Dépouillements

Editorial: ADHD persistence – the interplay of genes, socioeconomic context, and symptom domains over development / Phoebe THOMSON in Journal of Child Psychology and Psychiatry, 67-5 (May 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.605-608 Titre : Editorial: ADHD persistence – the interplay of genes, socioeconomic context, and symptom domains over development Type de document : texte imprimé Auteurs : Phoebe THOMSON, Auteur ; Divyangana RAKESH, Auteur Article en page(s) : p.605-608 Langues : Anglais (eng) Mots-clés : ADHD persistence  inattention  hyperactivity  genes  environment Index. décimale : PER Périodiques Résumé : Persistence of childhood ADHD symptoms into adolescence and adulthood is common. However, persistence is not simply a continuation of early high severity ADHD. Rather, it is the product of influences from individual-level genetic liability, one's environmental context, and their interplay. The field has often focused on cross-sectional ADHD severity and genetic load. However, environments ? such as one's socioeconomic context ? exert their own influence over development independently of genetics, as well as modulate genetic influences. Importantly, these genetic and environmental effects vary significantly between inattention and hyperactivity/impulsivity symptom domains, emphasizing the need to consider these domains separately when studying persistence risk. This article outlines a unifying persistence framework reflecting the changing contributions of genes, environmental context, and their interaction over time, offering a path to a more complete understanding of risk for symptom persistence. En ligne : https://doi.org/10.1111/jcpp.70150 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586 [article] Editorial: ADHD persistence – the interplay of genes, socioeconomic context, and symptom domains over development [texte imprimé] / Phoebe THOMSON, Auteur ; Divyangana RAKESH, Auteur . - p.605-608. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.605-608 Mots-clés : ADHD persistence  inattention  hyperactivity  genes  environment Index. décimale : PER Périodiques Résumé : Persistence of childhood ADHD symptoms into adolescence and adulthood is common. However, persistence is not simply a continuation of early high severity ADHD. Rather, it is the product of influences from individual-level genetic liability, one's environmental context, and their interplay. The field has often focused on cross-sectional ADHD severity and genetic load. However, environments ? such as one's socioeconomic context ? exert their own influence over development independently of genetics, as well as modulate genetic influences. Importantly, these genetic and environmental effects vary significantly between inattention and hyperactivity/impulsivity symptom domains, emphasizing the need to consider these domains separately when studying persistence risk. This article outlines a unifying persistence framework reflecting the changing contributions of genes, environmental context, and their interaction over time, offering a path to a more complete understanding of risk for symptom persistence. En ligne : https://doi.org/10.1111/jcpp.70150 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586

Multilevel risk and protective factors for self-harm, suicidal ideation and suicide attempt in adolescents / Alison L. CALEAR in Journal of Child Psychology and Psychiatry, 67-5 (May 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.609-619 Titre : Multilevel risk and protective factors for self-harm, suicidal ideation and suicide attempt in adolescents Type de document : texte imprimé Auteurs : Alison L. CALEAR, Auteur ; Philip J. BATTERHAM, Auteur ; Aliza WERNER-SEIDLER, Auteur ; Kate MASTON, Auteur ; Michelle TOROK, Auteur ; Bridianne O'DEA, Auteur ; Mark E. LARSEN, Auteur ; Helen CHRISTENSEN, Auteur Article en page(s) : p.609-619 Langues : Anglais (eng) Mots-clés : Suicide  self-harm  adolescent  risk factors  protective factors Index. décimale : PER Périodiques Résumé : Background Better characterising risk and protective factors for suicidal distress and self-harm in adolescents may facilitate better targeting of interventions that address underlying vulnerabilities. However, few previous longitudinal studies have: (1) sufficient power to identify key risk and protective factors, (2) limited representativeness to the community and (3) accounted for multilevel factors (individual, family, community). This study aimed to assess prevalence and identify risk and protective factors for self-harm, suicidal ideation and suicide attempts in a large cohort of Australian adolescents. Methods Data from 4,122 adolescents from 134 Australian schools were collected as part of the Future Proofing Study, a prospective cohort study of adolescent mental health and wellbeing. Generalised linear mixed models were used to assess the effect of baseline mental health, lifestyle, social and school-level factors on self-harm, suicidal ideation and suicide attempt at 12-month follow-up. Results At 12-month follow-up, 17.7% of adolescents reported self-harming behaviour, 18.6% reported suicidal ideation and 3.0% reported a suicide attempt. In addition to mental health history, female and gender-diverse identities, LGBTQA+ identity and greater levels of prosocial behaviour were significantly associated with self-harm and suicidal ideation. Peer problems were associated with suicidal ideation and suicide attempt. Conclusions Rates of suicidal distress and self-harm remain high in Australian adolescents. Reducing symptoms of depression, improving peer relationships, mitigating online bullying and providing social support for families may be suitable targets for future prevention and early intervention programs. En ligne : https://doi.org/10.1111/jcpp.70024 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586 [article] Multilevel risk and protective factors for self-harm, suicidal ideation and suicide attempt in adolescents [texte imprimé] / Alison L. CALEAR, Auteur ; Philip J. BATTERHAM, Auteur ; Aliza WERNER-SEIDLER, Auteur ; Kate MASTON, Auteur ; Michelle TOROK, Auteur ; Bridianne O'DEA, Auteur ; Mark E. LARSEN, Auteur ; Helen CHRISTENSEN, Auteur . - p.609-619. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.609-619 Mots-clés : Suicide  self-harm  adolescent  risk factors  protective factors Index. décimale : PER Périodiques Résumé : Background Better characterising risk and protective factors for suicidal distress and self-harm in adolescents may facilitate better targeting of interventions that address underlying vulnerabilities. However, few previous longitudinal studies have: (1) sufficient power to identify key risk and protective factors, (2) limited representativeness to the community and (3) accounted for multilevel factors (individual, family, community). This study aimed to assess prevalence and identify risk and protective factors for self-harm, suicidal ideation and suicide attempts in a large cohort of Australian adolescents. Methods Data from 4,122 adolescents from 134 Australian schools were collected as part of the Future Proofing Study, a prospective cohort study of adolescent mental health and wellbeing. Generalised linear mixed models were used to assess the effect of baseline mental health, lifestyle, social and school-level factors on self-harm, suicidal ideation and suicide attempt at 12-month follow-up. Results At 12-month follow-up, 17.7% of adolescents reported self-harming behaviour, 18.6% reported suicidal ideation and 3.0% reported a suicide attempt. In addition to mental health history, female and gender-diverse identities, LGBTQA+ identity and greater levels of prosocial behaviour were significantly associated with self-harm and suicidal ideation. Peer problems were associated with suicidal ideation and suicide attempt. Conclusions Rates of suicidal distress and self-harm remain high in Australian adolescents. Reducing symptoms of depression, improving peer relationships, mitigating online bullying and providing social support for families may be suitable targets for future prevention and early intervention programs. En ligne : https://doi.org/10.1111/jcpp.70024 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586

Effects of social context information on neural face processing in youth with social anxiety disorder / Anna-Lina RAUSCHENBACH in Journal of Child Psychology and Psychiatry, 67-5 (May 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.620-630 Titre : Effects of social context information on neural face processing in youth with social anxiety disorder Type de document : texte imprimé Auteurs : Anna-Lina RAUSCHENBACH, Auteur ; Vera HAUFFE, Auteur ; Jakob FINK-LAMOTTE, Auteur ; Brunna TUSCHEN-CAFFIER, Auteur ; Julian SCHMITZ, Auteur Article en page(s) : p.620-630 Langues : Anglais (eng) Mots-clés : children  social anxiety  face processing  context effects  event-related potentials Index. décimale : PER Périodiques Résumé : Background Social anxiety disorder (SAD) in youth is associated with significant psychosocial impairments; however, the cognitive and neural mechanisms that maintain it, particularly during childhood and adolescence, remain underexplored. Cognitive models emphasize the role of altered face processing, and neutral facial expressions may be perceived as threatening. Due to their ambiguous nature, contextual cues may play a particularly important role in interpretation. Methods We presented neutral child faces paired with social context information varying in valence (negative, neutral, positive) while continuous EEG was recorded. Subjective valence ratings and neural responses (P100, N170, and LPP) were assessed in children and adolescents aged 10?15?years with SAD (n?=?53), clinical controls with specific phobias (SP; n?=?41), and healthy controls (HC; n?=?61). Results Overall, context information affected both the subjective and neural responses to neutral faces in all children and adolescents, for example, more negative ratings for negatively contextualized faces. Further, participants with SAD generally rated all faces as more negative compared to HCs. Neurally, they showed lower N170 amplitudes compared to both control groups in response to all neutral faces, independent of the context valence. However, only younger children (aged 10?12?years) with SAD showed higher LPP amplitudes than younger HCs. Conclusions Processing biases seem to be already present in children and adolescents with SAD, both at the subjective and neural level. Social context information influences neutral face processing but is independent of psychopathology. Future studies examining age effects are needed to investigate whether childhood reflects a particularly sensitive period for the development of processing biases. En ligne : https://doi.org/10.1111/jcpp.70026 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586 [article] Effects of social context information on neural face processing in youth with social anxiety disorder [texte imprimé] / Anna-Lina RAUSCHENBACH, Auteur ; Vera HAUFFE, Auteur ; Jakob FINK-LAMOTTE, Auteur ; Brunna TUSCHEN-CAFFIER, Auteur ; Julian SCHMITZ, Auteur . - p.620-630. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.620-630 Mots-clés : children  social anxiety  face processing  context effects  event-related potentials Index. décimale : PER Périodiques Résumé : Background Social anxiety disorder (SAD) in youth is associated with significant psychosocial impairments; however, the cognitive and neural mechanisms that maintain it, particularly during childhood and adolescence, remain underexplored. Cognitive models emphasize the role of altered face processing, and neutral facial expressions may be perceived as threatening. Due to their ambiguous nature, contextual cues may play a particularly important role in interpretation. Methods We presented neutral child faces paired with social context information varying in valence (negative, neutral, positive) while continuous EEG was recorded. Subjective valence ratings and neural responses (P100, N170, and LPP) were assessed in children and adolescents aged 10?15?years with SAD (n?=?53), clinical controls with specific phobias (SP; n?=?41), and healthy controls (HC; n?=?61). Results Overall, context information affected both the subjective and neural responses to neutral faces in all children and adolescents, for example, more negative ratings for negatively contextualized faces. Further, participants with SAD generally rated all faces as more negative compared to HCs. Neurally, they showed lower N170 amplitudes compared to both control groups in response to all neutral faces, independent of the context valence. However, only younger children (aged 10?12?years) with SAD showed higher LPP amplitudes than younger HCs. Conclusions Processing biases seem to be already present in children and adolescents with SAD, both at the subjective and neural level. Social context information influences neutral face processing but is independent of psychopathology. Future studies examining age effects are needed to investigate whether childhood reflects a particularly sensitive period for the development of processing biases. En ligne : https://doi.org/10.1111/jcpp.70026 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586

Neuroimaging biomarkers in school-aged children with autism: MRI-measured lipid content in the limbic system / Ya-Yin DENG in Journal of Child Psychology and Psychiatry, 67-5 (May 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.631-640 Titre : Neuroimaging biomarkers in school-aged children with autism: MRI-measured lipid content in the limbic system Type de document : texte imprimé Auteurs : Ya-Yin DENG, Auteur ; Xiang ZHOU, Auteur ; Bo-Ya YIN, Auteur ; Feng-Yun ZOU, Auteur ; Shuang-Shuang ZHONG, Auteur ; Xiao-Wen LUO, Auteur ; Li-Shan SHEN, Auteur ; Yang FAN, Auteur ; Ruo-Mi GUO, Auteur Article en page(s) : p.631-640 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  brain  lipid content  limbic system Index. décimale : PER Périodiques Résumé : Background Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder. Alterations in brain lipids may elucidate ASD's neurophysiological mechanisms, but evidence remains limited. This study aims to assess whether the MRI-measured lipid content in limbic brain regions could serve as novel biomarkers for neurophysiological changes in school-aged children with ASD. Methods This prospective study included 98 school-aged (7?16?years) children with ASD and 94 age- and gender-matched typically developing (TD) children, an age window selected based on established milestones of structural brain maturation. Lipid content in limbic regions was quantified via MRI-based proton density fat fraction (PDFF). Between-group differences, blood lipid correlations, and clinical scale associations were analyzed. In vitro validation and histopathology in ASD mice confirmed lipid quantification accuracy and deposits. Receiver operating characteristic (ROC) analyses evaluated diagnostic utility. Results Children with ASD exhibited significantly elevated MRI-measured lipid content in the bilateral fusiform gyrus (FUS) (pfdr? En ligne : https://doi.org/10.1111/jcpp.70033 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586 [article] Neuroimaging biomarkers in school-aged children with autism: MRI-measured lipid content in the limbic system [texte imprimé] / Ya-Yin DENG, Auteur ; Xiang ZHOU, Auteur ; Bo-Ya YIN, Auteur ; Feng-Yun ZOU, Auteur ; Shuang-Shuang ZHONG, Auteur ; Xiao-Wen LUO, Auteur ; Li-Shan SHEN, Auteur ; Yang FAN, Auteur ; Ruo-Mi GUO, Auteur . - p.631-640. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.631-640 Mots-clés : Autism spectrum disorder  brain  lipid content  limbic system Index. décimale : PER Périodiques Résumé : Background Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder. Alterations in brain lipids may elucidate ASD's neurophysiological mechanisms, but evidence remains limited. This study aims to assess whether the MRI-measured lipid content in limbic brain regions could serve as novel biomarkers for neurophysiological changes in school-aged children with ASD. Methods This prospective study included 98 school-aged (7?16?years) children with ASD and 94 age- and gender-matched typically developing (TD) children, an age window selected based on established milestones of structural brain maturation. Lipid content in limbic regions was quantified via MRI-based proton density fat fraction (PDFF). Between-group differences, blood lipid correlations, and clinical scale associations were analyzed. In vitro validation and histopathology in ASD mice confirmed lipid quantification accuracy and deposits. Receiver operating characteristic (ROC) analyses evaluated diagnostic utility. Results Children with ASD exhibited significantly elevated MRI-measured lipid content in the bilateral fusiform gyrus (FUS) (pfdr? En ligne : https://doi.org/10.1111/jcpp.70033 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586

Sensory hyperacusis as a predictor of anxiety in adolescence / Foteini TSELIOU in Journal of Child Psychology and Psychiatry, 67-5 (May 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.641-651 Titre : Sensory hyperacusis as a predictor of anxiety in adolescence Type de document : texte imprimé Auteurs : Foteini TSELIOU, Auteur ; Stephan COLLISHAW, Auteur ; Alice PRICE, Auteur ; Petroc SUMNER, Auteur Article en page(s) : p.641-651 Langues : Anglais (eng) Mots-clés : Hyperacusis  youth  anxiety  ALSPAC Index. décimale : PER Périodiques Résumé : Background An increasing number of children report anxiety in early to mid-adolescence. Early identification of risk during the transition from primary to secondary schools (age 11) could enhance family- or school-based interventions. While known predictors of adolescent anxiety provide some insight, there is a need to identify and understand additional risk factors. Hyperacusis (aversive sensitivity to sound) is correlated with anxiety in children and adults and thus a candidate risk factor longitudinally. Methods We explored the predictive potential of auditory hyperacusis using data from the Avon Longitudinal Study of Parents and Children (ALSPAC, n?=?6,621). Hyperacusis at age 11 was assessed with a single question, while anxiety and related emotional problems were captured by the emotional subscale of the Strength and Difficulties Questionnaire (SDQ-E) at ages 13, 16 and through longitudinal trajectories (4?16?years). Results Hyperacusis significantly predicted anxiety at ages 13 and 16. This predictive effect remained for age 13 even when accounting for pre-existing anxiety/emotional problems, autism traits and other neurodiversity characteristics (ADHD, dyslexia, dyspraxia). Similar, though less pronounced, patterns emerged at age 16. When testing the four previously identified childhood trajectories of emotional problems, hyperacusis predicted persistent versus decreasing trajectories (the two cases when preschool anxiety is already high) more reliably than increasing from low trajectories (the two cases when preschool anxiety is low). Additional exploratory analyses found that hyperacusis was most strongly associated with SDQ-E items related to fear, worry, and nervousness; still predicted SDQ-E scores at age 25, but not adult generalised anxiety disorder, major depressive disorder or suicidal self-harm. Conclusions Taken together, our findings suggest that assessing hyperacusis at age 11 can provide additional predictive insights into the exacerbation and maintenance of anxiety in adolescence. En ligne : https://doi.org/10.1111/jcpp.70027 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586 [article] Sensory hyperacusis as a predictor of anxiety in adolescence [texte imprimé] / Foteini TSELIOU, Auteur ; Stephan COLLISHAW, Auteur ; Alice PRICE, Auteur ; Petroc SUMNER, Auteur . - p.641-651. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.641-651 Mots-clés : Hyperacusis  youth  anxiety  ALSPAC Index. décimale : PER Périodiques Résumé : Background An increasing number of children report anxiety in early to mid-adolescence. Early identification of risk during the transition from primary to secondary schools (age 11) could enhance family- or school-based interventions. While known predictors of adolescent anxiety provide some insight, there is a need to identify and understand additional risk factors. Hyperacusis (aversive sensitivity to sound) is correlated with anxiety in children and adults and thus a candidate risk factor longitudinally. Methods We explored the predictive potential of auditory hyperacusis using data from the Avon Longitudinal Study of Parents and Children (ALSPAC, n?=?6,621). Hyperacusis at age 11 was assessed with a single question, while anxiety and related emotional problems were captured by the emotional subscale of the Strength and Difficulties Questionnaire (SDQ-E) at ages 13, 16 and through longitudinal trajectories (4?16?years). Results Hyperacusis significantly predicted anxiety at ages 13 and 16. This predictive effect remained for age 13 even when accounting for pre-existing anxiety/emotional problems, autism traits and other neurodiversity characteristics (ADHD, dyslexia, dyspraxia). Similar, though less pronounced, patterns emerged at age 16. When testing the four previously identified childhood trajectories of emotional problems, hyperacusis predicted persistent versus decreasing trajectories (the two cases when preschool anxiety is already high) more reliably than increasing from low trajectories (the two cases when preschool anxiety is low). Additional exploratory analyses found that hyperacusis was most strongly associated with SDQ-E items related to fear, worry, and nervousness; still predicted SDQ-E scores at age 25, but not adult generalised anxiety disorder, major depressive disorder or suicidal self-harm. Conclusions Taken together, our findings suggest that assessing hyperacusis at age 11 can provide additional predictive insights into the exacerbation and maintenance of anxiety in adolescence. En ligne : https://doi.org/10.1111/jcpp.70027 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586

Early manifestations of unexpected bilingualism in minimally verbal autism / David GAGNON in Journal of Child Psychology and Psychiatry, 67-5 (May 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.652-662 Titre : Early manifestations of unexpected bilingualism in minimally verbal autism Type de document : texte imprimé Auteurs : David GAGNON, Auteur ; Alexia OSTROLENK, Auteur ; Laurent MOTTRON, Auteur Article en page(s) : p.652-662 Langues : Anglais (eng) Mots-clés : Autism  unexpected bilingualism  language  early development  hyperlexia Index. décimale : PER Périodiques Résumé : Background Unexpected bilingualism (UB) in autism, in which children speak languages not spoken in their social environment, has been sporadically reported. UB implies that autistic children can acquire languages in a non-socially interactive way. The early minimally verbal period in autism could be critical for non-interactive language acquisition, given the predominance of non-social interests at that time. However, evidence of language acquisition outside social interaction during this period remains limited and restricted to small case studies. Methods Caregivers of 119 autistic, 102 non-autistic clinical, and 75 typically developing (TD) children aged 2?6?years completed a structured questionnaire about their children's language-related interests and use. They were also asked to estimate the relative proportion of each language their children were exposed to in their social environment. UB was operationalized as the use of at least one language not spoken in the child's social environment to name letters and/or numbers. Results Of the autistic group, 53% were considered minimally verbal. A total of 38.7% of autistic children displayed UB, with autistic children being 4.38 times more likely to show UB than TD children (p? En ligne : https://doi.org/10.1111/jcpp.70032 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586 [article] Early manifestations of unexpected bilingualism in minimally verbal autism [texte imprimé] / David GAGNON, Auteur ; Alexia OSTROLENK, Auteur ; Laurent MOTTRON, Auteur . - p.652-662. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.652-662 Mots-clés : Autism  unexpected bilingualism  language  early development  hyperlexia Index. décimale : PER Périodiques Résumé : Background Unexpected bilingualism (UB) in autism, in which children speak languages not spoken in their social environment, has been sporadically reported. UB implies that autistic children can acquire languages in a non-socially interactive way. The early minimally verbal period in autism could be critical for non-interactive language acquisition, given the predominance of non-social interests at that time. However, evidence of language acquisition outside social interaction during this period remains limited and restricted to small case studies. Methods Caregivers of 119 autistic, 102 non-autistic clinical, and 75 typically developing (TD) children aged 2?6?years completed a structured questionnaire about their children's language-related interests and use. They were also asked to estimate the relative proportion of each language their children were exposed to in their social environment. UB was operationalized as the use of at least one language not spoken in the child's social environment to name letters and/or numbers. Results Of the autistic group, 53% were considered minimally verbal. A total of 38.7% of autistic children displayed UB, with autistic children being 4.38 times more likely to show UB than TD children (p? En ligne : https://doi.org/10.1111/jcpp.70032 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586

Understanding the link between adolescent depression and precarious employment in adulthood: evidence from a sibling fixed effects analysis / Jinho KIM in Journal of Child Psychology and Psychiatry, 67-5 (May 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.663-672 Titre : Understanding the link between adolescent depression and precarious employment in adulthood: evidence from a sibling fixed effects analysis Type de document : texte imprimé Auteurs : Jinho KIM, Auteur ; Hayun JANG, Auteur ; Keun Young KWON, Auteur ; Hansol PARK, Auteur Article en page(s) : p.663-672 Langues : Anglais (eng) Mots-clés : Adolescent depressive symptoms  precarious employment  life course  sibling fixed effects  mediation  educational attainment Index. décimale : PER Périodiques Résumé : Background Adolescent depressive symptoms may mark the beginning of long-term trajectories of socioeconomic disadvantage, yet their role in shaping labor market outcomes remains understudied. This study investigates the longitudinal association between depressive symptoms in adolescence and precarious employment in adulthood and explores the mediating roles of persistent depressive symptoms and educational attainment. Methods Using a sample of 3,703 individuals from full sibling pairs in the National Longitudinal Study of Adolescent to Adult Health, we employed sibling fixed effects models to control for unobserved family-level confounding. Precarious employment in adulthood was measured using a multidimensional index reflecting job instability, material insecurity, lack of benefits, and limited decision-making autonomy. Results Adolescent depressive symptoms were positively associated with precarious employment in adulthood (b?=?0.0165, p? En ligne : https://doi.org/10.1111/jcpp.70047 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586 [article] Understanding the link between adolescent depression and precarious employment in adulthood: evidence from a sibling fixed effects analysis [texte imprimé] / Jinho KIM, Auteur ; Hayun JANG, Auteur ; Keun Young KWON, Auteur ; Hansol PARK, Auteur . - p.663-672. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.663-672 Mots-clés : Adolescent depressive symptoms  precarious employment  life course  sibling fixed effects  mediation  educational attainment Index. décimale : PER Périodiques Résumé : Background Adolescent depressive symptoms may mark the beginning of long-term trajectories of socioeconomic disadvantage, yet their role in shaping labor market outcomes remains understudied. This study investigates the longitudinal association between depressive symptoms in adolescence and precarious employment in adulthood and explores the mediating roles of persistent depressive symptoms and educational attainment. Methods Using a sample of 3,703 individuals from full sibling pairs in the National Longitudinal Study of Adolescent to Adult Health, we employed sibling fixed effects models to control for unobserved family-level confounding. Precarious employment in adulthood was measured using a multidimensional index reflecting job instability, material insecurity, lack of benefits, and limited decision-making autonomy. Results Adolescent depressive symptoms were positively associated with precarious employment in adulthood (b?=?0.0165, p? En ligne : https://doi.org/10.1111/jcpp.70047 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586

Sex-specific pathways from early irritability trajectories to later suicidal ideations and behaviors: Findings from the ABCD study® / Nellia BELLAERT in Journal of Child Psychology and Psychiatry, 67-5 (May 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.673-685 Titre : Sex-specific pathways from early irritability trajectories to later suicidal ideations and behaviors: Findings from the ABCD study® Type de document : texte imprimé Auteurs : Nellia BELLAERT, Auteur ; Angelique SIMEONE, Auteur ; Lanting ZHANG, Auteur ; Haoran ZHUO, Auteur ; Massimiliano ORRI, Auteur ; Zeyan LIEW, Auteur ; Wan-Ling TSENG, Auteur Article en page(s) : p.673-685 Langues : Anglais (eng) Mots-clés : Irritability  developmental trajectories  suicidal ideations and behaviors  sex differences Index. décimale : PER Périodiques Résumé : Background Previous studies have demonstrated that children with high irritability are at increased risk for suicidal ideations and behaviors. However, they have mostly relied on teacher reports and shown mixed findings regarding sex differences. We aimed to identify developmental trajectories of childhood irritability, test their direct and indirect (through psychopathology) associations with adolescent suicidal ideations and behaviors, and examine whether these associations differed by sex. Methods This study used five waves of data from the adolescent brain cognitive development (ABCD) Study (N?=?4,583). Parents rated their children's irritability yearly from ages 9?10 to ages 11?12, internalizing (e.g. depression) and externalizing (e.g. aggression) symptoms at ages 12?13, and suicidal ideations and behaviors (SIBs) at ages 13?14 using the child behavior checklist. Subgroups of irritability trajectories were derived using growth mixture modeling. Path analysis was conducted to test the total, direct, and indirect pathways from irritability trajectories to SIBs through internalizing and externalizing symptoms, and sex differences in those paths. Results Four irritability trajectories were identified: low-stable (73.01%), rising (12.04%), declining (10.28%), and high-stable (4.67%). Compared with the other trajectories, children on the high-stable irritability trajectory were at higher risk for suicidal ideations (??=?.13, p? En ligne : https://doi.org/10.1111/jcpp.70044 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586 [article] Sex-specific pathways from early irritability trajectories to later suicidal ideations and behaviors: Findings from the ABCD study® [texte imprimé] / Nellia BELLAERT, Auteur ; Angelique SIMEONE, Auteur ; Lanting ZHANG, Auteur ; Haoran ZHUO, Auteur ; Massimiliano ORRI, Auteur ; Zeyan LIEW, Auteur ; Wan-Ling TSENG, Auteur . - p.673-685. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.673-685 Mots-clés : Irritability  developmental trajectories  suicidal ideations and behaviors  sex differences Index. décimale : PER Périodiques Résumé : Background Previous studies have demonstrated that children with high irritability are at increased risk for suicidal ideations and behaviors. However, they have mostly relied on teacher reports and shown mixed findings regarding sex differences. We aimed to identify developmental trajectories of childhood irritability, test their direct and indirect (through psychopathology) associations with adolescent suicidal ideations and behaviors, and examine whether these associations differed by sex. Methods This study used five waves of data from the adolescent brain cognitive development (ABCD) Study (N?=?4,583). Parents rated their children's irritability yearly from ages 9?10 to ages 11?12, internalizing (e.g. depression) and externalizing (e.g. aggression) symptoms at ages 12?13, and suicidal ideations and behaviors (SIBs) at ages 13?14 using the child behavior checklist. Subgroups of irritability trajectories were derived using growth mixture modeling. Path analysis was conducted to test the total, direct, and indirect pathways from irritability trajectories to SIBs through internalizing and externalizing symptoms, and sex differences in those paths. Results Four irritability trajectories were identified: low-stable (73.01%), rising (12.04%), declining (10.28%), and high-stable (4.67%). Compared with the other trajectories, children on the high-stable irritability trajectory were at higher risk for suicidal ideations (??=?.13, p? En ligne : https://doi.org/10.1111/jcpp.70044 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586

Subclinical hypomania, psychiatric and neurodevelopmental diagnoses: phenotypic and aetiological overlap / Georgina M. HOSANG in Journal of Child Psychology and Psychiatry, 67-5 (May 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.686-695 Titre : Subclinical hypomania, psychiatric and neurodevelopmental diagnoses: phenotypic and aetiological overlap Type de document : texte imprimé Auteurs : Georgina M. HOSANG, Auteur ; Miriam I. MARTINI, Auteur ; Angelica RONALD, Auteur ; Henrik LARSSON, Auteur ; Sebastian LUNDSTROM, Auteur ; Paul LICHTENSTEIN, Auteur ; Mark J. TAYLOR, Auteur Article en page(s) : p.686-695 Langues : Anglais (eng) Mots-clés : Hypomania  psychiatric illnesses  neurodevelopmental conditions  twin study  genetic Index. décimale : PER Périodiques Résumé : Background Subclinical hypomanic symptoms are fairly common in the general population but are linked to psychiatric and neurodevelopmental conditions. However, the genetic and environmental origins of these associations are unclear. This twin study examined the phenotypic and aetiological associations between subclinical hypomania and psychiatric and neurodevelopmental diagnoses. Methods Participants were 4,932 twin pairs from the Child and Adolescent Twin Study in Sweden. Hypomanic symptoms were assessed using the parent-rated Mood Disorders Questionnaire when the twins were aged 18. Specialist diagnoses of 14 conditions and symptoms were ascertained from Swedish population registries. Phenotypic associations between hypomania and these conditions/symptoms were investigated, and their aetiological overlap was examined using the twin method. Results Subclinical hypomania was significantly associated with all 14 diagnoses. The highest odds were for psychotic disorders (odds ratio [OR]?=?1.48, 95% confidence intervals [CI]?=?1.33?1.64, p? En ligne : https://doi.org/10.1111/jcpp.70045 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586 [article] Subclinical hypomania, psychiatric and neurodevelopmental diagnoses: phenotypic and aetiological overlap [texte imprimé] / Georgina M. HOSANG, Auteur ; Miriam I. MARTINI, Auteur ; Angelica RONALD, Auteur ; Henrik LARSSON, Auteur ; Sebastian LUNDSTROM, Auteur ; Paul LICHTENSTEIN, Auteur ; Mark J. TAYLOR, Auteur . - p.686-695. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.686-695 Mots-clés : Hypomania  psychiatric illnesses  neurodevelopmental conditions  twin study  genetic Index. décimale : PER Périodiques Résumé : Background Subclinical hypomanic symptoms are fairly common in the general population but are linked to psychiatric and neurodevelopmental conditions. However, the genetic and environmental origins of these associations are unclear. This twin study examined the phenotypic and aetiological associations between subclinical hypomania and psychiatric and neurodevelopmental diagnoses. Methods Participants were 4,932 twin pairs from the Child and Adolescent Twin Study in Sweden. Hypomanic symptoms were assessed using the parent-rated Mood Disorders Questionnaire when the twins were aged 18. Specialist diagnoses of 14 conditions and symptoms were ascertained from Swedish population registries. Phenotypic associations between hypomania and these conditions/symptoms were investigated, and their aetiological overlap was examined using the twin method. Results Subclinical hypomania was significantly associated with all 14 diagnoses. The highest odds were for psychotic disorders (odds ratio [OR]?=?1.48, 95% confidence intervals [CI]?=?1.33?1.64, p? En ligne : https://doi.org/10.1111/jcpp.70045 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586

Psychostimulant treatment uniquely reduces left uncinate fasciculus microstructural integrity in ADHD youth with a familial risk for bipolar I disorder: a 12-week DTI study / Kun QIN in Journal of Child Psychology and Psychiatry, 67-5 (May 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.696-706 Titre : Psychostimulant treatment uniquely reduces left uncinate fasciculus microstructural integrity in ADHD youth with a familial risk for bipolar I disorder: a 12-week DTI study Type de document : texte imprimé Auteurs : Kun QIN, Auteur ; Wen CHEN, Auteur ; Du LEI, Auteur ; Ziyu ZHU, Auteur ; Maxwell J. TALLMAN, Auteur ; Nanfang PAN, Auteur ; Lisha ZHANG, Auteur ; Luis RODRIGO PATINO, Auteur ; John A. SWEENEY, Auteur ; Melissa P. DELBELLO, Auteur ; Robert K. MCNAMARA, Auteur Article en page(s) : p.696-706 Langues : Anglais (eng) Mots-clés : Attention-deficit/hyperactivity disorder  bipolar I disorder  familial risk  stimulants  adolescent Index. décimale : PER Périodiques Résumé : Background Bipolar I disorder (BD) is associated with reduced white matter microstructural integrity in the uncinate fasciculus (UF), a primary fiber tract connecting frontolimbic systems. Although familial history for BD, attention-deficit/hyperactivity disorder (ADHD), and psychostimulants are important risk factors implicated in BD pathoetiology, their impact on UF microstructure remains poorly understood. Methods This diffusion tensor imaging study investigated UF microstructural integrity prior to and following 12?weeks of psychostimulant treatment in ADHD youth with (?high-risk?, HR) and without (?low-risk?, LR) a first-degree relative with BD. Healthy controls were included for comparative purposes. LR youth received 12-week open-label mixed amphetamine salts-extended release (MAS-XR), and HR youth were randomized to either MAS-XR or placebo (PLA). Bilateral UF fractional anisotropy (FA) and axial diffusivity (AD) were assessed using automated fiber quantification. Results A total of 137 participants were included in the analyses. At baseline, there were no significant group differences in bilateral UF microstructural metrics. Following 12-week MAS-XR treatment, significant group-by-time interactions were found for left UF FA and AD between HR-MAS and LR-MAS, as well as for left UF FA between HR-MAS and HR-PLA. Specifically, left UF FA and UF AD decreased significantly in HR-MAS but remained unchanged in LR-MAS and HR-PLA groups. At week 12, left UF FA was lower in HR-MAS relative to HC but not in LR-MAS or HR-PLA. Segment-wise analyses further revealed that UF microstructural changes in the HR-MAS group were localized to the anterior segments. Conclusions These results suggest that HR-ADHD youth are uniquely vulnerable to reductions in left UF microstructural integrity following psychostimulant treatment, suggesting potential relevance to BD pathoprogression. En ligne : https://doi.org/10.1111/jcpp.70053 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586 [article] Psychostimulant treatment uniquely reduces left uncinate fasciculus microstructural integrity in ADHD youth with a familial risk for bipolar I disorder: a 12-week DTI study [texte imprimé] / Kun QIN, Auteur ; Wen CHEN, Auteur ; Du LEI, Auteur ; Ziyu ZHU, Auteur ; Maxwell J. TALLMAN, Auteur ; Nanfang PAN, Auteur ; Lisha ZHANG, Auteur ; Luis RODRIGO PATINO, Auteur ; John A. SWEENEY, Auteur ; Melissa P. DELBELLO, Auteur ; Robert K. MCNAMARA, Auteur . - p.696-706. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.696-706 Mots-clés : Attention-deficit/hyperactivity disorder  bipolar I disorder  familial risk  stimulants  adolescent Index. décimale : PER Périodiques Résumé : Background Bipolar I disorder (BD) is associated with reduced white matter microstructural integrity in the uncinate fasciculus (UF), a primary fiber tract connecting frontolimbic systems. Although familial history for BD, attention-deficit/hyperactivity disorder (ADHD), and psychostimulants are important risk factors implicated in BD pathoetiology, their impact on UF microstructure remains poorly understood. Methods This diffusion tensor imaging study investigated UF microstructural integrity prior to and following 12?weeks of psychostimulant treatment in ADHD youth with (?high-risk?, HR) and without (?low-risk?, LR) a first-degree relative with BD. Healthy controls were included for comparative purposes. LR youth received 12-week open-label mixed amphetamine salts-extended release (MAS-XR), and HR youth were randomized to either MAS-XR or placebo (PLA). Bilateral UF fractional anisotropy (FA) and axial diffusivity (AD) were assessed using automated fiber quantification. Results A total of 137 participants were included in the analyses. At baseline, there were no significant group differences in bilateral UF microstructural metrics. Following 12-week MAS-XR treatment, significant group-by-time interactions were found for left UF FA and AD between HR-MAS and LR-MAS, as well as for left UF FA between HR-MAS and HR-PLA. Specifically, left UF FA and UF AD decreased significantly in HR-MAS but remained unchanged in LR-MAS and HR-PLA groups. At week 12, left UF FA was lower in HR-MAS relative to HC but not in LR-MAS or HR-PLA. Segment-wise analyses further revealed that UF microstructural changes in the HR-MAS group were localized to the anterior segments. Conclusions These results suggest that HR-ADHD youth are uniquely vulnerable to reductions in left UF microstructural integrity following psychostimulant treatment, suggesting potential relevance to BD pathoprogression. En ligne : https://doi.org/10.1111/jcpp.70053 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586

Trajectories of childhood adversity, social welfare dependence in young adulthood, and the mediating role of mental health problems: a Danish population-based cohort study / Tjeerd Rudmer DE VRIES in Journal of Child Psychology and Psychiatry, 67-5 (May 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.707-717 Titre : Trajectories of childhood adversity, social welfare dependence in young adulthood, and the mediating role of mental health problems: a Danish population-based cohort study Type de document : texte imprimé Auteurs : Tjeerd Rudmer DE VRIES, Auteur ; Signe Kær BENNETSEN, Auteur ; Leonie K. ELSENBURG, Auteur ; Signe Hald ANDERSEN, Auteur ; Bertina KRESHPAJ, Auteur ; Karsten THIELEN, Auteur ; Naja Hulvej ROD, Auteur Article en page(s) : p.707-717 Langues : Anglais (eng) Mots-clés : Mental health  social welfare  childhood adversity  mediation  young adults Index. décimale : PER Périodiques Résumé : Background Childhood adversity is associated with increased risks of long-term social welfare dependence in young adulthood. Mental health problems may mediate this relation, but evidence remains lacking. Methods 613,643 individuals from the Danish Life Course cohort (DANLIFE) were categorized into five trajectory groups based on their annual exposure to adversity: low adversity, early-life material deprivation, persistent material deprivation, loss or threat of loss, or high adversity. Mental health problems were identified through hospital contacts and psychotropic medication use. Long-term social welfare dependence was defined as receiving social benefits for at least 52 consecutive weeks within the follow-up period. We examined the contribution of differential exposure and susceptibility to mental health problems in relation to childhood adversity and long-term social welfare dependence through causal mediation analysis. Results The different childhood adversity groups saw 54?319 additional cases of long-term social welfare dependence per 1,000 individuals compared with the low adversity group. These associations were partly mediated through mental health problems. To illustrate, in the high adversity group, differential exposure to mental health problems accounted for 15.0% (95% CI: 14.4?15.6) of the total effect, while differential susceptibility accounted for an additional 9.8% (95% CI: 8.8?10.9). Conclusions Mental health problems partly mediate the relation between childhood adversity and long-term social welfare dependence in young adulthood through both elevated exposure and increased susceptibility. Addressing mental health problems and increasing resilience among individuals with a history of childhood adversity may mitigate the risk of subsequent social welfare dependence. En ligne : https://doi.org/10.1111/jcpp.70062 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586 [article] Trajectories of childhood adversity, social welfare dependence in young adulthood, and the mediating role of mental health problems: a Danish population-based cohort study [texte imprimé] / Tjeerd Rudmer DE VRIES, Auteur ; Signe Kær BENNETSEN, Auteur ; Leonie K. ELSENBURG, Auteur ; Signe Hald ANDERSEN, Auteur ; Bertina KRESHPAJ, Auteur ; Karsten THIELEN, Auteur ; Naja Hulvej ROD, Auteur . - p.707-717. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.707-717 Mots-clés : Mental health  social welfare  childhood adversity  mediation  young adults Index. décimale : PER Périodiques Résumé : Background Childhood adversity is associated with increased risks of long-term social welfare dependence in young adulthood. Mental health problems may mediate this relation, but evidence remains lacking. Methods 613,643 individuals from the Danish Life Course cohort (DANLIFE) were categorized into five trajectory groups based on their annual exposure to adversity: low adversity, early-life material deprivation, persistent material deprivation, loss or threat of loss, or high adversity. Mental health problems were identified through hospital contacts and psychotropic medication use. Long-term social welfare dependence was defined as receiving social benefits for at least 52 consecutive weeks within the follow-up period. We examined the contribution of differential exposure and susceptibility to mental health problems in relation to childhood adversity and long-term social welfare dependence through causal mediation analysis. Results The different childhood adversity groups saw 54?319 additional cases of long-term social welfare dependence per 1,000 individuals compared with the low adversity group. These associations were partly mediated through mental health problems. To illustrate, in the high adversity group, differential exposure to mental health problems accounted for 15.0% (95% CI: 14.4?15.6) of the total effect, while differential susceptibility accounted for an additional 9.8% (95% CI: 8.8?10.9). Conclusions Mental health problems partly mediate the relation between childhood adversity and long-term social welfare dependence in young adulthood through both elevated exposure and increased susceptibility. Addressing mental health problems and increasing resilience among individuals with a history of childhood adversity may mitigate the risk of subsequent social welfare dependence. En ligne : https://doi.org/10.1111/jcpp.70062 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586

Editorial Perspective: The challenge of evaluating ADHD parenting interventions – towards a hybrid approach / Saskia VAN DER OORD in Journal of Child Psychology and Psychiatry, 67-5 (May 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.718-722 Titre : Editorial Perspective: The challenge of evaluating ADHD parenting interventions – towards a hybrid approach Type de document : texte imprimé Auteurs : Saskia VAN DER OORD, Auteur ; Tycho J. DEKKERS, Auteur ; Barbara J. VAN DEN HOOFDAKKER, Auteur ; Manfred DOPFNER, Auteur ; Edmund SONUGA-BARKE, Auteur Article en page(s) : p.718-722 Langues : Anglais (eng) Mots-clés : ADHD Index. décimale : PER Périodiques Résumé : Abstract Behavioural parent training (BPT) has been recommended as part of multi-modal intervention strategies for children with attention-deficit/hyperactivity disorder (ADHD). The evaluation of its effectiveness, however, is challenging, as meta-analyses have indicated a discrepancy between effects on most proximal (MPROX) and probably blinded (PBLIND) outcome measures. In this editorial perspective, we provide five hypotheses that may explain this discrepancy. The first three hypotheses assume that the MPROX-PBLIND discrepancy demonstrates that BPT does not reduce actual ADHD characteristics and that MPROX is picking up a false positive. The final two focus on the limitations of the PBLIND assessments reported in the meta-analyses and the assumption that they are giving false negatives. We conclude that a hybrid approach, integrating parent ratings and observational measures within a multimethod assessment approach, may provide a path forward. In conclusion, we argue that for parents and clinicians, parent ratings of ADHD characteristics and other parent- or child-rated outcomes, such as mental health, quality of life and general well-being, are more important than ?objective? symptom change, which encourages us to shift the focus from the control of symptoms to the promotion of general functioning and well-being. En ligne : https://doi.org/10.1111/jcpp.70069 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586 [article] Editorial Perspective: The challenge of evaluating ADHD parenting interventions – towards a hybrid approach [texte imprimé] / Saskia VAN DER OORD, Auteur ; Tycho J. DEKKERS, Auteur ; Barbara J. VAN DEN HOOFDAKKER, Auteur ; Manfred DOPFNER, Auteur ; Edmund SONUGA-BARKE, Auteur . - p.718-722. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.718-722 Mots-clés : ADHD Index. décimale : PER Périodiques Résumé : Abstract Behavioural parent training (BPT) has been recommended as part of multi-modal intervention strategies for children with attention-deficit/hyperactivity disorder (ADHD). The evaluation of its effectiveness, however, is challenging, as meta-analyses have indicated a discrepancy between effects on most proximal (MPROX) and probably blinded (PBLIND) outcome measures. In this editorial perspective, we provide five hypotheses that may explain this discrepancy. The first three hypotheses assume that the MPROX-PBLIND discrepancy demonstrates that BPT does not reduce actual ADHD characteristics and that MPROX is picking up a false positive. The final two focus on the limitations of the PBLIND assessments reported in the meta-analyses and the assumption that they are giving false negatives. We conclude that a hybrid approach, integrating parent ratings and observational measures within a multimethod assessment approach, may provide a path forward. In conclusion, we argue that for parents and clinicians, parent ratings of ADHD characteristics and other parent- or child-rated outcomes, such as mental health, quality of life and general well-being, are more important than ?objective? symptom change, which encourages us to shift the focus from the control of symptoms to the promotion of general functioning and well-being. En ligne : https://doi.org/10.1111/jcpp.70069 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586

Practitioner Review: Clinical insights from attachment theory and research for professionals working with young children and their families / Jessica E. OPIE in Journal of Child Psychology and Psychiatry, 67-5 (May 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.723-739 Titre : Practitioner Review: Clinical insights from attachment theory and research for professionals working with young children and their families Type de document : texte imprimé Auteurs : Jessica E. OPIE, Auteur ; Everett WATERS, Auteur ; Robbie DUSCHINSKY, Auteur ; MÃ¥rten HAMMARLUND, Auteur ; Sheri MADIGAN, Auteur ; Sarah FOSTER, Auteur ; Tommie FORSLUND, Auteur ; Ross THOMPSON, Auteur ; Howard STEELE, Auteur ; Miriam STEELE, Auteur ; Glenn I. ROISMAN, Auteur ; Ashley M. GROH, Auteur ; Peter FONAGY, Auteur ; Or DAGAN, Auteur ; Alessandro TALIA, Auteur ; Larissa ROSSEN, Auteur ; L. Alan SROUFE, Auteur ; Ed TRONICK, Auteur ; R. M. Pasco FEARON, Auteur ; Pehr GRANQVIST, Auteur ; Abraham SAGI-SCHWARTZ, Auteur ; Alicia LIEBERMAN, Auteur ; Elizabeth CARLSON, Auteur ; Peter ZIMMERMANN, Auteur ; Mary DOZIER, Auteur ; Ashley WAZANA, Auteur ; Jay BELSKY, Auteur ; Phillip R. SHAVER, Auteur ; Dante CICCHETTI, Auteur ; Guy BOSMANS, Auteur ; Carlo SCHUENGEL, Auteur ; Karin GROSSMANN, Auteur ; Chantal CYR, Auteur ; Karine DUBOIS-COMTOIS, Auteur ; Marije VERHAGE, Auteur ; Anne THARNER, Auteur ; Mirjam OOSTERMAN, Auteur ; Brian ALLEN, Auteur ; Judith A. CROWELL, Auteur ; Pascal VRTIÄŒKA, Auteur ; Matthew WOOLGAR, Auteur ; K. Lee RABY, Auteur ; Megan GALBALLY, Auteur ; Jeremy HOLMES, Auteur ; Robert S. MARVIN, Auteur ; Marinus H. VAN IJZENDOORN, Auteur ; Marian J. BAKERMANS-KRANENBURG, Auteur Article en page(s) : p.723-739 Langues : Anglais (eng) Mots-clés : Clinical translation  Early childhood  Parent–child relationships  Parenting  Attachment myths  Attachment-informed interventions Index. décimale : PER Périodiques Résumé : Attachment theory, with its core concepts, perspectives, and insights developed over the past five decades, is influential for professionals working with young children. However, practitioners face challenges translating attachment theory and research into practical applications. This manifests in attachment myths, theoretical misinterpretations, and inconsistency of application. This state-of-the-art review is authored by 47 attachment researchers and practitioners and examines key insights from attachment theory to facilitate attachment-aware practice for professionals working with children and their caregivers. Following the ongoing debate on practical relevance in attachment theory, we present both ?strict? and ?expansive? translational perspectives on applications for addressing preventative or clinical attachment concerns. We first review core attachment propositions, based on replicated research of attachment and caregiving. We next address common misconceptions that hinder adequate practical applications. We present measures of attachment and sensitive parenting that might be helpful for practitioners. We also review evidence-based and promising attachment interventions, discussing core components of (preventative) support for parents or caregivers and the children in their care. We emphasize that attachment theory's clinical value lies not in assigning attachment classifications, but rather in understanding crucial insights into caregiving and early socioemotional development (e.g., secure base phenomena; the value of safe, stable, and shared good-enough care), developed in attachment research over the past 50?years, that may inform policy and clinical reasoning and areas for prevention and intervention. En ligne : https://doi.org/10.1111/jcpp.70126 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586 [article] Practitioner Review: Clinical insights from attachment theory and research for professionals working with young children and their families [texte imprimé] / Jessica E. OPIE, Auteur ; Everett WATERS, Auteur ; Robbie DUSCHINSKY, Auteur ; MÃ¥rten HAMMARLUND, Auteur ; Sheri MADIGAN, Auteur ; Sarah FOSTER, Auteur ; Tommie FORSLUND, Auteur ; Ross THOMPSON, Auteur ; Howard STEELE, Auteur ; Miriam STEELE, Auteur ; Glenn I. ROISMAN, Auteur ; Ashley M. GROH, Auteur ; Peter FONAGY, Auteur ; Or DAGAN, Auteur ; Alessandro TALIA, Auteur ; Larissa ROSSEN, Auteur ; L. Alan SROUFE, Auteur ; Ed TRONICK, Auteur ; R. M. Pasco FEARON, Auteur ; Pehr GRANQVIST, Auteur ; Abraham SAGI-SCHWARTZ, Auteur ; Alicia LIEBERMAN, Auteur ; Elizabeth CARLSON, Auteur ; Peter ZIMMERMANN, Auteur ; Mary DOZIER, Auteur ; Ashley WAZANA, Auteur ; Jay BELSKY, Auteur ; Phillip R. SHAVER, Auteur ; Dante CICCHETTI, Auteur ; Guy BOSMANS, Auteur ; Carlo SCHUENGEL, Auteur ; Karin GROSSMANN, Auteur ; Chantal CYR, Auteur ; Karine DUBOIS-COMTOIS, Auteur ; Marije VERHAGE, Auteur ; Anne THARNER, Auteur ; Mirjam OOSTERMAN, Auteur ; Brian ALLEN, Auteur ; Judith A. CROWELL, Auteur ; Pascal VRTIÄŒKA, Auteur ; Matthew WOOLGAR, Auteur ; K. Lee RABY, Auteur ; Megan GALBALLY, Auteur ; Jeremy HOLMES, Auteur ; Robert S. MARVIN, Auteur ; Marinus H. VAN IJZENDOORN, Auteur ; Marian J. BAKERMANS-KRANENBURG, Auteur . - p.723-739. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.723-739 Mots-clés : Clinical translation  Early childhood  Parent–child relationships  Parenting  Attachment myths  Attachment-informed interventions Index. décimale : PER Périodiques Résumé : Attachment theory, with its core concepts, perspectives, and insights developed over the past five decades, is influential for professionals working with young children. However, practitioners face challenges translating attachment theory and research into practical applications. This manifests in attachment myths, theoretical misinterpretations, and inconsistency of application. This state-of-the-art review is authored by 47 attachment researchers and practitioners and examines key insights from attachment theory to facilitate attachment-aware practice for professionals working with children and their caregivers. Following the ongoing debate on practical relevance in attachment theory, we present both ?strict? and ?expansive? translational perspectives on applications for addressing preventative or clinical attachment concerns. We first review core attachment propositions, based on replicated research of attachment and caregiving. We next address common misconceptions that hinder adequate practical applications. We present measures of attachment and sensitive parenting that might be helpful for practitioners. We also review evidence-based and promising attachment interventions, discussing core components of (preventative) support for parents or caregivers and the children in their care. We emphasize that attachment theory's clinical value lies not in assigning attachment classifications, but rather in understanding crucial insights into caregiving and early socioemotional development (e.g., secure base phenomena; the value of safe, stable, and shared good-enough care), developed in attachment research over the past 50?years, that may inform policy and clinical reasoning and areas for prevention and intervention. En ligne : https://doi.org/10.1111/jcpp.70126 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586

The spectrum of communication abilities in children with 12 rare neurodevelopmental disorders: a qualitative study with caregivers / Christina K. ZIGLER in Journal of Child Psychology and Psychiatry, 67-5 (May 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.740-754 Titre : The spectrum of communication abilities in children with 12 rare neurodevelopmental disorders: a qualitative study with caregivers Type de document : texte imprimé Auteurs : Christina K. ZIGLER, Auteur ; Molly MCFATRICH, Auteur ; Nicole LUCAS, Auteur ; Kate PLYLER, Auteur ; Leslie ZAPATA-LEIVA, Auteur ; Kelly GORDON, Auteur ; Harrison N. JONES, Auteur ; Li LIN, Auteur ; Jennifer KERN, Auteur ; Abigail RADAR, Auteur ; Dandan CHEN, Auteur ; Elika BERGELSON, Auteur ; Kate STILL, Auteur ; Brigette HINGER, Auteur ; Christal G. DELAGRAMMATIKAS, Auteur ; Sarah POLIQUIN, Auteur ; Brittany P. SHORT, Auteur ; Liz MARFIA-ASH, Auteur ; Kimberly STEPHENS, Auteur ; Haley O. OYLER, Auteur ; J. Michael GRAGLIA, Auteur ; Kali WORTH, Auteur ; Charlene SON RIGBY, Auteur ; James R. GOSS, Auteur ; Bo BIGELOW, Auteur ; Geraldine BLISS, Auteur ; Karen BEATTY, Auteur ; Leah SCHUST MYERS, Auteur ; Melissa THELEN, Auteur ; Nuala SUMMERFIELD, Auteur ; Terry Jo BICHELL, Auteur ; Bryce B. REEVE, Auteur Article en page(s) : p.740-754 Langues : Anglais (eng) Mots-clés : Communication  non-verbal communication  behavioural measures  qualitative methods  caregiver Index. décimale : PER Périodiques Résumé : Background Our aim was to update an existing model of communication ability for children with rare neurodevelopmental disorders (NDDs) by centring caregiver and family perspectives. This project is part of a larger initiative to improve the measurement of communication ability for these children in the context of clinical trials. Methods We conducted concept elicitation interviews with purposively selected clinical experts and caregivers of children with 12 NDDs, focusing on a broad definition of communication ability based on the Observer-Reported Communication Ability (ORCA) measure, which is inclusive of different communication modalities and covers expressive, receptive and pragmatic communication concepts. Content-based and thematic analysis was performed on the qualitative data. Results Altogether, 115 interviews were conducted with caregivers across the 12 NDDs and with 9 clinicians. Commonly mentioned concepts across NDDs included requesting an object, refusing an object, responding to familiar directions and seeking attention. There was notable heterogeneity within and across NDD groups in terms of the specific communication behaviours described for each communication concept. One common example was requesting; children used verbal speech, gestures, sign language, eye gaze, body movements and augmentative and assistive communication to ask for what they wanted. Novel communication concepts identified that were not part of the existing model were (1) feelings, emotions, and bodily sensations, (2) commenting on likes and dislikes, and (3) communicating and understanding humour. Conclusions Caregivers offered a detailed and nuanced picture of their child's day-to-day communication. There was a considerable overlap between the communication concepts discussed by caregivers in the interviews and the existing conceptual model of communication ability. Some newly identified concepts underscore the need for further adaptation of the model and subsequent validation of any clinical outcome assessment before communication ability can be confidently measured for these individuals in clinical trials. En ligne : https://doi.org/10.1111/jcpp.70063 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586 [article] The spectrum of communication abilities in children with 12 rare neurodevelopmental disorders: a qualitative study with caregivers [texte imprimé] / Christina K. ZIGLER, Auteur ; Molly MCFATRICH, Auteur ; Nicole LUCAS, Auteur ; Kate PLYLER, Auteur ; Leslie ZAPATA-LEIVA, Auteur ; Kelly GORDON, Auteur ; Harrison N. JONES, Auteur ; Li LIN, Auteur ; Jennifer KERN, Auteur ; Abigail RADAR, Auteur ; Dandan CHEN, Auteur ; Elika BERGELSON, Auteur ; Kate STILL, Auteur ; Brigette HINGER, Auteur ; Christal G. DELAGRAMMATIKAS, Auteur ; Sarah POLIQUIN, Auteur ; Brittany P. SHORT, Auteur ; Liz MARFIA-ASH, Auteur ; Kimberly STEPHENS, Auteur ; Haley O. OYLER, Auteur ; J. Michael GRAGLIA, Auteur ; Kali WORTH, Auteur ; Charlene SON RIGBY, Auteur ; James R. GOSS, Auteur ; Bo BIGELOW, Auteur ; Geraldine BLISS, Auteur ; Karen BEATTY, Auteur ; Leah SCHUST MYERS, Auteur ; Melissa THELEN, Auteur ; Nuala SUMMERFIELD, Auteur ; Terry Jo BICHELL, Auteur ; Bryce B. REEVE, Auteur . - p.740-754. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.740-754 Mots-clés : Communication  non-verbal communication  behavioural measures  qualitative methods  caregiver Index. décimale : PER Périodiques Résumé : Background Our aim was to update an existing model of communication ability for children with rare neurodevelopmental disorders (NDDs) by centring caregiver and family perspectives. This project is part of a larger initiative to improve the measurement of communication ability for these children in the context of clinical trials. Methods We conducted concept elicitation interviews with purposively selected clinical experts and caregivers of children with 12 NDDs, focusing on a broad definition of communication ability based on the Observer-Reported Communication Ability (ORCA) measure, which is inclusive of different communication modalities and covers expressive, receptive and pragmatic communication concepts. Content-based and thematic analysis was performed on the qualitative data. Results Altogether, 115 interviews were conducted with caregivers across the 12 NDDs and with 9 clinicians. Commonly mentioned concepts across NDDs included requesting an object, refusing an object, responding to familiar directions and seeking attention. There was notable heterogeneity within and across NDD groups in terms of the specific communication behaviours described for each communication concept. One common example was requesting; children used verbal speech, gestures, sign language, eye gaze, body movements and augmentative and assistive communication to ask for what they wanted. Novel communication concepts identified that were not part of the existing model were (1) feelings, emotions, and bodily sensations, (2) commenting on likes and dislikes, and (3) communicating and understanding humour. Conclusions Caregivers offered a detailed and nuanced picture of their child's day-to-day communication. There was a considerable overlap between the communication concepts discussed by caregivers in the interviews and the existing conceptual model of communication ability. Some newly identified concepts underscore the need for further adaptation of the model and subsequent validation of any clinical outcome assessment before communication ability can be confidently measured for these individuals in clinical trials. En ligne : https://doi.org/10.1111/jcpp.70063 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586

Perinatal hardship and infant neurodevelopment: insights from a global pandemic / Jonathan POSNER in Journal of Child Psychology and Psychiatry, 67-5 (May 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.755-765 Titre : Perinatal hardship and infant neurodevelopment: insights from a global pandemic Type de document : texte imprimé Auteurs : Jonathan POSNER, Auteur ; Andrew MICHAEL, Auteur ; Pratik KASHYAP, Auteur ; Meredith FAY, Auteur ; Ana Carolina Coelho MILANI, Auteur ; Ivaldo SILVA, Auteur ; Nitamar ABDALA, Auteur ; Célia Maria DE ARAÚJO, Auteur ; Aline Camargo RAMOS, Auteur ; Yun WANG, Auteur ; Mateus MAZZAFERRO, Auteur ; Andrea JACKOWSKI, Auteur ; Cristiane S. DUARTE, Auteur Article en page(s) : p.755-765 Langues : Anglais (eng) Mots-clés : Neurodevelopment  perinatal hardship  hippocampus  COVID-19  infant MRI  socioeconomic adversity Index. décimale : PER Périodiques Résumé : Background Material and emotional hardship during pregnancy can shape early brain development and behavior in infants. This study used the COVID-19 pandemic as a natural context in which such hardships were widespread, particularly in low-resource settings. Methods This cohort study examined associations between pandemic-related maternal emotional distress and material hardship during pregnancy and early neurodevelopmental outcomes in infants. A total of 235 mother?infant dyads from low-resource healthcare settings in Brazil were enrolled during the COVID-19 pandemic. Maternal hardships were assessed using a COVID-19-specific questionnaire, which included self-reported COVID-19 exposure/infection. Infant neurodevelopment was evaluated via MRI at 2?6?weeks of age and behavioral assessments at 14?months using the Bayley Scales of Infant Development. Results Material hardship was associated with reduced hippocampal volumes in the left (pfdr?=?.008) and right (pfdr?=?.025) hemispheres. Among female infants, material hardship was linked to lower functional connectivity between the right hippocampus and the right rostral anterior cingulate cortex (p?=?.004). Smaller hippocampal volumes correlated with weaker gross motor skills at 14?months (r?=?.23; p?=?.02). Maternal emotional distress and self-reported COVID-19 exposure/infection were not significantly associated with infant neurodevelopmental outcomes. Conclusions Material hardship may adversely affect early neurodevelopment, particularly hippocampal structure and connectivity, with potential downstream effects on motor skills. These findings underscore the importance of addressing material hardship during the perinatal period to support infant brain health and development. En ligne : https://doi.org/10.1111/jcpp.70060 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586 [article] Perinatal hardship and infant neurodevelopment: insights from a global pandemic [texte imprimé] / Jonathan POSNER, Auteur ; Andrew MICHAEL, Auteur ; Pratik KASHYAP, Auteur ; Meredith FAY, Auteur ; Ana Carolina Coelho MILANI, Auteur ; Ivaldo SILVA, Auteur ; Nitamar ABDALA, Auteur ; Célia Maria DE ARAÚJO, Auteur ; Aline Camargo RAMOS, Auteur ; Yun WANG, Auteur ; Mateus MAZZAFERRO, Auteur ; Andrea JACKOWSKI, Auteur ; Cristiane S. DUARTE, Auteur . - p.755-765. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.755-765 Mots-clés : Neurodevelopment  perinatal hardship  hippocampus  COVID-19  infant MRI  socioeconomic adversity Index. décimale : PER Périodiques Résumé : Background Material and emotional hardship during pregnancy can shape early brain development and behavior in infants. This study used the COVID-19 pandemic as a natural context in which such hardships were widespread, particularly in low-resource settings. Methods This cohort study examined associations between pandemic-related maternal emotional distress and material hardship during pregnancy and early neurodevelopmental outcomes in infants. A total of 235 mother?infant dyads from low-resource healthcare settings in Brazil were enrolled during the COVID-19 pandemic. Maternal hardships were assessed using a COVID-19-specific questionnaire, which included self-reported COVID-19 exposure/infection. Infant neurodevelopment was evaluated via MRI at 2?6?weeks of age and behavioral assessments at 14?months using the Bayley Scales of Infant Development. Results Material hardship was associated with reduced hippocampal volumes in the left (pfdr?=?.008) and right (pfdr?=?.025) hemispheres. Among female infants, material hardship was linked to lower functional connectivity between the right hippocampus and the right rostral anterior cingulate cortex (p?=?.004). Smaller hippocampal volumes correlated with weaker gross motor skills at 14?months (r?=?.23; p?=?.02). Maternal emotional distress and self-reported COVID-19 exposure/infection were not significantly associated with infant neurodevelopmental outcomes. Conclusions Material hardship may adversely affect early neurodevelopment, particularly hippocampal structure and connectivity, with potential downstream effects on motor skills. These findings underscore the importance of addressing material hardship during the perinatal period to support infant brain health and development. En ligne : https://doi.org/10.1111/jcpp.70060 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586

Regional cerebellar structural deficits distinguish psychostimulant-free ADHD youth with and without familial risk for bipolar I disorder: a cross-sectional morphometric analysis / Biqiu TANG in Journal of Child Psychology and Psychiatry, 67-5 (May 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.766-776 Titre : Regional cerebellar structural deficits distinguish psychostimulant-free ADHD youth with and without familial risk for bipolar I disorder: a cross-sectional morphometric analysis Type de document : texte imprimé Auteurs : Biqiu TANG, Auteur ; L. Rodrigo PATINO, Auteur ; Wenjing ZHANG, Auteur ; Su LUI, Auteur ; Melissa P. DELBELLO, Auteur ; Robert K. MCNAMARA, Auteur Article en page(s) : p.766-776 Langues : Anglais (eng) Mots-clés : Bipolar disorder  attention-deficit/hyperactivity disorder  familial risk  adolescence  cerebellum Index. décimale : PER Périodiques Résumé : Background Although attention-deficit/hyperactivity disorder (ADHD) with familial risk for bipolar I disorder (BD) may represent a more severe illness conferring greater risk for developing BD, associated neurostructural substrates remain poorly understood. This study examined cerebellum structural alterations, which prior studies suggested may be associated with BD risk. Methods We enrolled 151 youth (ages 10?18?years) in three groups: psychostimulant-free ADHD youth with a biological parent or sibling with BD (high-risk, n?=?52, mean age 13.8?±?2.6?years), psychostimulant-free ADHD youth without any first- or second-degree relative with mood or psychotic disorders (low-risk, n?=?50, mean age 14.1?±?2.5?years), and healthy controls (HC, n?=?49, mean age 14.6?±?2.4?years). ADHD youth were stimulant-naïve or had no psychostimulant exposure within 3?months prior to enrollment. Region-of-interest (ROI) analyses were conducted on the whole cerebellum and 28 lobules to quantify cerebellar volumes using the SUIT toolbox, and voxel-based morphometry (VBM) analyses were also performed. Exploratory analyses evaluated associations between regional cerebellar volumes and symptom measures. Results Significant group differences in volume were observed for the whole cerebellum, bilateral lobules VIIIa, right VIIb, and left X. Post hoc comparisons showed that the high-risk group exhibited volume deficits in the whole cerebellum, bilateral lobules VIIIa, and right VIIb, compared with HC and low-risk groups, whereas both high-risk and low-risk groups exhibited left X volume deficits compared to HC. Similar results were obtained using VBM. Among all ADHD youth, significant inverse correlations were observed between significant ROI volumes and Child Behavior Checklist (CBCL) total score and several subscales, including the dysregulation profile. Conclusions Psychostimulant-free ADHD youth with BD familial risk exhibit whole and regional cerebellar volume deficits compared with those without such risk and healthy youth. Inverse associations between regional cerebellar volumes and CBCL total and subscale scores among ADHD youth suggest clinical relevance and may represent a potential BD risk biomarker. En ligne : https://doi.org/10.1111/jcpp.70072 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586 [article] Regional cerebellar structural deficits distinguish psychostimulant-free ADHD youth with and without familial risk for bipolar I disorder: a cross-sectional morphometric analysis [texte imprimé] / Biqiu TANG, Auteur ; L. Rodrigo PATINO, Auteur ; Wenjing ZHANG, Auteur ; Su LUI, Auteur ; Melissa P. DELBELLO, Auteur ; Robert K. MCNAMARA, Auteur . - p.766-776. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.766-776 Mots-clés : Bipolar disorder  attention-deficit/hyperactivity disorder  familial risk  adolescence  cerebellum Index. décimale : PER Périodiques Résumé : Background Although attention-deficit/hyperactivity disorder (ADHD) with familial risk for bipolar I disorder (BD) may represent a more severe illness conferring greater risk for developing BD, associated neurostructural substrates remain poorly understood. This study examined cerebellum structural alterations, which prior studies suggested may be associated with BD risk. Methods We enrolled 151 youth (ages 10?18?years) in three groups: psychostimulant-free ADHD youth with a biological parent or sibling with BD (high-risk, n?=?52, mean age 13.8?±?2.6?years), psychostimulant-free ADHD youth without any first- or second-degree relative with mood or psychotic disorders (low-risk, n?=?50, mean age 14.1?±?2.5?years), and healthy controls (HC, n?=?49, mean age 14.6?±?2.4?years). ADHD youth were stimulant-naïve or had no psychostimulant exposure within 3?months prior to enrollment. Region-of-interest (ROI) analyses were conducted on the whole cerebellum and 28 lobules to quantify cerebellar volumes using the SUIT toolbox, and voxel-based morphometry (VBM) analyses were also performed. Exploratory analyses evaluated associations between regional cerebellar volumes and symptom measures. Results Significant group differences in volume were observed for the whole cerebellum, bilateral lobules VIIIa, right VIIb, and left X. Post hoc comparisons showed that the high-risk group exhibited volume deficits in the whole cerebellum, bilateral lobules VIIIa, and right VIIb, compared with HC and low-risk groups, whereas both high-risk and low-risk groups exhibited left X volume deficits compared to HC. Similar results were obtained using VBM. Among all ADHD youth, significant inverse correlations were observed between significant ROI volumes and Child Behavior Checklist (CBCL) total score and several subscales, including the dysregulation profile. Conclusions Psychostimulant-free ADHD youth with BD familial risk exhibit whole and regional cerebellar volume deficits compared with those without such risk and healthy youth. Inverse associations between regional cerebellar volumes and CBCL total and subscale scores among ADHD youth suggest clinical relevance and may represent a potential BD risk biomarker. En ligne : https://doi.org/10.1111/jcpp.70072 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586

Neurodevelopmental conditions and adaptive functioning – a co-twin control study / Johan ISAKSSON in Journal of Child Psychology and Psychiatry, 67-5 (May 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.777-787 Titre : Neurodevelopmental conditions and adaptive functioning – a co-twin control study Type de document : texte imprimé Auteurs : Johan ISAKSSON, Auteur ; Filippa EKLUND, Auteur ; Karl Lundin REMNÉLIUS, Auteur ; Melissa H. BLACK, Auteur ; Sven BÖLTE, Auteur Article en page(s) : p.777-787 Langues : Anglais (eng) Mots-clés : Adaptive behavior  impairment  ADHD  ASD  intellectual disability Index. décimale : PER Périodiques Résumé : Background Challenges in adaptive or daily functioning are inherent to diagnostic criteria for neurodevelopmental conditions (NDCs). However, less is known regarding the influence of factors that may confound the association between NDCs and adaptive functioning. Therefore, we examined the associations between different NDCs and adaptive functioning while adjusting for co-occurring conditions, genetics, and shared environment. Methods We used a co-twin control study design in a sample of Swedish twins (N?=?314, age range 8?21?years), including both monozygotic (MZ) and dizygotic (DZ) twins. Adaptive function was assessed using the parent-rated Adaptive Behavior Assessment System, second edition. A generalized estimating equations (GEE) model was fitted, using NDC diagnoses of Autism Spectrum Disorder, Attention-Deficit/Hyperactivity Disorder (ADHD), and Intellectual Disability (ID), as well as other psychiatric conditions, as exposure and adaptive functioning as the outcome. The model was first fitted across twin pairs and subsequently within the twin pairs, thus adjusting for genetic and shared environmental influences. Interaction effects of age and sex by different NDCs on adaptive functioning were assessed. Results All forms of NDCs were independently associated with challenges in adaptive function across pairs. The co-occurrence of multiple NDCs was associated with adaptive functioning, with a greater number of NDCs being associated with more functioning challenges. Higher age was associated with more challenges in adaptive functioning among autistic individuals. In the within-pair models, the association remained for autism and ID, but the association between ADHD and adaptive functioning was lost in the MZ sub-sample when adjusting fully for all genetic factors. Conclusions NDCs are associated with challenges in adaptive function, even when adjusting for other psychiatric conditions, stressing the importance of adequate community support. Findings indicate the importance of non-shared environmental factors for understanding the challenges in adaptive function experienced by individuals with autism and ID and genetic factors for individuals with ADHD. En ligne : https://doi.org/10.1111/jcpp.70073 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586 [article] Neurodevelopmental conditions and adaptive functioning – a co-twin control study [texte imprimé] / Johan ISAKSSON, Auteur ; Filippa EKLUND, Auteur ; Karl Lundin REMNÉLIUS, Auteur ; Melissa H. BLACK, Auteur ; Sven BÖLTE, Auteur . - p.777-787. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.777-787 Mots-clés : Adaptive behavior  impairment  ADHD  ASD  intellectual disability Index. décimale : PER Périodiques Résumé : Background Challenges in adaptive or daily functioning are inherent to diagnostic criteria for neurodevelopmental conditions (NDCs). However, less is known regarding the influence of factors that may confound the association between NDCs and adaptive functioning. Therefore, we examined the associations between different NDCs and adaptive functioning while adjusting for co-occurring conditions, genetics, and shared environment. Methods We used a co-twin control study design in a sample of Swedish twins (N?=?314, age range 8?21?years), including both monozygotic (MZ) and dizygotic (DZ) twins. Adaptive function was assessed using the parent-rated Adaptive Behavior Assessment System, second edition. A generalized estimating equations (GEE) model was fitted, using NDC diagnoses of Autism Spectrum Disorder, Attention-Deficit/Hyperactivity Disorder (ADHD), and Intellectual Disability (ID), as well as other psychiatric conditions, as exposure and adaptive functioning as the outcome. The model was first fitted across twin pairs and subsequently within the twin pairs, thus adjusting for genetic and shared environmental influences. Interaction effects of age and sex by different NDCs on adaptive functioning were assessed. Results All forms of NDCs were independently associated with challenges in adaptive function across pairs. The co-occurrence of multiple NDCs was associated with adaptive functioning, with a greater number of NDCs being associated with more functioning challenges. Higher age was associated with more challenges in adaptive functioning among autistic individuals. In the within-pair models, the association remained for autism and ID, but the association between ADHD and adaptive functioning was lost in the MZ sub-sample when adjusting fully for all genetic factors. Conclusions NDCs are associated with challenges in adaptive function, even when adjusting for other psychiatric conditions, stressing the importance of adequate community support. Findings indicate the importance of non-shared environmental factors for understanding the challenges in adaptive function experienced by individuals with autism and ID and genetic factors for individuals with ADHD. En ligne : https://doi.org/10.1111/jcpp.70073 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586

Individual differences in effects of stressful life events on childhood ADHD: genetic, neural, and familial contributions / Seung Yun CHOI in Journal of Child Psychology and Psychiatry, 67-5 (May 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.788-800 Titre : Individual differences in effects of stressful life events on childhood ADHD: genetic, neural, and familial contributions Type de document : texte imprimé Auteurs : Seung Yun CHOI, Auteur ; Jinwoo LEE, Auteur ; Junghoon PARK, Auteur ; Eunji LEE, Auteur ; Bo-Gyeom KIM, Auteur ; Gakyung KIM, Auteur ; Yoonjung Yoonie JOO, Auteur ; Jiook CHA, Auteur Article en page(s) : p.788-800 Langues : Anglais (eng) Mots-clés : Early-life stress  ADHD  gene-brain-environment  vulnerability  individual differences Index. décimale : PER Périodiques Résumé : Background This study elucidates the intricate relationship between stressful life events and the development of ADHD symptoms in children, acknowledging the considerable variability in individual responses. By examining these differences, we aim to uncover the unique combinations of factors contributing to varying levels of vulnerability and resilience among children. Methods Utilizing longitudinal data from the Adolescent Brain Cognitive Development study (baseline: N?=?6,303, age?=?9.9), we applied Generalized Random Forest (GRF) to model the nonlinear relationships among genetic predispositions, brain features, and environmental factors. Results Significant individual variability was observed in children's ADHD symptoms post-stress, particularly at the 1-year and 2-year follow-ups. At the 1-year follow-up, increased vulnerability was indicated by heightened parental mental health problems and a lower polygenic risk score for smoking. By the 2-year follow-up, escalated parental mental health disorders, higher ADHD polygenic risk scores (PRS), and altered structural connectivity in the cognitive control network were significant contributors to individual differences. Conclusions These findings underscore the importance of integrating environmental, genetic, and neural variables to identify children vulnerable or resilient to developing ADHD symptoms following early-life stress. This study demonstrates how multimodal data combined with nonparametric machine learning can advance precision psychology and psychiatry, aiding targeted support for affected children. En ligne : https://doi.org/10.1111/jcpp.70074 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586 [article] Individual differences in effects of stressful life events on childhood ADHD: genetic, neural, and familial contributions [texte imprimé] / Seung Yun CHOI, Auteur ; Jinwoo LEE, Auteur ; Junghoon PARK, Auteur ; Eunji LEE, Auteur ; Bo-Gyeom KIM, Auteur ; Gakyung KIM, Auteur ; Yoonjung Yoonie JOO, Auteur ; Jiook CHA, Auteur . - p.788-800. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.788-800 Mots-clés : Early-life stress  ADHD  gene-brain-environment  vulnerability  individual differences Index. décimale : PER Périodiques Résumé : Background This study elucidates the intricate relationship between stressful life events and the development of ADHD symptoms in children, acknowledging the considerable variability in individual responses. By examining these differences, we aim to uncover the unique combinations of factors contributing to varying levels of vulnerability and resilience among children. Methods Utilizing longitudinal data from the Adolescent Brain Cognitive Development study (baseline: N?=?6,303, age?=?9.9), we applied Generalized Random Forest (GRF) to model the nonlinear relationships among genetic predispositions, brain features, and environmental factors. Results Significant individual variability was observed in children's ADHD symptoms post-stress, particularly at the 1-year and 2-year follow-ups. At the 1-year follow-up, increased vulnerability was indicated by heightened parental mental health problems and a lower polygenic risk score for smoking. By the 2-year follow-up, escalated parental mental health disorders, higher ADHD polygenic risk scores (PRS), and altered structural connectivity in the cognitive control network were significant contributors to individual differences. Conclusions These findings underscore the importance of integrating environmental, genetic, and neural variables to identify children vulnerable or resilient to developing ADHD symptoms following early-life stress. This study demonstrates how multimodal data combined with nonparametric machine learning can advance precision psychology and psychiatry, aiding targeted support for affected children. En ligne : https://doi.org/10.1111/jcpp.70074 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586