ventral diencephalon (DC) volumes (Î2 = -0.384, p = 0.010; Î2 = -0.336, p = 0.030; Î2 = -0.317, p = 0.040; Î2 = 0.322, p = 0.010; Î2 = 0.295, p = 0.021, respectively) and between ASD diagnosis and right and left ventral DC volumes regarding the VABS scores (Î2 = 0.434, p = 0.014; Î2 = 0.495, p = 0.007, respectively). However, each subcortical structure volume included in the ventral DC area could not be measured separately. The results identified subcortical volumes differentially associated with obesity in children with ASD compared with typically developing peers. BMI may need to be considered an important confounder in future research examining brain subcortical volumes within ASD. En ligne : http://dx.doi.org/10.1002/aur.2834 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Association between body mass index and subcortical volume in pre-adolescent children with autism spectrum disorder: An exploratory study [Texte imprimé et/ou numérique] / In-Seong HWANG, Auteur ; Soon-Beom HONG, Auteur . - p.2238-2249. Langues : Anglais (eng) in Autism Research > 15-12 (December 2022) . - p.2238-2249 Mots-clés : Child  Humans  Adolescent  Autism Spectrum Disorder/diagnostic imaging/pathology  Body Mass Index  Pediatric Obesity/complications/diagnostic imaging  Magnetic Resonance Imaging/methods  Brain/diagnostic imaging/pathology  autism spectrum disorder  caudate nucleus  obesity  subcortical volume  ventral diencephalon Index. décimale : PER Périodiques Résumé : Conflicting associations exist between autism spectrum disorder (ASD) and subcortical brain volumes. This study assessed whether obesity might have a confounding influence on associations between ASD and brain subcortical volumes. A comprehensive investigation evaluating the relationship between ASD, obesity, and subcortical structure volumes was conducted. Data obtained included body mass index (BMI) and T1-weighted structural magnetic resonance images for children with and without ASD diagnoses from the Autism Brain Imaging Data Exchange database. Brain subcortical volumes were calculated using vol2Brain software. Hierarchical linear regression analyses were performed to explore the subcortical volumes similarly or differentially associated with BMI in children with or without ASD and examine association and interaction effects regarding ASD and subcortical volume impact on the Social Responsiveness Scale and Vineland Adaptive Behavior Scale (VABS) scores. Bilateral caudate nuclei were smaller in children with ASD than in control participants. Significant interactions were observed between ASD diagnosis and BMI regarding the left caudate, right and left putamen, and right and left ventral diencephalon (DC) volumes (Î2 = -0.384, p = 0.010; Î2 = -0.336, p = 0.030; Î2 = -0.317, p = 0.040; Î2 = 0.322, p = 0.010; Î2 = 0.295, p = 0.021, respectively) and between ASD diagnosis and right and left ventral DC volumes regarding the VABS scores (Î2 = 0.434, p = 0.014; Î2 = 0.495, p = 0.007, respectively). However, each subcortical structure volume included in the ventral DC area could not be measured separately. The results identified subcortical volumes differentially associated with obesity in children with ASD compared with typically developing peers. BMI may need to be considered an important confounder in future research examining brain subcortical volumes within ASD. En ligne : http://dx.doi.org/10.1002/aur.2834 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Measures of tonic and phasic activity of the locus coeruleus-norepinephrine system in children with autism spectrum disorder: An event-related potential and pupillometry study / Yesol KIM in Autism Research, 15-12 (December 2022)  

Public ISBD [article]  inAutism Research > 15-12 (December 2022) . - p.2250-2264 Titre : Measures of tonic and phasic activity of the locus coeruleus-norepinephrine system in children with autism spectrum disorder: An event-related potential and pupillometry study Type de document : Texte imprimé et/ou numérique Auteurs : Yesol KIM, Auteur ; Girija KADLASKAR, Auteur ; Rebecca McNally KEEHN, Auteur ; Brandon KEEHN, Auteur Article en page(s) : p.2250-2264 Langues : Anglais (eng) Mots-clés : Child  Humans  Locus Coeruleus  Autism Spectrum Disorder  Norepinephrine  Attention/physiology  Evoked Potentials  autism spectrum disorder  electrophysiology  eye-tracking  locus coeruleus Index. décimale : PER Périodiques Résumé : A growing body of research suggests that locus coeruleus-norepinephrine (LC-NE) system may function differently in individuals with autism spectrum disorder (ASD). Understanding the dynamics of both tonic (resting pupil diameter) and phasic (pupil dilation response [PDR] and event-related potential [ERP]) indices may provide meaningful insights about the nature of LC-NE function in ASD. Twenty-four children with ASD and 27 age- and nonverbal-IQ matched typically developing (TD) children completed two experiments: (1) a resting eye-tracking task to measure tonic pupil diameter, and (2) a three-stimulus oddball paradigm to measure phasic responsivity using PDR and ERP. Consistent with prior reports, our results indicate that children with ASD exhibit increased tonic (resting pupil diameter) and reduced phasic (PDR and ERP) activity of the LC-NE system compared to their TD peers. For both groups, decreased phasic responsivity was associated with increased resting pupil diameter. Lastly, tonic and phasic LC-NE indices were primarily related to measures of attention-deficit/hyperactivity disorder (ADHD), and not ASD, symptomatology. These findings expand our understanding of neurophysiological differences present in ASD and demonstrate that aberrant LC-NE activation may be associated with atypical arousal and decreased responsivity to behaviorally-relevant information in ASD. En ligne : http://dx.doi.org/10.1002/aur.2820 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Measures of tonic and phasic activity of the locus coeruleus-norepinephrine system in children with autism spectrum disorder: An event-related potential and pupillometry study [Texte imprimé et/ou numérique] / Yesol KIM, Auteur ; Girija KADLASKAR, Auteur ; Rebecca McNally KEEHN, Auteur ; Brandon KEEHN, Auteur . - p.2250-2264. Langues : Anglais (eng) in Autism Research > 15-12 (December 2022) . - p.2250-2264 Mots-clés : Child  Humans  Locus Coeruleus  Autism Spectrum Disorder  Norepinephrine  Attention/physiology  Evoked Potentials  autism spectrum disorder  electrophysiology  eye-tracking  locus coeruleus Index. décimale : PER Périodiques Résumé : A growing body of research suggests that locus coeruleus-norepinephrine (LC-NE) system may function differently in individuals with autism spectrum disorder (ASD). Understanding the dynamics of both tonic (resting pupil diameter) and phasic (pupil dilation response [PDR] and event-related potential [ERP]) indices may provide meaningful insights about the nature of LC-NE function in ASD. Twenty-four children with ASD and 27 age- and nonverbal-IQ matched typically developing (TD) children completed two experiments: (1) a resting eye-tracking task to measure tonic pupil diameter, and (2) a three-stimulus oddball paradigm to measure phasic responsivity using PDR and ERP. Consistent with prior reports, our results indicate that children with ASD exhibit increased tonic (resting pupil diameter) and reduced phasic (PDR and ERP) activity of the LC-NE system compared to their TD peers. For both groups, decreased phasic responsivity was associated with increased resting pupil diameter. Lastly, tonic and phasic LC-NE indices were primarily related to measures of attention-deficit/hyperactivity disorder (ADHD), and not ASD, symptomatology. These findings expand our understanding of neurophysiological differences present in ASD and demonstrate that aberrant LC-NE activation may be associated with atypical arousal and decreased responsivity to behaviorally-relevant information in ASD. En ligne : http://dx.doi.org/10.1002/aur.2820 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Examining the relationship between cognitive inflexibility and internalizing and externalizing symptoms in autistic children and adolescents: A systematic review and meta-analysis / Jiedi LEI in Autism Research, 15-12 (December 2022)  

Public ISBD [article]  inAutism Research > 15-12 (December 2022) . - p.2265-2295 Titre : Examining the relationship between cognitive inflexibility and internalizing and externalizing symptoms in autistic children and adolescents: A systematic review and meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : Jiedi LEI, Auteur ; Tony CHARMAN, Auteur ; Eleanor LEIGH, Auteur ; Ailsa RUSSELL, Auteur ; Zameer MOHAMED, Auteur ; Matthew J. HOLLOCKS, Auteur Article en page(s) : p.2265-2295 Langues : Anglais (eng) Mots-clés : Child  Humans  Adolescent  Autistic Disorder/complications  Autism Spectrum Disorder  Cognition  Databases, Factual  Mental Health  autism spectrum disorder  cognitive flexibility  cognitive inflexibility  externalizing  internalizing  meta-analysis  systematic review Index. décimale : PER Périodiques Résumé : Compared to neurotypical peers, autistic adolescents show greater cognitive inflexibility (CI) which manifests at the behavioral and cognitive level and potentially increases vulnerability for the development of internalizing (INT) and externalizing (EXT) symptoms. This systematic review and meta-analysis explored the association between CI and INT/EXT in autistic adolescents. PubMed, EMBASE, MEDLINE, PsycINFO and Web of Science databases were searched to identify relevant studies until April 2022 (PROSPERO protocol: CRD42021277294). Systematic review included 21 studies (n = 1608) of CI and INT, and 15 studies (n = 1115) of CI and EXT. A pooled effect size using Pearson's correlation between CI and INT/EXT was calculated and the moderating effects of age, sex, IQ and study quality were investigated using meta-regressions. Sensitivity analyses were completed to investigate the impact of measure variance for CI and co-occurring ADHD on the overall effects. Greater CI is associated with increased INT (nine studies; n = 833; r = 0.39 (moderate effect), 95% confidence interval [0.32, 0.46]) and EXT (six studies; n = 295; r = 0.48 (large effect), 95% confidence interval [0.38, 0.58]). Results withheld when only using parental reports of CI and excluding autistic adolescents with co-occurring ADHD. Increased CI may be a transdiagnostic vulnerability factor that can increase autistic adolescents' rigid or perseverative patterns of unhelpful cognition and behaviors and reduce their ability to access psychological interventions. Addressing CI may improve autistic children and adolescents' engagement with psychological therapy for co-occurring mental health difficulties. En ligne : http://dx.doi.org/10.1002/aur.2826 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Examining the relationship between cognitive inflexibility and internalizing and externalizing symptoms in autistic children and adolescents: A systematic review and meta-analysis [Texte imprimé et/ou numérique] / Jiedi LEI, Auteur ; Tony CHARMAN, Auteur ; Eleanor LEIGH, Auteur ; Ailsa RUSSELL, Auteur ; Zameer MOHAMED, Auteur ; Matthew J. HOLLOCKS, Auteur . - p.2265-2295. Langues : Anglais (eng) in Autism Research > 15-12 (December 2022) . - p.2265-2295 Mots-clés : Child  Humans  Adolescent  Autistic Disorder/complications  Autism Spectrum Disorder  Cognition  Databases, Factual  Mental Health  autism spectrum disorder  cognitive flexibility  cognitive inflexibility  externalizing  internalizing  meta-analysis  systematic review Index. décimale : PER Périodiques Résumé : Compared to neurotypical peers, autistic adolescents show greater cognitive inflexibility (CI) which manifests at the behavioral and cognitive level and potentially increases vulnerability for the development of internalizing (INT) and externalizing (EXT) symptoms. This systematic review and meta-analysis explored the association between CI and INT/EXT in autistic adolescents. PubMed, EMBASE, MEDLINE, PsycINFO and Web of Science databases were searched to identify relevant studies until April 2022 (PROSPERO protocol: CRD42021277294). Systematic review included 21 studies (n = 1608) of CI and INT, and 15 studies (n = 1115) of CI and EXT. A pooled effect size using Pearson's correlation between CI and INT/EXT was calculated and the moderating effects of age, sex, IQ and study quality were investigated using meta-regressions. Sensitivity analyses were completed to investigate the impact of measure variance for CI and co-occurring ADHD on the overall effects. Greater CI is associated with increased INT (nine studies; n = 833; r = 0.39 (moderate effect), 95% confidence interval [0.32, 0.46]) and EXT (six studies; n = 295; r = 0.48 (large effect), 95% confidence interval [0.38, 0.58]). Results withheld when only using parental reports of CI and excluding autistic adolescents with co-occurring ADHD. Increased CI may be a transdiagnostic vulnerability factor that can increase autistic adolescents' rigid or perseverative patterns of unhelpful cognition and behaviors and reduce their ability to access psychological interventions. Addressing CI may improve autistic children and adolescents' engagement with psychological therapy for co-occurring mental health difficulties. En ligne : http://dx.doi.org/10.1002/aur.2826 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Cognitive flexibility in autism: Evidence from young autistic children / Maria ANDREOU in Autism Research, 15-12 (December 2022)  

Public ISBD [article]  inAutism Research > 15-12 (December 2022) . - p.2296-2309 Titre : Cognitive flexibility in autism: Evidence from young autistic children Type de document : Texte imprimé et/ou numérique Auteurs : Maria ANDREOU, Auteur ; Kostas KONSTANTOPOULOS, Auteur ; Eleni PERISTERI, Auteur Article en page(s) : p.2296-2309 Langues : Anglais (eng) Mots-clés : Child  Humans  Autistic Disorder/complications  Autism Spectrum Disorder/complications  Semantics  Language  Cognition  autism  children's color trails test  cognitive flexibility  fluency Index. décimale : PER Périodiques Résumé : We examined the cognitive flexibility performance of young autistic children and a group of neurotypical peers. Thirty-six autistic children (72-83 months) and 200 age-matched typically-developing children were assessed on the Children's Color Trails Test (CCTT), a semantic and a phonemic verbal fluency task. The results showed that the autistic children performed worse than their neurotypical peers in the switching component of the CCTT. In the fluency tests, the autistic group generated overall fewer word items than their neurotypical peers, however, their poorer performance was driven by specific linguistic stimuli in the fluency tasks. The findings suggest that cognitive flexibility for the autistic children was affected in the nonverbal CCTT only, while poor performance in semantic and phonemic fluency seemed to be inherent to the language properties of the verbal fluency tasks. En ligne : http://dx.doi.org/10.1002/aur.2828 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Cognitive flexibility in autism: Evidence from young autistic children [Texte imprimé et/ou numérique] / Maria ANDREOU, Auteur ; Kostas KONSTANTOPOULOS, Auteur ; Eleni PERISTERI, Auteur . - p.2296-2309. Langues : Anglais (eng) in Autism Research > 15-12 (December 2022) . - p.2296-2309 Mots-clés : Child  Humans  Autistic Disorder/complications  Autism Spectrum Disorder/complications  Semantics  Language  Cognition  autism  children's color trails test  cognitive flexibility  fluency Index. décimale : PER Périodiques Résumé : We examined the cognitive flexibility performance of young autistic children and a group of neurotypical peers. Thirty-six autistic children (72-83 months) and 200 age-matched typically-developing children were assessed on the Children's Color Trails Test (CCTT), a semantic and a phonemic verbal fluency task. The results showed that the autistic children performed worse than their neurotypical peers in the switching component of the CCTT. In the fluency tests, the autistic group generated overall fewer word items than their neurotypical peers, however, their poorer performance was driven by specific linguistic stimuli in the fluency tasks. The findings suggest that cognitive flexibility for the autistic children was affected in the nonverbal CCTT only, while poor performance in semantic and phonemic fluency seemed to be inherent to the language properties of the verbal fluency tasks. En ligne : http://dx.doi.org/10.1002/aur.2828 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Reduced social attention in autism is magnified by perceptual load in naturalistic environments / Amanda J. HASKINS in Autism Research, 15-12 (December 2022)  

Public ISBD [article]  inAutism Research > 15-12 (December 2022) . - p.2310-2323 Titre : Reduced social attention in autism is magnified by perceptual load in naturalistic environments Type de document : Texte imprimé et/ou numérique Auteurs : Amanda J. HASKINS, Auteur ; Jeff MENTCH, Auteur ; Thomas L. BOTCH, Auteur ; Brenda D. GARCIA, Auteur ; Alexandra L. BURROWS, Auteur ; Caroline E. ROBERTSON, Auteur Article en page(s) : p.2310-2323 Langues : Anglais (eng) Mots-clés : Humans  Autistic Disorder  Autism Spectrum Disorder  Cues  Attention  adults  eye movement  sensory  social cognition Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum conditions (ASC) describe differences in both social cognition and sensory processing, but little is known about the causal relationship between these disparate functional domains. In the present study, we sought to understand how a core characteristic of autism-reduced social attention-is impacted by the complex multisensory signals present in real-world environments. We tested the hypothesis that reductions in social attention associated with autism would be magnified by increasing perceptual load (e.g., motion, multisensory cues). Adult participants (N = 40; 19 ASC) explored a diverse set of 360° real-world scenes in a naturalistic, active viewing paradigm (immersive virtual reality + eyetracking). Across three conditions, we systematically varied perceptual load while holding the social and semantic information present in each scene constant. We demonstrate that reduced social attention is not a static signature of the autistic phenotype. Rather, group differences in social attention emerged with increasing perceptual load in naturalistic environments, and the susceptibility of social attention to perceptual load predicted continuous measures of autistic traits across groups. Crucially, this pattern was specific to the social domain: we did not observe differential impacts of perceptual load on attention directed toward nonsocial semantic (i.e., object, place) information or low-level fixation behavior (i.e., overall fixation frequency or duration). This study provides a direct link between social and sensory processing in autism. Moreover, reduced social attention may be an inaccurate characterization of autism. Instead, our results suggest that social attention in autism is better explained by "social vulnerability," particularly to the perceptual load of real-world environments. En ligne : http://dx.doi.org/10.1002/aur.2829 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Reduced social attention in autism is magnified by perceptual load in naturalistic environments [Texte imprimé et/ou numérique] / Amanda J. HASKINS, Auteur ; Jeff MENTCH, Auteur ; Thomas L. BOTCH, Auteur ; Brenda D. GARCIA, Auteur ; Alexandra L. BURROWS, Auteur ; Caroline E. ROBERTSON, Auteur . - p.2310-2323. Langues : Anglais (eng) in Autism Research > 15-12 (December 2022) . - p.2310-2323 Mots-clés : Humans  Autistic Disorder  Autism Spectrum Disorder  Cues  Attention  adults  eye movement  sensory  social cognition Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum conditions (ASC) describe differences in both social cognition and sensory processing, but little is known about the causal relationship between these disparate functional domains. In the present study, we sought to understand how a core characteristic of autism-reduced social attention-is impacted by the complex multisensory signals present in real-world environments. We tested the hypothesis that reductions in social attention associated with autism would be magnified by increasing perceptual load (e.g., motion, multisensory cues). Adult participants (N = 40; 19 ASC) explored a diverse set of 360° real-world scenes in a naturalistic, active viewing paradigm (immersive virtual reality + eyetracking). Across three conditions, we systematically varied perceptual load while holding the social and semantic information present in each scene constant. We demonstrate that reduced social attention is not a static signature of the autistic phenotype. Rather, group differences in social attention emerged with increasing perceptual load in naturalistic environments, and the susceptibility of social attention to perceptual load predicted continuous measures of autistic traits across groups. Crucially, this pattern was specific to the social domain: we did not observe differential impacts of perceptual load on attention directed toward nonsocial semantic (i.e., object, place) information or low-level fixation behavior (i.e., overall fixation frequency or duration). This study provides a direct link between social and sensory processing in autism. Moreover, reduced social attention may be an inaccurate characterization of autism. Instead, our results suggest that social attention in autism is better explained by "social vulnerability," particularly to the perceptual load of real-world environments. En ligne : http://dx.doi.org/10.1002/aur.2829 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Bidding on the go: Links between walking, social actions, and caregiver responses in infant siblings of children with autism spectrum disorder / Bianca T. CALABRETTA in Autism Research, 15-12 (December 2022)  

Public ISBD [article]  inAutism Research > 15-12 (December 2022) . - p.2324-2335 Titre : Bidding on the go: Links between walking, social actions, and caregiver responses in infant siblings of children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Bianca T. CALABRETTA, Auteur ; Joshua L. SCHNEIDER, Auteur ; Jana M. IVERSON, Auteur Article en page(s) : p.2324-2335 Langues : Anglais (eng) Mots-clés : Infant  Child  Humans  Autism Spectrum Disorder/diagnosis  Siblings  Caregivers  Walking  approaching  caregiver responses  developmental cascades  infant walking  language input  moving bids  object carrying Index. décimale : PER Périodiques Résumé : The development of walking is associated with a shift in how neurotypical infants initiate social interactions. Walking infants are more likely to locate objects in distant places, carry them, and then share those objects by approaching caregivers and using gestures to show or offer their discoveries (i.e., moving bids). The simultaneous organization of the behaviors necessary to generate moving bids requires the coordination of multiple skills-walking, fine motor skills, and gesturing. Infants with an elevated likelihood (EL) for autism spectrum disorder (ASD) exhibit differences and delays in each of these behaviors. This study investigated interconnections between infant walking, social actions, and caregiver responses in 18-month-old EL infants with diverse developmental outcomes (ASD, non-ASD language delay, no diagnosis). We observed 85 infant-caregiver dyads at home during everyday activities for 45 minutes and identified all times when infants walked, instances of walking paired with social action (i.e., approaching the caregiver, approaching while carrying an object, producing a moving bid), and whether caregivers responded to their infants' social actions. There were no group differences in infants' production of social actions. Caregiver responses, however, were more clearly modulated by outcome group. While all caregivers were similarly and highly likely to respond to moving bids, caregivers of EL-ASD infants were substantially more likely to respond when their infants simply approached them (with or without an object in hand). Taken together, this research underscores the complexity of EL infant-caregiver interactions and highlights the role that each partner plays in shaping how they unfold. En ligne : http://dx.doi.org/10.1002/aur.2830 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Bidding on the go: Links between walking, social actions, and caregiver responses in infant siblings of children with autism spectrum disorder [Texte imprimé et/ou numérique] / Bianca T. CALABRETTA, Auteur ; Joshua L. SCHNEIDER, Auteur ; Jana M. IVERSON, Auteur . - p.2324-2335. Langues : Anglais (eng) in Autism Research > 15-12 (December 2022) . - p.2324-2335 Mots-clés : Infant  Child  Humans  Autism Spectrum Disorder/diagnosis  Siblings  Caregivers  Walking  approaching  caregiver responses  developmental cascades  infant walking  language input  moving bids  object carrying Index. décimale : PER Périodiques Résumé : The development of walking is associated with a shift in how neurotypical infants initiate social interactions. Walking infants are more likely to locate objects in distant places, carry them, and then share those objects by approaching caregivers and using gestures to show or offer their discoveries (i.e., moving bids). The simultaneous organization of the behaviors necessary to generate moving bids requires the coordination of multiple skills-walking, fine motor skills, and gesturing. Infants with an elevated likelihood (EL) for autism spectrum disorder (ASD) exhibit differences and delays in each of these behaviors. This study investigated interconnections between infant walking, social actions, and caregiver responses in 18-month-old EL infants with diverse developmental outcomes (ASD, non-ASD language delay, no diagnosis). We observed 85 infant-caregiver dyads at home during everyday activities for 45 minutes and identified all times when infants walked, instances of walking paired with social action (i.e., approaching the caregiver, approaching while carrying an object, producing a moving bid), and whether caregivers responded to their infants' social actions. There were no group differences in infants' production of social actions. Caregiver responses, however, were more clearly modulated by outcome group. While all caregivers were similarly and highly likely to respond to moving bids, caregivers of EL-ASD infants were substantially more likely to respond when their infants simply approached them (with or without an object in hand). Taken together, this research underscores the complexity of EL infant-caregiver interactions and highlights the role that each partner plays in shaping how they unfold. En ligne : http://dx.doi.org/10.1002/aur.2830 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Using percentiles in the interpretation of Patient-Reported Outcomes Measurement Information System scores: Guidelines for autism / Julia SCHUCHARD in Autism Research, 15-12 (December 2022)  

Public ISBD [article]  inAutism Research > 15-12 (December 2022) . - p.2336-2345 Titre : Using percentiles in the interpretation of Patient-Reported Outcomes Measurement Information System scores: Guidelines for autism Type de document : Texte imprimé et/ou numérique Auteurs : Julia SCHUCHARD, Auteur ; Elizabeth A. KAPLAN-KAHN, Auteur ; Adam C CARLE, Auteur ; Laura GRAHAM HOLMES, Auteur ; Kiely LAW, Auteur ; Judith S MILLER, Auteur ; Julia PARISH-MORRIS, Auteur ; Christopher B. FORREST, Auteur Article en page(s) : p.2336-2345 Langues : Anglais (eng) Mots-clés : Child  Adolescent  Humans  United States  Child, Preschool  Autistic Disorder/complications/diagnosis  Surveys and Questionnaires  Quality of Life  Autism Spectrum Disorder  Patient Reported Outcome Measures  Sleep Wake Disorders/diagnosis/epidemiology  Information Systems  Promis  autism  material hardship  parent-report  patient-reported outcomes Index. décimale : PER Périodiques Résumé : The objectives of this study were to (1) demonstrate the application of percentiles to advance the interpretation of patient-reported outcomes and (2) establish autism-specific percentiles for four Patient-Reported Outcomes Measurement Information System (PROMIS) measures. PROMIS measures were completed by parents of autistic children and adolescents ages 5-17 years as part of two studies (n = 939 parents in the first study and n = 406 parents in the second study). Data from the first study were used to develop autism-specific percentiles for PROMIS parent-proxy sleep disturbance, sleep-related impairment, fatigue, and anxiety. Previously established United States general population percentiles were applied to interpret PROMIS scores in both studies. Results of logistic regression models showed that parent-reported material hardship was associated with scoring in the moderate-severe range (defined as â¥75th percentile in the general population) on all four PROMIS measures (odds ratios 1.7-2.2). In the second study, the percentage of children with severe scores (defined as â¥95th percentile in the general population) was 30% for anxiety, 25% for sleep disturbance, and 17% for sleep-related impairment, indicating a high burden of these problems among autistic children. Few children had scores at or above the autism-specific 95th percentile on these measures (3%-4%), indicating that their scores were similar to other autistic children. The general population and condition-specific percentiles provide two complementary reference points to aid interpretation of PROMIS scores, including corresponding severity categories that are comparable across different PROMIS measures. En ligne : http://dx.doi.org/10.1002/aur.2833 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Using percentiles in the interpretation of Patient-Reported Outcomes Measurement Information System scores: Guidelines for autism [Texte imprimé et/ou numérique] / Julia SCHUCHARD, Auteur ; Elizabeth A. KAPLAN-KAHN, Auteur ; Adam C CARLE, Auteur ; Laura GRAHAM HOLMES, Auteur ; Kiely LAW, Auteur ; Judith S MILLER, Auteur ; Julia PARISH-MORRIS, Auteur ; Christopher B. FORREST, Auteur . - p.2336-2345. Langues : Anglais (eng) in Autism Research > 15-12 (December 2022) . - p.2336-2345 Mots-clés : Child  Adolescent  Humans  United States  Child, Preschool  Autistic Disorder/complications/diagnosis  Surveys and Questionnaires  Quality of Life  Autism Spectrum Disorder  Patient Reported Outcome Measures  Sleep Wake Disorders/diagnosis/epidemiology  Information Systems  Promis  autism  material hardship  parent-report  patient-reported outcomes Index. décimale : PER Périodiques Résumé : The objectives of this study were to (1) demonstrate the application of percentiles to advance the interpretation of patient-reported outcomes and (2) establish autism-specific percentiles for four Patient-Reported Outcomes Measurement Information System (PROMIS) measures. PROMIS measures were completed by parents of autistic children and adolescents ages 5-17 years as part of two studies (n = 939 parents in the first study and n = 406 parents in the second study). Data from the first study were used to develop autism-specific percentiles for PROMIS parent-proxy sleep disturbance, sleep-related impairment, fatigue, and anxiety. Previously established United States general population percentiles were applied to interpret PROMIS scores in both studies. Results of logistic regression models showed that parent-reported material hardship was associated with scoring in the moderate-severe range (defined as â¥75th percentile in the general population) on all four PROMIS measures (odds ratios 1.7-2.2). In the second study, the percentage of children with severe scores (defined as â¥95th percentile in the general population) was 30% for anxiety, 25% for sleep disturbance, and 17% for sleep-related impairment, indicating a high burden of these problems among autistic children. Few children had scores at or above the autism-specific 95th percentile on these measures (3%-4%), indicating that their scores were similar to other autistic children. The general population and condition-specific percentiles provide two complementary reference points to aid interpretation of PROMIS scores, including corresponding severity categories that are comparable across different PROMIS measures. En ligne : http://dx.doi.org/10.1002/aur.2833 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Mental health issues in parents of children with autism spectrum disorder: A multi-time-point study related to COVID-19 pandemic / Luxi WANG in Autism Research, 15-12 (December 2022)  

Public ISBD [article]  inAutism Research > 15-12 (December 2022) . - p.2346-2358 Titre : Mental health issues in parents of children with autism spectrum disorder: A multi-time-point study related to COVID-19 pandemic Type de document : Texte imprimé et/ou numérique Auteurs : Luxi WANG, Auteur ; Huiying ZHANG, Auteur ; Chuang SHANG, Auteur ; Huirong LIANG, Auteur ; Wenlong LIU, Auteur ; Bing HAN, Auteur ; Wei XIA, Auteur ; Mingyang ZOU, Auteur Article en page(s) : p.2346-2358 Langues : Anglais (eng) Mots-clés : Child  Humans  covid-19  Pandemics  Autism Spectrum Disorder/complications/epidemiology/psychology  Mental Health  Cross-Sectional Studies  Parents/psychology  Anxiety/epidemiology  Covid-19  autism spectrum disorder  multi-time-point study  parents Index. décimale : PER Périodiques Résumé : Given the unpredictability and challenges brought about by the 2019 novel coronavirus (COVID-19) pandemic, this study aimed to investigate the impact trend of the prolonged pandemic on the mental health of parents of children with autism spectrum disorder (ASD). The 8112 participants included parents of children with ASD and parents of typically developing (TD) children at two sites (Heilongjiang and Fujian province, China). The parents completed a set of self-report questionnaires covering demographic characteristics, influences related to COVID-19, COVID-19 concerns and perceived behaviors, as well as the Connor-Davidson resilience scale (CD-RISC), self-rating anxiety scale (SAS), and self-rating depression scale (SDS) by means of an online survey platform. Data were collected by three cross-sectional surveys carried out in April 2020 (Time 1), October 2020 (Time 2), and October 2021 (Time 3). The results of quantitative and qualitative comparisons showed that: (i) parents of children with ASD had lower levels of resilience, and more symptoms of anxiety and depression than parents of TD children at each time point (all P < 0.05); and (ii) there were significant time-cumulative changes in resilience, anxiety, and depression among all participants (all P < 0.05). The logistic regression analyzes after adjusting for demographic characteristics revealed that the following factors were significantly associated with poor resilience and a higher rate of anxiety and depression in parents of children with ASD: time-point, the effect of COVID-19 on children's emotions and parents' emotions, changes in relationships, changes in physical exercise, changes in daily diet during the COVID-19 pandemic, and COVID-19-related psychological distress. In conclusions, the parents did not report improvements in resilience, anxiety, or depression symptoms from Time 1 to Time 2 or 3, indicating that cumulative mental health issues increased when, surprisingly, the COVID-19 restrictions were eased. The psychological harm resulting from the COVID-19 pandemic is far-reaching, especially among parents of children with ASD. En ligne : http://dx.doi.org/10.1002/aur.2836 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Mental health issues in parents of children with autism spectrum disorder: A multi-time-point study related to COVID-19 pandemic [Texte imprimé et/ou numérique] / Luxi WANG, Auteur ; Huiying ZHANG, Auteur ; Chuang SHANG, Auteur ; Huirong LIANG, Auteur ; Wenlong LIU, Auteur ; Bing HAN, Auteur ; Wei XIA, Auteur ; Mingyang ZOU, Auteur . - p.2346-2358. Langues : Anglais (eng) in Autism Research > 15-12 (December 2022) . - p.2346-2358 Mots-clés : Child  Humans  covid-19  Pandemics  Autism Spectrum Disorder/complications/epidemiology/psychology  Mental Health  Cross-Sectional Studies  Parents/psychology  Anxiety/epidemiology  Covid-19  autism spectrum disorder  multi-time-point study  parents Index. décimale : PER Périodiques Résumé : Given the unpredictability and challenges brought about by the 2019 novel coronavirus (COVID-19) pandemic, this study aimed to investigate the impact trend of the prolonged pandemic on the mental health of parents of children with autism spectrum disorder (ASD). The 8112 participants included parents of children with ASD and parents of typically developing (TD) children at two sites (Heilongjiang and Fujian province, China). The parents completed a set of self-report questionnaires covering demographic characteristics, influences related to COVID-19, COVID-19 concerns and perceived behaviors, as well as the Connor-Davidson resilience scale (CD-RISC), self-rating anxiety scale (SAS), and self-rating depression scale (SDS) by means of an online survey platform. Data were collected by three cross-sectional surveys carried out in April 2020 (Time 1), October 2020 (Time 2), and October 2021 (Time 3). The results of quantitative and qualitative comparisons showed that: (i) parents of children with ASD had lower levels of resilience, and more symptoms of anxiety and depression than parents of TD children at each time point (all P < 0.05); and (ii) there were significant time-cumulative changes in resilience, anxiety, and depression among all participants (all P < 0.05). The logistic regression analyzes after adjusting for demographic characteristics revealed that the following factors were significantly associated with poor resilience and a higher rate of anxiety and depression in parents of children with ASD: time-point, the effect of COVID-19 on children's emotions and parents' emotions, changes in relationships, changes in physical exercise, changes in daily diet during the COVID-19 pandemic, and COVID-19-related psychological distress. In conclusions, the parents did not report improvements in resilience, anxiety, or depression symptoms from Time 1 to Time 2 or 3, indicating that cumulative mental health issues increased when, surprisingly, the COVID-19 restrictions were eased. The psychological harm resulting from the COVID-19 pandemic is far-reaching, especially among parents of children with ASD. En ligne : http://dx.doi.org/10.1002/aur.2836 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Associations between accelerated parental biologic age, autism spectrum disorder, social traits, and developmental and cognitive outcomes in their children / Ashley Y. SONG in Autism Research, 15-12 (December 2022)  

Public ISBD [article]  inAutism Research > 15-12 (December 2022) . - p.2359-2370 Titre : Associations between accelerated parental biologic age, autism spectrum disorder, social traits, and developmental and cognitive outcomes in their children Type de document : Texte imprimé et/ou numérique Auteurs : Ashley Y. SONG, Auteur ; Kelly BAKULSKI, Auteur ; Jason I. FEINBERG, Auteur ; Craig NEWSCHAFFER, Auteur ; Lisa A. CROEN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Rebecca J. SCHMIDT, Auteur ; Homayoon FARZADEGAN, Auteur ; Kristen LYALL, Auteur ; M Daniele FALLIN, Auteur ; Heather E. VOLK, Auteur ; Christine LADD-ACOSTA, Auteur Article en page(s) : p.2359-2370 Langues : Anglais (eng) Mots-clés : Child  Male  Pregnancy  Female  Humans  Autism Spectrum Disorder/epidemiology/genetics  Prospective Studies  Parents  Cognition  Biological Products  Epigenesis, Genetic  DNA methylation  age acceleration  autism spectrum disorder  autism-related traits  biologic age  epigenetic age  parental age Index. décimale : PER Périodiques Résumé : Parental age is a known risk factor for autism spectrum disorder (ASD), however, studies to identify the biologic changes underpinning this association are limited. In recent years, "epigenetic clock" algorithms have been developed to estimate biologic age and to evaluate how the epigenetic aging impacts health and disease. In this study, we examined the relationship between parental epigenetic aging and their child's prospective risk of ASD and autism related quantitative traits in the Early Autism Risk Longitudinal Investigation study. Estimates of epigenetic age were computed using three robust clock algorithms and DNA methylation measures from the Infinium HumanMethylation450k platform for maternal blood and paternal blood specimens collected during pregnancy. Epigenetic age acceleration was defined as the residual of regressing chronological age on epigenetic age while accounting for cell type proportions. Multinomial logistic regression and linear regression models were completed adjusting for potential confounders for both maternal epigenetic age acceleration (n = 163) and paternal epigenetic age acceleration (n = 80). We found accelerated epigenetic aging in mothers estimated by Hannum's clock was significantly associated with lower cognitive ability and function in offspring at 12 months, as measured by Mullen Scales of Early Learning scores (Î2 = -1.66, 95% CI: -3.28, -0.04 for a one-unit increase). We also observed a marginal association between accelerated maternal epigenetic aging by Horvath's clock and increased odds of ASD in offspring at 36 months of age (aOR = 1.12, 95% CI: 0.99, 1.26). By contrast, fathers accelerated aging was marginally associated with decreased ASD risk in their offspring (aOR = 0.83, 95% CI: 0.68, 1.01). Our findings suggest epigenetic aging could play a role in parental age risks on child brain development. En ligne : http://dx.doi.org/10.1002/aur.2822 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Associations between accelerated parental biologic age, autism spectrum disorder, social traits, and developmental and cognitive outcomes in their children [Texte imprimé et/ou numérique] / Ashley Y. SONG, Auteur ; Kelly BAKULSKI, Auteur ; Jason I. FEINBERG, Auteur ; Craig NEWSCHAFFER, Auteur ; Lisa A. CROEN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Rebecca J. SCHMIDT, Auteur ; Homayoon FARZADEGAN, Auteur ; Kristen LYALL, Auteur ; M Daniele FALLIN, Auteur ; Heather E. VOLK, Auteur ; Christine LADD-ACOSTA, Auteur . - p.2359-2370. Langues : Anglais (eng) in Autism Research > 15-12 (December 2022) . - p.2359-2370 Mots-clés : Child  Male  Pregnancy  Female  Humans  Autism Spectrum Disorder/epidemiology/genetics  Prospective Studies  Parents  Cognition  Biological Products  Epigenesis, Genetic  DNA methylation  age acceleration  autism spectrum disorder  autism-related traits  biologic age  epigenetic age  parental age Index. décimale : PER Périodiques Résumé : Parental age is a known risk factor for autism spectrum disorder (ASD), however, studies to identify the biologic changes underpinning this association are limited. In recent years, "epigenetic clock" algorithms have been developed to estimate biologic age and to evaluate how the epigenetic aging impacts health and disease. In this study, we examined the relationship between parental epigenetic aging and their child's prospective risk of ASD and autism related quantitative traits in the Early Autism Risk Longitudinal Investigation study. Estimates of epigenetic age were computed using three robust clock algorithms and DNA methylation measures from the Infinium HumanMethylation450k platform for maternal blood and paternal blood specimens collected during pregnancy. Epigenetic age acceleration was defined as the residual of regressing chronological age on epigenetic age while accounting for cell type proportions. Multinomial logistic regression and linear regression models were completed adjusting for potential confounders for both maternal epigenetic age acceleration (n = 163) and paternal epigenetic age acceleration (n = 80). We found accelerated epigenetic aging in mothers estimated by Hannum's clock was significantly associated with lower cognitive ability and function in offspring at 12 months, as measured by Mullen Scales of Early Learning scores (Î2 = -1.66, 95% CI: -3.28, -0.04 for a one-unit increase). We also observed a marginal association between accelerated maternal epigenetic aging by Horvath's clock and increased odds of ASD in offspring at 36 months of age (aOR = 1.12, 95% CI: 0.99, 1.26). By contrast, fathers accelerated aging was marginally associated with decreased ASD risk in their offspring (aOR = 0.83, 95% CI: 0.68, 1.01). Our findings suggest epigenetic aging could play a role in parental age risks on child brain development. En ligne : http://dx.doi.org/10.1002/aur.2822 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Association of maternal autoimmune disease and early childhood infections with offspring autism spectrum disorder: A population-based cohort study / Timothy C. NIELSEN in Autism Research, 15-12 (December 2022)  

Public ISBD [article]  inAutism Research > 15-12 (December 2022) . - p.2371-2380 Titre : Association of maternal autoimmune disease and early childhood infections with offspring autism spectrum disorder: A population-based cohort study Type de document : Texte imprimé et/ou numérique Auteurs : Timothy C. NIELSEN, Auteur ; Natasha NASSAR, Auteur ; Antonia W. SHAND, Auteur ; Hannah F. JONES, Auteur ; Velda X. HAN, Auteur ; Shrujna PATEL, Auteur ; Adam J. GUASTELLA, Auteur ; Russell C DALE, Auteur ; Samantha J. LAIN, Auteur Article en page(s) : p.2371-2380 Langues : Anglais (eng) Mots-clés : Child  Child, Preschool  Humans  Autism Spectrum Disorder/epidemiology/etiology  Cohort Studies  Odds Ratio  Logistic Models  Autoimmune Diseases/epidemiology/complications  Australia  autism Spectrum disorder  autoimmune diseases  infections  pregnancy Index. décimale : PER Périodiques Résumé : The aim of this study was to examine potential synergistic effects between maternal autoimmune disease and early childhood infections and their association with autism spectrum disorder (ASD) in offspring. Both exposures have been associated with increased risk of ASD in previous studies, but potential synergistic effects remain underexplored. We conducted a population-based cohort study of singleton children born at term gestation (37-41 weeks) in New South Wales, Australia from January 2002 to December 2008. Maternal autoimmune diagnoses and childhood infections before age 2 years were identified from linked maternal and child hospital admissions, and ASD diagnoses by age 9 years were identified from linked disability services data. Multivariable logistic regression assessed the association between each exposure and ASD and additive interaction between exposures, controlling for potential confounders. A total of 18,451 children exposed to maternal autoimmune disease were propensity score matched (1:2) to 36,902 unexposed children. Any maternal autoimmune disease (adjusted odds ratio (aOR) 1.25, 95% confidence interval (CI) 1.07-1.47) and any childhood infection before age 2 years (aOR 1.38, 95% CI 1.15-1.67) were each associated with ASD. However, there was no evidence of additive interaction between the two exposures (relative excess risk due to interaction [RERI] 0.128, 95% CI -0.418-0.675) resulting in increased odds of ASD in offspring. Future studies could examine potential interactions between other sources of maternal immune activation and childhood infection and impact on ASD and other neurodevelopmental disorders. En ligne : http://dx.doi.org/10.1002/aur.2824 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Association of maternal autoimmune disease and early childhood infections with offspring autism spectrum disorder: A population-based cohort study [Texte imprimé et/ou numérique] / Timothy C. NIELSEN, Auteur ; Natasha NASSAR, Auteur ; Antonia W. SHAND, Auteur ; Hannah F. JONES, Auteur ; Velda X. HAN, Auteur ; Shrujna PATEL, Auteur ; Adam J. GUASTELLA, Auteur ; Russell C DALE, Auteur ; Samantha J. LAIN, Auteur . - p.2371-2380. Langues : Anglais (eng) in Autism Research > 15-12 (December 2022) . - p.2371-2380 Mots-clés : Child  Child, Preschool  Humans  Autism Spectrum Disorder/epidemiology/etiology  Cohort Studies  Odds Ratio  Logistic Models  Autoimmune Diseases/epidemiology/complications  Australia  autism Spectrum disorder  autoimmune diseases  infections  pregnancy Index. décimale : PER Périodiques Résumé : The aim of this study was to examine potential synergistic effects between maternal autoimmune disease and early childhood infections and their association with autism spectrum disorder (ASD) in offspring. Both exposures have been associated with increased risk of ASD in previous studies, but potential synergistic effects remain underexplored. We conducted a population-based cohort study of singleton children born at term gestation (37-41 weeks) in New South Wales, Australia from January 2002 to December 2008. Maternal autoimmune diagnoses and childhood infections before age 2 years were identified from linked maternal and child hospital admissions, and ASD diagnoses by age 9 years were identified from linked disability services data. Multivariable logistic regression assessed the association between each exposure and ASD and additive interaction between exposures, controlling for potential confounders. A total of 18,451 children exposed to maternal autoimmune disease were propensity score matched (1:2) to 36,902 unexposed children. Any maternal autoimmune disease (adjusted odds ratio (aOR) 1.25, 95% confidence interval (CI) 1.07-1.47) and any childhood infection before age 2 years (aOR 1.38, 95% CI 1.15-1.67) were each associated with ASD. However, there was no evidence of additive interaction between the two exposures (relative excess risk due to interaction [RERI] 0.128, 95% CI -0.418-0.675) resulting in increased odds of ASD in offspring. Future studies could examine potential interactions between other sources of maternal immune activation and childhood infection and impact on ASD and other neurodevelopmental disorders. En ligne : http://dx.doi.org/10.1002/aur.2824 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Resilience, and positive parenting in parents of children with syndromic autism and intellectual disability. Evidence from the impact of the COVID-19 pandemic on family's quality of life and parent-child relationships / Corneliu BOLBOCEAN in Autism Research, 15-12 (December 2022)  

Public ISBD [article]  inAutism Research > 15-12 (December 2022) . - p.2381-2398 Titre : Resilience, and positive parenting in parents of children with syndromic autism and intellectual disability. Evidence from the impact of the COVID-19 pandemic on family's quality of life and parent-child relationships Type de document : Texte imprimé et/ou numérique Auteurs : Corneliu BOLBOCEAN, Auteur ; Kayla B. RHIDENOUR, Auteur ; Maria MCCORMACK, Auteur ; Bernhard SUTER, Auteur ; Jimmy Lloyd HOLDER, Auteur Article en page(s) : p.2381-2398 Langues : Anglais (eng) Mots-clés : Humans  Parenting  Quality of Life  Intellectual Disability/epidemiology  covid-19  Autistic Disorder/epidemiology  Pandemics  Autism Spectrum Disorder  Parents  Parent-Child Relations  Covid-19  Phelan-McDermid syndrome  Rett syndrome  Syngap1-id  autism  families of autistic children  intellectual disabilities  resilience Index. décimale : PER Périodiques Résumé : Family quality of life (FQoL) outcomes collected during the first year of COVID-19 has been combined with 2018 data to estimate the outbreak's impact on parental outcomes on a sample of 230 families with syndromic autistic children and those with intellectual disabilities (IDs). Despite challenges imposed by the COVID-19 outbreak, our study found that FQoL outcomes reported by participating parents during the first year of COVID-19 appears to be similar to ratings from a prepandemic study of families with the same conditions. Parents of children in our sample generally displayed a stable functioning trajectory as measured by the validated FQoL instrument. Across syndromic autistic groups considered, families reported that their relationships with their children were positive. Our findings provide evidence of families' resilience which might explain the presence of positive parent-child interactions during COVID-19. Exploring mechanisms which would explain how families with autistic and ID children confront, manage disruptive experiences, and buffer COVID-19 induced stress is a fruitful direction for future research. En ligne : http://dx.doi.org/10.1002/aur.2825 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Resilience, and positive parenting in parents of children with syndromic autism and intellectual disability. Evidence from the impact of the COVID-19 pandemic on family's quality of life and parent-child relationships [Texte imprimé et/ou numérique] / Corneliu BOLBOCEAN, Auteur ; Kayla B. RHIDENOUR, Auteur ; Maria MCCORMACK, Auteur ; Bernhard SUTER, Auteur ; Jimmy Lloyd HOLDER, Auteur . - p.2381-2398. Langues : Anglais (eng) in Autism Research > 15-12 (December 2022) . - p.2381-2398 Mots-clés : Humans  Parenting  Quality of Life  Intellectual Disability/epidemiology  covid-19  Autistic Disorder/epidemiology  Pandemics  Autism Spectrum Disorder  Parents  Parent-Child Relations  Covid-19  Phelan-McDermid syndrome  Rett syndrome  Syngap1-id  autism  families of autistic children  intellectual disabilities  resilience Index. décimale : PER Périodiques Résumé : Family quality of life (FQoL) outcomes collected during the first year of COVID-19 has been combined with 2018 data to estimate the outbreak's impact on parental outcomes on a sample of 230 families with syndromic autistic children and those with intellectual disabilities (IDs). Despite challenges imposed by the COVID-19 outbreak, our study found that FQoL outcomes reported by participating parents during the first year of COVID-19 appears to be similar to ratings from a prepandemic study of families with the same conditions. Parents of children in our sample generally displayed a stable functioning trajectory as measured by the validated FQoL instrument. Across syndromic autistic groups considered, families reported that their relationships with their children were positive. Our findings provide evidence of families' resilience which might explain the presence of positive parent-child interactions during COVID-19. Exploring mechanisms which would explain how families with autistic and ID children confront, manage disruptive experiences, and buffer COVID-19 induced stress is a fruitful direction for future research. En ligne : http://dx.doi.org/10.1002/aur.2825 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

The role of intellectual disability with autism spectrum disorder and the documented cooccurring conditions: A population-based study / Semra ETYEMEZ in Autism Research, 15-12 (December 2022)  

Public ISBD [article]  inAutism Research > 15-12 (December 2022) . - p.2399-2408 Titre : The role of intellectual disability with autism spectrum disorder and the documented cooccurring conditions: A population-based study Type de document : Texte imprimé et/ou numérique Auteurs : Semra ETYEMEZ, Auteur ; Amy ESLER, Auteur ; Aniket KINI, Auteur ; Peng-Chou TSAI, Auteur ; Monica DIRIENZO, Auteur ; Matthew MAENNER, Auteur ; Li-Ching LEE, Auteur Article en page(s) : p.2399-2408 Langues : Anglais (eng) Mots-clés : Child  Humans  Autism Spectrum Disorder/complications/epidemiology  Intellectual Disability/complications/epidemiology  Prevalence  Research  Autistic Disorder  autism spectrum disorder  autistic disorder  developmental disabilities  intellectual disability  nervous system diseases Index. décimale : PER Périodiques Résumé : Previous research has identified that patterns of cooccurring conditions (CoCs) associated with autism spectrum disorder (ASD) differ based on the presence of intellectual disability (ID). This study explored the association of documented CoCs among 8-year-old children with ASD and ID (ASD+ID, n = 2416) and ASD without ID (ASD-ID, n = 5372) identified by the Autism and Developmental Disabilities Monitoring Network, surveillance years (SYs) 2012 and 2014. After adjusting for demographic variables, record source, surveillance site, and SY, children with ASD+ID, as compared with children with ASD-ID, were more likely to have histories of nonspecific developmental delays and neurological disorders documented in their records but were less likely to have behavioral and psychiatric disorders. ID plays a key role on how children with ASD would experience other CoCs. Our results emphasize how understanding the pattern of CoCs in ASD+ID and ASD-ID can inform comprehensive and multidisciplinary approaches in assessment and management of children in order to develop targeted interventions to reduce possible CoCs or CoCs-related impairments. En ligne : http://dx.doi.org/10.1002/aur.2831 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] The role of intellectual disability with autism spectrum disorder and the documented cooccurring conditions: A population-based study [Texte imprimé et/ou numérique] / Semra ETYEMEZ, Auteur ; Amy ESLER, Auteur ; Aniket KINI, Auteur ; Peng-Chou TSAI, Auteur ; Monica DIRIENZO, Auteur ; Matthew MAENNER, Auteur ; Li-Ching LEE, Auteur . - p.2399-2408. Langues : Anglais (eng) in Autism Research > 15-12 (December 2022) . - p.2399-2408 Mots-clés : Child  Humans  Autism Spectrum Disorder/complications/epidemiology  Intellectual Disability/complications/epidemiology  Prevalence  Research  Autistic Disorder  autism spectrum disorder  autistic disorder  developmental disabilities  intellectual disability  nervous system diseases Index. décimale : PER Périodiques Résumé : Previous research has identified that patterns of cooccurring conditions (CoCs) associated with autism spectrum disorder (ASD) differ based on the presence of intellectual disability (ID). This study explored the association of documented CoCs among 8-year-old children with ASD and ID (ASD+ID, n = 2416) and ASD without ID (ASD-ID, n = 5372) identified by the Autism and Developmental Disabilities Monitoring Network, surveillance years (SYs) 2012 and 2014. After adjusting for demographic variables, record source, surveillance site, and SY, children with ASD+ID, as compared with children with ASD-ID, were more likely to have histories of nonspecific developmental delays and neurological disorders documented in their records but were less likely to have behavioral and psychiatric disorders. ID plays a key role on how children with ASD would experience other CoCs. Our results emphasize how understanding the pattern of CoCs in ASD+ID and ASD-ID can inform comprehensive and multidisciplinary approaches in assessment and management of children in order to develop targeted interventions to reduce possible CoCs or CoCs-related impairments. En ligne : http://dx.doi.org/10.1002/aur.2831 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Associations between parental psychiatric disorders and autism spectrum disorder in the offspring / Yi-Ling CHIEN in Autism Research, 15-12 (December 2022)  

Public ISBD [article]  inAutism Research > 15-12 (December 2022) . - p.2409-2419 Titre : Associations between parental psychiatric disorders and autism spectrum disorder in the offspring Type de document : Texte imprimé et/ou numérique Auteurs : Yi-Ling CHIEN, Auteur ; Chi-Shin WU, Auteur ; Yen-Chen CHANG, Auteur ; Mei-Leng CHEONG, Auteur ; Tsung-Chieh YAO, Auteur ; Hui-Ju TSAI, Auteur Article en page(s) : p.2409-2419 Langues : Anglais (eng) Mots-clés : Child  Female  Humans  Autism Spectrum Disorder/epidemiology/genetics/complications  Case-Control Studies  Parents/psychology  Attention Deficit Disorder with Hyperactivity/epidemiology/genetics  Mothers/psychology  autism spectrum disorder  offspring  parental  psychiatric disorders Index. décimale : PER Périodiques Résumé : Whether parental psychiatric disorders are associated with autism spectrum disorder (ASD) in offspring has remained inconclusive. We examined the associations of parental psychiatric disorders with ASD in offspring. This population-based case-control study used Taiwan's National Health Insurance Research Database to identify a cohort of children born from 2004 to 2017 and their parents. A total of 24,279 children with ASD (diagnostic ICD-9-CM code: 299.x or ICD-10 code F84.x) and 97,715 matched controls were included. Parental psychiatric disorders, including depressive disorders, bipolar spectrum disorders, anxiety disorders, obsessive-compulsive disorder, schizophrenia, substance use disorders, autism spectrum disorder, attention-deficit hyperactivity disorder (ADHD), and adjustment disorders were identified. Conditional logistic regressions with covariate adjustment were performed. The results suggest that parental diagnosis with any of the psychiatric disorders is associated with ASD in offspring (adjusted odds ratio [AOR] = 1.45, 95%CI: 1.40-1.51 for mothers; and AOR = 1.12, 95%CI: 1.08-1.17 for fathers). ASD in offspring was associated with schizophrenia, depressive disorders, obsessive-compulsive disorder, adjustment disorders, ADHD and ASD in both parents. The relationship between parental psychiatric disorders and the timing of the child's birth and ASD diagnosis varied across the different psychiatric disorders. The present study provides supportive evidence that parental psychiatric disorders are associated with autistic children. Furthermore, because the associations between parental psychiatric disorders and the timing of child's birth and ASD diagnosis varied across psychiatric disorders, the observed relationships may be affected by both genetic and environmental factors. Future studies are needed to disentangle the potential influence of genetic and environmental factors on the observed associations. En ligne : http://dx.doi.org/10.1002/aur.2835 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Associations between parental psychiatric disorders and autism spectrum disorder in the offspring [Texte imprimé et/ou numérique] / Yi-Ling CHIEN, Auteur ; Chi-Shin WU, Auteur ; Yen-Chen CHANG, Auteur ; Mei-Leng CHEONG, Auteur ; Tsung-Chieh YAO, Auteur ; Hui-Ju TSAI, Auteur . - p.2409-2419. Langues : Anglais (eng) in Autism Research > 15-12 (December 2022) . - p.2409-2419 Mots-clés : Child  Female  Humans  Autism Spectrum Disorder/epidemiology/genetics/complications  Case-Control Studies  Parents/psychology  Attention Deficit Disorder with Hyperactivity/epidemiology/genetics  Mothers/psychology  autism spectrum disorder  offspring  parental  psychiatric disorders Index. décimale : PER Périodiques Résumé : Whether parental psychiatric disorders are associated with autism spectrum disorder (ASD) in offspring has remained inconclusive. We examined the associations of parental psychiatric disorders with ASD in offspring. This population-based case-control study used Taiwan's National Health Insurance Research Database to identify a cohort of children born from 2004 to 2017 and their parents. A total of 24,279 children with ASD (diagnostic ICD-9-CM code: 299.x or ICD-10 code F84.x) and 97,715 matched controls were included. Parental psychiatric disorders, including depressive disorders, bipolar spectrum disorders, anxiety disorders, obsessive-compulsive disorder, schizophrenia, substance use disorders, autism spectrum disorder, attention-deficit hyperactivity disorder (ADHD), and adjustment disorders were identified. Conditional logistic regressions with covariate adjustment were performed. The results suggest that parental diagnosis with any of the psychiatric disorders is associated with ASD in offspring (adjusted odds ratio [AOR] = 1.45, 95%CI: 1.40-1.51 for mothers; and AOR = 1.12, 95%CI: 1.08-1.17 for fathers). ASD in offspring was associated with schizophrenia, depressive disorders, obsessive-compulsive disorder, adjustment disorders, ADHD and ASD in both parents. The relationship between parental psychiatric disorders and the timing of the child's birth and ASD diagnosis varied across the different psychiatric disorders. The present study provides supportive evidence that parental psychiatric disorders are associated with autistic children. Furthermore, because the associations between parental psychiatric disorders and the timing of child's birth and ASD diagnosis varied across psychiatric disorders, the observed relationships may be affected by both genetic and environmental factors. Future studies are needed to disentangle the potential influence of genetic and environmental factors on the observed associations. En ligne : http://dx.doi.org/10.1002/aur.2835 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488