Dépouillements

The impact of COVID-19 on the mental health and wellbeing of caregivers of autistic children and youth: A scoping review / V. LEE in Autism Research, 14-12 (December 2021)  

Public ISBD [article]  inAutism Research > 14-12 (December 2021) . - p.2477-2494 Titre : The impact of COVID-19 on the mental health and wellbeing of caregivers of autistic children and youth: A scoping review Type de document : Texte imprimé et/ou numérique Auteurs : V. LEE, Auteur ; Carly ALBAUM, Auteur ; Paula TABLON-MODICA, Auteur ; F. AHMAD, Auteur ; J. W. GORTER, Auteur ; N. KHANLOU, Auteur ; C. MCMORRIS, Auteur ; J. LAI, Auteur ; C. HARRISON, Auteur ; T. HEDLEY, Auteur ; P. JOHNSTON, Auteur ; C. PUTTERMAN, Auteur ; M. SPOELSTRA, Auteur ; J. A. WEISS, Auteur Article en page(s) : p.2477-2494 Langues : Anglais (eng) Mots-clés : Adolescent  Autism Spectrum Disorder  Autistic Disorder  Covid-19  Caregivers  Child  Communicable Disease Control  Humans  Mental Health  Pandemics  SARS-CoV-2  Covid  autism  caregivers  literature review  mental health Index. décimale : PER Périodiques Résumé : Caregivers and families of autistic people have experienced stress and increase in demands due to the COVID-19 pandemic that may have long-term negative consequences for both their own and their children's mental health. A scoping review was conducted to identify pandemic related demands experienced by caregivers and families of autistic children and youth. The review also consolidated information on coping strategies and parenting-related guidelines that have emerged to help parents meet these demands. Search strategies were approved by a research librarian and were conducted in peer-reviewed and gray literature databases between May 2020 and February 2021. Additional resources were solicited through author networks and social media. All articles were published between December 2019 and February 2021. Article summaries were charted, and a thematic analysis was conducted with confirmation of findings with our knowledge users. Twenty-three published articles and 14 pieces of gray literature were included in the review. The majority of articles characterized and highlighted the increase in demands on caregivers of autistic children and youth during the pandemic globally. Both quantitative and qualitative studies suggest that parents have experienced an increase in stress and mental health-related symptoms during lockdown measures. Findings suggest that families are employing coping strategies, but there no evidence-based supports were identified. The review highlighted the potential long-term impact of prolonged exposure to increasing demands on the mental health and wellbeing of caregivers and families of autistic people, and pointed to a need for the rapid development and evaluation of flexible and timely support programs. LAY SUMMARY: Caregivers and families of autistic children and youth have faced increased demands due to pandemic-related lockdown measures. We reviewed the literature to outline sources of stress, links to their influence on caregiver mental health, and if support programs have emerged to help them. Our findings suggest a number of demands have increased caregivers' risk to mental health challenges, and their potential impact on family wellbeing. Ongoing development of evidence-based supports of all families of autistic children and youth are needed. En ligne : http://dx.doi.org/10.1002/aur.2616 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] The impact of COVID-19 on the mental health and wellbeing of caregivers of autistic children and youth: A scoping review [Texte imprimé et/ou numérique] / V. LEE, Auteur ; Carly ALBAUM, Auteur ; Paula TABLON-MODICA, Auteur ; F. AHMAD, Auteur ; J. W. GORTER, Auteur ; N. KHANLOU, Auteur ; C. MCMORRIS, Auteur ; J. LAI, Auteur ; C. HARRISON, Auteur ; T. HEDLEY, Auteur ; P. JOHNSTON, Auteur ; C. PUTTERMAN, Auteur ; M. SPOELSTRA, Auteur ; J. A. WEISS, Auteur . - p.2477-2494. Langues : Anglais (eng) in Autism Research > 14-12 (December 2021) . - p.2477-2494 Mots-clés : Adolescent  Autism Spectrum Disorder  Autistic Disorder  Covid-19  Caregivers  Child  Communicable Disease Control  Humans  Mental Health  Pandemics  SARS-CoV-2  Covid  autism  caregivers  literature review  mental health Index. décimale : PER Périodiques Résumé : Caregivers and families of autistic people have experienced stress and increase in demands due to the COVID-19 pandemic that may have long-term negative consequences for both their own and their children's mental health. A scoping review was conducted to identify pandemic related demands experienced by caregivers and families of autistic children and youth. The review also consolidated information on coping strategies and parenting-related guidelines that have emerged to help parents meet these demands. Search strategies were approved by a research librarian and were conducted in peer-reviewed and gray literature databases between May 2020 and February 2021. Additional resources were solicited through author networks and social media. All articles were published between December 2019 and February 2021. Article summaries were charted, and a thematic analysis was conducted with confirmation of findings with our knowledge users. Twenty-three published articles and 14 pieces of gray literature were included in the review. The majority of articles characterized and highlighted the increase in demands on caregivers of autistic children and youth during the pandemic globally. Both quantitative and qualitative studies suggest that parents have experienced an increase in stress and mental health-related symptoms during lockdown measures. Findings suggest that families are employing coping strategies, but there no evidence-based supports were identified. The review highlighted the potential long-term impact of prolonged exposure to increasing demands on the mental health and wellbeing of caregivers and families of autistic people, and pointed to a need for the rapid development and evaluation of flexible and timely support programs. LAY SUMMARY: Caregivers and families of autistic children and youth have faced increased demands due to pandemic-related lockdown measures. We reviewed the literature to outline sources of stress, links to their influence on caregiver mental health, and if support programs have emerged to help them. Our findings suggest a number of demands have increased caregivers' risk to mental health challenges, and their potential impact on family wellbeing. Ongoing development of evidence-based supports of all families of autistic children and youth are needed. En ligne : http://dx.doi.org/10.1002/aur.2616 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Social cognitive skills groups increase medial prefrontal cortex activity in children with autism spectrum disorder / K. IBRAHIM in Autism Research, 14-12 (December 2021)  

Public ISBD [article]  inAutism Research > 14-12 (December 2021) . - p.2495-2511 Titre : Social cognitive skills groups increase medial prefrontal cortex activity in children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : K. IBRAHIM, Auteur ; L. V. SOORYA, Auteur ; Danielle B. HALPERN, Auteur ; M. GORENSTEIN, Auteur ; P. M. SIPER, Auteur ; A. Ting WANG, Auteur Article en page(s) : p.2495-2511 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnostic imaging  Brain  Child  Cognition  Humans  Prefrontal Cortex/diagnostic imaging  Social Skills  Asd  eye gaze  fMRI  irony  medial prefrontal cortex  social cognitive skills groups Index. décimale : PER Périodiques Résumé : Few studies have examined the neural mechanisms of change following social skills interventions for children with autism spectrum disorder (ASD). This study examined the neural effects of social cognitive skills groups during functional MRI (fMRI) tasks of irony comprehension and eye gaze processing in school-aged children with ASD. Verbally fluent children (ages 8-11) were randomized to social cognitive skills groups or facilitated play comparison groups. Behavioral assessments and fMRI scans were obtained at baseline and endpoint (12?weeks). During fMRI, children completed two separate tasks to engage social cognition circuitry: comprehension of potentially ironic scenarios (n =?34) and viewing emotionally expressive faces with direct or averted gaze (n =?24). Whole-brain analyses were conducted to examine neural changes following treatment. Regression analyses were also conducted to explore the relationship between neural and behavioral changes. When comparing the two groups directly, the social cognitive skills group showed greater increases in activity in the medial prefrontal cortex (mPFC), implicated in theory of mind, relative to the comparison group for both irony comprehension and gaze processing tasks. Increased mPFC activity during the irony task was associated with improvement in social functioning on the Social Responsiveness Scale across both groups. Findings indicate that social cognitive skills interventions may increase activity in regions associated with social cognition and mentalizing abilities. LAY SUMMARY: Social skills groups are a common intervention for school-aged children with ASD. However, few studies have examined the neural response to social skills groups in school-aged children with ASD. Here, we report on a study evaluating neural outcomes from an empirically supported social cognitive skills training curriculum using fMRI. This study seeks to understand the effects of targeting emotion recognition and theory of mind on the brain circuitry involved in social cognition in verbally fluent children ages 8-11. Results indicate increased neural activity in the mPFC, a region considered to be a central hub of the "social brain," in children randomized to social cognitive skills groups relative to a comparison group that received a high-quality, child-directed play approach. In addition, increased activation in the mPFC during an irony comprehension task was associated with gains in social functioning across both groups from pre- to post-treatment. This is the first fMRI study of social skills treatment outcomes following a randomized trial with an active treatment condition in school-aged children with ASD. En ligne : http://dx.doi.org/10.1002/aur.2603 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Social cognitive skills groups increase medial prefrontal cortex activity in children with autism spectrum disorder [Texte imprimé et/ou numérique] / K. IBRAHIM, Auteur ; L. V. SOORYA, Auteur ; Danielle B. HALPERN, Auteur ; M. GORENSTEIN, Auteur ; P. M. SIPER, Auteur ; A. Ting WANG, Auteur . - p.2495-2511. Langues : Anglais (eng) in Autism Research > 14-12 (December 2021) . - p.2495-2511 Mots-clés : Autism Spectrum Disorder/diagnostic imaging  Brain  Child  Cognition  Humans  Prefrontal Cortex/diagnostic imaging  Social Skills  Asd  eye gaze  fMRI  irony  medial prefrontal cortex  social cognitive skills groups Index. décimale : PER Périodiques Résumé : Few studies have examined the neural mechanisms of change following social skills interventions for children with autism spectrum disorder (ASD). This study examined the neural effects of social cognitive skills groups during functional MRI (fMRI) tasks of irony comprehension and eye gaze processing in school-aged children with ASD. Verbally fluent children (ages 8-11) were randomized to social cognitive skills groups or facilitated play comparison groups. Behavioral assessments and fMRI scans were obtained at baseline and endpoint (12?weeks). During fMRI, children completed two separate tasks to engage social cognition circuitry: comprehension of potentially ironic scenarios (n =?34) and viewing emotionally expressive faces with direct or averted gaze (n =?24). Whole-brain analyses were conducted to examine neural changes following treatment. Regression analyses were also conducted to explore the relationship between neural and behavioral changes. When comparing the two groups directly, the social cognitive skills group showed greater increases in activity in the medial prefrontal cortex (mPFC), implicated in theory of mind, relative to the comparison group for both irony comprehension and gaze processing tasks. Increased mPFC activity during the irony task was associated with improvement in social functioning on the Social Responsiveness Scale across both groups. Findings indicate that social cognitive skills interventions may increase activity in regions associated with social cognition and mentalizing abilities. LAY SUMMARY: Social skills groups are a common intervention for school-aged children with ASD. However, few studies have examined the neural response to social skills groups in school-aged children with ASD. Here, we report on a study evaluating neural outcomes from an empirically supported social cognitive skills training curriculum using fMRI. This study seeks to understand the effects of targeting emotion recognition and theory of mind on the brain circuitry involved in social cognition in verbally fluent children ages 8-11. Results indicate increased neural activity in the mPFC, a region considered to be a central hub of the "social brain," in children randomized to social cognitive skills groups relative to a comparison group that received a high-quality, child-directed play approach. In addition, increased activation in the mPFC during an irony comprehension task was associated with gains in social functioning across both groups from pre- to post-treatment. This is the first fMRI study of social skills treatment outcomes following a randomized trial with an active treatment condition in school-aged children with ASD. En ligne : http://dx.doi.org/10.1002/aur.2603 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Unified framework for early stage status prediction of autism based on infant structural magnetic resonance imaging / K. GAO in Autism Research, 14-12 (December 2021)  

Public ISBD [article]  inAutism Research > 14-12 (December 2021) . - p.2512-2523 Titre : Unified framework for early stage status prediction of autism based on infant structural magnetic resonance imaging Type de document : Texte imprimé et/ou numérique Auteurs : K. GAO, Auteur ; Y. SUN, Auteur ; S. NIU, Auteur ; L. WANG, Auteur Article en page(s) : p.2512-2523 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnostic imaging  Autistic Disorder  Brain/diagnostic imaging  Child, Preschool  Humans  Infant  Magnetic Resonance Imaging  Neuroimaging  autism Spectrum disorder (ASD)  deep learning algorithm  early-stage status prediction  infant structural MRI  subject-specific autism attention  interest. Index. décimale : PER Périodiques Résumé : Autism, or autism spectrum disorder (ASD), is a developmental disability that is diagnosed at about 2?years of age based on abnormal behaviors. Existing neuroimaging-based methods for the prediction of ASD typically focus on functional magnetic resonance imaging (fMRI); however, most of these fMRI-based studies include subjects older than 5?years of age. Due to challenges in the application of fMRI for infants, structural magnetic resonance imaging (sMRI) has increasingly received attention in the field for early status prediction of ASD. In this study, we propose an automated prediction framework based on infant sMRI at about 24?months of age. Specifically, by leveraging an infant-dedicated pipeline, iBEAT V2.0 Cloud, we derived segmentation and parcellation maps from infant sMRI. We employed a convolutional neural network to extract features from pairwise maps and a Siamese network to distinguish whether paired subjects were from the same or different classes. As compared to T1w imaging without segmentation and parcellation maps, our proposed approach with segmentation and parcellation maps yielded greater sensitivity, specificity, and accuracy of ASD prediction, which was validated using two datasets with different imaging protocols/scanners and was confirmed by receiver operating characteristic analysis. Furthermore, comparison with state-of-the-art methods demonstrated the superior effectiveness and robustness of the proposed method. Finally, attention maps were generated to identify subject-specific autism effects, supporting the reasonability of the predictive results. Collectively, these findings demonstrate the utility of our unified framework for the early-stage status prediction of ASD by sMRI. LAY SUMMARY: The status prediction of autism spectrum disorder (ASD) at an early age is highly desirable, as early intervention may significantly reduce autism symptoms. However, current methods for diagnosing young children are limited to behavioral assays. In this study, we propose an automated method for ASD status prediction at the age of 24?months that uses infant structural magnetic resonance imaging to identify neural features. En ligne : http://dx.doi.org/10.1002/aur.2626 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Unified framework for early stage status prediction of autism based on infant structural magnetic resonance imaging [Texte imprimé et/ou numérique] / K. GAO, Auteur ; Y. SUN, Auteur ; S. NIU, Auteur ; L. WANG, Auteur . - p.2512-2523. Langues : Anglais (eng) in Autism Research > 14-12 (December 2021) . - p.2512-2523 Mots-clés : Autism Spectrum Disorder/diagnostic imaging  Autistic Disorder  Brain/diagnostic imaging  Child, Preschool  Humans  Infant  Magnetic Resonance Imaging  Neuroimaging  autism Spectrum disorder (ASD)  deep learning algorithm  early-stage status prediction  infant structural MRI  subject-specific autism attention  interest. Index. décimale : PER Périodiques Résumé : Autism, or autism spectrum disorder (ASD), is a developmental disability that is diagnosed at about 2?years of age based on abnormal behaviors. Existing neuroimaging-based methods for the prediction of ASD typically focus on functional magnetic resonance imaging (fMRI); however, most of these fMRI-based studies include subjects older than 5?years of age. Due to challenges in the application of fMRI for infants, structural magnetic resonance imaging (sMRI) has increasingly received attention in the field for early status prediction of ASD. In this study, we propose an automated prediction framework based on infant sMRI at about 24?months of age. Specifically, by leveraging an infant-dedicated pipeline, iBEAT V2.0 Cloud, we derived segmentation and parcellation maps from infant sMRI. We employed a convolutional neural network to extract features from pairwise maps and a Siamese network to distinguish whether paired subjects were from the same or different classes. As compared to T1w imaging without segmentation and parcellation maps, our proposed approach with segmentation and parcellation maps yielded greater sensitivity, specificity, and accuracy of ASD prediction, which was validated using two datasets with different imaging protocols/scanners and was confirmed by receiver operating characteristic analysis. Furthermore, comparison with state-of-the-art methods demonstrated the superior effectiveness and robustness of the proposed method. Finally, attention maps were generated to identify subject-specific autism effects, supporting the reasonability of the predictive results. Collectively, these findings demonstrate the utility of our unified framework for the early-stage status prediction of ASD by sMRI. LAY SUMMARY: The status prediction of autism spectrum disorder (ASD) at an early age is highly desirable, as early intervention may significantly reduce autism symptoms. However, current methods for diagnosing young children are limited to behavioral assays. In this study, we propose an automated method for ASD status prediction at the age of 24?months that uses infant structural magnetic resonance imaging to identify neural features. En ligne : http://dx.doi.org/10.1002/aur.2626 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Autism severity aggregates with family psychiatric history in a community-based autism sample / D. SIPSOCK in Autism Research, 14-12 (December 2021)  

Public ISBD [article]  inAutism Research > 14-12 (December 2021) . - p.2524-2532 Titre : Autism severity aggregates with family psychiatric history in a community-based autism sample Type de document : Texte imprimé et/ou numérique Auteurs : D. SIPSOCK, Auteur ; H. TOKADJIAN, Auteur ; G. RIGHI, Auteur ; E. M. MORROW, Auteur ; S. J. SHEINKOPF, Auteur Article en page(s) : p.2524-2532 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/complications/genetics  Autistic Disorder/genetics  Family  Humans  Longitudinal Studies  Registries  autism spectrum disorder  disease severity  family medical history  population study  registry Index. décimale : PER Périodiques Résumé : The purpose of this study was to examine family psychiatric history in individuals with autism spectrum disorder (ASD) and its association with clinical presentation. Participants were 798 individuals with a clinical diagnosis of ASD, confirmed by the Autism Diagnostic Observation Schedule, Second Edition (ADOS-2), enrolled in Rhode Island Consortium for Autism Research and Treatment, a statewide research registry. Prior research suggests a specific behavioral phenotype in individuals with ASD who have family members with psychiatric diagnoses, including higher IQ and less severe language impairment. However, studies have not specifically investigated autism severity. We hypothesized that increased psychiatric family history would be associated with increased autism severity symptoms. Results show a strong association of increased burden of first-degree family psychiatric history with higher autism symptom severity as measured by Social Responsiveness Scale, Second Edition (SRS-2), but not with ADOS-2 severity scores, IQ, or adaptive functioning. These findings support the importance of investigating the contribution of psychiatric family history toward clinical ASD presentation. LAY SUMMARY: This study explored how family psychiatric history is related to clinical presentation of Autism Spectrum Disorder (ASD). Higher amounts of first-degree family psychiatric history was associated with higher autism symptom severity as measured by the Social Responsiveness Scale, Second Edition (SRS-2). The contribution of psychiatric family history requires ongoing investigation. En ligne : http://dx.doi.org/10.1002/aur.2625 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Autism severity aggregates with family psychiatric history in a community-based autism sample [Texte imprimé et/ou numérique] / D. SIPSOCK, Auteur ; H. TOKADJIAN, Auteur ; G. RIGHI, Auteur ; E. M. MORROW, Auteur ; S. J. SHEINKOPF, Auteur . - p.2524-2532. Langues : Anglais (eng) in Autism Research > 14-12 (December 2021) . - p.2524-2532 Mots-clés : Autism Spectrum Disorder/complications/genetics  Autistic Disorder/genetics  Family  Humans  Longitudinal Studies  Registries  autism spectrum disorder  disease severity  family medical history  population study  registry Index. décimale : PER Périodiques Résumé : The purpose of this study was to examine family psychiatric history in individuals with autism spectrum disorder (ASD) and its association with clinical presentation. Participants were 798 individuals with a clinical diagnosis of ASD, confirmed by the Autism Diagnostic Observation Schedule, Second Edition (ADOS-2), enrolled in Rhode Island Consortium for Autism Research and Treatment, a statewide research registry. Prior research suggests a specific behavioral phenotype in individuals with ASD who have family members with psychiatric diagnoses, including higher IQ and less severe language impairment. However, studies have not specifically investigated autism severity. We hypothesized that increased psychiatric family history would be associated with increased autism severity symptoms. Results show a strong association of increased burden of first-degree family psychiatric history with higher autism symptom severity as measured by Social Responsiveness Scale, Second Edition (SRS-2), but not with ADOS-2 severity scores, IQ, or adaptive functioning. These findings support the importance of investigating the contribution of psychiatric family history toward clinical ASD presentation. LAY SUMMARY: This study explored how family psychiatric history is related to clinical presentation of Autism Spectrum Disorder (ASD). Higher amounts of first-degree family psychiatric history was associated with higher autism symptom severity as measured by the Social Responsiveness Scale, Second Edition (SRS-2). The contribution of psychiatric family history requires ongoing investigation. En ligne : http://dx.doi.org/10.1002/aur.2625 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Maternal prenatal selenium levels and child risk of neurodevelopmental disorders: A prospective birth cohort study / A. S. E. LEE in Autism Research, 14-12 (December 2021)  

Public ISBD [article]  inAutism Research > 14-12 (December 2021) . - p.2533-2543 Titre : Maternal prenatal selenium levels and child risk of neurodevelopmental disorders: A prospective birth cohort study Type de document : Texte imprimé et/ou numérique Auteurs : A. S. E. LEE, Auteur ; Y. JI, Auteur ; R. RAGHAVAN, Auteur ; G. WANG, Auteur ; X. HONG, Auteur ; C. PEARSON, Auteur ; G. MIROLLI, Auteur ; E. BIND, Auteur ; A. STEFFENS, Auteur ; J. MUKHERJEE, Auteur ; D. HALTMEIER, Auteur ; Z. T. FAN, Auteur ; X. WANG, Auteur Article en page(s) : p.2533-2543 Langues : Anglais (eng) Mots-clés : Attention Deficit Disorder with Hyperactivity  Autism Spectrum Disorder/epidemiology  Birth Cohort  Cohort Studies  Female  Humans  Neurodevelopmental Disorders/epidemiology  Pregnancy  Prenatal Exposure Delayed Effects  Prospective Studies  Selenium  attention deficit-hyperactivity disorder  children  environmental risk factors  epigenetics  gene-environment interaction  pediatrics  pre- and perinatal risk factors Index. décimale : PER Périodiques Résumé : Selenium (Se) is an essential trace element involved in various biological processes, including neurodevelopment. Available literature indicates that both Se deficiency and excess may be detrimental to health. It is also known that Se can cross the placenta from maternal to fetal circulation. To date, the role of maternal Se status in child long-term neurodevelopment is largely unexplored. This study investigated the temporal and dose-response associations between maternal Se status and child risk of neurodevelopmental disorders including autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). It consisted of 1550 mother-infant dyads from the Boston Birth Cohort. Maternal red blood cell (RBC) Se levels were measured in samples collected within 72?h of delivery (biomarker of third trimester Se status). Pediatric neurodevelopmental diagnoses were obtained from electronic medical records. Data analyses showed that maternal RBC Se levels were positively associated with child risk of developing ASD, with an adjusted odds ratio of 1.49 for ASD (95% CI: 1.09, 2.02) per IQR increase in Se. There was also a positive association between maternal Se and ADHD (OR: 1.29; 95% CI: 1.04, 1.56, per IQR increase in Se). These associations remained robust even after adjusting for pertinent covariables; and there was no significant interaction between Se and these covariables. Our findings suggest that prenatal exposure to high maternal Se levels may adversely affect child neurodevelopment. Our findings warrant further investigation; if confirmed, optimizing maternal prenatal Se levels may be necessary to maximize its health benefits while preventing undue risk. LAY SUMMARY: Selenium (Se) is an essential nutrient for the health of the pregnant mother and her baby. While Se can readily cross the placenta from maternal to fetal circulation, little is known about maternal Se status on her child's neurodevelopmental outcomes. We studied over 1500 mother-child dyads from birth to school age of the child. We found that babies born from mothers with high blood Se levels may be at increased risk of developing autism spectrum disorder or attention deficit hyperactivity disorder. Given this is the first study of the kind, more study is needed to confirm our findings. En ligne : http://dx.doi.org/10.1002/aur.2617 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Maternal prenatal selenium levels and child risk of neurodevelopmental disorders: A prospective birth cohort study [Texte imprimé et/ou numérique] / A. S. E. LEE, Auteur ; Y. JI, Auteur ; R. RAGHAVAN, Auteur ; G. WANG, Auteur ; X. HONG, Auteur ; C. PEARSON, Auteur ; G. MIROLLI, Auteur ; E. BIND, Auteur ; A. STEFFENS, Auteur ; J. MUKHERJEE, Auteur ; D. HALTMEIER, Auteur ; Z. T. FAN, Auteur ; X. WANG, Auteur . - p.2533-2543. Langues : Anglais (eng) in Autism Research > 14-12 (December 2021) . - p.2533-2543 Mots-clés : Attention Deficit Disorder with Hyperactivity  Autism Spectrum Disorder/epidemiology  Birth Cohort  Cohort Studies  Female  Humans  Neurodevelopmental Disorders/epidemiology  Pregnancy  Prenatal Exposure Delayed Effects  Prospective Studies  Selenium  attention deficit-hyperactivity disorder  children  environmental risk factors  epigenetics  gene-environment interaction  pediatrics  pre- and perinatal risk factors Index. décimale : PER Périodiques Résumé : Selenium (Se) is an essential trace element involved in various biological processes, including neurodevelopment. Available literature indicates that both Se deficiency and excess may be detrimental to health. It is also known that Se can cross the placenta from maternal to fetal circulation. To date, the role of maternal Se status in child long-term neurodevelopment is largely unexplored. This study investigated the temporal and dose-response associations between maternal Se status and child risk of neurodevelopmental disorders including autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). It consisted of 1550 mother-infant dyads from the Boston Birth Cohort. Maternal red blood cell (RBC) Se levels were measured in samples collected within 72?h of delivery (biomarker of third trimester Se status). Pediatric neurodevelopmental diagnoses were obtained from electronic medical records. Data analyses showed that maternal RBC Se levels were positively associated with child risk of developing ASD, with an adjusted odds ratio of 1.49 for ASD (95% CI: 1.09, 2.02) per IQR increase in Se. There was also a positive association between maternal Se and ADHD (OR: 1.29; 95% CI: 1.04, 1.56, per IQR increase in Se). These associations remained robust even after adjusting for pertinent covariables; and there was no significant interaction between Se and these covariables. Our findings suggest that prenatal exposure to high maternal Se levels may adversely affect child neurodevelopment. Our findings warrant further investigation; if confirmed, optimizing maternal prenatal Se levels may be necessary to maximize its health benefits while preventing undue risk. LAY SUMMARY: Selenium (Se) is an essential nutrient for the health of the pregnant mother and her baby. While Se can readily cross the placenta from maternal to fetal circulation, little is known about maternal Se status on her child's neurodevelopmental outcomes. We studied over 1500 mother-child dyads from birth to school age of the child. We found that babies born from mothers with high blood Se levels may be at increased risk of developing autism spectrum disorder or attention deficit hyperactivity disorder. Given this is the first study of the kind, more study is needed to confirm our findings. En ligne : http://dx.doi.org/10.1002/aur.2617 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Measurement invariance of the Childhood Autism Rating Scale (CARS) across six countries / D. STEVANOVIC in Autism Research, 14-12 (December 2021)  

Public ISBD [article]  inAutism Research > 14-12 (December 2021) . - p.2544-2554 Titre : Measurement invariance of the Childhood Autism Rating Scale (CARS) across six countries Type de document : Texte imprimé et/ou numérique Auteurs : D. STEVANOVIC, Auteur ; F. COSTANZO, Auteur ; E. FUCÀ, Auteur ; G. VALERI, Auteur ; S. VICARI, Auteur ; Diana L. ROBINS, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; H. OZEK ERKURAN, Auteur ; F. YAYLACI, Auteur ; S. N. DESHPANDE, Auteur ; V. DESHMUKH, Auteur ; N. K. ARORA, Auteur ; Lilia ALBORES-GALLO, Auteur ; C. GARCÍA-LÓPEZ, Auteur ; G. GATICA-BAHAMONDE, Auteur ; M. GABUNIA, Auteur ; M. ZIRAKASHVILI, Auteur ; F. P. MACHADO, Auteur ; M. RADAN, Auteur ; Sayyed Ali SAMADI, Auteur ; T. H. TOH, Auteur ; W. GAYLE, Auteur ; L. BRENNAN, Auteur ; T. ZORCEC, Auteur ; Alejandra AUZA, Auteur ; M. DE JONGE, Auteur ; N. SHOQIRAT, Auteur ; A. MARINI, Auteur ; R. KNEZ, Auteur Article en page(s) : p.2544-2554 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis  Autistic Disorder  Bayes Theorem  Child  Cross-Cultural Comparison  Humans  Psychometrics  United States  assessment  children  cross-cultural validity  differential item functioning Index. décimale : PER Périodiques Résumé : The Childhood Autism Rating Scale (CARS) is a simple and inexpensive tool for Autism spectrum disorder (ASD) assessments, with evidenced psychometric data from different countries. However, it is still unclear whether ASD symptoms are measured the same way across different societies and world regions with this tool, since data on its cross-cultural validity are lacking. This study evaluated the cross-cultural measurement invariance of the CARS among children with ASD from six countries, for whom data were aggregated from previous studies in India (n = 101), Jamaica (n = 139), Mexico (n = 72), Spain (n = 99), Turkey (n = 150), and the United States of America (n = 186). We analyzed the approximate measurement invariance based on Bayesian structural equation modeling. The model did not fit the data and its measurement invariance did not hold, with all items found non-invariant across the countries. Items related to social communication and interaction (i.e., relating to people, imitation, emotional response, and verbal and nonverbal communication) displayed lower levels of cross-country non-invariance compared to items about stereotyped behaviors/sensory sensitivity (i.e., body and object use, adaptation to change, or taste, smell, and touch response). This study found that the CARS may not provide cross-culturally valid ASD assessments. Thus, cross-cultural comparisons with the CARS should consider first which items operate differently across samples of interest, since its cross-cultural measurement non-invariance could be a source of cross-cultural variability in ASD presentations. Additional studies are needed before drawing valid recommendations in relation to the cultural sensitivity of particular items. En ligne : http://dx.doi.org/10.1002/aur.2586 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Measurement invariance of the Childhood Autism Rating Scale (CARS) across six countries [Texte imprimé et/ou numérique] / D. STEVANOVIC, Auteur ; F. COSTANZO, Auteur ; E. FUCÀ, Auteur ; G. VALERI, Auteur ; S. VICARI, Auteur ; Diana L. ROBINS, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; H. OZEK ERKURAN, Auteur ; F. YAYLACI, Auteur ; S. N. DESHPANDE, Auteur ; V. DESHMUKH, Auteur ; N. K. ARORA, Auteur ; Lilia ALBORES-GALLO, Auteur ; C. GARCÍA-LÓPEZ, Auteur ; G. GATICA-BAHAMONDE, Auteur ; M. GABUNIA, Auteur ; M. ZIRAKASHVILI, Auteur ; F. P. MACHADO, Auteur ; M. RADAN, Auteur ; Sayyed Ali SAMADI, Auteur ; T. H. TOH, Auteur ; W. GAYLE, Auteur ; L. BRENNAN, Auteur ; T. ZORCEC, Auteur ; Alejandra AUZA, Auteur ; M. DE JONGE, Auteur ; N. SHOQIRAT, Auteur ; A. MARINI, Auteur ; R. KNEZ, Auteur . - p.2544-2554. Langues : Anglais (eng) in Autism Research > 14-12 (December 2021) . - p.2544-2554 Mots-clés : Autism Spectrum Disorder/diagnosis  Autistic Disorder  Bayes Theorem  Child  Cross-Cultural Comparison  Humans  Psychometrics  United States  assessment  children  cross-cultural validity  differential item functioning Index. décimale : PER Périodiques Résumé : The Childhood Autism Rating Scale (CARS) is a simple and inexpensive tool for Autism spectrum disorder (ASD) assessments, with evidenced psychometric data from different countries. However, it is still unclear whether ASD symptoms are measured the same way across different societies and world regions with this tool, since data on its cross-cultural validity are lacking. This study evaluated the cross-cultural measurement invariance of the CARS among children with ASD from six countries, for whom data were aggregated from previous studies in India (n = 101), Jamaica (n = 139), Mexico (n = 72), Spain (n = 99), Turkey (n = 150), and the United States of America (n = 186). We analyzed the approximate measurement invariance based on Bayesian structural equation modeling. The model did not fit the data and its measurement invariance did not hold, with all items found non-invariant across the countries. Items related to social communication and interaction (i.e., relating to people, imitation, emotional response, and verbal and nonverbal communication) displayed lower levels of cross-country non-invariance compared to items about stereotyped behaviors/sensory sensitivity (i.e., body and object use, adaptation to change, or taste, smell, and touch response). This study found that the CARS may not provide cross-culturally valid ASD assessments. Thus, cross-cultural comparisons with the CARS should consider first which items operate differently across samples of interest, since its cross-cultural measurement non-invariance could be a source of cross-cultural variability in ASD presentations. Additional studies are needed before drawing valid recommendations in relation to the cultural sensitivity of particular items. En ligne : http://dx.doi.org/10.1002/aur.2586 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Muscle strength and executive function in children and adolescents with autism spectrum disorder / S. LUDYGA in Autism Research, 14-12 (December 2021)  

Public ISBD [article]  inAutism Research > 14-12 (December 2021) . - p.2555-2563 Titre : Muscle strength and executive function in children and adolescents with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : S. LUDYGA, Auteur ; U. PÜHSE, Auteur ; M. GERBER, Auteur ; M. MÜCKE, Auteur Article en page(s) : p.2555-2563 Langues : Anglais (eng) Mots-clés : Adolescent  Autism Spectrum Disorder/complications  Child  Cognition  Cross-Sectional Studies  Executive Function  Humans  Muscle Strength  cognitive performance  development  information processing  mental disorder  physical fitness Index. décimale : PER Périodiques Résumé : The development of effective (non-pharmacological) treatment approaches for executive dysfunction in autism spectrum disorder (ASD) requires evidence that factors influencing this domain can be modified by behavioral interventions. The present cross-sectional study investigated the relative associations of ASD, muscle strength and body mass index with executive function and information processing among the Healthy Brain Network cohort. Patients with ASD (N = 174) and healthy peers (N = 202) aged 5 to 18?years completed cognitive tasks of the NIH toolbox (Pattern Comparison, Flanker, List Sorting, Card Sorting) to assess core components of executive function and information processing. Additionally, anthropometrics and muscle strength were collected from selected items (push-ups, curl-ups, trunk lift, and grip strength) of the Fitnessgram battery. Based on structural equation modeling, ASD was related to impaired muscle strength and executive function, when confounders (age, sex, pubertal status, and socioeconomic status) were accounted for. Muscle strength further showed independent contributions to information processing and executive function. This association was moderated by ASD, so that higher muscle strength was related to higher executive function in ASD patients only. The present findings provide a first indication that the promotion of muscle strength may have the potential to generally enhance information processing and to reduce ASD-related executive dysfunction in children and adolescents. LAY SUMMARY: In comparison to healthy peers, children with ASD showed impairments in executive function and muscle strength. Moreover, higher muscle strength was independently associated with better executive function, but only in ASD patients. This is a first indication that the promotion of muscle strength, for example, by regular exercise, could contribute to a reduction of ASD-related executive dysfunction. En ligne : http://dx.doi.org/10.1002/aur.2587 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Muscle strength and executive function in children and adolescents with autism spectrum disorder [Texte imprimé et/ou numérique] / S. LUDYGA, Auteur ; U. PÜHSE, Auteur ; M. GERBER, Auteur ; M. MÜCKE, Auteur . - p.2555-2563. Langues : Anglais (eng) in Autism Research > 14-12 (December 2021) . - p.2555-2563 Mots-clés : Adolescent  Autism Spectrum Disorder/complications  Child  Cognition  Cross-Sectional Studies  Executive Function  Humans  Muscle Strength  cognitive performance  development  information processing  mental disorder  physical fitness Index. décimale : PER Périodiques Résumé : The development of effective (non-pharmacological) treatment approaches for executive dysfunction in autism spectrum disorder (ASD) requires evidence that factors influencing this domain can be modified by behavioral interventions. The present cross-sectional study investigated the relative associations of ASD, muscle strength and body mass index with executive function and information processing among the Healthy Brain Network cohort. Patients with ASD (N = 174) and healthy peers (N = 202) aged 5 to 18?years completed cognitive tasks of the NIH toolbox (Pattern Comparison, Flanker, List Sorting, Card Sorting) to assess core components of executive function and information processing. Additionally, anthropometrics and muscle strength were collected from selected items (push-ups, curl-ups, trunk lift, and grip strength) of the Fitnessgram battery. Based on structural equation modeling, ASD was related to impaired muscle strength and executive function, when confounders (age, sex, pubertal status, and socioeconomic status) were accounted for. Muscle strength further showed independent contributions to information processing and executive function. This association was moderated by ASD, so that higher muscle strength was related to higher executive function in ASD patients only. The present findings provide a first indication that the promotion of muscle strength may have the potential to generally enhance information processing and to reduce ASD-related executive dysfunction in children and adolescents. LAY SUMMARY: In comparison to healthy peers, children with ASD showed impairments in executive function and muscle strength. Moreover, higher muscle strength was independently associated with better executive function, but only in ASD patients. This is a first indication that the promotion of muscle strength, for example, by regular exercise, could contribute to a reduction of ASD-related executive dysfunction. En ligne : http://dx.doi.org/10.1002/aur.2587 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Feasibility and acceptability of a telehealth model for autism diagnostic evaluations in children, adolescents, and adults / N. L. MATTHEWS in Autism Research, 14-12 (December 2021)  

Public ISBD [article]  inAutism Research > 14-12 (December 2021) . - p.2564-2579 Titre : Feasibility and acceptability of a telehealth model for autism diagnostic evaluations in children, adolescents, and adults Type de document : Texte imprimé et/ou numérique Auteurs : N. L. MATTHEWS, Auteur ; E. SKEPNEK, Auteur ; M. A. MAMMEN, Auteur ; J. S. JAMES, Auteur ; A. MALLIGO, Auteur ; A. LYON, Auteur ; M. MITCHELL, Auteur ; S. L. KIEFER, Auteur ; C. J. SMITH, Auteur Article en page(s) : p.2564-2579 Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Autism Spectrum Disorder/diagnosis/epidemiology  Autistic Disorder  Covid-19  Child  Child, Preschool  Feasibility Studies  Female  Humans  Male  Pandemics  Parents  SARS-CoV-2  Telemedicine  adolescents  adults  autism spectrum disorder  children  diagnosis  telehealth Index. décimale : PER Périodiques Résumé : This study examined the feasibility and acceptability of a telehealth diagnostic model deployed at an autism center in the southwestern United States to safely provide autism spectrum disorder (ASD) diagnostic evaluations to children, adolescents, and adults during the COVID-19 pandemic. Participants included all clients for whom a telehealth diagnostic evaluation was scheduled at the diagnostic clinic (n = 121) over a 6-month period. Of 121 scheduled clients, 102 (84%) completed the telehealth evaluation. A diagnostic determination was made for 91% of clients (93 out of 102) using only telehealth procedures. Nine participants (two females; ages 3 to 11?years) required an in-person evaluation. Responses from psychologist and parent acceptability surveys indicated the model was acceptable for most clients. Psychologist ratings suggested that telehealth modalities used in the current study may be less acceptable for evaluating school-aged children with subtle presentations compared to children in the early developmental period, adolescents, and adults. Parents of females reported higher acceptability than parents of males. Findings contribute to the small but growing literature on feasibility and acceptability of telehealth evaluations for ASD and have implications for improving access to care during and after the COVID-19 pandemic. LAY SUMMARY: This study described telehealth methods for evaluating children, adolescents, and adults for autism spectrum disorder. Telehealth methods were generally acceptable to psychologists conducting the evaluations and parents of diagnostic clients. Psychologists reported the methods to be less acceptable for school-aged children and parents of males found the methods less acceptable than parents of females. The telehealth methods described may help to increase access to diagnostic professionals and reduce wait times for evaluations during and after the COVID-19 pandemic. En ligne : http://dx.doi.org/10.1002/aur.2591 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Feasibility and acceptability of a telehealth model for autism diagnostic evaluations in children, adolescents, and adults [Texte imprimé et/ou numérique] / N. L. MATTHEWS, Auteur ; E. SKEPNEK, Auteur ; M. A. MAMMEN, Auteur ; J. S. JAMES, Auteur ; A. MALLIGO, Auteur ; A. LYON, Auteur ; M. MITCHELL, Auteur ; S. L. KIEFER, Auteur ; C. J. SMITH, Auteur . - p.2564-2579. Langues : Anglais (eng) in Autism Research > 14-12 (December 2021) . - p.2564-2579 Mots-clés : Adolescent  Adult  Autism Spectrum Disorder/diagnosis/epidemiology  Autistic Disorder  Covid-19  Child  Child, Preschool  Feasibility Studies  Female  Humans  Male  Pandemics  Parents  SARS-CoV-2  Telemedicine  adolescents  adults  autism spectrum disorder  children  diagnosis  telehealth Index. décimale : PER Périodiques Résumé : This study examined the feasibility and acceptability of a telehealth diagnostic model deployed at an autism center in the southwestern United States to safely provide autism spectrum disorder (ASD) diagnostic evaluations to children, adolescents, and adults during the COVID-19 pandemic. Participants included all clients for whom a telehealth diagnostic evaluation was scheduled at the diagnostic clinic (n = 121) over a 6-month period. Of 121 scheduled clients, 102 (84%) completed the telehealth evaluation. A diagnostic determination was made for 91% of clients (93 out of 102) using only telehealth procedures. Nine participants (two females; ages 3 to 11?years) required an in-person evaluation. Responses from psychologist and parent acceptability surveys indicated the model was acceptable for most clients. Psychologist ratings suggested that telehealth modalities used in the current study may be less acceptable for evaluating school-aged children with subtle presentations compared to children in the early developmental period, adolescents, and adults. Parents of females reported higher acceptability than parents of males. Findings contribute to the small but growing literature on feasibility and acceptability of telehealth evaluations for ASD and have implications for improving access to care during and after the COVID-19 pandemic. LAY SUMMARY: This study described telehealth methods for evaluating children, adolescents, and adults for autism spectrum disorder. Telehealth methods were generally acceptable to psychologists conducting the evaluations and parents of diagnostic clients. Psychologists reported the methods to be less acceptable for school-aged children and parents of males found the methods less acceptable than parents of females. The telehealth methods described may help to increase access to diagnostic professionals and reduce wait times for evaluations during and after the COVID-19 pandemic. En ligne : http://dx.doi.org/10.1002/aur.2591 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Basic oculomotor function is similar in young children with ASD and typically developing controls / Inbar AVNI in Autism Research, 14-12 (December 2021)  

Public ISBD [article]  inAutism Research > 14-12 (December 2021) . - p.2580-2591 Titre : Basic oculomotor function is similar in young children with ASD and typically developing controls Type de document : Texte imprimé et/ou numérique Auteurs : Inbar AVNI, Auteur ; G. MEIRI, Auteur ; A. MICHAELOVSKI, Auteur ; I. MENASHE, Auteur ; L. SHMUELOF, Auteur ; I. DINSTEIN, Auteur Article en page(s) : p.2580-2591 Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Autism Spectrum Disorder  Child  Child, Preschool  Eye Movements  Humans  Infant  Saccades  eye position  eye tracking  gaze  kinematic characteristics  movies  oculomotor control  saccade Index. décimale : PER Périodiques Résumé : A variety of eye tracking studies have demonstrated that young children with ASD gaze at images and movies of social interactions differently than typically developing children. These findings have supported the hypothesis that gaze behavior differences are generated by a weaker preference for social stimuli in ASD children. The hypothesis assumes that gaze differences are not caused by abnormalities in oculomotor function including saccade frequency and kinematics. Previous studies of oculomotor function have mostly been performed with school-age children, adolescents, and adults using visual search, anti-saccade, and gap saccade tasks that are less suitable for young pre-school children. Here, we examined oculomotor function in 144 children (90 with ASD and 54 controls), 1-10-years-old, as they watched two animated movies interleaved with the presentation of multiple salient stimuli that elicited saccades-to-targets. The results revealed that the number of fixations, fixation duration, number of saccades, saccade duration, saccade accuracy, and saccade latency did not differ significantly across groups. Minor initial differences in saccade peak velocity were not supported by analysis with a linear mixed model. These findings suggest that most children with ASD exhibit similar oculomotor function to that of controls, when performing saccades-to-targets or freely viewing child-friendly movies. This suggests that previously reported gaze abnormalities in children with ASD are not due to underlying oculomotor deficiencies. LAY SUMMARY: This study demonstrates that children with ASD perform similar eye movements to those of controls when freely observing movies or making eye movements to targets. Similar results were apparent across groups in the number of eye movements, their accuracy, duration, and other measures that assess eye movement control. These findings are important for interpreting previously reported differences in gaze behavior of children with ASD, which are likely due to atypical social preferences rather than impaired control of eye movements. En ligne : http://dx.doi.org/10.1002/aur.2592 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Basic oculomotor function is similar in young children with ASD and typically developing controls [Texte imprimé et/ou numérique] / Inbar AVNI, Auteur ; G. MEIRI, Auteur ; A. MICHAELOVSKI, Auteur ; I. MENASHE, Auteur ; L. SHMUELOF, Auteur ; I. DINSTEIN, Auteur . - p.2580-2591. Langues : Anglais (eng) in Autism Research > 14-12 (December 2021) . - p.2580-2591 Mots-clés : Adolescent  Adult  Autism Spectrum Disorder  Child  Child, Preschool  Eye Movements  Humans  Infant  Saccades  eye position  eye tracking  gaze  kinematic characteristics  movies  oculomotor control  saccade Index. décimale : PER Périodiques Résumé : A variety of eye tracking studies have demonstrated that young children with ASD gaze at images and movies of social interactions differently than typically developing children. These findings have supported the hypothesis that gaze behavior differences are generated by a weaker preference for social stimuli in ASD children. The hypothesis assumes that gaze differences are not caused by abnormalities in oculomotor function including saccade frequency and kinematics. Previous studies of oculomotor function have mostly been performed with school-age children, adolescents, and adults using visual search, anti-saccade, and gap saccade tasks that are less suitable for young pre-school children. Here, we examined oculomotor function in 144 children (90 with ASD and 54 controls), 1-10-years-old, as they watched two animated movies interleaved with the presentation of multiple salient stimuli that elicited saccades-to-targets. The results revealed that the number of fixations, fixation duration, number of saccades, saccade duration, saccade accuracy, and saccade latency did not differ significantly across groups. Minor initial differences in saccade peak velocity were not supported by analysis with a linear mixed model. These findings suggest that most children with ASD exhibit similar oculomotor function to that of controls, when performing saccades-to-targets or freely viewing child-friendly movies. This suggests that previously reported gaze abnormalities in children with ASD are not due to underlying oculomotor deficiencies. LAY SUMMARY: This study demonstrates that children with ASD perform similar eye movements to those of controls when freely observing movies or making eye movements to targets. Similar results were apparent across groups in the number of eye movements, their accuracy, duration, and other measures that assess eye movement control. These findings are important for interpreting previously reported differences in gaze behavior of children with ASD, which are likely due to atypical social preferences rather than impaired control of eye movements. En ligne : http://dx.doi.org/10.1002/aur.2592 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Face-viewing patterns predict audiovisual speech integration in autistic children / S. FENG in Autism Research, 14-12 (December 2021)  

Public ISBD [article]  inAutism Research > 14-12 (December 2021) . - p.2592-2602 Titre : Face-viewing patterns predict audiovisual speech integration in autistic children Type de document : Texte imprimé et/ou numérique Auteurs : S. FENG, Auteur ; H. LU, Auteur ; Q. WANG, Auteur ; T. LI, Auteur ; J. FANG, Auteur ; L. CHEN, Auteur ; L. YI, Auteur Article en page(s) : p.2592-2602 Langues : Anglais (eng) Mots-clés : Acoustic Stimulation  Autism Spectrum Disorder/complications  Autistic Disorder/complications  Child  Child, Preschool  Female  Humans  Mouth  Speech  Speech Perception  Visual Perception  McGurk effect  atypical face-viewing patterns  audiovisual speech integration  autistic children  eye movements Index. décimale : PER Périodiques Résumé : Autistic children show audiovisual speech integration deficits, though the underlying mechanisms remain unclear. The present study examined how audiovisual speech integration deficits in autistic children could be affected by their looking patterns. We measured audiovisual speech integration in 26 autistic children and 26 typically developing (TD) children (4- to 7-year-old) employing the McGurk task (a videotaped speaker uttering phonemes with her eyes open or closed) and tracked their eye movements. We found that, compared with TD children, autistic children showed weaker audiovisual speech integration (i.e., the McGurk effect) in the open-eyes condition and similar audiovisual speech integration in the closed-eyes condition. Autistic children viewed the speaker's mouth less in non-McGurk trials than in McGurk trials in both conditions. Importantly, autistic children's weaker audiovisual speech integration could be predicted by their reduced mouth-looking time. The present study indicated that atypical face-viewing patterns could serve as one of the cognitive mechanisms of audiovisual speech integration deficits in autistic children. LAY SUMMARY: McGurk effect occurs when the visual part of a phoneme (e.g., "ga") and the auditory part of another phoneme (e.g., "ba") uttered by a speaker were integrated into a fused perception (e.g., "da"). The present study examined how McGurk effect in autistic children could be affected by their looking patterns for the speaker's face. We found that less looking time for the speaker's mouth in autistic children could predict weaker McGurk effect. As McGurk effect manifests audiovisual speech integration, our findings imply that we could improve audiovisual speech integration in autistic children by directing them to look at the speaker's mouth in future intervention. En ligne : http://dx.doi.org/10.1002/aur.2598 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Face-viewing patterns predict audiovisual speech integration in autistic children [Texte imprimé et/ou numérique] / S. FENG, Auteur ; H. LU, Auteur ; Q. WANG, Auteur ; T. LI, Auteur ; J. FANG, Auteur ; L. CHEN, Auteur ; L. YI, Auteur . - p.2592-2602. Langues : Anglais (eng) in Autism Research > 14-12 (December 2021) . - p.2592-2602 Mots-clés : Acoustic Stimulation  Autism Spectrum Disorder/complications  Autistic Disorder/complications  Child  Child, Preschool  Female  Humans  Mouth  Speech  Speech Perception  Visual Perception  McGurk effect  atypical face-viewing patterns  audiovisual speech integration  autistic children  eye movements Index. décimale : PER Périodiques Résumé : Autistic children show audiovisual speech integration deficits, though the underlying mechanisms remain unclear. The present study examined how audiovisual speech integration deficits in autistic children could be affected by their looking patterns. We measured audiovisual speech integration in 26 autistic children and 26 typically developing (TD) children (4- to 7-year-old) employing the McGurk task (a videotaped speaker uttering phonemes with her eyes open or closed) and tracked their eye movements. We found that, compared with TD children, autistic children showed weaker audiovisual speech integration (i.e., the McGurk effect) in the open-eyes condition and similar audiovisual speech integration in the closed-eyes condition. Autistic children viewed the speaker's mouth less in non-McGurk trials than in McGurk trials in both conditions. Importantly, autistic children's weaker audiovisual speech integration could be predicted by their reduced mouth-looking time. The present study indicated that atypical face-viewing patterns could serve as one of the cognitive mechanisms of audiovisual speech integration deficits in autistic children. LAY SUMMARY: McGurk effect occurs when the visual part of a phoneme (e.g., "ga") and the auditory part of another phoneme (e.g., "ba") uttered by a speaker were integrated into a fused perception (e.g., "da"). The present study examined how McGurk effect in autistic children could be affected by their looking patterns for the speaker's face. We found that less looking time for the speaker's mouth in autistic children could predict weaker McGurk effect. As McGurk effect manifests audiovisual speech integration, our findings imply that we could improve audiovisual speech integration in autistic children by directing them to look at the speaker's mouth in future intervention. En ligne : http://dx.doi.org/10.1002/aur.2598 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Joint attention and intelligence in children with autism spectrum disorder without severe intellectual disability / M. SANO in Autism Research, 14-12 (December 2021)  

Public ISBD [article]  inAutism Research > 14-12 (December 2021) . - p.2603-2612 Titre : Joint attention and intelligence in children with autism spectrum disorder without severe intellectual disability Type de document : Texte imprimé et/ou numérique Auteurs : M. SANO, Auteur ; Y. YOSHIMURA, Auteur ; T. HIROSAWA, Auteur ; C. HASEGAWA, Auteur ; Kyung-Min AN, Auteur ; S. TANAKA, Auteur ; N. NAITOU, Auteur ; M. KIKUCHI, Auteur Article en page(s) : p.2603-2612 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/complications  Child  Child, Preschool  Cognition  Early Intervention, Educational  Humans  Intellectual Disability/complications  Intelligence  Kaufman Assessment Battery (K-ABC)  autism  autism diagnostic observation schedule  children  intelligence  joint attention Index. décimale : PER Périodiques Résumé : In children with autism spectrum disorder (ASD), joint attention is regarded as a predictor of language function, social skills, communication, adaptive function, and intelligence. However, existing information about the association between joint attention and intelligence is limited. Most such studies have examined children with low intelligence. For this study, we investigated whether joint attention is related to intelligence in young children with autism spectrum disorder (ASD) without severe intellectual disability. We analyzed 113 children with ASD aged 40-98?months. Their Kaufman Assessment Battery (K-ABC) Mental Processing Index (MPI) scores are 60 and more (mean 93.4). We evaluated their intelligence using K-ABC and evaluated their joint attention using ADOS-2. After we performed simple regression analyses using K-ABC MPI and its nine subscales as dependent variables, using joint attention as the independent variable, we identified joint attention as a positive predictor of the MPI and its two subscales. From this result, we conclude that joint attention is related to intelligence in young children with ASD without severe intellectual disability. This result suggests a beneficial effect of early intervention targeting joint attention for children with ASD. LAY SUMMARY: Joint attention is the ability to coordinate visual attention with another person and then shift one's gaze toward an object or event. Impairment of joint attention is regarded as an early marker of autism spectrum disorder (ASD). This study revealed impairment of joint attention as associated with lower intelligence in ASD children. These results are expected to constitute a rationale for future studies, particularly addressing beneficial effects of early intervention targeting joint attention for children with ASD. En ligne : http://dx.doi.org/10.1002/aur.2600 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Joint attention and intelligence in children with autism spectrum disorder without severe intellectual disability [Texte imprimé et/ou numérique] / M. SANO, Auteur ; Y. YOSHIMURA, Auteur ; T. HIROSAWA, Auteur ; C. HASEGAWA, Auteur ; Kyung-Min AN, Auteur ; S. TANAKA, Auteur ; N. NAITOU, Auteur ; M. KIKUCHI, Auteur . - p.2603-2612. Langues : Anglais (eng) in Autism Research > 14-12 (December 2021) . - p.2603-2612 Mots-clés : Autism Spectrum Disorder/complications  Child  Child, Preschool  Cognition  Early Intervention, Educational  Humans  Intellectual Disability/complications  Intelligence  Kaufman Assessment Battery (K-ABC)  autism  autism diagnostic observation schedule  children  intelligence  joint attention Index. décimale : PER Périodiques Résumé : In children with autism spectrum disorder (ASD), joint attention is regarded as a predictor of language function, social skills, communication, adaptive function, and intelligence. However, existing information about the association between joint attention and intelligence is limited. Most such studies have examined children with low intelligence. For this study, we investigated whether joint attention is related to intelligence in young children with autism spectrum disorder (ASD) without severe intellectual disability. We analyzed 113 children with ASD aged 40-98?months. Their Kaufman Assessment Battery (K-ABC) Mental Processing Index (MPI) scores are 60 and more (mean 93.4). We evaluated their intelligence using K-ABC and evaluated their joint attention using ADOS-2. After we performed simple regression analyses using K-ABC MPI and its nine subscales as dependent variables, using joint attention as the independent variable, we identified joint attention as a positive predictor of the MPI and its two subscales. From this result, we conclude that joint attention is related to intelligence in young children with ASD without severe intellectual disability. This result suggests a beneficial effect of early intervention targeting joint attention for children with ASD. LAY SUMMARY: Joint attention is the ability to coordinate visual attention with another person and then shift one's gaze toward an object or event. Impairment of joint attention is regarded as an early marker of autism spectrum disorder (ASD). This study revealed impairment of joint attention as associated with lower intelligence in ASD children. These results are expected to constitute a rationale for future studies, particularly addressing beneficial effects of early intervention targeting joint attention for children with ASD. En ligne : http://dx.doi.org/10.1002/aur.2600 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Work and well-being: Vocational activity trajectories in young adults with autism spectrum disorder / Elaine B. CLARKE in Autism Research, 14-12 (December 2021)  

Public ISBD [article]  inAutism Research > 14-12 (December 2021) . - p.2613-2624 Titre : Work and well-being: Vocational activity trajectories in young adults with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Elaine B. CLARKE, Auteur ; K. STERRETT, Auteur ; C. LORD, Auteur Article en page(s) : p.2613-2624 Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Autism Spectrum Disorder  Employment  Happiness  Humans  Longitudinal Studies  Young Adult  adults  aging/ASD in adults  developmental psychology  longitudinal data analysis  phenotype Index. décimale : PER Périodiques Résumé : Young adults with autism spectrum disorder (ASD) experience limited social connectedness, difficulty living independently, and other poor outcomes at high rates. Vocational activities, including employment and postsecondary education, are associated with increased positive outcomes and subjective well-being in typical adults. This study identified vocational activity trajectory groups in adults with ASD, examined change in these trajectories from ages 18 to 28, and compared levels of parent- and self-report subjective well-being across trajectory groups. One hundred fifty-one adults with ASD were drawn from an ongoing longitudinal study. Data on psychosocial outcomes and vocational activities were compiled from parent-report demographic forms. Vocational activities were scored using the vocational index (VDI). There was no significant effect of age on the slope of vocational trajectories (p =?0.787). Participants in the Independent Activities group had significantly higher parent-report happiness factor scores than participants in the No Activities group (F [3, 107] = 3.56, p =?0.017) and significantly higher self-report happiness factor scores than participants in the Volunteer Activities group (F [2, 35] = 6.46, p =?0.004). The Independent Activities group was also significantly more likely to have at least one social contact (X(2) [3, 118] = 10.54, p =?0.014), however, there was no difference in trajectories groups in the likelihood of living independently (X(2) [3, 120] = 1.71, p =?0.634). The results of this study indicate vocational activities in young adults with ASD are stable across time. In the current sample, participation in independent vocational activities was associated with increased levels of subjective well-being. En ligne : http://dx.doi.org/10.1002/aur.2606 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Work and well-being: Vocational activity trajectories in young adults with autism spectrum disorder [Texte imprimé et/ou numérique] / Elaine B. CLARKE, Auteur ; K. STERRETT, Auteur ; C. LORD, Auteur . - p.2613-2624. Langues : Anglais (eng) in Autism Research > 14-12 (December 2021) . - p.2613-2624 Mots-clés : Adolescent  Adult  Autism Spectrum Disorder  Employment  Happiness  Humans  Longitudinal Studies  Young Adult  adults  aging/ASD in adults  developmental psychology  longitudinal data analysis  phenotype Index. décimale : PER Périodiques Résumé : Young adults with autism spectrum disorder (ASD) experience limited social connectedness, difficulty living independently, and other poor outcomes at high rates. Vocational activities, including employment and postsecondary education, are associated with increased positive outcomes and subjective well-being in typical adults. This study identified vocational activity trajectory groups in adults with ASD, examined change in these trajectories from ages 18 to 28, and compared levels of parent- and self-report subjective well-being across trajectory groups. One hundred fifty-one adults with ASD were drawn from an ongoing longitudinal study. Data on psychosocial outcomes and vocational activities were compiled from parent-report demographic forms. Vocational activities were scored using the vocational index (VDI). There was no significant effect of age on the slope of vocational trajectories (p =?0.787). Participants in the Independent Activities group had significantly higher parent-report happiness factor scores than participants in the No Activities group (F [3, 107] = 3.56, p =?0.017) and significantly higher self-report happiness factor scores than participants in the Volunteer Activities group (F [2, 35] = 6.46, p =?0.004). The Independent Activities group was also significantly more likely to have at least one social contact (X(2) [3, 118] = 10.54, p =?0.014), however, there was no difference in trajectories groups in the likelihood of living independently (X(2) [3, 120] = 1.71, p =?0.634). The results of this study indicate vocational activities in young adults with ASD are stable across time. In the current sample, participation in independent vocational activities was associated with increased levels of subjective well-being. En ligne : http://dx.doi.org/10.1002/aur.2606 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Atypical gaze patterns to facial feature areas in autism spectrum disorders reveal age and culture effects: A meta-analysis of eye-tracking studies / X. MA in Autism Research, 14-12 (December 2021)  

Public ISBD [article]  inAutism Research > 14-12 (December 2021) . - p.2625-2639 Titre : Atypical gaze patterns to facial feature areas in autism spectrum disorders reveal age and culture effects: A meta-analysis of eye-tracking studies Type de document : Texte imprimé et/ou numérique Auteurs : X. MA, Auteur ; H. GU, Auteur ; J. ZHAO, Auteur Article en page(s) : p.2625-2639 Langues : Anglais (eng) Mots-clés : Adult  Autism Spectrum Disorder/complications  Child  Eye-Tracking Technology  Facial Recognition  Fixation, Ocular  Humans  Mouth  autism spectrum disorder  culture  development  face processing  facial features  meta-analysis Index. décimale : PER Périodiques Résumé : Children and adults with autism spectrum disorder (ASD) often present with atypical gaze patterns to others' faces, a finding substantiated throughout the literature. Yet, a quantification of atypical gaze patterns to different facial regions (e.g., eyes versus mouth) in ASD remains controversial. Also few study has investigated how age and culture impacted the pattern of gaze abnormalities in ASD. This research therefore conducted a meta-analysis of eye-tracking studies to evaluate age and culture effect on atypical gaze patterns of face processing in ASD. A total of 75 articles (91 studies) and 4209 individuals (ASD: 2027; controls: 2182) across all age ranges (i.e., childhood through to adulthood) from both Eastern and Western cultures were included in this meta-analysis. Individuals with ASD yielded shorter fixation durations to the eyes than individuals without ASD. Group differences in the time spent fixating on the eyes were not modulated by age, but affected by culture. Effect size in the eastern culture was larger than that in the western culture. In contrast, group differences on time spent looking at the mouth were not significant, but changed with age and modulated by culture. Relative to the neurotypical controls, Western individuals with ASD spent more time looking at the mouth from school age, whereas Eastern individuals with ASD did not gaze longer on mouth until adulthood. These results add to the body of evidence supporting atypical gaze behaviors to eyes in ASD and provide new insights into a potential mouth compensation strategy that develops with age in ASD. LAY SUMMARY: Individuals with autism spectrum disorder (ASD) often show atypical gaze patterns when looking at others' faces compared to neurotypical individuals. This paper examines the role of age and culture on pattern of gaze abnormalities in individuals with ASD. Results show that reduction of gaze on eyes in ASD is stable across all ages and cultures, while increase of gaze on mouth emerges as individuals with ASD get older. The findings provide a developmental insight to the gaze patterns on the autism spectrum across culture. En ligne : http://dx.doi.org/10.1002/aur.2607 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Atypical gaze patterns to facial feature areas in autism spectrum disorders reveal age and culture effects: A meta-analysis of eye-tracking studies [Texte imprimé et/ou numérique] / X. MA, Auteur ; H. GU, Auteur ; J. ZHAO, Auteur . - p.2625-2639. Langues : Anglais (eng) in Autism Research > 14-12 (December 2021) . - p.2625-2639 Mots-clés : Adult  Autism Spectrum Disorder/complications  Child  Eye-Tracking Technology  Facial Recognition  Fixation, Ocular  Humans  Mouth  autism spectrum disorder  culture  development  face processing  facial features  meta-analysis Index. décimale : PER Périodiques Résumé : Children and adults with autism spectrum disorder (ASD) often present with atypical gaze patterns to others' faces, a finding substantiated throughout the literature. Yet, a quantification of atypical gaze patterns to different facial regions (e.g., eyes versus mouth) in ASD remains controversial. Also few study has investigated how age and culture impacted the pattern of gaze abnormalities in ASD. This research therefore conducted a meta-analysis of eye-tracking studies to evaluate age and culture effect on atypical gaze patterns of face processing in ASD. A total of 75 articles (91 studies) and 4209 individuals (ASD: 2027; controls: 2182) across all age ranges (i.e., childhood through to adulthood) from both Eastern and Western cultures were included in this meta-analysis. Individuals with ASD yielded shorter fixation durations to the eyes than individuals without ASD. Group differences in the time spent fixating on the eyes were not modulated by age, but affected by culture. Effect size in the eastern culture was larger than that in the western culture. In contrast, group differences on time spent looking at the mouth were not significant, but changed with age and modulated by culture. Relative to the neurotypical controls, Western individuals with ASD spent more time looking at the mouth from school age, whereas Eastern individuals with ASD did not gaze longer on mouth until adulthood. These results add to the body of evidence supporting atypical gaze behaviors to eyes in ASD and provide new insights into a potential mouth compensation strategy that develops with age in ASD. LAY SUMMARY: Individuals with autism spectrum disorder (ASD) often show atypical gaze patterns when looking at others' faces compared to neurotypical individuals. This paper examines the role of age and culture on pattern of gaze abnormalities in individuals with ASD. Results show that reduction of gaze on eyes in ASD is stable across all ages and cultures, while increase of gaze on mouth emerges as individuals with ASD get older. The findings provide a developmental insight to the gaze patterns on the autism spectrum across culture. En ligne : http://dx.doi.org/10.1002/aur.2607 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Differences in the production and perception of communicative kinematics in autism / J. P. TRUJILLO in Autism Research, 14-12 (December 2021)  

Public ISBD [article]  inAutism Research > 14-12 (December 2021) . - p.2640-2653 Titre : Differences in the production and perception of communicative kinematics in autism Type de document : Texte imprimé et/ou numérique Auteurs : J. P. TRUJILLO, Auteur ; A. ÖZYÜREK, Auteur ; C. C. KAN, Auteur ; I. SHEFTEL-SIMANOVA, Auteur ; Harold BEKKERING, Auteur Article en page(s) : p.2640-2653 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Autistic Disorder  Biomechanical Phenomena  Gestures  Humans  Perception  autism  gesture  kinematics  motion tracking  movement Index. décimale : PER Périodiques Résumé : In human communication, social intentions and meaning are often revealed in the way we move. In this study, we investigate the flexibility of human communication in terms of kinematic modulation in a clinical population, namely, autistic individuals. The aim of this study was twofold: to assess (a) whether communicatively relevant kinematic features of gestures differ between autistic and neurotypical individuals, and (b) if autistic individuals use communicative kinematic modulation to support gesture recognition. We tested autistic and neurotypical individuals on a silent gesture production task and a gesture comprehension task. We measured movement during the gesture production task using a Kinect motion tracking device in order to determine if autistic individuals differed from neurotypical individuals in their gesture kinematics. For the gesture comprehension task, we assessed whether autistic individuals used communicatively relevant kinematic cues to support recognition. This was done by using stick-light figures as stimuli and testing for a correlation between the kinematics of these videos and recognition performance. We found that (a) silent gestures produced by autistic and neurotypical individuals differ in communicatively relevant kinematic features, such as the number of meaningful holds between movements, and (b) while autistic individuals are overall unimpaired at recognizing gestures, they processed repetition and complexity, measured as the amount of submovements perceived, differently than neurotypicals do. These findings highlight how subtle aspects of neurotypical behavior can be experienced differently by autistic individuals. They further demonstrate the relationship between movement kinematics and social interaction in high-functioning autistic individuals. LAY SUMMARY: Hand gestures are an important part of how we communicate, and the way that we move when gesturing can influence how easy a gesture is to understand. We studied how autistic and typical individuals produce and recognize hand gestures, and how this relates to movement characteristics. We found that autistic individuals moved differently when gesturing compared to typical individuals. In addition, while autistic individuals were not worse at recognizing gestures, they differed from typical individuals in how they interpreted certain movement characteristics. En ligne : http://dx.doi.org/10.1002/aur.2611 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Differences in the production and perception of communicative kinematics in autism [Texte imprimé et/ou numérique] / J. P. TRUJILLO, Auteur ; A. ÖZYÜREK, Auteur ; C. C. KAN, Auteur ; I. SHEFTEL-SIMANOVA, Auteur ; Harold BEKKERING, Auteur . - p.2640-2653. Langues : Anglais (eng) in Autism Research > 14-12 (December 2021) . - p.2640-2653 Mots-clés : Autism Spectrum Disorder  Autistic Disorder  Biomechanical Phenomena  Gestures  Humans  Perception  autism  gesture  kinematics  motion tracking  movement Index. décimale : PER Périodiques Résumé : In human communication, social intentions and meaning are often revealed in the way we move. In this study, we investigate the flexibility of human communication in terms of kinematic modulation in a clinical population, namely, autistic individuals. The aim of this study was twofold: to assess (a) whether communicatively relevant kinematic features of gestures differ between autistic and neurotypical individuals, and (b) if autistic individuals use communicative kinematic modulation to support gesture recognition. We tested autistic and neurotypical individuals on a silent gesture production task and a gesture comprehension task. We measured movement during the gesture production task using a Kinect motion tracking device in order to determine if autistic individuals differed from neurotypical individuals in their gesture kinematics. For the gesture comprehension task, we assessed whether autistic individuals used communicatively relevant kinematic cues to support recognition. This was done by using stick-light figures as stimuli and testing for a correlation between the kinematics of these videos and recognition performance. We found that (a) silent gestures produced by autistic and neurotypical individuals differ in communicatively relevant kinematic features, such as the number of meaningful holds between movements, and (b) while autistic individuals are overall unimpaired at recognizing gestures, they processed repetition and complexity, measured as the amount of submovements perceived, differently than neurotypicals do. These findings highlight how subtle aspects of neurotypical behavior can be experienced differently by autistic individuals. They further demonstrate the relationship between movement kinematics and social interaction in high-functioning autistic individuals. LAY SUMMARY: Hand gestures are an important part of how we communicate, and the way that we move when gesturing can influence how easy a gesture is to understand. We studied how autistic and typical individuals produce and recognize hand gestures, and how this relates to movement characteristics. We found that autistic individuals moved differently when gesturing compared to typical individuals. In addition, while autistic individuals were not worse at recognizing gestures, they differed from typical individuals in how they interpreted certain movement characteristics. En ligne : http://dx.doi.org/10.1002/aur.2611 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Early adversity and positive parenting: Association with cognitive outcomes in children with autism spectrum disorder / E. KUENZEL in Autism Research, 14-12 (December 2021)  

Public ISBD [article]  inAutism Research > 14-12 (December 2021) . - p.2654-2662 Titre : Early adversity and positive parenting: Association with cognitive outcomes in children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : E. KUENZEL, Auteur ; D. SEGUIN, Auteur ; R. NICOLSON, Auteur ; E. G. DUERDEN, Auteur Article en page(s) : p.2654-2662 Langues : Anglais (eng) Mots-clés : Adolescent  Autism Spectrum Disorder/complications  Child  Child, Preschool  Cognition  Executive Function  Humans  Parenting  Peer Group  Children  Clinical Psychology  Cognitive Neuroscience  Environmental risk factors  Neuropsychology  Parent Training  Pediatrics Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social communication and repetitive behaviors. Children with ASD are statistically more likely to experience early adversity; however, little is known about the types of early adversity that place these children at risk, the role of parenting as a protective factor, and how this early life stress impacts cognitive outcomes. We assessed early adversity in 302 children (ASD = 98) aged 6-16?years old, using parent-based report. To identify protective factors, we assessed parenting styles using parent surveys. Executive functions were assessed in the children using the WISC-V. Children with ASD had an increased incidence of familial stressors compared to the typically developing (TD) group. Positive parenting was associated with a significant decrease in the incidence of familial adverse events for both children with ASD and TD children. Examining the relationship between adversity and cognitive outcomes, in young children (6-11?years) with ASD, environmental stressors were associated with cognitive impairments. Findings suggest children with ASD may be at higher risk for familial adversity than their TD peers. However, all children benefit from positive parenting styles, which may mitigate the adverse effects of family-based early life stress. LAY SUMMARY: Some key features of Autism Spectrum Disorder (ASD) include difficulties with communication and social impairments. This means that children with ASD may be more likely to experience early adversity (stressful social interactions which take place during childhood) than children without ASD. Research in typically developing (TD) children has shown that experiencing more stressful events in childhood can cause changes in the brain, which can potentially impact the child's memory, reasoning, and decision-making skills later in life. However, there is evidence to suggest that having a nurturing relationship with a parent can offset some of the negative impacts of childhood adversity. In our study, we found that children with ASD are more likely to experience family-related stress compared to TD children. Having a positive relationship with a parent, however, was linked to experiencing this type of stress less often for all children, regardless of whether they were diagnosed with ASD. We also found that stressors related to environmental factors like financial instability were associated with lower cognitive abilities in children with ASD under 12?years of age. Understanding how these factors interact and differ in children with ASD can help to build stronger families and help children with ASD to thrive throughout their development. En ligne : http://dx.doi.org/10.1002/aur.2613 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Early adversity and positive parenting: Association with cognitive outcomes in children with autism spectrum disorder [Texte imprimé et/ou numérique] / E. KUENZEL, Auteur ; D. SEGUIN, Auteur ; R. NICOLSON, Auteur ; E. G. DUERDEN, Auteur . - p.2654-2662. Langues : Anglais (eng) in Autism Research > 14-12 (December 2021) . - p.2654-2662 Mots-clés : Adolescent  Autism Spectrum Disorder/complications  Child  Child, Preschool  Cognition  Executive Function  Humans  Parenting  Peer Group  Children  Clinical Psychology  Cognitive Neuroscience  Environmental risk factors  Neuropsychology  Parent Training  Pediatrics Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social communication and repetitive behaviors. Children with ASD are statistically more likely to experience early adversity; however, little is known about the types of early adversity that place these children at risk, the role of parenting as a protective factor, and how this early life stress impacts cognitive outcomes. We assessed early adversity in 302 children (ASD = 98) aged 6-16?years old, using parent-based report. To identify protective factors, we assessed parenting styles using parent surveys. Executive functions were assessed in the children using the WISC-V. Children with ASD had an increased incidence of familial stressors compared to the typically developing (TD) group. Positive parenting was associated with a significant decrease in the incidence of familial adverse events for both children with ASD and TD children. Examining the relationship between adversity and cognitive outcomes, in young children (6-11?years) with ASD, environmental stressors were associated with cognitive impairments. Findings suggest children with ASD may be at higher risk for familial adversity than their TD peers. However, all children benefit from positive parenting styles, which may mitigate the adverse effects of family-based early life stress. LAY SUMMARY: Some key features of Autism Spectrum Disorder (ASD) include difficulties with communication and social impairments. This means that children with ASD may be more likely to experience early adversity (stressful social interactions which take place during childhood) than children without ASD. Research in typically developing (TD) children has shown that experiencing more stressful events in childhood can cause changes in the brain, which can potentially impact the child's memory, reasoning, and decision-making skills later in life. However, there is evidence to suggest that having a nurturing relationship with a parent can offset some of the negative impacts of childhood adversity. In our study, we found that children with ASD are more likely to experience family-related stress compared to TD children. Having a positive relationship with a parent, however, was linked to experiencing this type of stress less often for all children, regardless of whether they were diagnosed with ASD. We also found that stressors related to environmental factors like financial instability were associated with lower cognitive abilities in children with ASD under 12?years of age. Understanding how these factors interact and differ in children with ASD can help to build stronger families and help children with ASD to thrive throughout their development. En ligne : http://dx.doi.org/10.1002/aur.2613 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

The association between COVID-19, personal wellbeing, depression, and suicide risk factors in Australian autistic adults / D. HEDLEY in Autism Research, 14-12 (December 2021)  

Public ISBD [article]  inAutism Research > 14-12 (December 2021) . - p.2663-2676 Titre : The association between COVID-19, personal wellbeing, depression, and suicide risk factors in Australian autistic adults Type de document : Texte imprimé et/ou numérique Auteurs : D. HEDLEY, Auteur ; S. M. HAYWARD, Auteur ; K. DENNEY, Auteur ; M. ULJAREVIC, Auteur ; S. BURY, Auteur ; E. SAHIN, Auteur ; C. M. BROWN, Auteur ; A. CLAPPERTON, Auteur ; Cheryl DISSANAYAKE, Auteur ; J. ROBINSON, Auteur ; J. TROLLOR, Auteur ; M. A. STOKES, Auteur Article en page(s) : p.2663-2676 Langues : Anglais (eng) Mots-clés : Adult  Australia/epidemiology  Autism Spectrum Disorder  Autistic Disorder  Covid-19  Depression/epidemiology  Female  Humans  Male  Pandemics  Risk Factors  SARS-CoV-2  Suicide  COVID-19 pandemic  adults  depression  gender  wellbeing  Prevention Research fellowship. Mirko Uljarevi? is supported by a Discovery Early  Career Researcher Award from the Australian Research Council (DE180100632). Jo  Robinson is supported by a National Health and Medical Research Council (NHMRC)  Career Development Fellowship (APP1142348) and a University of Melbourne Dame Kate  Campbell Fellowship. The authors declare no actual or potential conflict of  interest. Index. décimale : PER Périodiques Résumé : The COVID-19 pandemic has had a significant impact on the mental health and wellbeing of the world's population, with particularly negative effects on vulnerable populations, including autistic people. Although some consensus regarding specific impact on aspects of wellbeing and mental health in autism is starting to emerge, it is unclear whether the pandemic has increased suicide risk. The goals of this study were to examine (a) potential associations between COVID-19 impact and depression, personal wellbeing, and suicide risk factors in Australian autistic adults and (b) age and gender effects. The COVID-19 Impact Scale (CIS), Personal Wellbeing Index, Patient Health Questionnaire, and the Suicide Behavior Questionnaire, Revised (SBQ-R), were administered to 111 autistic adults aged 20 to 71?years during the second wave of the COVID-19 pandemic in Australia. COVID-19 impact showed small associations with poorer personal wellbeing (r?=?-0.224, p?= 0.023, [-0.409, -0.016]) and higher depressive symptoms (r?= 0.268, p?= 0.006, [0.056, 0.445]) and was not associated with the SBQ-R suicide risk score (r?= 0.081, p?= 0.418, [-0.118, 0.264). No significant effects were identified for age. Although model results were similar for women and men, the strength of the associations between personal wellbeing and depression (z?=?-2.16, p?= 0.015), and depression and SBQ-R suicide risk (z?= 1.961, p?= 0.025), were stronger in women than in men. Qualitative analysis of an open response question from the CIS suggested that the pandemic had both positive and negative impacts on participants. The COVID-19 pandemic has had a large impact on the mental health and wellbeing of the world's population, particularly vulnerable populations such as autistic people. It is not known if these impacts on mental health and wellbeing have increased suicide risk. Our findings suggest that the impact of the COVID-19 pandemic may be associated with poorer wellbeing and higher depression, but is not associated with suicide risk. Overall, autistic people reported both positive and negative impacts of the pandemic on their lives. En ligne : http://dx.doi.org/10.1002/aur.2614 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] The association between COVID-19, personal wellbeing, depression, and suicide risk factors in Australian autistic adults [Texte imprimé et/ou numérique] / D. HEDLEY, Auteur ; S. M. HAYWARD, Auteur ; K. DENNEY, Auteur ; M. ULJAREVIC, Auteur ; S. BURY, Auteur ; E. SAHIN, Auteur ; C. M. BROWN, Auteur ; A. CLAPPERTON, Auteur ; Cheryl DISSANAYAKE, Auteur ; J. ROBINSON, Auteur ; J. TROLLOR, Auteur ; M. A. STOKES, Auteur . - p.2663-2676. Langues : Anglais (eng) in Autism Research > 14-12 (December 2021) . - p.2663-2676 Mots-clés : Adult  Australia/epidemiology  Autism Spectrum Disorder  Autistic Disorder  Covid-19  Depression/epidemiology  Female  Humans  Male  Pandemics  Risk Factors  SARS-CoV-2  Suicide  COVID-19 pandemic  adults  depression  gender  wellbeing  Prevention Research fellowship. Mirko Uljarevi? is supported by a Discovery Early  Career Researcher Award from the Australian Research Council (DE180100632). Jo  Robinson is supported by a National Health and Medical Research Council (NHMRC)  Career Development Fellowship (APP1142348) and a University of Melbourne Dame Kate  Campbell Fellowship. The authors declare no actual or potential conflict of  interest. Index. décimale : PER Périodiques Résumé : The COVID-19 pandemic has had a significant impact on the mental health and wellbeing of the world's population, with particularly negative effects on vulnerable populations, including autistic people. Although some consensus regarding specific impact on aspects of wellbeing and mental health in autism is starting to emerge, it is unclear whether the pandemic has increased suicide risk. The goals of this study were to examine (a) potential associations between COVID-19 impact and depression, personal wellbeing, and suicide risk factors in Australian autistic adults and (b) age and gender effects. The COVID-19 Impact Scale (CIS), Personal Wellbeing Index, Patient Health Questionnaire, and the Suicide Behavior Questionnaire, Revised (SBQ-R), were administered to 111 autistic adults aged 20 to 71?years during the second wave of the COVID-19 pandemic in Australia. COVID-19 impact showed small associations with poorer personal wellbeing (r?=?-0.224, p?= 0.023, [-0.409, -0.016]) and higher depressive symptoms (r?= 0.268, p?= 0.006, [0.056, 0.445]) and was not associated with the SBQ-R suicide risk score (r?= 0.081, p?= 0.418, [-0.118, 0.264). No significant effects were identified for age. Although model results were similar for women and men, the strength of the associations between personal wellbeing and depression (z?=?-2.16, p?= 0.015), and depression and SBQ-R suicide risk (z?= 1.961, p?= 0.025), were stronger in women than in men. Qualitative analysis of an open response question from the CIS suggested that the pandemic had both positive and negative impacts on participants. The COVID-19 pandemic has had a large impact on the mental health and wellbeing of the world's population, particularly vulnerable populations such as autistic people. It is not known if these impacts on mental health and wellbeing have increased suicide risk. Our findings suggest that the impact of the COVID-19 pandemic may be associated with poorer wellbeing and higher depression, but is not associated with suicide risk. Overall, autistic people reported both positive and negative impacts of the pandemic on their lives. En ligne : http://dx.doi.org/10.1002/aur.2614 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Factors associated with age at autism diagnosis in a community sample of Australian adults / Y. HUANG in Autism Research, 14-12 (December 2021)  

Public ISBD [article]  inAutism Research > 14-12 (December 2021) . - p.2677-2687 Titre : Factors associated with age at autism diagnosis in a community sample of Australian adults Type de document : Texte imprimé et/ou numérique Auteurs : Y. HUANG, Auteur ; Samuel R. C. ARNOLD, Auteur ; K. R. FOLEY, Auteur ; L. P. LAWSON, Auteur ; A. L. RICHDALE, Auteur ; J. N. TROLLOR, Auteur Article en page(s) : p.2677-2687 Langues : Anglais (eng) Mots-clés : Adult  Aged  Australia/epidemiology  Autism Spectrum Disorder  Autistic Disorder/diagnosis/epidemiology  Child  Cross-Sectional Studies  Female  Humans  Longitudinal Studies  adults  aging/ASD in adults  diagnosis  gender/female ASD Index. décimale : PER Périodiques Résumé : Autism diagnosis in adulthood has become increasingly common due to a range of factors including changes in awareness, diagnostic criteria, and professional practices. Past research identified a range of demographic and autism-related factors associated with autism diagnosis age in children. However, it is unclear whether these apply to autistic adults. This study aimed to examine predictors of autism diagnosis age in adults while controlling for current age and autistic traits. We used a cross-sectional sample of 657 adults aged 15-80 from three self and carer-report studies: the Australian Longitudinal Study of Autism in Adulthood (ALSAA), Study of Australian School-Leavers with Autism (SASLA) and Pathways, Predictors and Impact of Receiving an Autism Spectrum Diagnosis in Adulthood (Pathways). Using hierarchical multiplicative heteroscedastic regression, we found that older current age and higher self-reported autistic traits predicted older diagnosis age, and that female gender, lack of intellectual disability, language other than English, family history of autism, lifetime depression, and no obsessive-compulsive disorder predicted older diagnosis age beyond current age and autistic traits. The paradoxical relationship between high autistic traits and older diagnosis age requires further investigation. Based on these findings, we recommended strategies to improve autism recognition in women and people from non-English-speaking backgrounds. Future studies could extend the findings by examining the effects of childhood and adulthood socioeconomic status on adult diagnosis age. LAY SUMMARY: We studied the relationship between age at autism diagnosis and other characteristics in adults. We found that both older current age and higher autistic traits, female gender, language other than English, family history of autism, and history of depression were related to older age at diagnosis, while intellectual disability and history of obsessive-compulsive disorder were related to younger age at diagnosis. Our findings suggest more work is needed to help recognize autism in women and people from non-English-speaking backgrounds. En ligne : http://dx.doi.org/10.1002/aur.2610 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Factors associated with age at autism diagnosis in a community sample of Australian adults [Texte imprimé et/ou numérique] / Y. HUANG, Auteur ; Samuel R. C. ARNOLD, Auteur ; K. R. FOLEY, Auteur ; L. P. LAWSON, Auteur ; A. L. RICHDALE, Auteur ; J. N. TROLLOR, Auteur . - p.2677-2687. Langues : Anglais (eng) in Autism Research > 14-12 (December 2021) . - p.2677-2687 Mots-clés : Adult  Aged  Australia/epidemiology  Autism Spectrum Disorder  Autistic Disorder/diagnosis/epidemiology  Child  Cross-Sectional Studies  Female  Humans  Longitudinal Studies  adults  aging/ASD in adults  diagnosis  gender/female ASD Index. décimale : PER Périodiques Résumé : Autism diagnosis in adulthood has become increasingly common due to a range of factors including changes in awareness, diagnostic criteria, and professional practices. Past research identified a range of demographic and autism-related factors associated with autism diagnosis age in children. However, it is unclear whether these apply to autistic adults. This study aimed to examine predictors of autism diagnosis age in adults while controlling for current age and autistic traits. We used a cross-sectional sample of 657 adults aged 15-80 from three self and carer-report studies: the Australian Longitudinal Study of Autism in Adulthood (ALSAA), Study of Australian School-Leavers with Autism (SASLA) and Pathways, Predictors and Impact of Receiving an Autism Spectrum Diagnosis in Adulthood (Pathways). Using hierarchical multiplicative heteroscedastic regression, we found that older current age and higher self-reported autistic traits predicted older diagnosis age, and that female gender, lack of intellectual disability, language other than English, family history of autism, lifetime depression, and no obsessive-compulsive disorder predicted older diagnosis age beyond current age and autistic traits. The paradoxical relationship between high autistic traits and older diagnosis age requires further investigation. Based on these findings, we recommended strategies to improve autism recognition in women and people from non-English-speaking backgrounds. Future studies could extend the findings by examining the effects of childhood and adulthood socioeconomic status on adult diagnosis age. LAY SUMMARY: We studied the relationship between age at autism diagnosis and other characteristics in adults. We found that both older current age and higher autistic traits, female gender, language other than English, family history of autism, and history of depression were related to older age at diagnosis, while intellectual disability and history of obsessive-compulsive disorder were related to younger age at diagnosis. Our findings suggest more work is needed to help recognize autism in women and people from non-English-speaking backgrounds. En ligne : http://dx.doi.org/10.1002/aur.2610 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Overlap of autism spectrum disorder and borderline personality disorder: A systematic review and meta-analysis / T. MAY in Autism Research, 14-12 (December 2021)  

Public ISBD [article]  inAutism Research > 14-12 (December 2021) . - p.2688-2710 Titre : Overlap of autism spectrum disorder and borderline personality disorder: A systematic review and meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : T. MAY, Auteur ; P. D. PILKINGTON, Auteur ; R. YOUNAN, Auteur ; K. WILLIAMS, Auteur Article en page(s) : p.2688-2710 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/epidemiology  Borderline Personality Disorder/epidemiology  Case-Control Studies  Humans  Prevalence  autism spectrum disorder  borderline personality disorder Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) and borderline personality Disorder (BPD) share features, including social and emotion regulation difficulties. The evidence for the overlap in prevalence and clinical characteristics was systematically reviewed. Ovid Medline, PsycInfo, and PubMed were searched until November 30, 2020 using keywords relating to BPD and ASD. Studies that reported on the overlap of ASD and BPD diagnoses or traits and used a case, cohort, or case-controlled design were included. Of 1633 screened studies, 19 were included, of which 12 reported data suitable for meta-analysis. Most samples were of small, clinically ascertained groups, with 11 having high risk of bias. The pooled prevalence of BPD in ASD was 4% [95% CI 0%-9%] and of ASD in BPD, 3% [95% CI 1%-8%]. There were inconsistent findings across clinical areas. The prevalence of a dual diagnosis of BPD in ASD cohorts and of ASD in BPD cohorts was within population prevalence estimates of each disorder. Based on this data we were not able to assess whether there is misdiagnosis of one in favor of the other. Neurocognitive differences may underlie similar behavioral symptoms, but further research using larger, well-validated samples is needed. LAY SUMMARY: Autism spectrum disorder (ASD) and borderline personality disorder (BPD) have overlaps in their symptoms. The overlap in how frequently they co-occur and their presentation was systematically reviewed. We searched the key databases and including all studies that reported on the overlap of ASD and BPD diagnoses or traits and used a case, cohort or case-controlled design. Of 1633 studies, 19 were included, of which 12 reported data suitable for pooling. Most samples were of small, clinical groups, with 11 having high risk of bias. The pooled prevalence of BPD in ASD was 4% [95% CI 0%-9%] and of ASD in BPD, 3% [95% CI 1%-8%]. There were inconsistent findings across studies comparing ASD and BPD related symptoms and problems. The prevalence of a dual diagnosis of BPD in ASD cohorts and of ASD in BPD cohorts was similar to the population prevalence of each disorder. Further research using larger, well-validated samples is needed. En ligne : http://dx.doi.org/10.1002/aur.2619 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Overlap of autism spectrum disorder and borderline personality disorder: A systematic review and meta-analysis [Texte imprimé et/ou numérique] / T. MAY, Auteur ; P. D. PILKINGTON, Auteur ; R. YOUNAN, Auteur ; K. WILLIAMS, Auteur . - p.2688-2710. Langues : Anglais (eng) in Autism Research > 14-12 (December 2021) . - p.2688-2710 Mots-clés : Autism Spectrum Disorder/epidemiology  Borderline Personality Disorder/epidemiology  Case-Control Studies  Humans  Prevalence  autism spectrum disorder  borderline personality disorder Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) and borderline personality Disorder (BPD) share features, including social and emotion regulation difficulties. The evidence for the overlap in prevalence and clinical characteristics was systematically reviewed. Ovid Medline, PsycInfo, and PubMed were searched until November 30, 2020 using keywords relating to BPD and ASD. Studies that reported on the overlap of ASD and BPD diagnoses or traits and used a case, cohort, or case-controlled design were included. Of 1633 screened studies, 19 were included, of which 12 reported data suitable for meta-analysis. Most samples were of small, clinically ascertained groups, with 11 having high risk of bias. The pooled prevalence of BPD in ASD was 4% [95% CI 0%-9%] and of ASD in BPD, 3% [95% CI 1%-8%]. There were inconsistent findings across clinical areas. The prevalence of a dual diagnosis of BPD in ASD cohorts and of ASD in BPD cohorts was within population prevalence estimates of each disorder. Based on this data we were not able to assess whether there is misdiagnosis of one in favor of the other. Neurocognitive differences may underlie similar behavioral symptoms, but further research using larger, well-validated samples is needed. LAY SUMMARY: Autism spectrum disorder (ASD) and borderline personality disorder (BPD) have overlaps in their symptoms. The overlap in how frequently they co-occur and their presentation was systematically reviewed. We searched the key databases and including all studies that reported on the overlap of ASD and BPD diagnoses or traits and used a case, cohort or case-controlled design. Of 1633 studies, 19 were included, of which 12 reported data suitable for pooling. Most samples were of small, clinical groups, with 11 having high risk of bias. The pooled prevalence of BPD in ASD was 4% [95% CI 0%-9%] and of ASD in BPD, 3% [95% CI 1%-8%]. There were inconsistent findings across studies comparing ASD and BPD related symptoms and problems. The prevalence of a dual diagnosis of BPD in ASD cohorts and of ASD in BPD cohorts was similar to the population prevalence of each disorder. Further research using larger, well-validated samples is needed. En ligne : http://dx.doi.org/10.1002/aur.2619 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

INSAR President's message in Autism Research, 14-12 (December 2021)  

Public ISBD [article]  inAutism Research > 14-12 (December 2021) . - p.2711-2712 Titre : INSAR President's message Type de document : Texte imprimé et/ou numérique Article en page(s) : p.2711-2712 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Humans Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.2649 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] INSAR President's message [Texte imprimé et/ou numérique] . - p.2711-2712. Langues : Anglais (eng) in Autism Research > 14-12 (December 2021) . - p.2711-2712 Mots-clés : Autism Spectrum Disorder  Humans Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.2649 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450